Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 87199143

GI number: 87199143

Start: 1165884

End: 1166882

Strand: Direct

Name: cysK [H]

Synonym: Saro_1121

Alternate gene names: 87199143

Gene position: 1165884-1166882 (Clockwise)

Preceding gene: 87199142

Following gene: 87199144

Centisome position: 32.73

GC content: 64.66

Gene sequence:

>999_bases
ATGATGGCTCCTGCGATTGCTCCCGATACCATTTCCCTCATCGGCAACACGCCTCTCGTCCGGCTCAAGGGGCCGAGCGA
GGAGACCGGTTGCGAGATCTACGGCAAGTGCGAATTCACCAACCCCGGCGCTTCGGTGAAGGATCGCGCGGCCCTGTGGA
TCGTCCGCGACGCCGAAGAGCGCGGCATTCTCAAGCCCGGCGGCACCATTGTCGAGGGCACGGCGGGTAACACCGGGATC
GGCCTGGCACTCGTCGCCAATGCGCGCGGCTACAAGTCGGTCATCGTCATGCCCGAGACGCAATCGCGCGAGAAGATGGA
CACCTTGCGGGCACTGCGTTCGGAGCTGGTGCTGGTTCCGGCCGCCCCCTTCTCGAACCCCGGCCACTTCGTGCACACTT
CGCGCCGCATTGCCGAGGAGACCGAAGGCGCGGTCTGGGCGAACCAGTTCGACAACATCGCCAACCGCCGAGCGCACATC
GAAAGCACCGCGCCCGAAATCTGGGAGCAGATGGAGCATCGCATCGATGGCTTCACCTGCGCTGCGGGTACGGGTGGCAC
CATCGCGGGCGTGGGCATGGGCCTCAAGGCCTTCGACGAGAACATCACCATTGCCCTCACCGATCCGCATGGCGCCGCGC
TGTACAATTACTATGCCCACGGCGAACTGAAGGCGGAAGGCTCTTCGGTTGCCGAGGGGATCGGTCAGGGGCGCATCACG
GCGAACCTCGACGGTGCGCCCATCGACACCCAGTTCCGCATTTCGGACGAGGAAGGTCTGCACTGGGTCGAACGCCTGCT
GGCCGAGGAAGGCCTCTGTCTTGGCCTGTCGAGCGGCATCAACGTGGCGGGCGCGGTTGCGCTGGCAAGGCAACTGGGCA
AGGGCAGCCGCGTGGCGACGATCCTGTGCGACACGGGCTTCCGCTATCTCTCCTCGCTCTACAATCCGGAATGGCTCAAG
ACCAAGGGCCTGCGAGTGTTCCCTTGGCTGGAGCAATGA

Upstream 100 bases:

>100_bases
GCCGGCGGTGCGGCGATTCGGGCAGGCAGGGAGTAGGACTTCGCGGCATTGAAGCGCAAATTCGTTGGCATTCGCGCAAA
CTGCTCTTAACTCAGGCGCC

Downstream 100 bases:

>100_bases
GGTAGAAGGCGCGCATGGCCTTCTTCGCCAGATCGCAGTCCAGGCCCGTTGCGGCGACCGGCGTCGAGCCGGCCACGCAG
ACGAGCCCGCTTGCCTATGT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MMAPAIAPDTISLIGNTPLVRLKGPSEETGCEIYGKCEFTNPGASVKDRAALWIVRDAEERGILKPGGTIVEGTAGNTGI
GLALVANARGYKSVIVMPETQSREKMDTLRALRSELVLVPAAPFSNPGHFVHTSRRIAEETEGAVWANQFDNIANRRAHI
ESTAPEIWEQMEHRIDGFTCAAGTGGTIAGVGMGLKAFDENITIALTDPHGAALYNYYAHGELKAEGSSVAEGIGQGRIT
ANLDGAPIDTQFRISDEEGLHWVERLLAEEGLCLGLSSGINVAGAVALARQLGKGSRVATILCDTGFRYLSSLYNPEWLK
TKGLRVFPWLEQ

Sequences:

>Translated_332_residues
MMAPAIAPDTISLIGNTPLVRLKGPSEETGCEIYGKCEFTNPGASVKDRAALWIVRDAEERGILKPGGTIVEGTAGNTGI
GLALVANARGYKSVIVMPETQSREKMDTLRALRSELVLVPAAPFSNPGHFVHTSRRIAEETEGAVWANQFDNIANRRAHI
ESTAPEIWEQMEHRIDGFTCAAGTGGTIAGVGMGLKAFDENITIALTDPHGAALYNYYAHGELKAEGSSVAEGIGQGRIT
ANLDGAPIDTQFRISDEEGLHWVERLLAEEGLCLGLSSGINVAGAVALARQLGKGSRVATILCDTGFRYLSSLYNPEWLK
TKGLRVFPWLEQ
>Mature_332_residues
MMAPAIAPDTISLIGNTPLVRLKGPSEETGCEIYGKCEFTNPGASVKDRAALWIVRDAEERGILKPGGTIVEGTAGNTGI
GLALVANARGYKSVIVMPETQSREKMDTLRALRSELVLVPAAPFSNPGHFVHTSRRIAEETEGAVWANQFDNIANRRAHI
ESTAPEIWEQMEHRIDGFTCAAGTGGTIAGVGMGLKAFDENITIALTDPHGAALYNYYAHGELKAEGSSVAEGIGQGRIT
ANLDGAPIDTQFRISDEEGLHWVERLLAEEGLCLGLSSGINVAGAVALARQLGKGSRVATILCDTGFRYLSSLYNPEWLK
TKGLRVFPWLEQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=325, Percent_Identity=40.9230769230769, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI295821200, Length=325, Percent_Identity=40.9230769230769, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4557415, Length=325, Percent_Identity=40.9230769230769, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=35.9477124183007, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788754, Length=324, Percent_Identity=38.5802469135802, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566674, Length=304, Percent_Identity=37.5, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17562970, Length=310, Percent_Identity=37.0967741935484, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=309, Percent_Identity=35.9223300970874, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17534315, Length=334, Percent_Identity=36.8263473053892, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17561720, Length=310, Percent_Identity=36.7741935483871, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI115535073, Length=310, Percent_Identity=35.8064516129032, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=33.8414634146341, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=32.579185520362, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=357, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=37.6543209876543, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321594, Length=328, Percent_Identity=34.4512195121951, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24643623, Length=323, Percent_Identity=38.0804953560372, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129101, Length=323, Percent_Identity=38.0804953560372, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35588; Mature: 35588

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAPAIAPDTISLIGNTPLVRLKGPSEETGCEIYGKCEFTNPGASVKDRAALWIVRDAEE
CCCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEHHH
RGILKPGGTIVEGTAGNTGIGLALVANARGYKSVIVMPETQSREKMDTLRALRSELVLVP
CCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEE
AAPFSNPGHFVHTSRRIAEETEGAVWANQFDNIANRRAHIESTAPEIWEQMEHRIDGFTC
CCCCCCCCCEEECHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEE
AAGTGGTIAGVGMGLKAFDENITIALTDPHGAALYNYYAHGELKAEGSSVAEGIGQGRIT
ECCCCCCEEECCCCCEEECCCEEEEEECCCCCEEEEEEECCEEECCCHHHHHHCCCCEEE
ANLDGAPIDTQFRISDEEGLHWVERLLAEEGLCLGLSSGINVAGAVALARQLGKGSRVAT
EECCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCEEEE
ILCDTGFRYLSSLYNPEWLKTKGLRVFPWLEQ
EEECCHHHHHHHHCCCCCEEECCCEEECCCCC
>Mature Secondary Structure
MMAPAIAPDTISLIGNTPLVRLKGPSEETGCEIYGKCEFTNPGASVKDRAALWIVRDAEE
CCCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEHHH
RGILKPGGTIVEGTAGNTGIGLALVANARGYKSVIVMPETQSREKMDTLRALRSELVLVP
CCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEE
AAPFSNPGHFVHTSRRIAEETEGAVWANQFDNIANRRAHIESTAPEIWEQMEHRIDGFTC
CCCCCCCCCEEECHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEE
AAGTGGTIAGVGMGLKAFDENITIALTDPHGAALYNYYAHGELKAEGSSVAEGIGQGRIT
ECCCCCCEEECCCCCEEECCCEEEEEECCCCCEEEEEEECCEEECCCHHHHHHCCCCEEE
ANLDGAPIDTQFRISDEEGLHWVERLLAEEGLCLGLSSGINVAGAVALARQLGKGSRVAT
EECCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCEEEE
ILCDTGFRYLSSLYNPEWLKTKGLRVFPWLEQ
EEECCHHHHHHHHCCCCCEEECCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA