Click here to switch to the map view.

The map label for this gene is 88607853

Identifier: 88607853

GI number: 88607853

Start: 344436

End: 345128

Strand: Direct

Name: 88607853

Synonym: APH_0354

Alternate gene names: NA

Gene position: 344436-345128 (Clockwise)

Preceding gene: 88606716

Following gene: 88607709

Centisome position: 23.41

GC content: 42.28

Gene sequence:

>693_bases
ATGCTGCTGCTGACGCGTGCTATGTGTGACTCTGTGAAGTCGAGAGACGCTCTAATTGCGCTGGGGTTTGACGTTTTCAT
CGAGCCCATGTTTGAGGTACGTTATCTTGCCGCAGAAATAACGGGGCTAGAAGGCTACGAAGTTGTTTTAGCTACTAGCA
GACATGGCATTATTGGAATGGCACAAGCTACTGATAATAGAAGCATTCCCATTGTCACTGTGGGTGATAGCTCTATGAAG
CATGCACTTAGTTTAGGATTCCAAAATGTTAAAACGGTGAGCGGTACAGCAGAGGATCTCCTGCATTATCTGAGAACGAA
ATCATATAGTTCTAAAGTGCTATATATCCGGGGTACAAATATTTCGCATGACTTAAGTAAGATGGCCAGAAACTTTGGGA
TTACCGTCGAAGAGTTGATACTATACGAGACGATAAGGAGCACTGAACTGAGCCCTGAGTGTTGTTATTTGCTGAGTAAG
AGGAAAATTTCAGGAGTACTGTTTTATTCTATGGAAACCGCGAAAATTTTTATGAACTTAGTGGAAAAGAAGTACAAAGA
GTGTCTCGCTACTGTGGCTGCATACACCATTAGTAGCAGGGTATGTGATGCTCTGAATACGTGCAAGTGGAAAGGCGTGC
TTGTGTCAGAATCTCCCACGGAAGAATCATTATTTAGATTACTATTGAAATAA

Upstream 100 bases:

>100_bases
GGAATAAGAGATCATAGGATACTTAGTCGTTATGTAGTACTTGATTAAATAGAGTGCTTTATTCTATGAGCAATTGTTAC
AGAGTAATTTCCGGTATTTT

Downstream 100 bases:

>100_bases
AAAATTACATTATTCCTACGTTTAAATTATGATTATCAATTAATAAAGATATATCTTTGTTAAAATATTTAAAAACATTA
TGATTTAGCAAAAATTAGGG

Product: hypothetical protein

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen III Synthase

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MLLLTRAMCDSVKSRDALIALGFDVFIEPMFEVRYLAAEITGLEGYEVVLATSRHGIIGMAQATDNRSIPIVTVGDSSMK
HALSLGFQNVKTVSGTAEDLLHYLRTKSYSSKVLYIRGTNISHDLSKMARNFGITVEELILYETIRSTELSPECCYLLSK
RKISGVLFYSMETAKIFMNLVEKKYKECLATVAAYTISSRVCDALNTCKWKGVLVSESPTEESLFRLLLK

Sequences:

>Translated_230_residues
MLLLTRAMCDSVKSRDALIALGFDVFIEPMFEVRYLAAEITGLEGYEVVLATSRHGIIGMAQATDNRSIPIVTVGDSSMK
HALSLGFQNVKTVSGTAEDLLHYLRTKSYSSKVLYIRGTNISHDLSKMARNFGITVEELILYETIRSTELSPECCYLLSK
RKISGVLFYSMETAKIFMNLVEKKYKECLATVAAYTISSRVCDALNTCKWKGVLVSESPTEESLFRLLLK
>Mature_230_residues
MLLLTRAMCDSVKSRDALIALGFDVFIEPMFEVRYLAAEITGLEGYEVVLATSRHGIIGMAQATDNRSIPIVTVGDSSMK
HALSLGFQNVKTVSGTAEDLLHYLRTKSYSSKVLYIRGTNISHDLSKMARNFGITVEELILYETIRSTELSPECCYLLSK
RKISGVLFYSMETAKIFMNLVEKKYKECLATVAAYTISSRVCDALNTCKWKGVLVSESPTEESLFRLLLK

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 25680; Mature: 25680

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLTRAMCDSVKSRDALIALGFDVFIEPMFEVRYLAAEITGLEGYEVVLATSRHGIIGM
CEEEEHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEE
AQATDNRSIPIVTVGDSSMKHALSLGFQNVKTVSGTAEDLLHYLRTKSYSSKVLYIRGTN
EECCCCCCCCEEEECCHHHHHHHHHCHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECCC
ISHDLSKMARNFGITVEELILYETIRSTELSPECCYLLSKRKISGVLFYSMETAKIFMNL
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
VEKKYKECLATVAAYTISSRVCDALNTCKWKGVLVSESPTEESLFRLLLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MLLLTRAMCDSVKSRDALIALGFDVFIEPMFEVRYLAAEITGLEGYEVVLATSRHGIIGM
CEEEEHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEE
AQATDNRSIPIVTVGDSSMKHALSLGFQNVKTVSGTAEDLLHYLRTKSYSSKVLYIRGTN
EECCCCCCCCEEEECCHHHHHHHHHCHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECCC
ISHDLSKMARNFGITVEELILYETIRSTELSPECCYLLSKRKISGVLFYSMETAKIFMNL
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
VEKKYKECLATVAAYTISSRVCDALNTCKWKGVLVSESPTEESLFRLLLK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA