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The map label for this gene is hisB

Identifier: 87199028

GI number: 87199028

Start: 1048789

End: 1049382

Strand: Direct

Name: hisB

Synonym: Saro_1006

Alternate gene names: 87199028

Gene position: 1048789-1049382 (Clockwise)

Preceding gene: 87199024

Following gene: 87199029

Centisome position: 29.45

GC content: 64.48

Gene sequence:

>594_bases
ATGCGCACCGGATCGATCACGCGGAAGACCGAGGAAACCGACATCGCCGTGTCGGTGAACCTCGATGGCACCGGCACCTA
CAAGGTGGACACGGGCATCGGCTTTCTCGACCACATGATCGAGCAGTTCAGCCGTCACTCGCTGATCGACATCGAATGCC
GCGTGAAGGGCGATCTCCACGTCGACCAGCACCACACGACCGAGGACAGCGCCATCGCGCTGGGCCAGGCGATCTCGCAG
GCGCTCGGCGACAAGAAGGGCATCACCCGTTACGGCCACACCTACTCGCCGATGGACGAGGCGCTGTGCCGCGTCGCGCT
CGATATTTCGGGCCGTCCGGTGCTGGTGTGGAAGGCCGCCTTCACCCAGCCGCGCCTTGGCGAGATGGACACCGAGCTGT
TCGAGCACTGGTTCCAGTCGATCAGCCAGGCTGCGGGCATCACGCTCCACATCGAAAGCCTCTACGGCTCGAACAACCAC
CACATCATCGAGGGCATCTACAAGGGCTTCGCCCGTGCGATGCGCGCCGCCATCGCGATCGATCCGCGCAAGGCCGACGC
CGTCCCTTCGACCAAGGGCATCCTCGGTGGCTGA

Upstream 100 bases:

>100_bases
CGGGTGTGTCGCTCATGCCCAGACAACTGGCCCCGGTGACCGCGCCGGTCAAGTGGGGACGGTGATTGATTCTCGAGAGG
AGGGGCGTATAGGCGCGTCC

Downstream 100 bases:

>100_bases
GACGCTCGCGCTCGTCGACTATGGCGCGGGCAACCTGCGCTCGGTTGCAAATGCGCTCAAGGCGGCGGGGGCCGAGGGCG
TCGTGGTGACCGCCGATCCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MRTGSITRKTEETDIAVSVNLDGTGTYKVDTGIGFLDHMIEQFSRHSLIDIECRVKGDLHVDQHHTTEDSAIALGQAISQ
ALGDKKGITRYGHTYSPMDEALCRVALDISGRPVLVWKAAFTQPRLGEMDTELFEHWFQSISQAAGITLHIESLYGSNNH
HIIEGIYKGFARAMRAAIAIDPRKADAVPSTKGILGG

Sequences:

>Translated_197_residues
MRTGSITRKTEETDIAVSVNLDGTGTYKVDTGIGFLDHMIEQFSRHSLIDIECRVKGDLHVDQHHTTEDSAIALGQAISQ
ALGDKKGITRYGHTYSPMDEALCRVALDISGRPVLVWKAAFTQPRLGEMDTELFEHWFQSISQAAGITLHIESLYGSNNH
HIIEGIYKGFARAMRAAIAIDPRKADAVPSTKGILGG
>Mature_197_residues
MRTGSITRKTEETDIAVSVNLDGTGTYKVDTGIGFLDHMIEQFSRHSLIDIECRVKGDLHVDQHHTTEDSAIALGQAISQ
ALGDKKGITRYGHTYSPMDEALCRVALDISGRPVLVWKAAFTQPRLGEMDTELFEHWFQSISQAAGITLHIESLYGSNNH
HIIEGIYKGFARAMRAAIAIDPRKADAVPSTKGILGG

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=48.9690721649485, Blast_Score=197, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324776, Length=214, Percent_Identity=38.3177570093458, Blast_Score=159, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_NOVAD (Q2G9M2)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496285.1
- ProteinModelPortal:   Q2G9M2
- SMR:   Q2G9M2
- STRING:   Q2G9M2
- GeneID:   3915788
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1006
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q2G9M2
- ProtClustDB:   PRK00951
- BioCyc:   NARO279238:SARO_1006-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21590; Mature: 21590

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTGSITRKTEETDIAVSVNLDGTGTYKVDTGIGFLDHMIEQFSRHSLIDIECRVKGDLH
CCCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCEE
VDQHHTTEDSAIALGQAISQALGDKKGITRYGHTYSPMDEALCRVALDISGRPVLVWKAA
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEC
FTQPRLGEMDTELFEHWFQSISQAAGITLHIESLYGSNNHHIIEGIYKGFARAMRAAIAI
CCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEE
DPRKADAVPSTKGILGG
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTGSITRKTEETDIAVSVNLDGTGTYKVDTGIGFLDHMIEQFSRHSLIDIECRVKGDLH
CCCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCEE
VDQHHTTEDSAIALGQAISQALGDKKGITRYGHTYSPMDEALCRVALDISGRPVLVWKAA
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEC
FTQPRLGEMDTELFEHWFQSISQAAGITLHIESLYGSNNHHIIEGIYKGFARAMRAAIAI
CCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEE
DPRKADAVPSTKGILGG
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA