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The map label for this gene is rnr [H]

Identifier: 87199965

GI number: 87199965

Start: 2064303

End: 2066582

Strand: Reverse

Name: rnr [H]

Synonym: Saro_1948

Alternate gene names: 87199965

Gene position: 2066582-2064303 (Counterclockwise)

Preceding gene: 87199966

Following gene: 87199963

Centisome position: 58.02

GC content: 64.91

Gene sequence:

>2280_bases
ATGGCTAAGCACAAATTTCCCCAGGGTCTTCCCACGCGCCAACAGGTGCTGGATTTCATCGCGCAGTCTGACGAGCCTGC
CGGCAAGCGCGAGATCGCCAAGGCGTTCGGCCTCAAGGGTACAGAGAAGATCGCGCTCAAGGCGCTGCTCAAGGACATGG
CCGAGGAAGGCCTGATCGACGGCAATCGCAGTGCGTTCCACGCCATGGGCGGCGTGCCGCGCGTCACCGTACTGCGCATC
GTCGAGATCGACGAAGGCGAGCCGGTCGCCATTCCCGACACCTGGCAACCCGATGACGCAAGCCCGCCGCCGCGCTTGCG
AGTGGTCGAGCCGAGGGGCAAGCCGCGCGAGCGCAACGCCGCGCTCCGCGTCGGCGATCGCATCCTTGCCCGTACCGAGG
AGGCGGGGAAGGGCTGGCTCGCGCATCCGATGAAGAAGCTCCAGGGTGGCGAGGAACGGCTCATGGGGGTCGTCGAACTG
GACGGTACCGGCAAGGGCTGGCTAGCGCCAGTGGACAAGCGCGTGCGCAATGCCGTGCCCATTTCGGATTTGGGCGGCGC
CGAGGAAGGTCAACTCGTCCTTGCCGAACCGGCGGGCCGCTCGCCCCGCTCAGGAATGAGGGTTACCGCCGTTCTCGGTG
ATCCGCTCGCCCCGCGCGCATTCAGCCTGATCGCGATCCACAAACACGGCATTCCCTTTGTCTTCCCGCCAGCAGCGATC
GAGGAGGCAGAGGTTGCGGCGAAGCTGCCGCTCAGCGAAGCGCGCCGCGAGGACCTGCGCCATCTGCCCATCGTTGCAAT
CGATCCCGCAGACGCGCGCGATCACGACGATGCCATCTGGGCCGAGCCGGATGGGGAAGGCGGCTTCCGCGCGATCGTCG
CCATTGCCGACGTCAGCTTCTACGTCCGCCCCGGCGGCCAGACCGACCGAGAGGCCCGCAAGCGCGGCAACTCGGTCTAC
TTCCCTGATCGTGTCGTGCCGATGCTGCCCGAGGTATTGAGCGCCGACGTCTGTTCGCTCAAGTCCGGTGCCGACCGTGC
GGCGATGGCCTGCCACCTTTCGATCGACGCCCACGGGCGGGTCAAGGACTTCCGCTTCACGCGCGCGCTCGTTCGCATTG
CCGAAGTCATAGCCTATGAGGAGGCGCAGCGCCGGATCGATAGCAAGGAAGCAGCCCCTCATCTCGTCCATCTCTGGGAT
GCCTGGCGCCTGCTCGAAAAGGCCCGCCACGCTCGTGACCCTCTCGAACTCGAACTGCCGGAGCGCCGGGTCGTTCTGGA
TAGCGCGGGCAAGATCGCGGAGATCGCGATTCGCGAGAGGCTCGACGCGCATCGCGTGGTCGAGGACTTCATGATCGCGG
CCAACGTTGCCGCCGCAAAGGCGCTGGAAGCCAAGGTGGCGCCGGTCGTCTATCGCATCCACGAGCCGCCGAACCGGGAA
AAACTGGTCGCGCTCAAGGACTATCTCGCGACCTTCGACCGCAAATTGTCGCTCGGACAGGTGATCACGCCTTCGCTGTT
CAACCGCATGCTAAAGGACATCGCGGACGAGGCGGAGAAGGCACTCATCATGGAAGCGGTGCTGCGCAGCCAGACCCAGG
CCTATTATGGCCCGCGCAATGCCGGGCATTTCGGCCTGGCACTGGGTTCTTACGCCCACTTCACATCACCAATCCGTCGC
TATTCCGACCTCCTGGTACATCGGGCGCTGGTCGACGCTTACGATCTTGAACAGCCGCGTCCATCAGTCGGGGTGCCACC
CACGTCCGGCCTGTCCGACCGCGACCGCGCCGATCTCGCCCGCGTATCGGAAGCGATCAGTAACGCCGAGCGTCGAGCGA
TGGAGGCCGAGCGCGAGACTATCGATCGCTATGTCGCGGCCTGGCTGTCGGGCAAGGTCGGTGAGGTATTCGACACGAGG
ATCACCGGCGTCCAGAAGTTTGGCCTGTTCGCAACGATCATCGGGCTTGGTGGCGATGGTTTGGTACCGGTCTCCACGCT
CGGGGCCGAACGCTTCAACTACGACGAAAAGGCCCAGCGCCTTATCGGGGAGTTGAGAGGCGAGGAATTCGCGATGGGTC
AGATCCTCAAGCTCCGTCTCGCAGAGGCGAACCCGCTGACCGGAGCGCTGAAGTTTGAGCCGGTCGACGTTGCCGAAGGC
GTTCAGCGCATCGAACGGCGCGGCGGTCGGTCGGAGCAGAAACCGCGCAGGCAAGGCAACTACATGGCGGGAAAGCGCGG
ACGACCGTCCAACATCCGCCATCAGGGTCGCAAGAAGTAG

Upstream 100 bases:

>100_bases
GAAAGTCCGATTGCCTCGGCGGTGCCTGGCGGGCAGTTCGCCCCGCTGGCGAAACCGTAACCGCTTGCCATCCGGGGGCG
CAGGGACCACATGCCCCTCA

Downstream 100 bases:

>100_bases
CGAGCAGTTCCGTCAGCTGAACCGGTCGATTTCCTGATCGGAAATCGCACCGGGGACGATCATCAGAGGGCAGGGAAGCT
GTCCCGCGATCCCGGCGAAG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R [H]

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MAKHKFPQGLPTRQQVLDFIAQSDEPAGKREIAKAFGLKGTEKIALKALLKDMAEEGLIDGNRSAFHAMGGVPRVTVLRI
VEIDEGEPVAIPDTWQPDDASPPPRLRVVEPRGKPRERNAALRVGDRILARTEEAGKGWLAHPMKKLQGGEERLMGVVEL
DGTGKGWLAPVDKRVRNAVPISDLGGAEEGQLVLAEPAGRSPRSGMRVTAVLGDPLAPRAFSLIAIHKHGIPFVFPPAAI
EEAEVAAKLPLSEARREDLRHLPIVAIDPADARDHDDAIWAEPDGEGGFRAIVAIADVSFYVRPGGQTDREARKRGNSVY
FPDRVVPMLPEVLSADVCSLKSGADRAAMACHLSIDAHGRVKDFRFTRALVRIAEVIAYEEAQRRIDSKEAAPHLVHLWD
AWRLLEKARHARDPLELELPERRVVLDSAGKIAEIAIRERLDAHRVVEDFMIAANVAAAKALEAKVAPVVYRIHEPPNRE
KLVALKDYLATFDRKLSLGQVITPSLFNRMLKDIADEAEKALIMEAVLRSQTQAYYGPRNAGHFGLALGSYAHFTSPIRR
YSDLLVHRALVDAYDLEQPRPSVGVPPTSGLSDRDRADLARVSEAISNAERRAMEAERETIDRYVAAWLSGKVGEVFDTR
ITGVQKFGLFATIIGLGGDGLVPVSTLGAERFNYDEKAQRLIGELRGEEFAMGQILKLRLAEANPLTGALKFEPVDVAEG
VQRIERRGGRSEQKPRRQGNYMAGKRGRPSNIRHQGRKK

Sequences:

>Translated_759_residues
MAKHKFPQGLPTRQQVLDFIAQSDEPAGKREIAKAFGLKGTEKIALKALLKDMAEEGLIDGNRSAFHAMGGVPRVTVLRI
VEIDEGEPVAIPDTWQPDDASPPPRLRVVEPRGKPRERNAALRVGDRILARTEEAGKGWLAHPMKKLQGGEERLMGVVEL
DGTGKGWLAPVDKRVRNAVPISDLGGAEEGQLVLAEPAGRSPRSGMRVTAVLGDPLAPRAFSLIAIHKHGIPFVFPPAAI
EEAEVAAKLPLSEARREDLRHLPIVAIDPADARDHDDAIWAEPDGEGGFRAIVAIADVSFYVRPGGQTDREARKRGNSVY
FPDRVVPMLPEVLSADVCSLKSGADRAAMACHLSIDAHGRVKDFRFTRALVRIAEVIAYEEAQRRIDSKEAAPHLVHLWD
AWRLLEKARHARDPLELELPERRVVLDSAGKIAEIAIRERLDAHRVVEDFMIAANVAAAKALEAKVAPVVYRIHEPPNRE
KLVALKDYLATFDRKLSLGQVITPSLFNRMLKDIADEAEKALIMEAVLRSQTQAYYGPRNAGHFGLALGSYAHFTSPIRR
YSDLLVHRALVDAYDLEQPRPSVGVPPTSGLSDRDRADLARVSEAISNAERRAMEAERETIDRYVAAWLSGKVGEVFDTR
ITGVQKFGLFATIIGLGGDGLVPVSTLGAERFNYDEKAQRLIGELRGEEFAMGQILKLRLAEANPLTGALKFEPVDVAEG
VQRIERRGGRSEQKPRRQGNYMAGKRGRPSNIRHQGRKK
>Mature_758_residues
AKHKFPQGLPTRQQVLDFIAQSDEPAGKREIAKAFGLKGTEKIALKALLKDMAEEGLIDGNRSAFHAMGGVPRVTVLRIV
EIDEGEPVAIPDTWQPDDASPPPRLRVVEPRGKPRERNAALRVGDRILARTEEAGKGWLAHPMKKLQGGEERLMGVVELD
GTGKGWLAPVDKRVRNAVPISDLGGAEEGQLVLAEPAGRSPRSGMRVTAVLGDPLAPRAFSLIAIHKHGIPFVFPPAAIE
EAEVAAKLPLSEARREDLRHLPIVAIDPADARDHDDAIWAEPDGEGGFRAIVAIADVSFYVRPGGQTDREARKRGNSVYF
PDRVVPMLPEVLSADVCSLKSGADRAAMACHLSIDAHGRVKDFRFTRALVRIAEVIAYEEAQRRIDSKEAAPHLVHLWDA
WRLLEKARHARDPLELELPERRVVLDSAGKIAEIAIRERLDAHRVVEDFMIAANVAAAKALEAKVAPVVYRIHEPPNREK
LVALKDYLATFDRKLSLGQVITPSLFNRMLKDIADEAEKALIMEAVLRSQTQAYYGPRNAGHFGLALGSYAHFTSPIRRY
SDLLVHRALVDAYDLEQPRPSVGVPPTSGLSDRDRADLARVSEAISNAERRAMEAERETIDRYVAAWLSGKVGEVFDTRI
TGVQKFGLFATIIGLGGDGLVPVSTLGAERFNYDEKAQRLIGELRGEEFAMGQILKLRLAEANPLTGALKFEPVDVAEGV
QRIERRGGRSEQKPRRQGNYMAGKRGRPSNIRHQGRKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=428, Percent_Identity=30.1401869158879, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI190014625, Length=428, Percent_Identity=30.1401869158879, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI219521928, Length=466, Percent_Identity=30.2575107296137, Blast_Score=166, Evalue=1e-40,
Organism=Homo sapiens, GI19115966, Length=466, Percent_Identity=30.2575107296137, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI134288890, Length=375, Percent_Identity=29.6, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI156105693, Length=136, Percent_Identity=39.7058823529412, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI156105695, Length=134, Percent_Identity=38.8059701492537, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082383, Length=739, Percent_Identity=32.7469553450609, Blast_Score=353, Evalue=3e-98,
Organism=Escherichia coli, GI1787542, Length=479, Percent_Identity=27.348643006263, Blast_Score=152, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI212645896, Length=432, Percent_Identity=32.1759259259259, Blast_Score=176, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17553506, Length=361, Percent_Identity=31.3019390581717, Blast_Score=151, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324552, Length=442, Percent_Identity=32.1266968325792, Blast_Score=177, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6320499, Length=306, Percent_Identity=23.202614379085, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24649634, Length=463, Percent_Identity=30.4535637149028, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24654592, Length=446, Percent_Identity=26.6816143497758, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922976, Length=446, Percent_Identity=26.6816143497758, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24654597, Length=446, Percent_Identity=26.6816143497758, Blast_Score=138, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.13.1

