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The map label for this gene is hldE [H]

Identifier: 86750914

GI number: 86750914

Start: 4342480

End: 4343964

Strand: Reverse

Name: hldE [H]

Synonym: RPB_3805

Alternate gene names: 86750914

Gene position: 4343964-4342480 (Counterclockwise)

Preceding gene: 86750915

Following gene: 86750913

Centisome position: 81.47

GC content: 66.4

Gene sequence:

>1485_bases
ATGCTGCATCCCGAGACCGAAGCGACGCTGCAGGGGATCCGGGCCGAAGCCGGGCCGGACCGCGCCATCGTGTTCGTCTC
CGGCAATTTCAATATCGTCCATCCCGGCCATCTGCGGCTGCTGAAATTCGCAGCCGAATGCGGCGACGTTCTGGTCGTCG
GCGTCGTCGCCGATCCCGGCTTCGACTGGATGCTGCCGAGCGATCTGCGGCTCGAGGGCGTGCATGCGATCGGCTTCGTC
GATCATGCCTTCCTGCTGCGCGACAGGCCCGAGGACGTCGTCGCCGCGTTGAAGCCCGCGGTGGTGGTGAAGGGCAAGGA
GCACGAGGGCGCGGACAATCCCGAGAAGCCGGTGCTGGATTCCTACGGTGGTCGTTTGCTGTTTTCGTCCGGCGAGGTCG
CGTTCTCGTCGCTGGATCTGATCCGGCGCGAATTCCGCGAGTTCAATCCGTCGTCGATCTTCAAGCCGCTGGACTATCCG
CGCCGCCATCGCTTCGACGTCGCCGATCTCAAGACGGTGCTGGCGAAATTCCCGACGCTGAAGGTGCTGGTGATCGGCGA
TCTGATCGTCGACGAATACATCGCCTGCGATCCGCTCGGCATGTCGCAGGAAGATCCGACCATCGTGGTCACGCCGGTGC
TGCGTGAATTGTTCGTCGGCGGCGCCGGCATCGTCGCCGGCCATGCCGCGGGGATGGGCTGCAAGGTCAGCCTGCTCACC
GTCGGCGGCAAGGACGCGATGGCCGATCTCGCCCGCGAGCGGCTCGCCTCGTACGATGTCGACGCGACCATCCTGACCGA
CGAGAGCCGGCCGACCACCTGCAAGCAGCGTTTTCGCGCCGGTAACAAGACGCTGCTGCGCGTCAGCCACCTCAAGCAGC
ACGACATCGACGTCGATCTGCAGGACAGCATGCTGGCGACGGTGCGCGACAAGCTACCGAATATCGACCTCGTGGTGTTC
TCCGATTTCAACTATGGCTGCCTGCCGACCAAGCTGGTCGAGGCGATCTCGGCGCTGTGCCGCGAGCGGTCGATCCCGAT
GGTCGCCGACAGCCAGTCGTCGTCGCAGGTCGGCGACATCTCGCGCTTCCGCAACATGTTGTTGATCAAGCCGACCGAGC
GCGAGGCGCGGCTGGCGCTGCGCGATTTCGACTCCGGCCTGGTGGTGCTGGTCGAGGCGTTGCGGCAGAAGGCGAAGGCG
AAGAACGTGATCCTGACGCTCGCCGCCGAAGGCCTGCTGGTGCACGCCGCCGGCGGCCGCGGCGGCTCGGTGCTGACCGA
TCGGCTGCCGGCGTTCAACACCGCGCCGAAGGACGCCGCGGGGGCCGGGGATTCGTTCTTCGTCTGCGCGGGGCTCGCGC
TCGCCGTCGGCACCGACATCTGGCGCGCCGCCTATCTCGCCTCGATCGCGGCGGCCTGCCAGGTCGGCCGCATCGGCAAC
ATTCCGGTCACCGCCGCCGATATCATCAAGGAACTCGACGCGTGA

Upstream 100 bases:

>100_bases
GCTACGCGCTCGACGAGATCAACATCGCCCTCGACGATCTCGAACAGCGCCGCAGCGTGCGGCCGCTGATCGAAATCGAT
GCGACATTGGGCTGACCGCG

Downstream 100 bases:

>100_bases
GCGCGCCGGCGAAAGCGCTGCTGGTTGCGGCGGGGCTCGGCACGCGGCTGCATCCGCTGACCGATGTGCTGCCGAAATGC
CTGATGCCGATTGCCGGCCG

Product: cytidyltransferase-related

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MLHPETEATLQGIRAEAGPDRAIVFVSGNFNIVHPGHLRLLKFAAECGDVLVVGVVADPGFDWMLPSDLRLEGVHAIGFV
DHAFLLRDRPEDVVAALKPAVVVKGKEHEGADNPEKPVLDSYGGRLLFSSGEVAFSSLDLIRREFREFNPSSIFKPLDYP
RRHRFDVADLKTVLAKFPTLKVLVIGDLIVDEYIACDPLGMSQEDPTIVVTPVLRELFVGGAGIVAGHAAGMGCKVSLLT
VGGKDAMADLARERLASYDVDATILTDESRPTTCKQRFRAGNKTLLRVSHLKQHDIDVDLQDSMLATVRDKLPNIDLVVF
SDFNYGCLPTKLVEAISALCRERSIPMVADSQSSSQVGDISRFRNMLLIKPTEREARLALRDFDSGLVVLVEALRQKAKA
KNVILTLAAEGLLVHAAGGRGGSVLTDRLPAFNTAPKDAAGAGDSFFVCAGLALAVGTDIWRAAYLASIAAACQVGRIGN
IPVTAADIIKELDA

Sequences:

