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The map label for this gene is macA [H]

Identifier: 86750991

GI number: 86750991

Start: 4437635

End: 4438909

Strand: Reverse

Name: macA [H]

Synonym: RPB_3883

Alternate gene names: 86750991

Gene position: 4438909-4437635 (Counterclockwise)

Preceding gene: 86750996

Following gene: 86750990

Centisome position: 83.26

GC content: 70.35

Gene sequence:

>1275_bases
ATGCTGCACAAAGTCGATCCGTCGGGCGACCTGACGCTGCAGTCGCGGCCGCCTGTGGTCGTCCGCTGGGCGGGCGCGGT
CTGGCGCTACAAATGGGCGGTGCTCGGTATCGGGCTGGTGCTGATCGCGGCGGGGCTCGGGCTGGCCCGGCTGATGCTCG
GCCCGAAGGTCGTCGCCGTCGTCGTCGCGCGCGCCGATCTGGTGCAGAGCGTGGTCGCCTCCGGCCATATCGAGACGCCG
TACCGGGTCGAGATCGGCAGCCAGATCACCGGCACCGTCGCCGACGTGCTGGTGCGCGAGGGCGAGGTGGTTCGCGAAGG
CCAGAAGCTGATCGCGATCGAGGCCAGCGAGCTGGAAGCCGCGGTGGTCCAGGCCGAGGGCGCGGTGCAGCAGGCCGAGG
CGCGGGTGCGTCAGCTCCGTGAACTCACCAAGCCGGCCGCCGATCAGTCGCTGCAGCAGGCGCAGGCCAATCTGCTCAAC
GCCGAGGCGGCGTATGAACGCGCTTCCAAGCTCGCGGCCGGCGGCTTCGGCACCCGCGCCACGCTGGACGACGCCACCAG
AAATCTGAACGTCGCGCGCACCCAGGTGCGGACCGCCGAGTTGCAGGTCTATACGTCCAGTCCGGTCGGCAGCGATTTCG
TGATGGCGGAGACCCAGCTGGCGCAGGCCCGCGCCACGCTCAACACCACGCAGGCCCGGCTCGGCTATGCCAGCATTACT
GCGCCACGCGACGGCGTGCTGATCACCCGCAAGGTCGAGCGCGGCAGCGTGGTGCAGCCCGGCAAGGCGCTGCTGGTGCT
GGCGCCGGCCGGCGACAGCCAGATCGTGGTGCAGATCGACGAGAAGAATCTCGGCCAGCTCGCGCTCGGCCAGCACGCGC
TGGCCTCGGCCGACGCCTATCCGGACAAGCGCTTCGCGGCAAGGCTCAGCTACATCAACCCGTCGGTCGACATCAACCGC
GCGTCGGTCGAGATCAAGCTCGCGGTGATCGATCCGCCGGACTATCTGCGCCAGGACATGACGGTGTCGGTCGACATCGC
CACCGCGCGCCGTGACAATGCGGTGGTCGTCCCGGCGCGCGCGGTCAATGATGCGACGACGGTGCCCTATGTGCTGAAGG
TGGCGGGCGGCCGCGCGGTGCGGCAGCCGGTCAAGCTGGGTCTCCGCGGCGTCGGCGCCTACGAAGTGATCGAGGGGCTT
TCGCCGGGCGACCGGGTGATTCCGCTCGCCACCGGCGTCGTGCCCGACCAGCGCGTCCGCGTGGTCGCGCCGTGA

Upstream 100 bases:

>100_bases
GGAAATTTGATCACGCCCGGAGGTCCGCGCAATTGATCTTCCGCAATAGCGCATCGGGTCCCGCGGGTTACGGCTCGGTC
GGCTCCTGCAATGGGTTCTC

Downstream 100 bases:

>100_bases
AGCGCTGGCTGCCGTTCGCCTGGATCGCCGCGGTGCGCTTCCTGCTCGACGGCGCACTGCAGACGCTGGTGATCGTCGGC
GGCATCGCCATCGGCGTCGG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLHKVDPSGDLTLQSRPPVVVRWAGAVWRYKWAVLGIGLVLIAAGLGLARLMLGPKVVAVVVARADLVQSVVASGHIETP
YRVEIGSQITGTVADVLVREGEVVREGQKLIAIEASELEAAVVQAEGAVQQAEARVRQLRELTKPAADQSLQQAQANLLN
AEAAYERASKLAAGGFGTRATLDDATRNLNVARTQVRTAELQVYTSSPVGSDFVMAETQLAQARATLNTTQARLGYASIT
APRDGVLITRKVERGSVVQPGKALLVLAPAGDSQIVVQIDEKNLGQLALGQHALASADAYPDKRFAARLSYINPSVDINR
ASVEIKLAVIDPPDYLRQDMTVSVDIATARRDNAVVVPARAVNDATTVPYVLKVAGGRAVRQPVKLGLRGVGAYEVIEGL
SPGDRVIPLATGVVPDQRVRVVAP

Sequences:

