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The map label for this gene is emrY [H]

Identifier: 87199731

GI number: 87199731

Start: 1801488

End: 1803086

Strand: Reverse

Name: emrY [H]

Synonym: Saro_1714

Alternate gene names: 87199731

Gene position: 1803086-1801488 (Counterclockwise)

Preceding gene: 87199732

Following gene: 87199730

Centisome position: 50.63

GC content: 65.23

Gene sequence:

>1599_bases
GTGACAGCGGCAATCTCTTCCGACGCCGACACCGAAGACCTGGCGCTGCCGCCCCCCCGGGCGCGCGAGAAGGCGGACCT
GACCGCTTGGCTGGGCGTGGCCGCCGGCGCGATCGGCTCGCTCATGGCGACGCTCGACATCTCGATCGTCAACGCGTCCC
TGCCTACCATCCAGGGCGAGATCGGCGCATCGTCGAGCGAGGGCACCTGGATCGCCACAGCCTATCTCGTGGCCGAGATC
ATCATCATTCCCCTCACCGGGTGGCTCGAACGCGTGTTTGGCCTGCGCAGGTTCCTGCTTATCGCGGCCGCGCTGTTCAC
GGCCTTCTCGGTGTTGTGCGGCGTGTCCTCGACACTCACGATGATGATCATCGGTCGCGTCGGGCAGGGTTTTACCGGCG
GCGCGATGATTCCGACCGCGCTGACGATCATCGCCACGCGCCTGCCGCCATCGCAGCAGCCCATCGGCACCGCGATGTTC
GGCTCCACCGTCATCCTGGGGCCGGTGCTCGGTCCGCTGGCGGGCGGATGGCTGACCGAGAACTTCAGTTGGCACTATGC
CTTCTTCATCAACGTGCCGATCTGCATCATCCTCATGATCATGCTGATCGTGGGCCTGCCCAAGAGCAGGATGCGCCTCG
ACGAGCTTATCAACGCTGACTGGCTGGGCGTGGTCGGCATGGTCCTCGGGCTTGGCGGCATTACCGTCGTGCTCGAAGAA
GGCCACCGCGAACAGTGGTTCGAATCCGCGCTGATCTGGAAGCTTTCCGCCGTTACCCTGCTGGGCTTCGTGATGATCGG
CCTCGGGCAAATCTATGCGCGGCGGCCGGTGGTGAAGCTCGCGCTCTTGCGCAACCGCGCCTTTGCGGCGGTCTTCGGGC
TTTCGCTGGTGCTGGGCGCGGTGATGTTCGGCACGGCCTACGTGATCCCGCAGTTCCTCGCCGCGATTGCCGATTACAAT
GCGATGCAAGCAGGCAAGATCGTGTTCCTTTCGGGCATTCCGGCAATGCTGATGATGCCGCTCTTCCCGATACTCGTGGC
GCGGGTCGACTTGCGCGTGATCGTCGGGACGGGCGTCCTCCTGCTCGGCGTTTCCTGCTATCTCGACGTCACGCTGACCG
CACAATCACGCGGCGACGACTTCGTCGTCACGCAATTGCTGCGCGGGCTGGGCACGGTCTTCTGCATGCTGTTCCTCAAC
CAAGCGGCGATCAGTTCCGTGCCGATGGAAGATGCCGGCGACGGCGCGGGCCTGTTCAACGCGGGCCGCAACCTCGGCGG
ATCGATCGGCCTCGCCATGCTCGCCACCTTGCAGGACGAACGCTGGGAATTCCACCGCTGGACCCTGCACAGCGCGCTGG
GCGCCAACGACCTGCGCGTGCAGGACTGGGTGAGCCAGCAGGCGATGACGTATGGCGGCGGCCCGGACGGCCTGTCGGCC
GCGCTCCGTTCGCTCGACGGCATGGTCATGCGCGATGCGCTGGTCATGGCCTTCAACGACGACTTCATGGCGCTGACCAT
CGGGATACTTCTCGTCGCGCCGCTTGTCCTGCTCCTGCGCCCGCTTCCCAAGGGCTACCACGCAAAGGCTGCTCACTGA

Upstream 100 bases:

>100_bases
TGCTGGTGCCGGGCCTGTCGCTTACGGTCGAGGTGGATACCCGCTCGGCGAAGTCGGCCATCGACGCGATCCGCGATGAA
CAGGACCGGGTCTCGGCCAA

Downstream 100 bases:

>100_bases
TGACTGCCCTCCTCCCCCATCGCCGCCCGCTCCGCAGCATGGCCGGCGCCTTGGTCGTGGCCGCGCTTCTCGCCGGCTGC
ACCACGGTGGGCCCGAACTA

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTAAISSDADTEDLALPPPRAREKADLTAWLGVAAGAIGSLMATLDISIVNASLPTIQGEIGASSSEGTWIATAYLVAEI
IIIPLTGWLERVFGLRRFLLIAAALFTAFSVLCGVSSTLTMMIIGRVGQGFTGGAMIPTALTIIATRLPPSQQPIGTAMF
GSTVILGPVLGPLAGGWLTENFSWHYAFFINVPICIILMIMLIVGLPKSRMRLDELINADWLGVVGMVLGLGGITVVLEE
GHREQWFESALIWKLSAVTLLGFVMIGLGQIYARRPVVKLALLRNRAFAAVFGLSLVLGAVMFGTAYVIPQFLAAIADYN
AMQAGKIVFLSGIPAMLMMPLFPILVARVDLRVIVGTGVLLLGVSCYLDVTLTAQSRGDDFVVTQLLRGLGTVFCMLFLN
QAAISSVPMEDAGDGAGLFNAGRNLGGSIGLAMLATLQDERWEFHRWTLHSALGANDLRVQDWVSQQAMTYGGGPDGLSA
ALRSLDGMVMRDALVMAFNDDFMALTIGILLVAPLVLLLRPLPKGYHAKAAH

Sequences:

>Translated_532_residues
MTAAISSDADTEDLALPPPRAREKADLTAWLGVAAGAIGSLMATLDISIVNASLPTIQGEIGASSSEGTWIATAYLVAEI
IIIPLTGWLERVFGLRRFLLIAAALFTAFSVLCGVSSTLTMMIIGRVGQGFTGGAMIPTALTIIATRLPPSQQPIGTAMF
GSTVILGPVLGPLAGGWLTENFSWHYAFFINVPICIILMIMLIVGLPKSRMRLDELINADWLGVVGMVLGLGGITVVLEE
GHREQWFESALIWKLSAVTLLGFVMIGLGQIYARRPVVKLALLRNRAFAAVFGLSLVLGAVMFGTAYVIPQFLAAIADYN
AMQAGKIVFLSGIPAMLMMPLFPILVARVDLRVIVGTGVLLLGVSCYLDVTLTAQSRGDDFVVTQLLRGLGTVFCMLFLN
QAAISSVPMEDAGDGAGLFNAGRNLGGSIGLAMLATLQDERWEFHRWTLHSALGANDLRVQDWVSQQAMTYGGGPDGLSA
ALRSLDGMVMRDALVMAFNDDFMALTIGILLVAPLVLLLRPLPKGYHAKAAH
>Mature_531_residues
TAAISSDADTEDLALPPPRAREKADLTAWLGVAAGAIGSLMATLDISIVNASLPTIQGEIGASSSEGTWIATAYLVAEII
IIPLTGWLERVFGLRRFLLIAAALFTAFSVLCGVSSTLTMMIIGRVGQGFTGGAMIPTALTIIATRLPPSQQPIGTAMFG
STVILGPVLGPLAGGWLTENFSWHYAFFINVPICIILMIMLIVGLPKSRMRLDELINADWLGVVGMVLGLGGITVVLEEG
HREQWFESALIWKLSAVTLLGFVMIGLGQIYARRPVVKLALLRNRAFAAVFGLSLVLGAVMFGTAYVIPQFLAAIADYNA
MQAGKIVFLSGIPAMLMMPLFPILVARVDLRVIVGTGVLLLGVSCYLDVTLTAQSRGDDFVVTQLLRGLGTVFCMLFLNQ
AAISSVPMEDAGDGAGLFNAGRNLGGSIGLAMLATLQDERWEFHRWTLHSALGANDLRVQDWVSQQAMTYGGGPDGLSAA
LRSLDGMVMRDALVMAFNDDFMALTIGILLVAPLVLLLRPLPKGYHAKAAH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=498, Percent_Identity=29.3172690763052, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789042, Length=484, Percent_Identity=29.5454545454545, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI87081983, Length=445, Percent_Identity=26.0674157303371, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790195, Length=263, Percent_Identity=30.7984790874525, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788392, Length=406, Percent_Identity=27.8325123152709, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322958, Length=189, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=160, Percent_Identity=25.625, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323520, Length=413, Percent_Identity=23.9709443099274, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321663, Length=149, Percent_Identity=26.8456375838926, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=302, Percent_Identity=24.5033112582781, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56631; Mature: 56500

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAISSDADTEDLALPPPRAREKADLTAWLGVAAGAIGSLMATLDISIVNASLPTIQGE
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC
IGASSSEGTWIATAYLVAEIIIIPLTGWLERVFGLRRFLLIAAALFTAFSVLCGVSSTLT
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
MMIIGRVGQGFTGGAMIPTALTIIATRLPPSQQPIGTAMFGSTVILGPVLGPLAGGWLTE
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCEEC
NFSWHYAFFINVPICIILMIMLIVGLPKSRMRLDELINADWLGVVGMVLGLGGITVVLEE
CCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEC
GHREQWFESALIWKLSAVTLLGFVMIGLGQIYARRPVVKLALLRNRAFAAVFGLSLVLGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VMFGTAYVIPQFLAAIADYNAMQAGKIVFLSGIPAMLMMPLFPILVARVDLRVIVGTGVL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCHH
LLGVSCYLDVTLTAQSRGDDFVVTQLLRGLGTVFCMLFLNQAAISSVPMEDAGDGAGLFN
HHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
AGRNLGGSIGLAMLATLQDERWEFHRWTLHSALGANDLRVQDWVSQQAMTYGGGPDGLSA
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHH
ALRSLDGMVMRDALVMAFNDDFMALTIGILLVAPLVLLLRPLPKGYHAKAAH
HHHHHCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TAAISSDADTEDLALPPPRAREKADLTAWLGVAAGAIGSLMATLDISIVNASLPTIQGE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC
IGASSSEGTWIATAYLVAEIIIIPLTGWLERVFGLRRFLLIAAALFTAFSVLCGVSSTLT
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
MMIIGRVGQGFTGGAMIPTALTIIATRLPPSQQPIGTAMFGSTVILGPVLGPLAGGWLTE
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCEEC
NFSWHYAFFINVPICIILMIMLIVGLPKSRMRLDELINADWLGVVGMVLGLGGITVVLEE
CCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEC
GHREQWFESALIWKLSAVTLLGFVMIGLGQIYARRPVVKLALLRNRAFAAVFGLSLVLGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VMFGTAYVIPQFLAAIADYNAMQAGKIVFLSGIPAMLMMPLFPILVARVDLRVIVGTGVL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCHH
LLGVSCYLDVTLTAQSRGDDFVVTQLLRGLGTVFCMLFLNQAAISSVPMEDAGDGAGLFN
HHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
AGRNLGGSIGLAMLATLQDERWEFHRWTLHSALGANDLRVQDWVSQQAMTYGGGPDGLSA
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHH
ALRSLDGMVMRDALVMAFNDDFMALTIGILLVAPLVLLLRPLPKGYHAKAAH
HHHHHCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]