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The map label for this gene is clpA [C]

Identifier: 88607130

GI number: 88607130

Start: 472014

End: 474335

Strand: Direct

Name: clpA [C]

Synonym: APH_0450

Alternate gene names: 88607130

Gene position: 472014-474335 (Clockwise)

Preceding gene: 88607832

Following gene: 88607727

Centisome position: 32.08

GC content: 42.64

Gene sequence:

>2322_bases
GTGTTGTCGAAAAATCTTGAAGCGAGTTTGCACCGCGCTATATCGATAGCATTCGATTTTCGTCATGAATGTGCGACTCT
CGAGCACTTATTATTAGCGCTTACTGATGATGTTGATGTGCGTCGTGTGTTGTATGTGTGCAGAGTTTCAGTAGATAGGT
TAAGGCTTACGGTCATGAACTTTCTGCGATATGAAATGTCAGTATCTTCAGGGCACATTCTTGGGGAAGTAAAGCCTAGC
AGGGTTTTTGAGAAGGTGGTACACAGAGCTGTAGTTCATGCTCATGCTTCAGGTGCGGATGAAATTAATGGTGTGAATGT
CCTGGCTGAGATGTTTTTGGAAAAGGAATCCCATAGCTTTTCCTTTCTTAACGAGCATAACGTTAAGTACATCGATGTAG
TGAGTTGCATGTCTAGCGGCGAGAATATGCACGATGAGGGCTATGAGCAGCACGATATTATAAAGGATGCTGATGCTAGT
AGTAGGAGGGGTTCTGTTGCGTTTCCAAATATAGTCAAGGACTCAGTAAGGAAGGATGGTGACAGCCTTGAAGCGTATTG
TGTTAACCTTAATGACTTGGCCAGGGAAGGTAAGATAGATTACGTTATAGGCCGTCAATACGAACAGGAAAGAACAATAG
AGGTTTTGTTGCGGCGTAGGAAAAACAATCCTCTATACGTCGGAGATTCTGGGGTTGGTAAAACAGCTATAGTAGAGGGG
TTAGTACTTAGAATAGTAGAAGGTAATATAGTTTCGCAGTTGCGCTGTGTTGAAGTTTATTCCTTAGATATGGGGTCTCT
ATTAGCAGGAACAAGGTATAGAGGGGACTTTGAAGAAAGGATTAAGGCTGTTATTCGGGCTATAGAGAATAAGAAAAATG
CGGTACTGTTTATAGATGAGATTCATACTATCATCGGTGCTGGTTCTACTAGTGGCAGCCCTTTAGATGCCAGTAATCTT
CTTAAACCTGCGCTTGCTAGAGGTACTATCAGGTGTATTGGTGCTACTACTCACAAGGAGTACAACAGTAACTTTGAAAA
GGACCGTGCTCTAGCTAGAAGATATCAAAAAATCAATGTTGAAGAATCTACTGTAGAGGAAACCGTTCAAATATTGAGTG
GAATTAAGTCCTACTACGAAGTATATCACGACGTGCGCTATACAAACCAAGCGATCAGGTATGCTGCAGAGTTGTCGGAT
AGATATATAAGCGAAAGAATGTTGCCAGATAAGGCGGTGGATGTACTTGACGAAGCTGGTGTTTATAGCAAACTACGCTC
TCCAGAATCCAGCAGGATTGTTACGGGTAAGGATATAGGGGCTATAATCTCTAAAATTACTGAGGTTCCGTGTAGCGACC
TTTTGGCTTCTGATGATATACGAAAGGTGCGGGATCTTGAGGATAATCTTAAGAAGGTGATCTTCGGGCAGGATGAGGCT
ATAACGCATGTTGTAGATGCTATAAGGATAGCGAAAGCTGGGATGAGAAGTTCGCAGAAGCCTTTGGCGTGTTATTTATT
TGCAGGTCCTACGGGTGTTGGGAAGACGGAGCTAGTTAGGCAGTTTGCCAAATGTATGGGCATGAAGTTGATTAGATTTG
ACATGTCTGAGTATGTAGAATCCCATACAGTTTCCAGGATGATAGGTTCGCCGCCAGGTTATGTGGGATACGAACAGGGT
GGATTGTTAACTGATGCCATTTCCCGTAATCAGTATAGTGTTCTGCTATTAGATGAGATAGAAAAGGCCCATAGCAGCTT
ATATAACATACTGCTGCAAATTATGGATTATGGTTACATTACAGATACGTATGGCAAAAAGGTCAGTTTCCGCAATGTTG
TTATAATACTGACTACCAATGCTGGTGCTATGGAGCTTAGCCGCAATCCTATAGGATTTAATCGTGATAGTAACGTGCGG
ATTGACAATGCACGTAAGGTCATTGAAAAGATTTTTGGTCCGGAGTTTTGTAACAGGCTTGATGCGATAGTGCCATTTGC
GTACCTGGATTCTTGTGTCATAGCACAGGTTGTGGAGAAATTTATCAATGAGCTCAGGGAGCAGCTTGCTCATAAGGATG
TGAGCATCGATATTGATCAGGAATCGCTGAGTTATCTCGCAAAACTTGGTCAAAGGGAAGACTACGGCGTTAGAAAGATA
CAAGGTATTGTGGCGCAGAAGCTGAAGAAGCAGCTAGCTTTTGAAATGTTGTTTGGTAAACTTGTCCACGGAGGCAAGGT
TGAAGTTAGGTACGATCCCGACAGTGATGACTTCAAGTACACATTTTTTGAGAGATCTGCTGCTAGTAGCATGGTGGGAT
AA

