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The map label for this gene is cysM [C]

Identifier: 87199083

GI number: 87199083

Start: 1104677

End: 1105735

Strand: Direct

Name: cysM [C]

Synonym: Saro_1061

Alternate gene names: 87199083

Gene position: 1104677-1105735 (Clockwise)

Preceding gene: 87199082

Following gene: 87199084

Centisome position: 31.02

GC content: 65.63

Gene sequence:

>1059_bases
ATGCGGGAAGAATCCAGGGCCTGGGCCGACGAGGCGGTGCGGCGGATCGAGGCGGATTTCAACCGCTCAGCCGACACGCA
TCTCATCCGCGTAGAACTTCCACGCTTTCCGGGCATCACGCTCTATCTCAAGGACGAGAGCGTCCATCCGACCGGCAGTC
TCAAGCACCGGCTCGCCCGCTCGCTGATCCTCTATGGCCTGTGCAACAATCGCATCGGGCCCGACACGCTGTTGGTCGAT
GCGACGAGTGGCTCCACGGCGGTGTCGGAAGCCTATTTCGCCCGGCTGATCGGCCTGCGCTTCGTGGCGGTTATTCCGCG
CAGCACGTCACCCGCGAAGATCGATGCGATCCGCTTTCACGGCGGGGAGGTGCACATGGTCGATACCGCGGCGCAGATGT
ACGCGGAGGCGGCGCGCCTTGCGGACGACGCGGGCGGTTTGTTCCTTGACCAGTTCACGTATGCCGAGCGCGCGACCGAC
TGGCGCGGCAACAACAACATCGCGCAATCCATCTTCCAGCAGATGTCGCGCGAGGATCATCCGGTGCCGTCGTGGATCGT
GTGCGGGGCTGGGACCGGTGGTACTTCCGCCACGCTCGGGCGCTTCATCCGTTACGGCCGCCATGCGACACGGCTTTGCG
TTGCAGATCCTGAAGGCTCGGTGTTCCACCTCCACCATGCCGACCGAAGCGTCACAGAGCCGTCCCGGGGAGTGCGCTGC
ATGATCGAGGGAATCGGCCGGCCGCGCGTGGAGCCTTCTTTCCTGCCCGACGTGATCGACCGCATGATCGCGGTGCCCGA
TGCGGCGTCGATCGGTGCGATGCGGGCCATCGCAGCGCGGATCGGACGTCCGGTCGGGGGTTCGACAGGAACCAATGTCC
ACGCTTGCCTCGAGATCGCGCAGGAAATGGCAGCTTCCGGCGAGACCGGGTCGATCGTCACGATCCTGTGCGATTCCGGG
CTGCGCTATGCGGGGACCTACTACGACGATGCCTGGCTCGACGGGCAGGGCATCGACTGGCGGGCCGACGAGGTGCGCGT
CGCGGCGTTGCTTTCCTGA

Upstream 100 bases:

>100_bases
CGCGGCGAGCCTCGAGGACCTTCAGCGCGCACCGGGCGTAAGTGCGGCGGTCGCGCAGACGATCTACGACTTCTACCATC
CCTCGGGATAGGAGGACACG

Downstream 100 bases:

>100_bases
CACGCCCCAACGGCAAAGCTTCCTTTCCGACGAGGTAACCCTGTTTGTTGGGTGCCGGTTGACGGTCCGCAGCGCCAAGT
TCGCTTTGGACCTGCGGCTG

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MREESRAWADEAVRRIEADFNRSADTHLIRVELPRFPGITLYLKDESVHPTGSLKHRLARSLILYGLCNNRIGPDTLLVD
ATSGSTAVSEAYFARLIGLRFVAVIPRSTSPAKIDAIRFHGGEVHMVDTAAQMYAEAARLADDAGGLFLDQFTYAERATD
WRGNNNIAQSIFQQMSREDHPVPSWIVCGAGTGGTSATLGRFIRYGRHATRLCVADPEGSVFHLHHADRSVTEPSRGVRC
MIEGIGRPRVEPSFLPDVIDRMIAVPDAASIGAMRAIAARIGRPVGGSTGTNVHACLEIAQEMAASGETGSIVTILCDSG
LRYAGTYYDDAWLDGQGIDWRADEVRVAALLS

Sequences:

>Translated_352_residues
MREESRAWADEAVRRIEADFNRSADTHLIRVELPRFPGITLYLKDESVHPTGSLKHRLARSLILYGLCNNRIGPDTLLVD
ATSGSTAVSEAYFARLIGLRFVAVIPRSTSPAKIDAIRFHGGEVHMVDTAAQMYAEAARLADDAGGLFLDQFTYAERATD
WRGNNNIAQSIFQQMSREDHPVPSWIVCGAGTGGTSATLGRFIRYGRHATRLCVADPEGSVFHLHHADRSVTEPSRGVRC
MIEGIGRPRVEPSFLPDVIDRMIAVPDAASIGAMRAIAARIGRPVGGSTGTNVHACLEIAQEMAASGETGSIVTILCDSG
LRYAGTYYDDAWLDGQGIDWRADEVRVAALLS
>Mature_352_residues
MREESRAWADEAVRRIEADFNRSADTHLIRVELPRFPGITLYLKDESVHPTGSLKHRLARSLILYGLCNNRIGPDTLLVD
ATSGSTAVSEAYFARLIGLRFVAVIPRSTSPAKIDAIRFHGGEVHMVDTAAQMYAEAARLADDAGGLFLDQFTYAERATD
WRGNNNIAQSIFQQMSREDHPVPSWIVCGAGTGGTSATLGRFIRYGRHATRLCVADPEGSVFHLHHADRSVTEPSRGVRC
MIEGIGRPRVEPSFLPDVIDRMIAVPDAASIGAMRAIAARIGRPVGGSTGTNVHACLEIAQEMAASGETGSIVTILCDSG
LRYAGTYYDDAWLDGQGIDWRADEVRVAALLS

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=338, Percent_Identity=26.0355029585799, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI295821200, Length=338, Percent_Identity=26.0355029585799, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4557415, Length=338, Percent_Identity=26.0355029585799, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=27.2435897435897, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=352, Percent_Identity=32.1022727272727, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17539640, Length=362, Percent_Identity=28.4530386740331, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17539800, Length=354, Percent_Identity=28.8135593220339, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321594, Length=340, Percent_Identity=27.3529411764706, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=26.7267267267267, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643623, Length=333, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI20129101, Length=333, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38280; Mature: 38280

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREESRAWADEAVRRIEADFNRSADTHLIRVELPRFPGITLYLKDESVHPTGSLKHRLAR
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHH
SLILYGLCNNRIGPDTLLVDATSGSTAVSEAYFARLIGLRFVAVIPRSTSPAKIDAIRFH
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEC
GGEVHMVDTAAQMYAEAARLADDAGGLFLDQFTYAERATDWRGNNNIAQSIFQQMSREDH
CCEEEEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
PVPSWIVCGAGTGGTSATLGRFIRYGRHATRLCVADPEGSVFHLHHADRSVTEPSRGVRC
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEE
MIEGIGRPRVEPSFLPDVIDRMIAVPDAASIGAMRAIAARIGRPVGGSTGTNVHACLEIA
EEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
QEMAASGETGSIVTILCDSGLRYAGTYYDDAWLDGQGIDWRADEVRVAALLS
HHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MREESRAWADEAVRRIEADFNRSADTHLIRVELPRFPGITLYLKDESVHPTGSLKHRLAR
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHH
SLILYGLCNNRIGPDTLLVDATSGSTAVSEAYFARLIGLRFVAVIPRSTSPAKIDAIRFH
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEC
GGEVHMVDTAAQMYAEAARLADDAGGLFLDQFTYAERATDWRGNNNIAQSIFQQMSREDH
CCEEEEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
PVPSWIVCGAGTGGTSATLGRFIRYGRHATRLCVADPEGSVFHLHHADRSVTEPSRGVRC
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEE
MIEGIGRPRVEPSFLPDVIDRMIAVPDAASIGAMRAIAARIGRPVGGSTGTNVHACLEIA
EEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
QEMAASGETGSIVTILCDSGLRYAGTYYDDAWLDGQGIDWRADEVRVAALLS
HHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]