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The map label for this gene is lon [H]

Identifier: 86750179

GI number: 86750179

Start: 3494146

End: 3495732

Strand: Direct

Name: lon [H]

Synonym: RPB_3063

Alternate gene names: 86750179

Gene position: 3494146-3495732 (Clockwise)

Preceding gene: 86750178

Following gene: 86750180

Centisome position: 65.54

GC content: 61.75

Gene sequence:

>1587_bases
TTGATCGGAAACGATGATGACGGTGACGTTCCGCCGTCTCCCGATGCCGTCGATCTGGACGCTACCGTCGACGGTGCCGC
AGCAGACTCGGCCGATAGCGACCAAGAGCACTTTCAAGGACTGCCGAGGCTGCTGCGCTACGCAATGCTGGCCAGGGACA
ACGTCGACGACACCGTCGTGCATCGCCTGATCGCGGAGATCGATGAGCTTTCGCCGAAGCTGCCCCAGAACGCCGACTGG
GCGGCCGCGCAGAATTCCGAAACCGGCTTTGCCCTTGCTGCTGAACTCGATCAGCTGGCAGTGGTCCGTGACCTGCCCTT
ATTGCGCAGCCTCAGTGACTGCGTTCGGTTGCTCACCCTGACGCTGCCATGCGACCCGAAACGGTTCGGGGCGTATCGGC
GCGTGGCGCGGGCCATGATCTTTGCCTTCCGCCAGATCGAGGCGAGCCTCGACGACGAGCGCTGCGCCGAGCTTGAGCGA
ATTGTCTATGGCTTTGCGGCATTGCCGGCAGCAATCGGGGCAAACGACAGCGCCCGCTCATGGCCGGCTATTTCCAGCGC
CGCGCATCTGGGCGAGCAATCGGTGCGTCACCGCCTGCGGGCAGTTGTCGTGAGAACCTCCCAGAGCGTCCGACGTCAGA
TAGAACGGCAAACGGAGCCGAAGAAACCAAAAGATACTCCCTCGATCGACGCCACCACGCCCCATCCGCCAGTCAACGAA
CCAATAGCGCCCAACCACGTCATTGTGGCCCGGATCGAACAGACGGAGCTCAAGAACCTCAAGTTCATCGAGCCGTTCCG
ACATGTGCTCAACAATGCCCTGCCGCTGGTCGAGGCAACCGCTCTCGACCGGGTCCGCACCACCTTGGCGGCCGAGTTTC
CTTATGCTGTCGAAGTGGTGGACTTCATGCTCACCGACTTGATTGGCCGTCCGACTATACGGCTGCGACCATTGCTGCTG
GTCGAAGCACCCGGCAGTGGAAAATCACGTTTCGCACGCAGACTTGGCGAACTGCTGGGAGTCGCAATCTGGCGGACCGA
CGCATCTCAATCCGACGGGAACGTATTTGCCGGCACAGACCGGCGTTGGAATTCGGCCGAACCCTGCCATCCGCTGCTCG
CAATCGCACGCGGCAAGATTGCGAACCCGATCGTCATAATCGACGAGATCGAAAAAGCCGGCACGCGCAGCGACAATGGT
AGGCTTTGGGACTGCCTGCTCGGCCTTCTGGAGCCAGAGACCAACGCGCGATATCCCGATCCAGCGCTGCAAACTCCCCT
CGACCTCAGCCACGTCAGCTACGTCGCCACGGCAAACACTCTCGATCCATTGCCATCACCGCTGCTGGACCGTCTCCGGA
TCATCGCGTTCCCGAAGCCGACCCTGGACGATCTCAATGCCCTGTTGCCGGGTTTGATTGAGGCCATTGCTGAGGACCGT
GGTGTCGACGGACGTTGGATTGCCCCCCTGGACGCCCATGATTGCGCTGCAATCGCCGCTGTTTGGCCCGGCGGATCGGT
GCGCCGGCTACGCCGGGCTGTCGAATTTATCCTTCAGCAGCGAGATCGCACCGCGCCGAGACATTGA