Upstream 100 bases:

>100_bases
ATAGGTTACATCTTTTTTTGCAAGCAATCCAAGTTGTTTTCAACATATTTTAATGCTTACCTGATACCCTGATGCACAAG
AGAAATAGGGGTTGCGTTTA

Downstream 100 bases:

>100_bases
CTTACGAGAAGTGTGTTTTTATCTTTGATTATTTTGGCTAATAATATAGATTTATCCCATTGCGTTTTAGAGAAGATAAA
TAATGTCGAGTGGCTACGAT

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MLSKNLEASLHRAISIAFDFRHECATLEHLLLALTDDVDVRRVLYVCRVSVDRLRLTVMNFLRYEMSVSSGHILGEVKPS
RVFEKVVHRAVVHAHASGADEINGVNVLAEMFLEKESHSFSFLNEHNVKYIDVVSCMSSGENMHDEGYEQHDIIKDADAS
SRRGSVAFPNIVKDSVRKDGDSLEAYCVNLNDLAREGKIDYVIGRQYEQERTIEVLLRRRKNNPLYVGDSGVGKTAIVEG
LVLRIVEGNIVSQLRCVEVYSLDMGSLLAGTRYRGDFEERIKAVIRAIENKKNAVLFIDEIHTIIGAGSTSGSPLDASNL
LKPALARGTIRCIGATTHKEYNSNFEKDRALARRYQKINVEESTVEETVQILSGIKSYYEVYHDVRYTNQAIRYAAELSD
RYISERMLPDKAVDVLDEAGVYSKLRSPESSRIVTGKDIGAIISKITEVPCSDLLASDDIRKVRDLEDNLKKVIFGQDEA
ITHVVDAIRIAKAGMRSSQKPLACYLFAGPTGVGKTELVRQFAKCMGMKLIRFDMSEYVESHTVSRMIGSPPGYVGYEQG
GLLTDAISRNQYSVLLLDEIEKAHSSLYNILLQIMDYGYITDTYGKKVSFRNVVIILTTNAGAMELSRNPIGFNRDSNVR
IDNARKVIEKIFGPEFCNRLDAIVPFAYLDSCVIAQVVEKFINELREQLAHKDVSIDIDQESLSYLAKLGQREDYGVRKI
QGIVAQKLKKQLAFEMLFGKLVHGGKVEVRYDPDSDDFKYTFFERSAASSMVG

Sequences:

>Translated_773_residues
MLSKNLEASLHRAISIAFDFRHECATLEHLLLALTDDVDVRRVLYVCRVSVDRLRLTVMNFLRYEMSVSSGHILGEVKPS
RVFEKVVHRAVVHAHASGADEINGVNVLAEMFLEKESHSFSFLNEHNVKYIDVVSCMSSGENMHDEGYEQHDIIKDADAS
SRRGSVAFPNIVKDSVRKDGDSLEAYCVNLNDLAREGKIDYVIGRQYEQERTIEVLLRRRKNNPLYVGDSGVGKTAIVEG
LVLRIVEGNIVSQLRCVEVYSLDMGSLLAGTRYRGDFEERIKAVIRAIENKKNAVLFIDEIHTIIGAGSTSGSPLDASNL
LKPALARGTIRCIGATTHKEYNSNFEKDRALARRYQKINVEESTVEETVQILSGIKSYYEVYHDVRYTNQAIRYAAELSD
RYISERMLPDKAVDVLDEAGVYSKLRSPESSRIVTGKDIGAIISKITEVPCSDLLASDDIRKVRDLEDNLKKVIFGQDEA
ITHVVDAIRIAKAGMRSSQKPLACYLFAGPTGVGKTELVRQFAKCMGMKLIRFDMSEYVESHTVSRMIGSPPGYVGYEQG
GLLTDAISRNQYSVLLLDEIEKAHSSLYNILLQIMDYGYITDTYGKKVSFRNVVIILTTNAGAMELSRNPIGFNRDSNVR
IDNARKVIEKIFGPEFCNRLDAIVPFAYLDSCVIAQVVEKFINELREQLAHKDVSIDIDQESLSYLAKLGQREDYGVRKI
QGIVAQKLKKQLAFEMLFGKLVHGGKVEVRYDPDSDDFKYTFFERSAASSMVG
>Mature_773_residues
MLSKNLEASLHRAISIAFDFRHECATLEHLLLALTDDVDVRRVLYVCRVSVDRLRLTVMNFLRYEMSVSSGHILGEVKPS
RVFEKVVHRAVVHAHASGADEINGVNVLAEMFLEKESHSFSFLNEHNVKYIDVVSCMSSGENMHDEGYEQHDIIKDADAS
SRRGSVAFPNIVKDSVRKDGDSLEAYCVNLNDLAREGKIDYVIGRQYEQERTIEVLLRRRKNNPLYVGDSGVGKTAIVEG
LVLRIVEGNIVSQLRCVEVYSLDMGSLLAGTRYRGDFEERIKAVIRAIENKKNAVLFIDEIHTIIGAGSTSGSPLDASNL
LKPALARGTIRCIGATTHKEYNSNFEKDRALARRYQKINVEESTVEETVQILSGIKSYYEVYHDVRYTNQAIRYAAELSD
RYISERMLPDKAVDVLDEAGVYSKLRSPESSRIVTGKDIGAIISKITEVPCSDLLASDDIRKVRDLEDNLKKVIFGQDEA
ITHVVDAIRIAKAGMRSSQKPLACYLFAGPTGVGKTELVRQFAKCMGMKLIRFDMSEYVESHTVSRMIGSPPGYVGYEQG
GLLTDAISRNQYSVLLLDEIEKAHSSLYNILLQIMDYGYITDTYGKKVSFRNVVIILTTNAGAMELSRNPIGFNRDSNVR
IDNARKVIEKIFGPEFCNRLDAIVPFAYLDSCVIAQVVEKFINELREQLAHKDVSIDIDQESLSYLAKLGQREDYGVRKI
QGIVAQKLKKQLAFEMLFGKLVHGGKVEVRYDPDSDDFKYTFFERSAASSMVG

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=300, Percent_Identity=34.6666666666667, Blast_Score=153, Evalue=7e-37,
Organism=Escherichia coli, GI1787109, Length=765, Percent_Identity=48.1045751633987, Blast_Score=714, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=276, Percent_Identity=49.6376811594203, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6320464, Length=246, Percent_Identity=51.219512195122, Blast_Score=246, Evalue=9e-66,
Organism=Saccharomyces cerevisiae, GI6323002, Length=236, Percent_Identity=48.3050847457627, Blast_Score=232, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 86771; Mature: 86771