>Translated_424_residues
MLHKVDPSGDLTLQSRPPVVVRWAGAVWRYKWAVLGIGLVLIAAGLGLARLMLGPKVVAVVVARADLVQSVVASGHIETP
YRVEIGSQITGTVADVLVREGEVVREGQKLIAIEASELEAAVVQAEGAVQQAEARVRQLRELTKPAADQSLQQAQANLLN
AEAAYERASKLAAGGFGTRATLDDATRNLNVARTQVRTAELQVYTSSPVGSDFVMAETQLAQARATLNTTQARLGYASIT
APRDGVLITRKVERGSVVQPGKALLVLAPAGDSQIVVQIDEKNLGQLALGQHALASADAYPDKRFAARLSYINPSVDINR
ASVEIKLAVIDPPDYLRQDMTVSVDIATARRDNAVVVPARAVNDATTVPYVLKVAGGRAVRQPVKLGLRGVGAYEVIEGL
SPGDRVIPLATGVVPDQRVRVVAP
>Mature_424_residues
MLHKVDPSGDLTLQSRPPVVVRWAGAVWRYKWAVLGIGLVLIAAGLGLARLMLGPKVVAVVVARADLVQSVVASGHIETP
YRVEIGSQITGTVADVLVREGEVVREGQKLIAIEASELEAAVVQAEGAVQQAEARVRQLRELTKPAADQSLQQAQANLLN
AEAAYERASKLAAGGFGTRATLDDATRNLNVARTQVRTAELQVYTSSPVGSDFVMAETQLAQARATLNTTQARLGYASIT
APRDGVLITRKVERGSVVQPGKALLVLAPAGDSQIVVQIDEKNLGQLALGQHALASADAYPDKRFAARLSYINPSVDINR
ASVEIKLAVIDPPDYLRQDMTVSVDIATARRDNAVVVPARAVNDATTVPYVLKVAGGRAVRQPVKLGLRGVGAYEVIEGL
SPGDRVIPLATGVVPDQRVRVVAP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=381, Percent_Identity=26.7716535433071, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789900, Length=288, Percent_Identity=26.7361111111111, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787013, Length=282, Percent_Identity=26.9503546099291, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790012, Length=241, Percent_Identity=26.5560165975104, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44969; Mature: 44969

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHKVDPSGDLTLQSRPPVVVRWAGAVWRYKWAVLGIGLVLIAAGLGLARLMLGPKVVAV
CCCCCCCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VVARADLVQSVVASGHIETPYRVEIGSQITGTVADVLVREGEVVREGQKLIAIEASELEA
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHCCCEEEEEEHHHHHE
AVVQAEGAVQQAEARVRQLRELTKPAADQSLQQAQANLLNAEAAYERASKLAAGGFGTRA
EEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TLDDATRNLNVARTQVRTAELQVYTSSPVGSDFVMAETQLAQARATLNTTQARLGYASIT
CHHHHHCCCCHHHHEEEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEC
APRDGVLITRKVERGSVVQPGKALLVLAPAGDSQIVVQIDEKNLGQLALGQHALASADAY
CCCCCEEEEEEECCCCEECCCCEEEEEEECCCCEEEEEECCCCCCCHHHCCHHHHCCCCC
PDKRFAARLSYINPSVDINRASVEIKLAVIDPPDYLRQDMTVSVDIATARRDNAVVVPAR
CCHHHHHHHHHCCCCCEEEEEEEEEEEEEECCHHHHHCCCEEEEEEEECCCCCEEEEECC
AVNDATTVPYVLKVAGGRAVRQPVKLGLRGVGAYEVIEGLSPGDRVIPLATGVVPDQRVR
CCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEECCCCCCCEE
VVAP
EECC
>Mature Secondary Structure
MLHKVDPSGDLTLQSRPPVVVRWAGAVWRYKWAVLGIGLVLIAAGLGLARLMLGPKVVAV
CCCCCCCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VVARADLVQSVVASGHIETPYRVEIGSQITGTVADVLVREGEVVREGQKLIAIEASELEA
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHCCCEEEEEEHHHHHE
AVVQAEGAVQQAEARVRQLRELTKPAADQSLQQAQANLLNAEAAYERASKLAAGGFGTRA
EEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TLDDATRNLNVARTQVRTAELQVYTSSPVGSDFVMAETQLAQARATLNTTQARLGYASIT
CHHHHHCCCCHHHHEEEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEC
APRDGVLITRKVERGSVVQPGKALLVLAPAGDSQIVVQIDEKNLGQLALGQHALASADAY
CCCCCEEEEEEECCCCEECCCCEEEEEEECCCCEEEEEECCCCCCCHHHCCHHHHCCCCC
PDKRFAARLSYINPSVDINRASVEIKLAVIDPPDYLRQDMTVSVDIATARRDNAVVVPAR
CCHHHHHHHHHCCCCCEEEEEEEEEEEEEECCHHHHHCCCEEEEEEEECCCCCEEEEECC
AVNDATTVPYVLKVAGGRAVRQPVKLGLRGVGAYEVIEGLSPGDRVIPLATGVVPDQRVR
CCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEECCCCCCCEE
VVAP
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]