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The map label for this gene is uvrC

Identifier: 87199082

GI number: 87199082

Start: 1102691

End: 1104667

Strand: Direct

Name: uvrC

Synonym: Saro_1060

Alternate gene names: 87199082

Gene position: 1102691-1104667 (Clockwise)

Preceding gene: 87199081

Following gene: 87199083

Centisome position: 30.96

GC content: 66.16

Gene sequence:

>1977_bases
TTGCGCCGCGCGCCCGAGCGACTATCTGCTTGTCACGCCATGGCCCGCAAGCCCCAGACCCCGCCCGACCGAGAGACCGA
GCGCTTCCACGAGGAGCGGGCCGCCACGACCCTGCGCGGCGCCGACCGGCCGGACATTGAGCTTGGCGCCGGTGTGATCC
GCGAAACGGTACAGACGCTCAAGCCCAAGCCCGGCGTCTACCGCATGCTCGATGCGCGGGGCGATGTCCTCTACGTTGGC
AAGGCGCGCGCTCTGAAGAACCGGGTGGCGAACTACACCCAGGTCGAACGCCTGCCCAACCGTCTTCGCCGCATGGTCAG
CCAGACGCGCAGCATGACCATCGTCACCACCAATTCGGAAGCCGAGGCGCTGCTGCTCGAGGCACAGCTCATCAAGCGTT
TCCGGCCGCCCTACAATGTCCTGCTGCGTGACGACAAATCGTTCCCCTTCATCCTCCTGCGCGGGGATCACGCGTTCCCG
CGCATCAGCAAGCATCGCGGCGCGCGCAAGGCCAAGGGCAACTACTACGGTCCGTTCGCCAGTGCCGGCAGTGTGAACAC
CACGATCAACGCGCTGCAGAAGCTGTTCCTGTTGAGGAGTTGCAACGACGGGTTCATGGCGCGGCGTGACAGGCCGTGCC
TGCTTTACCAGATCCGGCGCTGCTCGGCCCCTTGCGTCGGCCGGATATCGGAAGCCGACTACGGCGAGCTGGTACGGCAG
GCGAAGGATTTCCTCGGCGGAAAGTCGGGCGCGGTGCAGCGCGAGATCGAGGCGCAGATGCACAAGGCGGCCGAGGACCT
CGATTTCGAGCGCGCCGCCATGTTGCGCGACCGGTTGCGCGCCGCGACGTTCATCCAGGGGAGCCAGGCGATCAATGCCG
AAGGCGTGGGCAATGCCGATGTCTTCGCCATGGCGACGAAGGGCGGGCAGGTGGCCGTGCAGGCCTTCTTCATCCGGGGC
GGCCAGAACTGGGGCCACCGCGCCTTCTTCCCCAGCCACACCGAGGGCTTGTCGGAAGAGGAAGTGATGACCAGCTTCCT
GGCGCAGTTCTACGAGGAAGTGCCGCCTGCAAGATTGATCCTCGTCGATCGCGCCTTGCCCGAGGCGGATCTGCTGGCCG
AAGCCTTGTGCGAAGCCGCCGGAGGGAAGGTCGAGATATCGGTGCCCCAGCGCGGCGACCGGCGCCGTCTCATGGAACAG
GCGCAGCGCAATGCCGTGGAAGCGCTCGACCGGCGCATGGCCGAAAGCGGAACCAAGGCGAAGGTCATGCGGGAACTGGC
CGAATTCCTCGAACTGCCTGAAGTCCCGCAGCGAATCGAGATCTACGACAACAGCCACATCCAGGGGACCAATGCCCTTG
GCGCGATGGTCGTCGCGGGGCCGGAAGGGTTTGTGAAGGGCCAGTACCGCAAATGGAACATCAAGCTGGCCCAGACGAAT
GACGACTTCGCGATGATGCGCGAGGTGATGACCCGCCGCTTCGGGCGCGCGCAGGAGGAGGACCCCGATCGGGAAAGCGG
CAACTGGCCCGATCTTGTGCTGATCGATGGCGGCAAGGGGCAGATGAGCGCGGTGAAGGAGGCCCTGGGCGAACTCGGCA
TCGAGGACGTTCCGCTGGTTGCCATCGCCAAGGGCCCGCACCATGGGCGCGAGGGGCGTGAGGTGTTCCATTTTCCCGAC
GGGCGCGAGAAGATGCTGCCGGTGAACTCGCCGGTGCTGTTCCAGCTTCAGGTCATGCGCGACGAAGTGCACCGTTTTGC
CATCGGCGCGCATCGGGCGAAGCGCAGCCGCGCGATCACCGCGAGCCCGCTGGACGAGATTCCCGGAATCGGCCCCGCGC
GCAAGCGGGCGCTGTTGCTGCACTTCGGCACTGCGGGCAAGGTGCGCGCGGCGAGCCTCGAGGACCTTCAGCGCGCACCG
GGCGTAAGTGCGGCGGTCGCGCAGACGATCTACGACTTCTACCATCCCTCGGGATAG

Upstream 100 bases:

>100_bases
CCCGTTCGCGGGACCGGGCCTGTGGGTTCAGGAGGTCCATGCGGGAAAACCCTGAGCCTGCGCTTCGTCGGAGCGCTGGG
GAAAGGGCAGGTGCGGCCCA

Downstream 100 bases:

>100_bases
GAGGACACGATGCGGGAAGAATCCAGGGCCTGGGCCGACGAGGCGGTGCGGCGGATCGAGGCGGATTTCAACCGCTCAGC
CGACACGCATCTCATCCGCG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MRRAPERLSACHAMARKPQTPPDRETERFHEERAATTLRGADRPDIELGAGVIRETVQTLKPKPGVYRMLDARGDVLYVG
KARALKNRVANYTQVERLPNRLRRMVSQTRSMTIVTTNSEAEALLLEAQLIKRFRPPYNVLLRDDKSFPFILLRGDHAFP
RISKHRGARKAKGNYYGPFASAGSVNTTINALQKLFLLRSCNDGFMARRDRPCLLYQIRRCSAPCVGRISEADYGELVRQ
AKDFLGGKSGAVQREIEAQMHKAAEDLDFERAAMLRDRLRAATFIQGSQAINAEGVGNADVFAMATKGGQVAVQAFFIRG
GQNWGHRAFFPSHTEGLSEEEVMTSFLAQFYEEVPPARLILVDRALPEADLLAEALCEAAGGKVEISVPQRGDRRRLMEQ
AQRNAVEALDRRMAESGTKAKVMRELAEFLELPEVPQRIEIYDNSHIQGTNALGAMVVAGPEGFVKGQYRKWNIKLAQTN
DDFAMMREVMTRRFGRAQEEDPDRESGNWPDLVLIDGGKGQMSAVKEALGELGIEDVPLVAIAKGPHHGREGREVFHFPD
GREKMLPVNSPVLFQLQVMRDEVHRFAIGAHRAKRSRAITASPLDEIPGIGPARKRALLLHFGTAGKVRAASLEDLQRAP
GVSAAVAQTIYDFYHPSG

Sequences:

>Translated_658_residues
MRRAPERLSACHAMARKPQTPPDRETERFHEERAATTLRGADRPDIELGAGVIRETVQTLKPKPGVYRMLDARGDVLYVG
KARALKNRVANYTQVERLPNRLRRMVSQTRSMTIVTTNSEAEALLLEAQLIKRFRPPYNVLLRDDKSFPFILLRGDHAFP
RISKHRGARKAKGNYYGPFASAGSVNTTINALQKLFLLRSCNDGFMARRDRPCLLYQIRRCSAPCVGRISEADYGELVRQ
AKDFLGGKSGAVQREIEAQMHKAAEDLDFERAAMLRDRLRAATFIQGSQAINAEGVGNADVFAMATKGGQVAVQAFFIRG
GQNWGHRAFFPSHTEGLSEEEVMTSFLAQFYEEVPPARLILVDRALPEADLLAEALCEAAGGKVEISVPQRGDRRRLMEQ
AQRNAVEALDRRMAESGTKAKVMRELAEFLELPEVPQRIEIYDNSHIQGTNALGAMVVAGPEGFVKGQYRKWNIKLAQTN
DDFAMMREVMTRRFGRAQEEDPDRESGNWPDLVLIDGGKGQMSAVKEALGELGIEDVPLVAIAKGPHHGREGREVFHFPD
GREKMLPVNSPVLFQLQVMRDEVHRFAIGAHRAKRSRAITASPLDEIPGIGPARKRALLLHFGTAGKVRAASLEDLQRAP
GVSAAVAQTIYDFYHPSG
>Mature_658_residues
MRRAPERLSACHAMARKPQTPPDRETERFHEERAATTLRGADRPDIELGAGVIRETVQTLKPKPGVYRMLDARGDVLYVG
KARALKNRVANYTQVERLPNRLRRMVSQTRSMTIVTTNSEAEALLLEAQLIKRFRPPYNVLLRDDKSFPFILLRGDHAFP
RISKHRGARKAKGNYYGPFASAGSVNTTINALQKLFLLRSCNDGFMARRDRPCLLYQIRRCSAPCVGRISEADYGELVRQ
AKDFLGGKSGAVQREIEAQMHKAAEDLDFERAAMLRDRLRAATFIQGSQAINAEGVGNADVFAMATKGGQVAVQAFFIRG
GQNWGHRAFFPSHTEGLSEEEVMTSFLAQFYEEVPPARLILVDRALPEADLLAEALCEAAGGKVEISVPQRGDRRRLMEQ
AQRNAVEALDRRMAESGTKAKVMRELAEFLELPEVPQRIEIYDNSHIQGTNALGAMVVAGPEGFVKGQYRKWNIKLAQTN
DDFAMMREVMTRRFGRAQEEDPDRESGNWPDLVLIDGGKGQMSAVKEALGELGIEDVPLVAIAKGPHHGREGREVFHFPD
GREKMLPVNSPVLFQLQVMRDEVHRFAIGAHRAKRSRAITASPLDEIPGIGPARKRALLLHFGTAGKVRAASLEDLQRAP
GVSAAVAQTIYDFYHPSG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=604, Percent_Identity=38.9072847682119, Blast_Score=433, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_NOVAD (Q2G9G8)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496339.1
- ProteinModelPortal:   Q2G9G8
- STRING:   Q2G9G8
- GeneID:   3916356
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1060
- NMPDR:   fig|48935.1.peg.2205
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q2G9G8
- ProtClustDB:   PRK00558
- BioCyc:   NARO279238:SARO_1060-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 73264; Mature: 73264

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAPERLSACHAMARKPQTPPDRETERFHEERAATTLRGADRPDIELGAGVIRETVQTL
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KPKPGVYRMLDARGDVLYVGKARALKNRVANYTQVERLPNRLRRMVSQTRSMTIVTTNSE
CCCCCHHHEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
AEALLLEAQLIKRFRPPYNVLLRDDKSFPFILLRGDHAFPRISKHRGARKAKGNYYGPFA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCC
SAGSVNTTINALQKLFLLRSCNDGFMARRDRPCLLYQIRRCSAPCVGRISEADYGELVRQ
CCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AKDFLGGKSGAVQREIEAQMHKAAEDLDFERAAMLRDRLRAATFIQGSQAINAEGVGNAD
HHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VFAMATKGGQVAVQAFFIRGGQNWGHRAFFPSHTEGLSEEEVMTSFLAQFYEEVPPARLI
EEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
LVDRALPEADLLAEALCEAAGGKVEISVPQRGDRRRLMEQAQRNAVEALDRRMAESGTKA
EEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KVMRELAEFLELPEVPQRIEIYDNSHIQGTNALGAMVVAGPEGFVKGQYRKWNIKLAQTN
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEEECC
DDFAMMREVMTRRFGRAQEEDPDRESGNWPDLVLIDGGKGQMSAVKEALGELGIEDVPLV
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEE
AIAKGPHHGREGREVFHFPDGREKMLPVNSPVLFQLQVMRDEVHRFAIGAHRAKRSRAIT
EEECCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCC
ASPLDEIPGIGPARKRALLLHFGTAGKVRAASLEDLQRAPGVSAAVAQTIYDFYHPSG
CCCHHHCCCCCCHHHCEEEEEECCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRAPERLSACHAMARKPQTPPDRETERFHEERAATTLRGADRPDIELGAGVIRETVQTL
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KPKPGVYRMLDARGDVLYVGKARALKNRVANYTQVERLPNRLRRMVSQTRSMTIVTTNSE
CCCCCHHHEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
AEALLLEAQLIKRFRPPYNVLLRDDKSFPFILLRGDHAFPRISKHRGARKAKGNYYGPFA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCC
SAGSVNTTINALQKLFLLRSCNDGFMARRDRPCLLYQIRRCSAPCVGRISEADYGELVRQ
CCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AKDFLGGKSGAVQREIEAQMHKAAEDLDFERAAMLRDRLRAATFIQGSQAINAEGVGNAD
HHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VFAMATKGGQVAVQAFFIRGGQNWGHRAFFPSHTEGLSEEEVMTSFLAQFYEEVPPARLI
EEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
LVDRALPEADLLAEALCEAAGGKVEISVPQRGDRRRLMEQAQRNAVEALDRRMAESGTKA
EEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KVMRELAEFLELPEVPQRIEIYDNSHIQGTNALGAMVVAGPEGFVKGQYRKWNIKLAQTN
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEEECC
DDFAMMREVMTRRFGRAQEEDPDRESGNWPDLVLIDGGKGQMSAVKEALGELGIEDVPLV
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEE
AIAKGPHHGREGREVFHFPDGREKMLPVNSPVLFQLQVMRDEVHRFAIGAHRAKRSRAIT
EEECCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCC
ASPLDEIPGIGPARKRALLLHFGTAGKVRAASLEDLQRAPGVSAAVAQTIYDFYHPSG
CCCHHHCCCCCCHHHCEEEEEECCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA