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The map label for this gene is tmk [H]

Identifier: 87199958

GI number: 87199958

Start: 2056549

End: 2057178

Strand: Reverse

Name: tmk [H]

Synonym: Saro_1941

Alternate gene names: 87199958

Gene position: 2057178-2056549 (Counterclockwise)

Preceding gene: 87199959

Following gene: 87199957

Centisome position: 57.76

GC content: 67.14

Gene sequence:

>630_bases
GTGAGCCGGGGACGTTTTGTTGCCTTCGAGGGGGGCGAGGGCGTCGGCAAGTCGACGCAGGGACGGCTTCTGGCGGAGTC
GCTGCGTGCGCGAGGGCTGGAAGTGGTGACCACGCGTGAACCTGGGGGGACCGCCGGCGCGGAAGCAATCCGCACGATGC
TGTTGAGCACCGAAGGCGAAGGTTGGGGCGCTCGGGCGGAGGCGTTGCTGTTCGCAGCGGCGCGTGCCGACCATGTCGAG
AAGCTGATCCGGCCATCGGTAGCGCGTGGCGCCTGGGTTGTGTGCGACCGATTCGTCGACAGCAGTCGAGCCTACCAGGG
CGGTGGTAGCGGTCTTTCGGATGCGGATGTGATGCAACTCCACAGGATCGGCAGCGCGGGGCTCTTGCCGGACGTGACGA
TCCTTCTGACCGTACGGCCAGAAATCTCGGCTGCGAGGCTGGCCATGCGCGATGGCAATGCGGCGGACCGCATCGGCGGG
CGCGGCGAAGAGTACCATGGACGTGTGGCGGCGGCCTTCCGGCGGTTCGCCGAGCAGGAACCCGACCGGTTCGCCGTTGT
CGACGCTGAAGGATCGCCGGAAGAAGTTCATGCCCGGGTCACTGCGGCCATCGACAAGGCGTTGGCATGA

Upstream 100 bases:

>100_bases
GAGAGCCAGTCCACGCATTGCCCCTCGTCGCAGCCAATGCGGTGCCGAAGGGCGGGGTGGCTTCGCGACTGCGCAATGGG
TTACTGGGGCTTGTCGGGCT

Downstream 100 bases:

>100_bases
TCGGGCACGACGAAGCCTGGCGCGCTTGGCGTTCAGCCATGGCGGGCCCGCGCATGCATCACGGATGGATACTCGCGGGG
CGCGAGGGGCTGGGCAAGGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSRGRFVAFEGGEGVGKSTQGRLLAESLRARGLEVVTTREPGGTAGAEAIRTMLLSTEGEGWGARAEALLFAAARADHVE
KLIRPSVARGAWVVCDRFVDSSRAYQGGGSGLSDADVMQLHRIGSAGLLPDVTILLTVRPEISAARLAMRDGNAADRIGG
RGEEYHGRVAAAFRRFAEQEPDRFAVVDAEGSPEEVHARVTAAIDKALA

Sequences:

>Translated_209_residues
MSRGRFVAFEGGEGVGKSTQGRLLAESLRARGLEVVTTREPGGTAGAEAIRTMLLSTEGEGWGARAEALLFAAARADHVE
KLIRPSVARGAWVVCDRFVDSSRAYQGGGSGLSDADVMQLHRIGSAGLLPDVTILLTVRPEISAARLAMRDGNAADRIGG
RGEEYHGRVAAAFRRFAEQEPDRFAVVDAEGSPEEVHARVTAAIDKALA
>Mature_208_residues
SRGRFVAFEGGEGVGKSTQGRLLAESLRARGLEVVTTREPGGTAGAEAIRTMLLSTEGEGWGARAEALLFAAARADHVEK
LIRPSVARGAWVVCDRFVDSSRAYQGGGSGLSDADVMQLHRIGSAGLLPDVTILLTVRPEISAARLAMRDGNAADRIGGR
GEEYHGRVAAAFRRFAEQEPDRFAVVDAEGSPEEVHARVTAAIDKALA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=182, Percent_Identity=36.2637362637363, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22112; Mature: 21981

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGRFVAFEGGEGVGKSTQGRLLAESLRARGLEVVTTREPGGTAGAEAIRTMLLSTEGE
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
GWGARAEALLFAAARADHVEKLIRPSVARGAWVVCDRFVDSSRAYQGGGSGLSDADVMQL
CCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
HRIGSAGLLPDVTILLTVRPEISAARLAMRDGNAADRIGGRGEEYHGRVAAAFRRFAEQE
HHCCCCCCCCCEEEEEEECCCCHHHHHEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHCC
PDRFAVVDAEGSPEEVHARVTAAIDKALA
CCCEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRGRFVAFEGGEGVGKSTQGRLLAESLRARGLEVVTTREPGGTAGAEAIRTMLLSTEGE
CCCCEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
GWGARAEALLFAAARADHVEKLIRPSVARGAWVVCDRFVDSSRAYQGGGSGLSDADVMQL
CCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
HRIGSAGLLPDVTILLTVRPEISAARLAMRDGNAADRIGGRGEEYHGRVAAAFRRFAEQE
HHCCCCCCCCCEEEEEEECCCCHHHHHEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHCC
PDRFAVVDAEGSPEEVHARVTAAIDKALA
CCCEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA