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The map label for this gene is mutM

Identifier: 87198620

GI number: 87198620

Start: 641330

End: 642142

Strand: Direct

Name: mutM

Synonym: Saro_0596

Alternate gene names: 87198620

Gene position: 641330-642142 (Clockwise)

Preceding gene: 87198616

Following gene: 87198622

Centisome position: 18.01

GC content: 67.53

Gene sequence:

>813_bases
ATGCCTGAACTTCCCGAAGTAGAAACGACCGTCCGTGGCCTCGCAACCGTCCTTGACGGGCAGGTGATACGCCGCGTGGC
GGTGAACCGCGCTGACCTGCGCCGGCCTTTTCCCGAGGACCTCGCCCAGGCGCTGACCGGTGCGCGGGTGACGGGCATGG
GACGCCGCGCGAAGTACGGCCTGATCCACACTGACCGCGAACGCACGATGGTGTTCCACCTGGGCATGTCGGGGCGCTGG
AGGATCGATCCGGAAGACATCGGCAAGCACGACCATCTTGTGCTGGAAACGGGCGAAGGGCGGGTGCTTTCGCTAAACGA
TGCGCGGCGTTTCGGTTCCGTCGATCTTGTCGATACCGGCAGGCTGGAGGAATGGCCGCCGTTCGCCGCGCTTGGGCCCG
AACCGTTGGGGCCGGGACTTAAGGCGCGCCATCTGGCGAAGGCATTCGAGGGCCGGATCGCGGCGGTGAAGCTCCTGCTG
CTCGACCAGCAGATCGTGGCCGGGCTGGGCAACATCTATGTCTGCGAGGCGCTGTACCGCGCGCGCATCCACCCCGAGCG
CGAAGGCGGCAAGGTTTCGGCAAGGGCGCTGGGCCTGCTGGTGCCGGCGATCCGCGCTGTGCTGGAGGAGTCCATCGCGG
CGGGCGGTTCCACCTTGCGCGACTATGCGCGGCCCGACGGCGAGCTTGGCTATTTCGCCAAGGACTGGCGCGTCTATGGC
CGCGAGGGCGAACCCTGCCAGTGCGGGGGCGTGGTGAAGCGGATCGTGCAGGGCGGGCGCTCGACCTTCTTCTGCCCCAG
GTGCCAGAAGTAG

Upstream 100 bases:

>100_bases
TGTCTTCGTAGCCAAACGATGCGGTTTCGGGGCTGGTCATGTCGAGTGCCTTTAGTGGGGAATTGCCCGGACGGCAAAGG
CTGTTAGGGGTTGGCGGGTC

Downstream 100 bases:

>100_bases
AGGCCGGGCGCCGCCGCGATCCGGTTTGCGGTCAGGCTTCGGTCTTGAGCACGCCGCGACGAAGCTGGTCGCGTTCCATC
GACTTGAACAGGGCGGTGAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MPELPEVETTVRGLATVLDGQVIRRVAVNRADLRRPFPEDLAQALTGARVTGMGRRAKYGLIHTDRERTMVFHLGMSGRW
RIDPEDIGKHDHLVLETGEGRVLSLNDARRFGSVDLVDTGRLEEWPPFAALGPEPLGPGLKARHLAKAFEGRIAAVKLLL
LDQQIVAGLGNIYVCEALYRARIHPEREGGKVSARALGLLVPAIRAVLEESIAAGGSTLRDYARPDGELGYFAKDWRVYG
REGEPCQCGGVVKRIVQGGRSTFFCPRCQK

Sequences:

>Translated_270_residues
MPELPEVETTVRGLATVLDGQVIRRVAVNRADLRRPFPEDLAQALTGARVTGMGRRAKYGLIHTDRERTMVFHLGMSGRW
RIDPEDIGKHDHLVLETGEGRVLSLNDARRFGSVDLVDTGRLEEWPPFAALGPEPLGPGLKARHLAKAFEGRIAAVKLLL
LDQQIVAGLGNIYVCEALYRARIHPEREGGKVSARALGLLVPAIRAVLEESIAAGGSTLRDYARPDGELGYFAKDWRVYG
REGEPCQCGGVVKRIVQGGRSTFFCPRCQK
>Mature_269_residues
PELPEVETTVRGLATVLDGQVIRRVAVNRADLRRPFPEDLAQALTGARVTGMGRRAKYGLIHTDRERTMVFHLGMSGRWR
IDPEDIGKHDHLVLETGEGRVLSLNDARRFGSVDLVDTGRLEEWPPFAALGPEPLGPGLKARHLAKAFEGRIAAVKLLLL
DQQIVAGLGNIYVCEALYRARIHPEREGGKVSARALGLLVPAIRAVLEESIAAGGSTLRDYARPDGELGYFAKDWRVYGR
EGEPCQCGGVVKRIVQGGRSTFFCPRCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=42.1245421245421, Blast_Score=194, Evalue=4e-51,
Organism=Escherichia coli, GI1786932, Length=281, Percent_Identity=27.4021352313167, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_NOVAD (Q2GAT0)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_495877.1
- HSSP:   P42371
- ProteinModelPortal:   Q2GAT0
- SMR:   Q2GAT0
- STRING:   Q2GAT0
- GeneID:   3915608
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0596
- NMPDR:   fig|48935.1.peg.1193
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q2GAT0
- ProtClustDB:   PRK01103
- BioCyc:   NARO279238:SARO_0596-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29698; Mature: 29566

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 260-260 BINDING 90-90 BINDING 109-109 BINDING 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTVRGLATVLDGQVIRRVAVNRADLRRPFPEDLAQALTGARVTGMGRRAKYG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHCCCEECCCCCCEEC
LIHTDRERTMVFHLGMSGRWRIDPEDIGKHDHLVLETGEGRVLSLNDARRFGSVDLVDTG
CEECCCCCEEEEEECCCCEEEECHHHCCCCCEEEEECCCCCEEEECCHHHCCCEEEEECC
RLEEWPPFAALGPEPLGPGLKARHLAKAFEGRIAAVKLLLLDQQIVAGLGNIYVCEALYR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ARIHPEREGGKVSARALGLLVPAIRAVLEESIAAGGSTLRDYARPDGELGYFAKDWRVYG
HHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEEC
REGEPCQCGGVVKRIVQGGRSTFFCPRCQK
CCCCCCHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure 
PELPEVETTVRGLATVLDGQVIRRVAVNRADLRRPFPEDLAQALTGARVTGMGRRAKYG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHCCCEECCCCCCEEC
LIHTDRERTMVFHLGMSGRWRIDPEDIGKHDHLVLETGEGRVLSLNDARRFGSVDLVDTG
CEECCCCCEEEEEECCCCEEEECHHHCCCCCEEEEECCCCCEEEECCHHHCCCEEEEECC
RLEEWPPFAALGPEPLGPGLKARHLAKAFEGRIAAVKLLLLDQQIVAGLGNIYVCEALYR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ARIHPEREGGKVSARALGLLVPAIRAVLEESIAAGGSTLRDYARPDGELGYFAKDWRVYG
HHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEEC
REGEPCQCGGVVKRIVQGGRSTFFCPRCQK
CCCCCCHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA