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The map label for this gene is pepQ [H]

Identifier: 88606716

GI number: 88606716

Start: 342279

End: 343988

Strand: Direct

Name: pepQ [H]

Synonym: APH_0353

Alternate gene names: 88606716

Gene position: 342279-343988 (Clockwise)

Preceding gene: 88607178

Following gene: 88607853

Centisome position: 23.26

GC content: 41.87

Gene sequence:

>1710_bases
ATGAATTTGAAGCTTAGAGATTTGAGGCTTGCGATGCGTGAGCAAGGTGTGGAAGTACTGTTGCTGAATCACGCGGATGA
ATATCAGTCAGGGTATGTGAATGAGAATAGGCAGAGAGTCGCGTGGTTGTGTGGATTTACGGGATCAAACGCGTTTCTTA
TAATACGTAGTGAGGGGAAATGTATCTTTTTTACCGATAGCAGATATTCCATTCAAGCTTCCCTAGAGGTTGATCAAAGT
TGCTATGATATTTACGATATGAGCGACGTTACTCCTGCGATATGGTTGAAAGAGAATTTGCCATTAGGAACTATAATAGG
CTACTATGGCGAATTATTTACCCTGCGCCAAATACAAAGATTTAAGCGCTTTTGTCTGAAAATGCTCTCGTGTCAAATGC
TGGATAAGCTCTGGGATAGACCTATGGAGATTCGGCAGCGTGTTGTGACACATCCAGTGAGATTTGCAGGGCTTGAAAGT
TGTGATAAGCGTGCAATTCTAGCATCTAAGATGCAGAGTTGTGAATCAATGCTCATAACGGATGTAGATTCTATATCATG
GTTGCTGAATATACGTAACTTAGACTTTGCCTATAATCCGGCTGTTTTATCTCGTGCTATCTTGTATAAGGATGAAAGGG
TAGACCTCTTTATCGAAGGTGCAGACCGAGTAGCCATAGATGGAAAAGGTATTAATGTACTTGAGATAGATGAGCTACCT
AATGTCCTGAAGGGCTTAAGCAACATAGCGGTAGATGCTTCAACTATTCCCATATACATATTCGATATGATAAAAGATCG
GGTGTCTGTAATTGAAGATCAGGACGCCTGTACTATATTCAAGGCAAAAAAGAATGCTATCGAAATTGATGGTATGAAGG
AAGCCCATGTTAGGGATGGGGTTGCAGTAGTCAATTTTTTGTATTGGCTTGATTGTAGTATCGCGAATAACCTGAGGGTG
ACCGAGCTTGATGCTGTATCGAAAATTAGGGAGTTTCGGCAGCAGCAGGATATGTTTATGGGAGAGAGTTTTGAGACTAT
TTCCGGATTCGGAGGCAATGGAGCAATTGTCCATTATAGGGTGGATGAGAAGAGCAATAAGGTACTTGAAAAAGATGGCA
TATACCTCATAGATTCTGGTGGTCAGTATAGCGATGGTACAACAGACATCACGCGTACAGTTGCGATAGGTGCTCCTTCA
GTAGAACAGGTAGCGCGTTTTACTATGGTTCTCAAAGGTTTTATAGCTGTTGCAAATGCAGCATTTCCCATAGGTACGAC
TGGTGCTGCATTGGACGTTTTAGCACGCCAATATCTGTGGCAAAAACAACTCAACTATGGGCATTCTACTGGTCATGGGG
TTGGGAGCTTTCTTTCGGTACATGAGGGACCTCAAGCTATTTCTCCTATTAATAGTGTGCCGTTGGAGCCGGGTATGGTT
TTGTCTAATGAGCCAGGATATTATGAGCAAGATGCTTATGGTATCAGAATAGAAAATCTTATGTACGTTGTGGATTGTGG
TAGGGGATTTTACAGATTCAGACAGCTGACGTGTGTTCCTATATGTTTGGATATGATAGATCGTAGCATGCTTAGTCGTG
AGGAGATTGAATATCTGAATGAATATCATAGCTTTGTGTTTGAGGTTATTGCACCACGCGTGAGTGAAGAAGTAAAACAG
TGGCTTCAAGTAGCGTGCAGAAGAATATAG

Upstream 100 bases:

>100_bases
AGTTGTAAATCGCCATAGTAGCTGTCTTCTATAATTTTCCAGGCTTGGATTTCCGAATGCTGCTGTAAAAACCCTGCATT
CTGTTATGAGGAACTGGTAT

Downstream 100 bases:

>100_bases
GGTTTGATAGACGGTTTTAGGGTAATGATGCAATATGGGGTAAGTGCTCAGCATTTTGCACAATGAAAGCGGTGTCTGAA
TGTGTTGTGTAGACAGCTTA

Product: M24 family metallopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MNLKLRDLRLAMREQGVEVLLLNHADEYQSGYVNENRQRVAWLCGFTGSNAFLIIRSEGKCIFFTDSRYSIQASLEVDQS
CYDIYDMSDVTPAIWLKENLPLGTIIGYYGELFTLRQIQRFKRFCLKMLSCQMLDKLWDRPMEIRQRVVTHPVRFAGLES
CDKRAILASKMQSCESMLITDVDSISWLLNIRNLDFAYNPAVLSRAILYKDERVDLFIEGADRVAIDGKGINVLEIDELP
NVLKGLSNIAVDASTIPIYIFDMIKDRVSVIEDQDACTIFKAKKNAIEIDGMKEAHVRDGVAVVNFLYWLDCSIANNLRV
TELDAVSKIREFRQQQDMFMGESFETISGFGGNGAIVHYRVDEKSNKVLEKDGIYLIDSGGQYSDGTTDITRTVAIGAPS
VEQVARFTMVLKGFIAVANAAFPIGTTGAALDVLARQYLWQKQLNYGHSTGHGVGSFLSVHEGPQAISPINSVPLEPGMV
LSNEPGYYEQDAYGIRIENLMYVVDCGRGFYRFRQLTCVPICLDMIDRSMLSREEIEYLNEYHSFVFEVIAPRVSEEVKQ
WLQVACRRI

Sequences:

>Translated_569_residues
MNLKLRDLRLAMREQGVEVLLLNHADEYQSGYVNENRQRVAWLCGFTGSNAFLIIRSEGKCIFFTDSRYSIQASLEVDQS
CYDIYDMSDVTPAIWLKENLPLGTIIGYYGELFTLRQIQRFKRFCLKMLSCQMLDKLWDRPMEIRQRVVTHPVRFAGLES
CDKRAILASKMQSCESMLITDVDSISWLLNIRNLDFAYNPAVLSRAILYKDERVDLFIEGADRVAIDGKGINVLEIDELP
NVLKGLSNIAVDASTIPIYIFDMIKDRVSVIEDQDACTIFKAKKNAIEIDGMKEAHVRDGVAVVNFLYWLDCSIANNLRV
TELDAVSKIREFRQQQDMFMGESFETISGFGGNGAIVHYRVDEKSNKVLEKDGIYLIDSGGQYSDGTTDITRTVAIGAPS
VEQVARFTMVLKGFIAVANAAFPIGTTGAALDVLARQYLWQKQLNYGHSTGHGVGSFLSVHEGPQAISPINSVPLEPGMV
LSNEPGYYEQDAYGIRIENLMYVVDCGRGFYRFRQLTCVPICLDMIDRSMLSREEIEYLNEYHSFVFEVIAPRVSEEVKQ
WLQVACRRI
>Mature_569_residues
MNLKLRDLRLAMREQGVEVLLLNHADEYQSGYVNENRQRVAWLCGFTGSNAFLIIRSEGKCIFFTDSRYSIQASLEVDQS
CYDIYDMSDVTPAIWLKENLPLGTIIGYYGELFTLRQIQRFKRFCLKMLSCQMLDKLWDRPMEIRQRVVTHPVRFAGLES
CDKRAILASKMQSCESMLITDVDSISWLLNIRNLDFAYNPAVLSRAILYKDERVDLFIEGADRVAIDGKGINVLEIDELP
NVLKGLSNIAVDASTIPIYIFDMIKDRVSVIEDQDACTIFKAKKNAIEIDGMKEAHVRDGVAVVNFLYWLDCSIANNLRV
TELDAVSKIREFRQQQDMFMGESFETISGFGGNGAIVHYRVDEKSNKVLEKDGIYLIDSGGQYSDGTTDITRTVAIGAPS
VEQVARFTMVLKGFIAVANAAFPIGTTGAALDVLARQYLWQKQLNYGHSTGHGVGSFLSVHEGPQAISPINSVPLEPGMV
LSNEPGYYEQDAYGIRIENLMYVVDCGRGFYRFRQLTCVPICLDMIDRSMLSREEIEYLNEYHSFVFEVIAPRVSEEVKQ
WLQVACRRI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=611, Percent_Identity=36.8248772504092, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI264681565, Length=611, Percent_Identity=35.0245499181669, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI93141226, Length=597, Percent_Identity=31.4907872696817, Blast_Score=292, Evalue=7e-79,
Organism=Escherichia coli, GI1788728, Length=195, Percent_Identity=29.7435897435897, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=592, Percent_Identity=34.4594594594595, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI25149105, Length=608, Percent_Identity=28.2894736842105, Blast_Score=209, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6322999, Length=627, Percent_Identity=30.622009569378, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17137632, Length=595, Percent_Identity=32.7731092436975, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI161078230, Length=584, Percent_Identity=28.5958904109589, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21357287, Length=584, Percent_Identity=28.5958904109589, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 64445; Mature: 64445

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKLRDLRLAMREQGVEVLLLNHADEYQSGYVNENRQRVAWLCGFTGSNAFLIIRSEGK
CCCCHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCEEEEEEEECCCCEEEEEECCCC
CIFFTDSRYSIQASLEVDQSCYDIYDMSDVTPAIWLKENLPLGTIIGYYGELFTLRQIQR
EEEEECCCEEEEEEEECCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
FKRFCLKMLSCQMLDKLWDRPMEIRQRVVTHPVRFAGLESCDKRAILASKMQSCESMLIT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCHHCCHHHHHHHHHHHHHHHHHH
DVDSISWLLNIRNLDFAYNPAVLSRAILYKDERVDLFIEGADRVAIDGKGINVLEIDELP
CHHHHEEEEEEECCCCEECHHHHHHHHHEECCCEEEEEECCCEEEECCCCCCEEEHHHHH
NVLKGLSNIAVDASTIPIYIFDMIKDRVSVIEDQDACTIFKAKKNAIEIDGMKEAHVRDG
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHCH
VAVVNFLYWLDCSIANNLRVTELDAVSKIREFRQQQDMFMGESFETISGFGGNGAIVHYR
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEE
VDEKSNKVLEKDGIYLIDSGGQYSDGTTDITRTVAIGAPSVEQVARFTMVLKGFIAVANA
ECCCCCCEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCC
AFPIGTTGAALDVLARQYLWQKQLNYGHSTGHGVGSFLSVHEGPQAISPINSVPLEPGMV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
LSNEPGYYEQDAYGIRIENLMYVVDCGRGFYRFRQLTCVPICLDMIDRSMLSREEIEYLN
ECCCCCCCCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYHSFVFEVIAPRVSEEVKQWLQVACRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLKLRDLRLAMREQGVEVLLLNHADEYQSGYVNENRQRVAWLCGFTGSNAFLIIRSEGK
CCCCHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCEEEEEEEECCCCEEEEEECCCC
CIFFTDSRYSIQASLEVDQSCYDIYDMSDVTPAIWLKENLPLGTIIGYYGELFTLRQIQR
EEEEECCCEEEEEEEECCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
FKRFCLKMLSCQMLDKLWDRPMEIRQRVVTHPVRFAGLESCDKRAILASKMQSCESMLIT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCHHCCHHHHHHHHHHHHHHHHHH
DVDSISWLLNIRNLDFAYNPAVLSRAILYKDERVDLFIEGADRVAIDGKGINVLEIDELP
CHHHHEEEEEEECCCCEECHHHHHHHHHEECCCEEEEEECCCEEEECCCCCCEEEHHHHH
NVLKGLSNIAVDASTIPIYIFDMIKDRVSVIEDQDACTIFKAKKNAIEIDGMKEAHVRDG
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCHHHHHCH
VAVVNFLYWLDCSIANNLRVTELDAVSKIREFRQQQDMFMGESFETISGFGGNGAIVHYR
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEEE
VDEKSNKVLEKDGIYLIDSGGQYSDGTTDITRTVAIGAPSVEQVARFTMVLKGFIAVANA
ECCCCCCEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCC
AFPIGTTGAALDVLARQYLWQKQLNYGHSTGHGVGSFLSVHEGPQAISPINSVPLEPGMV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
LSNEPGYYEQDAYGIRIENLMYVVDCGRGFYRFRQLTCVPICLDMIDRSMLSREEIEYLN
ECCCCCCCCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYHSFVFEVIAPRVSEEVKQWLQVACRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]