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKNLEASLHRAISIAFDFRHECATLEHLLLALTDDVDVRRVLYVCRVSVDRLRLTVMN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
FLRYEMSVSSGHILGEVKPSRVFEKVVHRAVVHAHASGADEINGVNVLAEMFLEKESHSF
HHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
SFLNEHNVKYIDVVSCMSSGENMHDEGYEQHDIIKDADASSRRGSVAFPNIVKDSVRKDG
CCCCCCCCEEEHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
DSLEAYCVNLNDLAREGKIDYVIGRQYEQERTIEVLLRRRKNNPLYVGDSGVGKTAIVEG
CCCEEEEECHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
LVLRIVEGNIVSQLRCVEVYSLDMGSLLAGTRYRGDFEERIKAVIRAIENKKNAVLFIDE
HHHHHHCCCHHHHHHHHHHEECCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
IHTIIGAGSTSGSPLDASNLLKPALARGTIRCIGATTHKEYNSNFEKDRALARRYQKINV
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHCCC
EESTVEETVQILSGIKSYYEVYHDVRYTNQAIRYAAELSDRYISERMLPDKAVDVLDEAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
VYSKLRSPESSRIVTGKDIGAIISKITEVPCSDLLASDDIRKVRDLEDNLKKVIFGQDEA
HHHHHCCCCCCCEECCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
ITHVVDAIRIAKAGMRSSQKPLACYLFAGPTGVGKTELVRQFAKCMGMKLIRFDMSEYVE
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
SHTVSRMIGSPPGYVGYEQGGLLTDAISRNQYSVLLLDEIEKAHSSLYNILLQIMDYGYI
HHHHHHHHCCCCCCCCCCCCCEEHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCE
TDTYGKKVSFRNVVIILTTNAGAMELSRNPIGFNRDSNVRIDNARKVIEKIFGPEFCNRL
ECCCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHCHHHHHHH
DAIVPFAYLDSCVIAQVVEKFINELREQLAHKDVSIDIDQESLSYLAKLGQREDYGVRKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCHHHH
QGIVAQKLKKQLAFEMLFGKLVHGGKVEVRYDPDSDDFKYTFFERSAASSMVG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHCCCC
>Mature Secondary Structure
MLSKNLEASLHRAISIAFDFRHECATLEHLLLALTDDVDVRRVLYVCRVSVDRLRLTVMN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
FLRYEMSVSSGHILGEVKPSRVFEKVVHRAVVHAHASGADEINGVNVLAEMFLEKESHSF
HHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
SFLNEHNVKYIDVVSCMSSGENMHDEGYEQHDIIKDADASSRRGSVAFPNIVKDSVRKDG
CCCCCCCCEEEHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
DSLEAYCVNLNDLAREGKIDYVIGRQYEQERTIEVLLRRRKNNPLYVGDSGVGKTAIVEG
CCCEEEEECHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
LVLRIVEGNIVSQLRCVEVYSLDMGSLLAGTRYRGDFEERIKAVIRAIENKKNAVLFIDE
HHHHHHCCCHHHHHHHHHHEECCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
IHTIIGAGSTSGSPLDASNLLKPALARGTIRCIGATTHKEYNSNFEKDRALARRYQKINV
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHCCC
EESTVEETVQILSGIKSYYEVYHDVRYTNQAIRYAAELSDRYISERMLPDKAVDVLDEAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
VYSKLRSPESSRIVTGKDIGAIISKITEVPCSDLLASDDIRKVRDLEDNLKKVIFGQDEA
HHHHHCCCCCCCEECCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
ITHVVDAIRIAKAGMRSSQKPLACYLFAGPTGVGKTELVRQFAKCMGMKLIRFDMSEYVE
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
SHTVSRMIGSPPGYVGYEQGGLLTDAISRNQYSVLLLDEIEKAHSSLYNILLQIMDYGYI
HHHHHHHHCCCCCCCCCCCCCEEHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCE
TDTYGKKVSFRNVVIILTTNAGAMELSRNPIGFNRDSNVRIDNARKVIEKIFGPEFCNRL
ECCCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHCHHHHHHH
DAIVPFAYLDSCVIAQVVEKFINELREQLAHKDVSIDIDQESLSYLAKLGQREDYGVRKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCHHHH
QGIVAQKLKKQLAFEMLFGKLVHGGKVEVRYDPDSDDFKYTFFERSAASSMVG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]