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The map label for this gene is rsh [H]

Identifier: 86749726

GI number: 86749726

Start: 2991336

End: 2993621

Strand: Direct

Name: rsh [H]

Synonym: RPB_2608

Alternate gene names: 86749726

Gene position: 2991336-2993621 (Clockwise)

Preceding gene: 86749725

Following gene: 86749727

Centisome position: 56.11

GC content: 65.35

Gene sequence:

>2286_bases
ATGGCGTCAGGCCGCCGCATCCCGAGACAGGTGGAGGCCGTGGCCGATGCGGCCACCGTGGCCACGCCCGTCGTCGTCCC
GCCGAAGCCGCGCGGCGCGCGCGCCAGGATGATGCGACAATACGACCTCGTCGAACTGGTTCGGAATTACAATCCGAACA
CCGACGAAGACATGCTCAACCGTGCCTATGTCTACGCGATGAAGGCGCATGGCGAGCAGACCCGCGCCTCGGGCGATCCG
TATTTCTCGCATCCGCTCGAAGTCGCGGCGATTCTCACCAATCTCAAGCTCGACGACGCCACCATCGTCGCGGCGCTGCT
GCACGACACGATCGAAGACACCGAGGCGACCCGGACCGAGATCGACAAATTGTTCGGCCATGAGATCGGCTCGCTGGTCG
AGGGGCTGACCAAGCTGAAGCGGCTCGAACTGGTGTCGCGCGAGGCCAAGCAGGCGGAGAACCTTCGCAAGCTGCTGCTG
GCAATCGCCGACGACGTTCGCGTGCTGCTGATCAAGCTCGCCGACCGCCTGCACAACATGCGCACGCTGGACTTCGTGCC
TCCGGCGGCGCGCCAACGCATCGCCGAAGAAACGCTCGACATCTACGCACCGCTCGCAGGCCGTATGGGCATGCAGGAGA
TGCGCGAGGAGCTGGAGGACCTGTCGTTCCGGACGCTGGATCCCGAGGCGTTCGCGGTGGTGATGCAGCGGCTCGACGCT
TTGGCCGAGCGCAATCGCAATCTGATCGGTGAGATCGAAACGCAGCTCTGCGCCAACCTCGCCAACAACGGCATCGCCGC
CGAGGTCACCGGCCGGCGCAAGCGGCCGTTTTCGATCTGGACCAAGATGGAGCGCAAGTCGGTCGGCTTCGAACAGCTGT
CGGACATCTACGGCTTCCGCGTCGTGCTCAACGACATCGAGGCCTGCTACCGCGCGCTCGGCGTGGTCCATACGACGTGG
CCGATGGTGCCTGGACGGTTCAAGGACTACATCTCGACGCCGAAGCAGAACGACTATCGTTCGCTGCACACGACGGTGAT
CGGCCCGGGCCAGCAGCGCGTCGAGCTGCAATTCCGTACCCAGGACATGAACCAGATTGCCGAATACGGCATCGCCGCGC
ACGCTTTCTACAAGGACGGCGTCGGCTCGCCGACCGAACTGCTCAATCGCGAATCCAACGCCTTCGCCTGGTTGCGCCAC
ACCGTCGAGATGCTGTCCGAGAGTACGAACCCGGAGGAATTCCTCGAGCACACCAAGCTCGAGCTGTTCCACGACCAGGT
GTTCTGCTTCACGCCGAAGGGCAAGCTGATCGCGTTGCCGCGGGCCGCCAACGTCATCGATTTCGCCTATGCGGTGCATA
CCGACGTCGGCAACAGCGCGGTCGGCTGCAAGATCAACGGCAAATTCGCGCCGCTGTCGTCGGAATTGCAGAACGGCGAC
GAGGTCGAGGTGCTGACGTCCAGCGTGCAGTCGGCGCCGCCGGCGGCGTGGGAGTCGCTGGCGCGAACCGGCAAGGCGCG
CGCCGCGATCCGCCGCGCCACCCGCACGGCGATGCGCGACCAATATGCGGGCCTCGGCCGCCGCATCGTCGAACGGCTGT
TCGCGCGCGCCAAGATCGAATACGCCGACGACAAGCTCAGGGGTGCGCTGCCGCGGCTGGCGCGGGCCTCCATCGAGGAG
GTGATGGCCTCCGTCGGGCGCGGTGAAATGAAAGCGTCCGACGTCGCCCGCGCGATGTATCCCGACTACAAGGAAGAGCG
CATCGCGCGGTTCGGCGGCAAGAAGCCCGAAAAGGCGGGGACCAAGGCCGTCGGTGAACCGAGCAAGGTGGGCGCCGCAG
TGCCGATCGGCGGGATTCACTCCGGATTGCCGGTGAAGTTCGCGCCGGACGGCGGCGCGGTGCCCGGTGATCGCATCATC
GGCATCGTCACGCCGGGCGAGGGCATCACCATCTATCCGATCCACTCGCCGGCGCTGAAGGACTTCGAGGAAGAGCCGGA
GCGCTGGCTCGATGTGAAGTGGGACATCGACGAGACCACGCCGCAGCGCTTCCCGGCGCGGCTGTTCGTGCAGAACGTCA
ACGAGCCCGGCAGCCTCGCGCAGATCGCCGGCGTGATCGCCGAGCACGACGGCAATATCGACAACATCAACATGAGCCGC
CGTTCGCCGGACTTCACCGAACTCACCATCGATCTCGAGGTCTACGACCTCAAGCATCTCAGCGCCATCATCGCCCAGCT
TCGCGCCAAGGCGGTCGTGGCCCACGTCGAGCGCGTCAATGGATAG

Upstream 100 bases:

>100_bases
TGACAAAACGCTTTACTGTTAAGCAGTCGGATTTCCAAAAGATCTGAAGTGTCGACCGGTGTAGTCCGTGGCGCCCGGCG
CCGCGATTGAGGTTTGTTCG

Downstream 100 bases:

>100_bases
CGCGGCGCCGCAAGTCCTTCCGTAGTACGTCCCGCAGGTTCAACATGCCGAAATCCTCTCCTCTGCGTCTTGGGGTCAAC
ATCGATCACATCGCCACGGT

Product: (p)ppGpp synthetase I

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MASGRRIPRQVEAVADAATVATPVVVPPKPRGARARMMRQYDLVELVRNYNPNTDEDMLNRAYVYAMKAHGEQTRASGDP
YFSHPLEVAAILTNLKLDDATIVAALLHDTIEDTEATRTEIDKLFGHEIGSLVEGLTKLKRLELVSREAKQAENLRKLLL
AIADDVRVLLIKLADRLHNMRTLDFVPPAARQRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPEAFAVVMQRLDA
LAERNRNLIGEIETQLCANLANNGIAAEVTGRRKRPFSIWTKMERKSVGFEQLSDIYGFRVVLNDIEACYRALGVVHTTW
PMVPGRFKDYISTPKQNDYRSLHTTVIGPGQQRVELQFRTQDMNQIAEYGIAAHAFYKDGVGSPTELLNRESNAFAWLRH
TVEMLSESTNPEEFLEHTKLELFHDQVFCFTPKGKLIALPRAANVIDFAYAVHTDVGNSAVGCKINGKFAPLSSELQNGD
EVEVLTSSVQSAPPAAWESLARTGKARAAIRRATRTAMRDQYAGLGRRIVERLFARAKIEYADDKLRGALPRLARASIEE
VMASVGRGEMKASDVARAMYPDYKEERIARFGGKKPEKAGTKAVGEPSKVGAAVPIGGIHSGLPVKFAPDGGAVPGDRII
GIVTPGEGITIYPIHSPALKDFEEEPERWLDVKWDIDETTPQRFPARLFVQNVNEPGSLAQIAGVIAEHDGNIDNINMSR
RSPDFTELTIDLEVYDLKHLSAIIAQLRAKAVVAHVERVNG