Upstream 100 bases:

>100_bases
TCGGCCGCCCCGCCGATCCCGATGGTCGGGAGCACATCACAAGCACGTCTTTGTTTACTTACGATGACCGAGACCTGGAC
GGCTGGCCCGGAGATTACGA

Downstream 100 bases:

>100_bases
TCGACTCTATAACCCCGGCAGCACATCAAAGTCGAAGCTTAGCGACCTGCCTAAGACCAAGCAGCCGCCGACAAACACGG
CCAGGCGCGGCGAGCTACGT

Product: ATPase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MIGNDDDGDVPPSPDAVDLDATVDGAAADSADSDQEHFQGLPRLLRYAMLARDNVDDTVVHRLIAEIDELSPKLPQNADW
AAAQNSETGFALAAELDQLAVVRDLPLLRSLSDCVRLLTLTLPCDPKRFGAYRRVARAMIFAFRQIEASLDDERCAELER
IVYGFAALPAAIGANDSARSWPAISSAAHLGEQSVRHRLRAVVVRTSQSVRRQIERQTEPKKPKDTPSIDATTPHPPVNE
PIAPNHVIVARIEQTELKNLKFIEPFRHVLNNALPLVEATALDRVRTTLAAEFPYAVEVVDFMLTDLIGRPTIRLRPLLL
VEAPGSGKSRFARRLGELLGVAIWRTDASQSDGNVFAGTDRRWNSAEPCHPLLAIARGKIANPIVIIDEIEKAGTRSDNG
RLWDCLLGLLEPETNARYPDPALQTPLDLSHVSYVATANTLDPLPSPLLDRLRIIAFPKPTLDDLNALLPGLIEAIAEDR
GVDGRWIAPLDAHDCAAIAAVWPGGSVRRLRRAVEFILQQRDRTAPRH

Sequences:

>Translated_528_residues
MIGNDDDGDVPPSPDAVDLDATVDGAAADSADSDQEHFQGLPRLLRYAMLARDNVDDTVVHRLIAEIDELSPKLPQNADW
AAAQNSETGFALAAELDQLAVVRDLPLLRSLSDCVRLLTLTLPCDPKRFGAYRRVARAMIFAFRQIEASLDDERCAELER
IVYGFAALPAAIGANDSARSWPAISSAAHLGEQSVRHRLRAVVVRTSQSVRRQIERQTEPKKPKDTPSIDATTPHPPVNE
PIAPNHVIVARIEQTELKNLKFIEPFRHVLNNALPLVEATALDRVRTTLAAEFPYAVEVVDFMLTDLIGRPTIRLRPLLL
VEAPGSGKSRFARRLGELLGVAIWRTDASQSDGNVFAGTDRRWNSAEPCHPLLAIARGKIANPIVIIDEIEKAGTRSDNG
RLWDCLLGLLEPETNARYPDPALQTPLDLSHVSYVATANTLDPLPSPLLDRLRIIAFPKPTLDDLNALLPGLIEAIAEDR
GVDGRWIAPLDAHDCAAIAAVWPGGSVRRLRRAVEFILQQRDRTAPRH
>Mature_528_residues
MIGNDDDGDVPPSPDAVDLDATVDGAAADSADSDQEHFQGLPRLLRYAMLARDNVDDTVVHRLIAEIDELSPKLPQNADW
AAAQNSETGFALAAELDQLAVVRDLPLLRSLSDCVRLLTLTLPCDPKRFGAYRRVARAMIFAFRQIEASLDDERCAELER
IVYGFAALPAAIGANDSARSWPAISSAAHLGEQSVRHRLRAVVVRTSQSVRRQIERQTEPKKPKDTPSIDATTPHPPVNE
PIAPNHVIVARIEQTELKNLKFIEPFRHVLNNALPLVEATALDRVRTTLAAEFPYAVEVVDFMLTDLIGRPTIRLRPLLL
VEAPGSGKSRFARRLGELLGVAIWRTDASQSDGNVFAGTDRRWNSAEPCHPLLAIARGKIANPIVIIDEIEKAGTRSDNG
RLWDCLLGLLEPETNARYPDPALQTPLDLSHVSYVATANTLDPLPSPLLDRLRIIAFPKPTLDDLNALLPGLIEAIAEDR
GVDGRWIAPLDAHDCAAIAAVWPGGSVRRLRRAVEFILQQRDRTAPRH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=166, Percent_Identity=32.5301204819277, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI31377667, Length=148, Percent_Identity=32.4324324324324, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1786643, Length=174, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17505831, Length=158, Percent_Identity=32.2784810126582, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17556486, Length=142, Percent_Identity=32.3943661971831, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319449, Length=250, Percent_Identity=26, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666867, Length=220, Percent_Identity=29.0909090909091, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221513036, Length=135, Percent_Identity=35.5555555555556, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 58045; Mature: 58045

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGNDDDGDVPPSPDAVDLDATVDGAAADSADSDQEHFQGLPRLLRYAMLARDNVDDTVV
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
HRLIAEIDELSPKLPQNADWAAAQNSETGFALAAELDQLAVVRDLPLLRSLSDCVRLLTL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLPCDPKRFGAYRRVARAMIFAFRQIEASLDDERCAELERIVYGFAALPAAIGANDSARS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WPAISSAAHLGEQSVRHRLRAVVVRTSQSVRRQIERQTEPKKPKDTPSIDATTPHPPVNE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PIAPNHVIVARIEQTELKNLKFIEPFRHVLNNALPLVEATALDRVRTTLAAEFPYAVEVV
CCCCCCEEEEEECHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
DFMLTDLIGRPTIRLRPLLLVEAPGSGKSRFARRLGELLGVAIWRTDASQSDGNVFAGTD
HHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCEEECCC
RRWNSAEPCHPLLAIARGKIANPIVIIDEIEKAGTRSDNGRLWDCLLGLLEPETNARYPD
CCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
PALQTPLDLSHVSYVATANTLDPLPSPLLDRLRIIAFPKPTLDDLNALLPGLIEAIAEDR
CHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCC
GVDGRWIAPLDAHDCAAIAAVWPGGSVRRLRRAVEFILQQRDRTAPRH
CCCCCEECCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIGNDDDGDVPPSPDAVDLDATVDGAAADSADSDQEHFQGLPRLLRYAMLARDNVDDTVV
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
HRLIAEIDELSPKLPQNADWAAAQNSETGFALAAELDQLAVVRDLPLLRSLSDCVRLLTL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLPCDPKRFGAYRRVARAMIFAFRQIEASLDDERCAELERIVYGFAALPAAIGANDSARS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WPAISSAAHLGEQSVRHRLRAVVVRTSQSVRRQIERQTEPKKPKDTPSIDATTPHPPVNE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PIAPNHVIVARIEQTELKNLKFIEPFRHVLNNALPLVEATALDRVRTTLAAEFPYAVEVV
CCCCCCEEEEEECHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
DFMLTDLIGRPTIRLRPLLLVEAPGSGKSRFARRLGELLGVAIWRTDASQSDGNVFAGTD
HHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCEEECCC
RRWNSAEPCHPLLAIARGKIANPIVIIDEIEKAGTRSDNGRLWDCLLGLLEPETNARYPD
CCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
PALQTPLDLSHVSYVATANTLDPLPSPLLDRLRIIAFPKPTLDDLNALLPGLIEAIAEDR
CHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCC
GVDGRWIAPLDAHDCAAIAAVWPGGSVRRLRRAVEFILQQRDRTAPRH
CCCCCEECCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA