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The map label for this gene is strD [H]

Identifier: 86750913

GI number: 86750913

Start: 4341566

End: 4342483

Strand: Reverse

Name: strD [H]

Synonym: RPB_3804

Alternate gene names: 86750913

Gene position: 4342483-4341566 (Counterclockwise)

Preceding gene: 86750914

Following gene: 86750912

Centisome position: 81.45

GC content: 65.47

Gene sequence:

>918_bases
GTGAGCGCGCCGGCGAAAGCGCTGCTGGTTGCGGCGGGGCTCGGCACGCGGCTGCATCCGCTGACCGATGTGCTGCCGAA
ATGCCTGATGCCGATTGCCGGCCGGCCGCTGCTCGGGCTGTGGCTGGCGATGCTGCGCGACGCAGGCTTTTCGGAGATCG
TCGTCAATCTGCATCACCACGCCGAATTGGTGGGCGAGTACATCCGGCGCTCGCCGTGGGCCGCCCACGTCGTGCTCGCG
CCTGAAGAGACGCTGCTCGGCACCGGCGGCACGCTGCTGCGGCACCGCGAACGCTTCGCCGAAGGACCGACGCTGTTCGC
CCATGCCGACAATCTCAGCCTGTTTTCGCCGCGCGATTTTCTTGCTGCGCACGCCGCGCGGCTGTCGGATTGCGCGATGA
CGATGATGAGTTTCGTCACCGATCATCCGCAGAGCTGCGGCATCCTCACGCTCGATGATCGAGGCCGCGTGCTGCAGATG
GACGAGAAGCCGCAGCAGCCCAAGGGCGATCTCGCCAATGCGGCGGTCTATGTGATCGAGCCCGCAGTGATCGATTTCAT
TGCCTCGCTCGGCAAGCCCGTGGTCGATTTCTCGACCGAAGTGCTGCCGGTGTTCATGGGCCGGATCTTCTCGTTTCACA
ACGGTAGCTATCATCGCGACGTCGGCACGCCAGCCAGCCTGGCGCTGGCGCAGCTCGATTATCCGCTGGCCGTCGCGCAG
TTCGACGCCTCTCGTCGTCATTGCGAGGAGGCGCAGCCGACGAAGCAATCCAGCTCAGTGCACGGGGCCATGGATTGCTT
CGCTTCGCTCGCAATGACGGGGGATGATCCCTGGTTCGGCCTGATGACCGACAACGATGGCACGCTGGCCAAGGCGTTCG
CGCGCGCGGCGGCGAAGACCTATGGCGGAGCACGCTAG

Upstream 100 bases:

>100_bases
GGCGCGCCGCCTATCTCGCCTCGATCGCGGCGGCCTGCCAGGTCGGCCGCATCGGCAACATTCCGGTCACCGCCGCCGAT
ATCATCAAGGAACTCGACGC

Downstream 100 bases:

>100_bases
ATGCCCGGCAGTGTGATCATCGCGGCGATCTCCAGCGACATCGGCGTGCAACTGGCGAGGCTGTATCGCGCGCAGGGCTT
CGCGGTGATCGGGACCTATC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSAPAKALLVAAGLGTRLHPLTDVLPKCLMPIAGRPLLGLWLAMLRDAGFSEIVVNLHHHAELVGEYIRRSPWAAHVVLA
PEETLLGTGGTLLRHRERFAEGPTLFAHADNLSLFSPRDFLAAHAARLSDCAMTMMSFVTDHPQSCGILTLDDRGRVLQM
DEKPQQPKGDLANAAVYVIEPAVIDFIASLGKPVVDFSTEVLPVFMGRIFSFHNGSYHRDVGTPASLALAQLDYPLAVAQ
FDASRRHCEEAQPTKQSSSVHGAMDCFASLAMTGDDPWFGLMTDNDGTLAKAFARAAAKTYGGAR

Sequences:

>Translated_305_residues
MSAPAKALLVAAGLGTRLHPLTDVLPKCLMPIAGRPLLGLWLAMLRDAGFSEIVVNLHHHAELVGEYIRRSPWAAHVVLA
PEETLLGTGGTLLRHRERFAEGPTLFAHADNLSLFSPRDFLAAHAARLSDCAMTMMSFVTDHPQSCGILTLDDRGRVLQM
DEKPQQPKGDLANAAVYVIEPAVIDFIASLGKPVVDFSTEVLPVFMGRIFSFHNGSYHRDVGTPASLALAQLDYPLAVAQ
FDASRRHCEEAQPTKQSSSVHGAMDCFASLAMTGDDPWFGLMTDNDGTLAKAFARAAAKTYGGAR
>Mature_304_residues
SAPAKALLVAAGLGTRLHPLTDVLPKCLMPIAGRPLLGLWLAMLRDAGFSEIVVNLHHHAELVGEYIRRSPWAAHVVLAP
EETLLGTGGTLLRHRERFAEGPTLFAHADNLSLFSPRDFLAAHAARLSDCAMTMMSFVTDHPQSCGILTLDDRGRVLQMD
EKPQQPKGDLANAAVYVIEPAVIDFIASLGKPVVDFSTEVLPVFMGRIFSFHNGSYHRDVGTPASLALAQLDYPLAVAQF
DASRRHCEEAQPTKQSSSVHGAMDCFASLAMTGDDPWFGLMTDNDGTLAKAFARAAAKTYGGAR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=226, Percent_Identity=24.7787610619469, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI11761621, Length=226, Percent_Identity=24.7787610619469, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790224, Length=190, Percent_Identity=27.8947368421053, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788351, Length=211, Percent_Identity=23.696682464455, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=225, Percent_Identity=26.2222222222222, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=246, Percent_Identity=25.609756097561, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=23.6947791164659, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=23.6947791164659, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32929; Mature: 32798

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPAKALLVAAGLGTRLHPLTDVLPKCLMPIAGRPLLGLWLAMLRDAGFSEIVVNLHHH
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
AELVGEYIRRSPWAAHVVLAPEETLLGTGGTLLRHRERFAEGPTLFAHADNLSLFSPRDF
HHHHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHH
LAAHAARLSDCAMTMMSFVTDHPQSCGILTLDDRGRVLQMDEKPQQPKGDLANAAVYVIE
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCCCCCCHHCEEEEEEC
PAVIDFIASLGKPVVDFSTEVLPVFMGRIFSFHNGSYHRDVGTPASLALAQLDYPLAVAQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
FDASRRHCEEAQPTKQSSSVHGAMDCFASLAMTGDDPWFGLMTDNDGTLAKAFARAAAKT
HCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHH
YGGAR
CCCCC
>Mature Secondary Structure 
SAPAKALLVAAGLGTRLHPLTDVLPKCLMPIAGRPLLGLWLAMLRDAGFSEIVVNLHHH
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
AELVGEYIRRSPWAAHVVLAPEETLLGTGGTLLRHRERFAEGPTLFAHADNLSLFSPRDF
HHHHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHH
LAAHAARLSDCAMTMMSFVTDHPQSCGILTLDDRGRVLQMDEKPQQPKGDLANAAVYVIE
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCCCCCCHHCEEEEEEC
PAVIDFIASLGKPVVDFSTEVLPVFMGRIFSFHNGSYHRDVGTPASLALAQLDYPLAVAQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
FDASRRHCEEAQPTKQSSSVHGAMDCFASLAMTGDDPWFGLMTDNDGTLAKAFARAAAKT
HCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHH
YGGAR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]