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The map label for this gene is lrp [H]

Identifier: 87198622

GI number: 87198622

Start: 643385

End: 643897

Strand: Direct

Name: lrp [H]

Synonym: Saro_0598

Alternate gene names: 87198622

Gene position: 643385-643897 (Clockwise)

Preceding gene: 87198620

Following gene: 87198623

Centisome position: 18.06

GC content: 65.89

Gene sequence:

>513_bases
GTGGGGCGCGCCAATGCTGCGTCATATCGCTCAAATGCGCGGATTTTCTGCATGGACGAAATAGATCGAAACATTCTTGC
GCAGCTTCAGATGGATTCGGGGCGTTCGCACGCGGACCTTGCCGAGGTGGTCCACCTCTCGGCCTCGCAGGTCTCGCGGC
GCATCTCGCGGCTTCAGGCCGAGGGGGTGATCCGCGGCCAGGTGGCGCTGCTCGACGAGCAAGCGCTGGGCCTTCAGGTG
GAGGCCTTCGTCGCGGTGGCTATGGCGAGCTATGCGCCCGACGCGGTGCGCGCGTTCCACGACCGCATCTCCGCACTGGA
AGAGGTGCTGGATTGCTGCGCGACGACGGGCGCTTCCGATTATCTGCTGCGGGTGGTCGCACGTGACCTGCGCGCCTACT
CGCGGCTGATGAACGAGGAAATCCTTGGTCACGGCGATGTCGCCAGCGTGCGGTCGAGCGTGGTGCTGGACCGCATCAAG
CGGACGACGGCGCTGCCGCTGGGCGGGCCATAG

Upstream 100 bases:

>100_bases
ACGCGTCACTCTCCATGCGATCGTCCGCCGTGCGGGATATCGAGCGGATGATACCACAAGCGGCTTGCGTGGTCCGCGCA
AAGTGGGCAGGGATTTACGG

Downstream 100 bases:

>100_bases
GCGCGGCGCGCGCCGTTTCCGTCGAGGGGGGGCATAGCCGGCGAGGGCATTTCGGCATCTTTTTCATCGATCCGATCTAT
GACCCGGCGCGCCGAGCGGG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MGRANAASYRSNARIFCMDEIDRNILAQLQMDSGRSHADLAEVVHLSASQVSRRISRLQAEGVIRGQVALLDEQALGLQV
EAFVAVAMASYAPDAVRAFHDRISALEEVLDCCATTGASDYLLRVVARDLRAYSRLMNEEILGHGDVASVRSSVVLDRIK
RTTALPLGGP

Sequences:

>Translated_170_residues
MGRANAASYRSNARIFCMDEIDRNILAQLQMDSGRSHADLAEVVHLSASQVSRRISRLQAEGVIRGQVALLDEQALGLQV
EAFVAVAMASYAPDAVRAFHDRISALEEVLDCCATTGASDYLLRVVARDLRAYSRLMNEEILGHGDVASVRSSVVLDRIK
RTTALPLGGP
>Mature_169_residues
GRANAASYRSNARIFCMDEIDRNILAQLQMDSGRSHADLAEVVHLSASQVSRRISRLQAEGVIRGQVALLDEQALGLQVE
AFVAVAMASYAPDAVRAFHDRISALEEVLDCCATTGASDYLLRVVARDLRAYSRLMNEEILGHGDVASVRSSVVLDRIKR
TTALPLGGP

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=35.1351351351351, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=34, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18453; Mature: 18322

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRANAASYRSNARIFCMDEIDRNILAQLQMDSGRSHADLAEVVHLSASQVSRRISRLQA
CCCCCCCHHCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGVIRGQVALLDEQALGLQVEAFVAVAMASYAPDAVRAFHDRISALEEVLDCCATTGASD
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
YLLRVVARDLRAYSRLMNEEILGHGDVASVRSSVVLDRIKRTTALPLGGP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GRANAASYRSNARIFCMDEIDRNILAQLQMDSGRSHADLAEVVHLSASQVSRRISRLQA
CCCCCCHHCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGVIRGQVALLDEQALGLQVEAFVAVAMASYAPDAVRAFHDRISALEEVLDCCATTGASD
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
YLLRVVARDLRAYSRLMNEEILGHGDVASVRSSVVLDRIKRTTALPLGGP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]