Sequences:

>Translated_761_residues
MASGRRIPRQVEAVADAATVATPVVVPPKPRGARARMMRQYDLVELVRNYNPNTDEDMLNRAYVYAMKAHGEQTRASGDP
YFSHPLEVAAILTNLKLDDATIVAALLHDTIEDTEATRTEIDKLFGHEIGSLVEGLTKLKRLELVSREAKQAENLRKLLL
AIADDVRVLLIKLADRLHNMRTLDFVPPAARQRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPEAFAVVMQRLDA
LAERNRNLIGEIETQLCANLANNGIAAEVTGRRKRPFSIWTKMERKSVGFEQLSDIYGFRVVLNDIEACYRALGVVHTTW
PMVPGRFKDYISTPKQNDYRSLHTTVIGPGQQRVELQFRTQDMNQIAEYGIAAHAFYKDGVGSPTELLNRESNAFAWLRH
TVEMLSESTNPEEFLEHTKLELFHDQVFCFTPKGKLIALPRAANVIDFAYAVHTDVGNSAVGCKINGKFAPLSSELQNGD
EVEVLTSSVQSAPPAAWESLARTGKARAAIRRATRTAMRDQYAGLGRRIVERLFARAKIEYADDKLRGALPRLARASIEE
VMASVGRGEMKASDVARAMYPDYKEERIARFGGKKPEKAGTKAVGEPSKVGAAVPIGGIHSGLPVKFAPDGGAVPGDRII
GIVTPGEGITIYPIHSPALKDFEEEPERWLDVKWDIDETTPQRFPARLFVQNVNEPGSLAQIAGVIAEHDGNIDNINMSR
RSPDFTELTIDLEVYDLKHLSAIIAQLRAKAVVAHVERVNG
>Mature_760_residues
ASGRRIPRQVEAVADAATVATPVVVPPKPRGARARMMRQYDLVELVRNYNPNTDEDMLNRAYVYAMKAHGEQTRASGDPY
FSHPLEVAAILTNLKLDDATIVAALLHDTIEDTEATRTEIDKLFGHEIGSLVEGLTKLKRLELVSREAKQAENLRKLLLA
IADDVRVLLIKLADRLHNMRTLDFVPPAARQRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPEAFAVVMQRLDAL
AERNRNLIGEIETQLCANLANNGIAAEVTGRRKRPFSIWTKMERKSVGFEQLSDIYGFRVVLNDIEACYRALGVVHTTWP
MVPGRFKDYISTPKQNDYRSLHTTVIGPGQQRVELQFRTQDMNQIAEYGIAAHAFYKDGVGSPTELLNRESNAFAWLRHT
VEMLSESTNPEEFLEHTKLELFHDQVFCFTPKGKLIALPRAANVIDFAYAVHTDVGNSAVGCKINGKFAPLSSELQNGDE
VEVLTSSVQSAPPAAWESLARTGKARAAIRRATRTAMRDQYAGLGRRIVERLFARAKIEYADDKLRGALPRLARASIEEV
MASVGRGEMKASDVARAMYPDYKEERIARFGGKKPEKAGTKAVGEPSKVGAAVPIGGIHSGLPVKFAPDGGAVPGDRIIG
IVTPGEGITIYPIHSPALKDFEEEPERWLDVKWDIDETTPQRFPARLFVQNVNEPGSLAQIAGVIAEHDGNIDNINMSRR
SPDFTELTIDLEVYDLKHLSAIIAQLRAKAVVAHVERVNG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=131, Percent_Identity=37.4045801526718, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790082, Length=718, Percent_Identity=37.3259052924791, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789147, Length=694, Percent_Identity=30.9798270893372, Blast_Score=338, Evalue=8e-94,
Organism=Caenorhabditis elegans, GI25143118, Length=147, Percent_Identity=34.6938775510204, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24650996, Length=129, Percent_Identity=37.984496124031, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84495; Mature: 84364

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGRRIPRQVEAVADAATVATPVVVPPKPRGARARMMRQYDLVELVRNYNPNTDEDMLN
CCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RAYVYAMKAHGEQTRASGDPYFSHPLEVAAILTNLKLDDATIVAALLHDTIEDTEATRTE
HHHHEEEHHCCCHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IDKLFGHEIGSLVEGLTKLKRLELVSREAKQAENLRKLLLAIADDVRVLLIKLADRLHNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTLDFVPPAARQRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPEAFAVVMQRLDA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAERNRNLIGEIETQLCANLANNGIAAEVTGRRKRPFSIWTKMERKSVGFEQLSDIYGFR
HHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
VVLNDIEACYRALGVVHTTWPMVPGRFKDYISTPKQNDYRSLHTTVIGPGQQRVELQFRT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHEEECCCCCEEEEEEEH
QDMNQIAEYGIAAHAFYKDGVGSPTELLNRESNAFAWLRHTVEMLSESTNPEEFLEHTKL
HHHHHHHHHCHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELFHDQVFCFTPKGKLIALPRAANVIDFAYAVHTDVGNSAVGCKINGKFAPLSSELQNGD
HHHHCCEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCC
EVEVLTSSVQSAPPAAWESLARTGKARAAIRRATRTAMRDQYAGLGRRIVERLFARAKIE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADDKLRGALPRLARASIEEVMASVGRGEMKASDVARAMYPDYKEERIARFGGKKPEKAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
TKAVGEPSKVGAAVPIGGIHSGLPVKFAPDGGAVPGDRIIGIVTPGEGITIYPIHSPALK
CCCCCCCHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEEECCCHHHH
DFEEEPERWLDVKWDIDETTPQRFPARLFVQNVNEPGSLAQIAGVIAEHDGNIDNINMSR
HHHHCHHHHEEEEECCCCCCCHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
RSPDFTELTIDLEVYDLKHLSAIIAQLRAKAVVAHVERVNG
CCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASGRRIPRQVEAVADAATVATPVVVPPKPRGARARMMRQYDLVELVRNYNPNTDEDMLN
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RAYVYAMKAHGEQTRASGDPYFSHPLEVAAILTNLKLDDATIVAALLHDTIEDTEATRTE
HHHHEEEHHCCCHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IDKLFGHEIGSLVEGLTKLKRLELVSREAKQAENLRKLLLAIADDVRVLLIKLADRLHNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTLDFVPPAARQRIAEETLDIYAPLAGRMGMQEMREELEDLSFRTLDPEAFAVVMQRLDA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAERNRNLIGEIETQLCANLANNGIAAEVTGRRKRPFSIWTKMERKSVGFEQLSDIYGFR
HHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
VVLNDIEACYRALGVVHTTWPMVPGRFKDYISTPKQNDYRSLHTTVIGPGQQRVELQFRT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHEEECCCCCEEEEEEEH
QDMNQIAEYGIAAHAFYKDGVGSPTELLNRESNAFAWLRHTVEMLSESTNPEEFLEHTKL
HHHHHHHHHCHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELFHDQVFCFTPKGKLIALPRAANVIDFAYAVHTDVGNSAVGCKINGKFAPLSSELQNGD
HHHHCCEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCC
EVEVLTSSVQSAPPAAWESLARTGKARAAIRRATRTAMRDQYAGLGRRIVERLFARAKIE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADDKLRGALPRLARASIEEVMASVGRGEMKASDVARAMYPDYKEERIARFGGKKPEKAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
TKAVGEPSKVGAAVPIGGIHSGLPVKFAPDGGAVPGDRIIGIVTPGEGITIYPIHSPALK
CCCCCCCHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEEECCCHHHH
DFEEEPERWLDVKWDIDETTPQRFPARLFVQNVNEPGSLAQIAGVIAEHDGNIDNINMSR
HHHHCHHHHEEEEECCCCCCCHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
RSPDFTELTIDLEVYDLKHLSAIIAQLRAKAVVAHVERVNG
CCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA