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The map label for this gene is 86750542

Identifier: 86750542

GI number: 86750542

Start: 3929616

End: 3930590

Strand: Direct

Name: 86750542

Synonym: RPB_3431

Alternate gene names: NA

Gene position: 3929616-3930590 (Clockwise)

Preceding gene: 86750541

Following gene: 86750543

Centisome position: 73.7

GC content: 66.77

Gene sequence:

>975_bases
ATGAAAGTCTGTATCTACGGCGCCGGCGCGATCGGCGGTTATCTCGGCGTGCAGCTCGCGCAATCCGGCGCCGACGTCAG
CCTGGTGGCGCGCGGCGCGCATCTGGCGGCGATGCAGCAGAACGGCCTCAAGCTGTTGATCGGCGACGAGGAGCGCGTGG
TGAAGGTGCGCGCCACCGACAAGCCGTCGGAGCTGGGCGTGCAGGACTTCATCATCATCTGCCTCAAGGCGCATTCGATC
ACCGGCGCGATCGACGCGATGAAGCCGCTGCTCGGCTCGCACACCCGCATCGTCACCGCCGTCAACGGCGTGCCGTATTG
GTACTTCTACAAGCACGGCAATCAGTTCGAGGGCCGCACGCTGGAGAGCATCGACCCGGGCGCACGGCAGTGGAACGAGC
TCGGCCCCGAGCGCGGCATCGGCTGCATCGTCTATCCGGCGACGGAGCTGGAAGGCCCGGGCGTGGTGCGCCATGTCTAT
GGCGACAAGTTCCCGGTCGGCGAAGCCTCCGGCGAGACCACCGCGGACGTTCAGAATCTGTCGAAGCTGCTGGAAGCCGC
CGGGCTGAAAGCGCCGATCCTCGATCGCATTCGCGACGAGATCTGGCTGAAGCTGTGGGGCAATGTCTGCTTCAACCCGA
TCAGCGCGCTGACCCACGCCACGCTCGACGTGATCGCGTCCGATCCGGCGACGCGGGCGCTGGCGAAGGCGATGATGCTG
GAAGCGCAGGCGATCGGCGAGACCTTCGGCGTCAAATTCCGCGTCGACGTCGAACGCCGCATCGAGGGCGCGCGCAAGGT
CGGCGCGCACAAGACCTCGATGCTGCAGGACCTCGAACGCGGCCGGCCGATGGAGATCGATCCCTTGGTCACCGTGGTGC
AGGAGATGGGCCGCATGACCGGCATTCCGACGCCGGCGATCGACAGCGTCCTCGGCCTGGTGATCCAGCGCGCCAAGGTG
GCCGGGCTGTACTGA

Upstream 100 bases:

>100_bases
AACGAGGCGCCGATCTGACCGATAAACCGCCGCACCGCGTCATTCGCGGCTGCAACTTCCACGATCGCCAGGCGTTCTGG
CGTTGAGCCCAGGAAATTCG

Downstream 100 bases:

>100_bases
ATACTAATCACTCTGCCCACCTCACCTCTGTCATTCCGGGGCGCGCGCCAGCGCGAACCCGGAATCCATAACCACCGCCG
GGGGATATGGATTCCGGGTC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKVCIYGAGAIGGYLGVQLAQSGADVSLVARGAHLAAMQQNGLKLLIGDEERVVKVRATDKPSELGVQDFIIICLKAHSI
TGAIDAMKPLLGSHTRIVTAVNGVPYWYFYKHGNQFEGRTLESIDPGARQWNELGPERGIGCIVYPATELEGPGVVRHVY
GDKFPVGEASGETTADVQNLSKLLEAAGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALAKAMML
EAQAIGETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMTGIPTPAIDSVLGLVIQRAKV
AGLY

Sequences:

>Translated_324_residues
MKVCIYGAGAIGGYLGVQLAQSGADVSLVARGAHLAAMQQNGLKLLIGDEERVVKVRATDKPSELGVQDFIIICLKAHSI
TGAIDAMKPLLGSHTRIVTAVNGVPYWYFYKHGNQFEGRTLESIDPGARQWNELGPERGIGCIVYPATELEGPGVVRHVY
GDKFPVGEASGETTADVQNLSKLLEAAGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALAKAMML
EAQAIGETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMTGIPTPAIDSVLGLVIQRAKV
AGLY
>Mature_324_residues
MKVCIYGAGAIGGYLGVQLAQSGADVSLVARGAHLAAMQQNGLKLLIGDEERVVKVRATDKPSELGVQDFIIICLKAHSI
TGAIDAMKPLLGSHTRIVTAVNGVPYWYFYKHGNQFEGRTLESIDPGARQWNELGPERGIGCIVYPATELEGPGVVRHVY
GDKFPVGEASGETTADVQNLSKLLEAAGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALAKAMML
EAQAIGETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMTGIPTPAIDSVLGLVIQRAKV
AGLY

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34949; Mature: 34949

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCIYGAGAIGGYLGVQLAQSGADVSLVARGAHLAAMQQNGLKLLIGDEERVVKVRATD
CEEEEEECCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCEEEECCCCEEEEEEECC
KPSELGVQDFIIICLKAHSITGAIDAMKPLLGSHTRIVTAVNGVPYWYFYKHGNQFEGRT
CCHHCCHHHHHEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCCC
LESIDPGARQWNELGPERGIGCIVYPATELEGPGVVRHVYGDKFPVGEASGETTADVQNL
CCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHH
SKLLEAAGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALAKAMML
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EAQAIGETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMT
HHHHHHHHHCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GIPTPAIDSVLGLVIQRAKVAGLY
CCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVCIYGAGAIGGYLGVQLAQSGADVSLVARGAHLAAMQQNGLKLLIGDEERVVKVRATD
CEEEEEECCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCEEEECCCCEEEEEEECC
KPSELGVQDFIIICLKAHSITGAIDAMKPLLGSHTRIVTAVNGVPYWYFYKHGNQFEGRT
CCHHCCHHHHHEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCCC
LESIDPGARQWNELGPERGIGCIVYPATELEGPGVVRHVYGDKFPVGEASGETTADVQNL
CCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHH
SKLLEAAGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALAKAMML
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EAQAIGETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMT
HHHHHHHHHCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GIPTPAIDSVLGLVIQRAKVAGLY
CCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]