>Translated_494_residues
MLHPETEATLQGIRAEAGPDRAIVFVSGNFNIVHPGHLRLLKFAAECGDVLVVGVVADPGFDWMLPSDLRLEGVHAIGFV
DHAFLLRDRPEDVVAALKPAVVVKGKEHEGADNPEKPVLDSYGGRLLFSSGEVAFSSLDLIRREFREFNPSSIFKPLDYP
RRHRFDVADLKTVLAKFPTLKVLVIGDLIVDEYIACDPLGMSQEDPTIVVTPVLRELFVGGAGIVAGHAAGMGCKVSLLT
VGGKDAMADLARERLASYDVDATILTDESRPTTCKQRFRAGNKTLLRVSHLKQHDIDVDLQDSMLATVRDKLPNIDLVVF
SDFNYGCLPTKLVEAISALCRERSIPMVADSQSSSQVGDISRFRNMLLIKPTEREARLALRDFDSGLVVLVEALRQKAKA
KNVILTLAAEGLLVHAAGGRGGSVLTDRLPAFNTAPKDAAGAGDSFFVCAGLALAVGTDIWRAAYLASIAAACQVGRIGN
IPVTAADIIKELDA
>Mature_494_residues
MLHPETEATLQGIRAEAGPDRAIVFVSGNFNIVHPGHLRLLKFAAECGDVLVVGVVADPGFDWMLPSDLRLEGVHAIGFV
DHAFLLRDRPEDVVAALKPAVVVKGKEHEGADNPEKPVLDSYGGRLLFSSGEVAFSSLDLIRREFREFNPSSIFKPLDYP
RRHRFDVADLKTVLAKFPTLKVLVIGDLIVDEYIACDPLGMSQEDPTIVVTPVLRELFVGGAGIVAGHAAGMGCKVSLLT
VGGKDAMADLARERLASYDVDATILTDESRPTTCKQRFRAGNKTLLRVSHLKQHDIDVDLQDSMLATVRDKLPNIDLVVF
SDFNYGCLPTKLVEAISALCRERSIPMVADSQSSSQVGDISRFRNMLLIKPTEREARLALRDFDSGLVVLVEALRQKAKA
KNVILTLAAEGLLVHAAGGRGGSVLTDRLPAFNTAPKDAAGAGDSFFVCAGLALAVGTDIWRAAYLASIAAACQVGRIGN
IPVTAADIIKELDA

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=321, Percent_Identity=25.2336448598131, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 53207; Mature: 53207

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHPETEATLQGIRAEAGPDRAIVFVSGNFNIVHPGHLRLLKFAAECGDVLVVGVVADPG
CCCCCCHHHHHHHHCCCCCCEEEEEEECCEEEECCCHHHHHHHHHCCCCEEEEEEEECCC
FDWMLPSDLRLEGVHAIGFVDHAFLLRDRPEDVVAALKPAVVVKGKEHEGADNPEKPVLD
CCCCCCCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCHH
SYGGRLLFSSGEVAFSSLDLIRREFREFNPSSIFKPLDYPRRHRFDVADLKTVLAKFPTL
CCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHCCCCHHHHHHHHHHCCCE
KVLVIGDLIVDEYIACDPLGMSQEDPTIVVTPVLRELFVGGAGIVAGHAAGMGCKVSLLT
EEEEEHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHCCCCCEEECCCCCCCCEEEEEE
VGGKDAMADLARERLASYDVDATILTDESRPTTCKQRFRAGNKTLLRVSHLKQHDIDVDL
ECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEEEEHHHHCCCCCCC
QDSMLATVRDKLPNIDLVVFSDFNYGCLPTKLVEAISALCRERSIPMVADSQSSSQVGDI
HHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHH
SRFRNMLLIKPTEREARLALRDFDSGLVVLVEALRQKAKAKNVILTLAAEGLLVHAAGGR
HHHCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCC
GGSVLTDRLPAFNTAPKDAAGAGDSFFVCAGLALAVGTDIWRAAYLASIAAACQVGRIGN
CCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IPVTAADIIKELDA
CCCCHHHHHHHHCC
>Mature Secondary Structure
MLHPETEATLQGIRAEAGPDRAIVFVSGNFNIVHPGHLRLLKFAAECGDVLVVGVVADPG
CCCCCCHHHHHHHHCCCCCCEEEEEEECCEEEECCCHHHHHHHHHCCCCEEEEEEEECCC
FDWMLPSDLRLEGVHAIGFVDHAFLLRDRPEDVVAALKPAVVVKGKEHEGADNPEKPVLD
CCCCCCCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCHH
SYGGRLLFSSGEVAFSSLDLIRREFREFNPSSIFKPLDYPRRHRFDVADLKTVLAKFPTL
CCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHCCCCHHHHHHHHHHCCCE
KVLVIGDLIVDEYIACDPLGMSQEDPTIVVTPVLRELFVGGAGIVAGHAAGMGCKVSLLT
EEEEEHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHCCCCCEEECCCCCCCCEEEEEE
VGGKDAMADLARERLASYDVDATILTDESRPTTCKQRFRAGNKTLLRVSHLKQHDIDVDL
ECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEEEEHHHHCCCCCCC
QDSMLATVRDKLPNIDLVVFSDFNYGCLPTKLVEAISALCRERSIPMVADSQSSSQVGDI
HHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHH
SRFRNMLLIKPTEREARLALRDFDSGLVVLVEALRQKAKAKNVILTLAAEGLLVHAAGGR
HHHCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCC
GGSVLTDRLPAFNTAPKDAAGAGDSFFVCAGLALAVGTDIWRAAYLASIAAACQVGRIGN
CCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IPVTAADIIKELDA
CCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA