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The map label for this gene is 86750996

Identifier: 86750996

GI number: 86750996

Start: 4441732

End: 4442706

Strand: Reverse

Name: 86750996

Synonym: RPB_3888

Alternate gene names: NA

Gene position: 4442706-4441732 (Counterclockwise)

Preceding gene: 86750997

Following gene: 86750991

Centisome position: 83.33

GC content: 73.54

Gene sequence:

>975_bases
GTGGCGCCCGTTACGCGCCTGAATGTCTGCGTGGTCGGCGCCGGCGCGATCGGCACCGCGCTGGCCGGGCGGCTGCATGC
CGCCGGCCATGCGGTATCGGTGCTGGCGCGCGGCGCGCGGCGGTCCTTTCTCGCGACGCACGGCCTGTCGCTGCGCGACG
GCGACCGCGATTTCGCCTTCCGGCCGGCATTGGCCGATCTCACCGATCTGTCGGCCTACGACCTGGTGATCGTCGCGGTG
AAGGCCGGCGCGCTGCCTTCGCTGCTGCCGCAGCTCGCCGCCGCGATGCGCCCCGACGCGCTGCTGATGCCGGCGATCAA
CGGGCTGCCGTGGTGGTACGGGCTCGGCGACAACGGGCCGCTGGCCGATCGGCCGATCGATGCGGTCGATCCCGGCGGCG
CGCTGCTGCCGCTGTTCGCGCCGCAGCGGCTGATCGGCTGCGTCGTCTACAGCCGGGTGACGATGCTCGGCAGCGGCCAC
GTCATCGTCAGCGGCCGGCAGGAGCTGCAGCTCGGCGCGGTCGGCGGCGCGCCGCCGCTGGCGCAGATCGCCGCGCGCTT
CAGCGACGCCGGCATCGCCGTCACCGTCGAGCCCGACATCCGCCGGGCGATGTGGCGCAAGCTGATCCGCAACGCCGCCA
CCAACGTCGTCTCCGCGCTCACCGGCGCGACGCTGGAGCAGATCGGCCACGACGCCGAAGCCATCCGCCTCGTCGCCGCG
ATCGCGCAGGAGGTTGCGGATCTCGCGGCGCGGCTCGGTCGCCCGGTCGATCCGGAAATCGAGGAACTGATCGCGGTGCT
ACGCAGCGCCGGCCCGTTCGCCACCTCGATGCTGCAGGACGTCCGCACCGGCCGCGAACCGGAACTCGGCGCGATTGCGC
AGGCGCCGCTCGAACTCGCCGACCAGATCGGCCACCCGATGCCGACCCTGCGCAGCGTCGCCGCGCTGCTGAAGCTGGCG
GTGCGGGTGAGGTGA

Upstream 100 bases:

>100_bases
TGCGGCGGATGATCAAGGCCCAGGGGCCGGCGTTCTGAACGCGGGCGTTTTGAACGCCATGAGCGGCAGCGCGCAAGGCA
CGGGCGCCATCGGGGCATCG

Downstream 100 bases:

>100_bases
ACGAACGCTTGCAACGGCACACCTCATGGTGAGGAGGCGCGAAGCGCCGTCTCGAACCATGCGCCTCCAGCGCTGCGTCG
CCCCATCCTTCGAGACGCCC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAPVTRLNVCVVGAGAIGTALAGRLHAAGHAVSVLARGARRSFLATHGLSLRDGDRDFAFRPALADLTDLSAYDLVIVAV
KAGALPSLLPQLAAAMRPDALLMPAINGLPWWYGLGDNGPLADRPIDAVDPGGALLPLFAPQRLIGCVVYSRVTMLGSGH
VIVSGRQELQLGAVGGAPPLAQIAARFSDAGIAVTVEPDIRRAMWRKLIRNAATNVVSALTGATLEQIGHDAEAIRLVAA
IAQEVADLAARLGRPVDPEIEELIAVLRSAGPFATSMLQDVRTGREPELGAIAQAPLELADQIGHPMPTLRSVAALLKLA
VRVR

Sequences:

>Translated_324_residues
MAPVTRLNVCVVGAGAIGTALAGRLHAAGHAVSVLARGARRSFLATHGLSLRDGDRDFAFRPALADLTDLSAYDLVIVAV
KAGALPSLLPQLAAAMRPDALLMPAINGLPWWYGLGDNGPLADRPIDAVDPGGALLPLFAPQRLIGCVVYSRVTMLGSGH
VIVSGRQELQLGAVGGAPPLAQIAARFSDAGIAVTVEPDIRRAMWRKLIRNAATNVVSALTGATLEQIGHDAEAIRLVAA
IAQEVADLAARLGRPVDPEIEELIAVLRSAGPFATSMLQDVRTGREPELGAIAQAPLELADQIGHPMPTLRSVAALLKLA
VRVR
>Mature_323_residues
APVTRLNVCVVGAGAIGTALAGRLHAAGHAVSVLARGARRSFLATHGLSLRDGDRDFAFRPALADLTDLSAYDLVIVAVK
AGALPSLLPQLAAAMRPDALLMPAINGLPWWYGLGDNGPLADRPIDAVDPGGALLPLFAPQRLIGCVVYSRVTMLGSGHV
IVSGRQELQLGAVGGAPPLAQIAARFSDAGIAVTVEPDIRRAMWRKLIRNAATNVVSALTGATLEQIGHDAEAIRLVAAI
AQEVADLAARLGRPVDPEIEELIAVLRSAGPFATSMLQDVRTGREPELGAIAQAPLELADQIGHPMPTLRSVAALLKLAV
RVR

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33766; Mature: 33635

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPVTRLNVCVVGAGAIGTALAGRLHAAGHAVSVLARGARRSFLATHGLSLRDGDRDFAF
CCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
RPALADLTDLSAYDLVIVAVKAGALPSLLPQLAAAMRPDALLMPAINGLPWWYGLGDNGP
CCHHHHHHCCCHHHEEEEEECCCCHHHHHHHHHHHHCCCCEECCCCCCCCCEEECCCCCC
LADRPIDAVDPGGALLPLFAPQRLIGCVVYSRVTMLGSGHVIVSGRQELQLGAVGGAPPL
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECCCCCCHH
AQIAARFSDAGIAVTVEPDIRRAMWRKLIRNAATNVVSALTGATLEQIGHDAEAIRLVAA
HHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IAQEVADLAARLGRPVDPEIEELIAVLRSAGPFATSMLQDVRTGREPELGAIAQAPLELA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
DQIGHPMPTLRSVAALLKLAVRVR
HHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
APVTRLNVCVVGAGAIGTALAGRLHAAGHAVSVLARGARRSFLATHGLSLRDGDRDFAF
CCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
RPALADLTDLSAYDLVIVAVKAGALPSLLPQLAAAMRPDALLMPAINGLPWWYGLGDNGP
CCHHHHHHCCCHHHEEEEEECCCCHHHHHHHHHHHHCCCCEECCCCCCCCCEEECCCCCC
LADRPIDAVDPGGALLPLFAPQRLIGCVVYSRVTMLGSGHVIVSGRQELQLGAVGGAPPL
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECCCCCCHH
AQIAARFSDAGIAVTVEPDIRRAMWRKLIRNAATNVVSALTGATLEQIGHDAEAIRLVAA
HHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IAQEVADLAARLGRPVDPEIEELIAVLRSAGPFATSMLQDVRTGREPELGAIAQAPLELA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
DQIGHPMPTLRSVAALLKLAVRVR
HHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]