Molecular weight: Translated: 83597; Mature: 83466

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHKFPQGLPTRQQVLDFIAQSDEPAGKREIAKAFGLKGTEKIALKALLKDMAEEGLID
CCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
GNRSAFHAMGGVPRVTVLRIVEIDEGEPVAIPDTWQPDDASPPPRLRVVEPRGKPRERNA
CCCHHHHHHCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCH
ALRVGDRILARTEEAGKGWLAHPMKKLQGGEERLMGVVELDGTGKGWLAPVDKRVRNAVP
HHHHHHHHHHHCHHHCCCCHHHHHHHHCCCHHHCEEEEEECCCCCCCCCHHHHHHHHCCC
ISDLGGAEEGQLVLAEPAGRSPRSGMRVTAVLGDPLAPRAFSLIAIHKHGIPFVFPPAAI
CHHCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCEEECCHHH
EEAEVAAKLPLSEARREDLRHLPIVAIDPADARDHDDAIWAEPDGEGGFRAIVAIADVSF
HHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCCCEEEEEEEEEEE
YVRPGGQTDREARKRGNSVYFPDRVVPMLPEVLSADVCSLKSGADRAAMACHLSIDAHGR
EECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCC
VKDFRFTRALVRIAEVIAYEEAQRRIDSKEAAPHLVHLWDAWRLLEKARHARDPLELELP
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
ERRVVLDSAGKIAEIAIRERLDAHRVVEDFMIAANVAAAKALEAKVAPVVYRIHEPPNRE
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHH
KLVALKDYLATFDRKLSLGQVITPSLFNRMLKDIADEAEKALIMEAVLRSQTQAYYGPRN
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGHFGLALGSYAHFTSPIRRYSDLLVHRALVDAYDLEQPRPSVGVPPTSGLSDRDRADLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
RVSEAISNAERRAMEAERETIDRYVAAWLSGKVGEVFDTRITGVQKFGLFATIIGLGGDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
LVPVSTLGAERFNYDEKAQRLIGELRGEEFAMGQILKLRLAEANPLTGALKFEPVDVAEG
CCCHHHHCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCCCEEEECCCCHHHH
VQRIERRGGRSEQKPRRQGNYMAGKRGRPSNIRHQGRKK
HHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKHKFPQGLPTRQQVLDFIAQSDEPAGKREIAKAFGLKGTEKIALKALLKDMAEEGLID
CCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
GNRSAFHAMGGVPRVTVLRIVEIDEGEPVAIPDTWQPDDASPPPRLRVVEPRGKPRERNA
CCCHHHHHHCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCH
ALRVGDRILARTEEAGKGWLAHPMKKLQGGEERLMGVVELDGTGKGWLAPVDKRVRNAVP
HHHHHHHHHHHCHHHCCCCHHHHHHHHCCCHHHCEEEEEECCCCCCCCCHHHHHHHHCCC
ISDLGGAEEGQLVLAEPAGRSPRSGMRVTAVLGDPLAPRAFSLIAIHKHGIPFVFPPAAI
CHHCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCEEECCHHH
EEAEVAAKLPLSEARREDLRHLPIVAIDPADARDHDDAIWAEPDGEGGFRAIVAIADVSF
HHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCCCEEEEEEEEEEE
YVRPGGQTDREARKRGNSVYFPDRVVPMLPEVLSADVCSLKSGADRAAMACHLSIDAHGR
EECCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCC
VKDFRFTRALVRIAEVIAYEEAQRRIDSKEAAPHLVHLWDAWRLLEKARHARDPLELELP
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
ERRVVLDSAGKIAEIAIRERLDAHRVVEDFMIAANVAAAKALEAKVAPVVYRIHEPPNRE
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHH
KLVALKDYLATFDRKLSLGQVITPSLFNRMLKDIADEAEKALIMEAVLRSQTQAYYGPRN
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGHFGLALGSYAHFTSPIRRYSDLLVHRALVDAYDLEQPRPSVGVPPTSGLSDRDRADLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
RVSEAISNAERRAMEAERETIDRYVAAWLSGKVGEVFDTRITGVQKFGLFATIIGLGGDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
LVPVSTLGAERFNYDEKAQRLIGELRGEEFAMGQILKLRLAEANPLTGALKFEPVDVAEG
CCCHHHHCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCCCEEEECCCCHHHH
VQRIERRGGRSEQKPRRQGNYMAGKRGRPSNIRHQGRKK
HHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]