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The map label for this gene is purM [H]

Identifier: 86749609

GI number: 86749609

Start: 2847061

End: 2848134

Strand: Reverse

Name: purM [H]

Synonym: RPB_2489

Alternate gene names: 86749609

Gene position: 2848134-2847061 (Counterclockwise)

Preceding gene: 86749614

Following gene: 86749608

Centisome position: 53.42

GC content: 67.13

Gene sequence:

>1074_bases
ATGACCGAGCGGAAGCACGGCCTCACCTATGCCGATTCCGGCGTCGATATCGACGCCGGCAATCGCCTCGTCGACCTGAT
CAAGCCGATGGTCCGGGCCACCGCCCGGGCCGGCGCGGACTCCGAAATCGGCGGCTTCGGCGGACTGTTCGACTTGAAGG
CCGCGGGCTTCAAGGACCCGGTGCTGGTGGCGGCGACCGACGGCGTCGGAACCAAGATCAAGGTCGCGATCGAGGCCGGG
GTGCACGCCGGGATCGGTATCGACCTGGTCGCGATGTCGGTCAATGATCTGGTCGTCCAGGGCGCCGAGCCGCTGTTCTT
TCTCGACTATTTCGCGTGCGGCAAACTCGATCCCGAGGCCGTGGCCGAAATCGTCGCAGGCGTCGCCGAAGGCTGCCGCG
AGTCTGGCTGTGCGCTGATCGGCGGCGAGACCGCGGAAATGCCGGGCCTCTACAAGGACGGCGACTATGATCTCGCCGGC
TTCGCGGTCGGCGCGGCGGAACGCGGCACGCTGCTGCCCTCCCCCGACATCACCGCCGGCGACGCGGTGATCGGGCTGGC
CTCATCCGGGGTGCATTCGAACGGGTTTTCGCTGGTCCGCAAGATCGTCGAAAAATCCGGCCTGCCCTACGACGCCAAGG
CGCCGTTCTCGCCGGTGATGACGCTCGGCGGAGCGCTGCTGACGCCGACCCGGCTCTACGTGAAATCCTGTCTGCAGGCG
ATCCGCACCACCGGCGCGATCAAGGGGCTGGCGCATATCACCGGTGGCGGTTTCACCGACAACATCCCGCGGGTGCTGCC
GAAGCATCTCGGCGTCGGCATCGACCTGCCGCGGCTGCCGGTGCTGCCGGTGTTCAAATGGCTGGCCGAACAAGGCGACA
TCGCCGAACTCGAACTGCTGCGCACCTTCAATTGCGGCATCGGCATGATCGCGATCGTCAAGGCGGACGCCGTCGACGCC
GTCACCGAGGCGCTGACCGCGGGCGGCGAGAGCGTGCATCTGCTCGGCGAAGTGATCGCGGCGAAGGGCGAACATCGCGT
CGTCTACGACGGTCACCTCGACCTGTCCTGGTGA

Upstream 100 bases:

>100_bases
GGACTTAGGTCTAGCGCGATCGACGGGGGTTCATCGGCGGCGGCTCGATGCCGGGCGGCAATCGTTGCCGCGCAGCGCCT
TTTTCTTGCGGGAGCCGGCC

Downstream 100 bases:

>100_bases
TCGCGTGAGCAAGCGTCGTGTCGCCATCCTGATTTCCGGGCGCGGGTCGAACATGGCCGCGCTGATCGAAGCCGCGGCCG
AAGACGGCTTCCCTGCCGAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTERKHGLTYADSGVDIDAGNRLVDLIKPMVRATARAGADSEIGGFGGLFDLKAAGFKDPVLVAATDGVGTKIKVAIEAG
VHAGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEAVAEIVAGVAEGCRESGCALIGGETAEMPGLYKDGDYDLAG
FAVGAAERGTLLPSPDITAGDAVIGLASSGVHSNGFSLVRKIVEKSGLPYDAKAPFSPVMTLGGALLTPTRLYVKSCLQA
IRTTGAIKGLAHITGGGFTDNIPRVLPKHLGVGIDLPRLPVLPVFKWLAEQGDIAELELLRTFNCGIGMIAIVKADAVDA
VTEALTAGGESVHLLGEVIAAKGEHRVVYDGHLDLSW

Sequences:

>Translated_357_residues
MTERKHGLTYADSGVDIDAGNRLVDLIKPMVRATARAGADSEIGGFGGLFDLKAAGFKDPVLVAATDGVGTKIKVAIEAG
VHAGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEAVAEIVAGVAEGCRESGCALIGGETAEMPGLYKDGDYDLAG
FAVGAAERGTLLPSPDITAGDAVIGLASSGVHSNGFSLVRKIVEKSGLPYDAKAPFSPVMTLGGALLTPTRLYVKSCLQA
IRTTGAIKGLAHITGGGFTDNIPRVLPKHLGVGIDLPRLPVLPVFKWLAEQGDIAELELLRTFNCGIGMIAIVKADAVDA
VTEALTAGGESVHLLGEVIAAKGEHRVVYDGHLDLSW
>Mature_356_residues
TERKHGLTYADSGVDIDAGNRLVDLIKPMVRATARAGADSEIGGFGGLFDLKAAGFKDPVLVAATDGVGTKIKVAIEAGV
HAGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEAVAEIVAGVAEGCRESGCALIGGETAEMPGLYKDGDYDLAGF
AVGAAERGTLLPSPDITAGDAVIGLASSGVHSNGFSLVRKIVEKSGLPYDAKAPFSPVMTLGGALLTPTRLYVKSCLQAI
RTTGAIKGLAHITGGGFTDNIPRVLPKHLGVGIDLPRLPVLPVFKWLAEQGDIAELELLRTFNCGIGMIAIVKADAVDAV
TEALTAGGESVHLLGEVIAAKGEHRVVYDGHLDLSW

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=348, Percent_Identity=54.5977011494253, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=348, Percent_Identity=54.5977011494253, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=348, Percent_Identity=54.5977011494253, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1788845, Length=351, Percent_Identity=50.1424501424501, Blast_Score=323, Evalue=8e-90,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=46.4912280701754, Blast_Score=290, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=57.1005917159763, Blast_Score=378, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24582400, Length=288, Percent_Identity=47.9166666666667, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36898; Mature: 36767

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERKHGLTYADSGVDIDAGNRLVDLIKPMVRATARAGADSEIGGFGGLFDLKAAGFKDP
CCCCCCCCEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCC
VLVAATDGVGTKIKVAIEAGVHAGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEA
EEEEEECCCCCEEEEEEECCCCCCCCCEEEEEEHHHHHHCCCCCEEEEHHHHCCCCCHHH
VAEIVAGVAEGCRESGCALIGGETAEMPGLYKDGDYDLAGFAVGAAERGTLLPSPDITAG
HHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
DAVIGLASSGVHSNGFSLVRKIVEKSGLPYDAKAPFSPVMTLGGALLTPTRLYVKSCLQA
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHCHHHHHHHHHHHH
IRTTGAIKGLAHITGGGFTDNIPRVLPKHLGVGIDLPRLPVLPVFKWLAEQGDIAELELL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
RTFNCGIGMIAIVKADAVDAVTEALTAGGESVHLLGEVIAAKGEHRVVYDGHLDLSW
HHHCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCEECCC
>Mature Secondary Structure 
TERKHGLTYADSGVDIDAGNRLVDLIKPMVRATARAGADSEIGGFGGLFDLKAAGFKDP
CCCCCCCEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCC
VLVAATDGVGTKIKVAIEAGVHAGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEA
EEEEEECCCCCEEEEEEECCCCCCCCCEEEEEEHHHHHHCCCCCEEEEHHHHCCCCCHHH
VAEIVAGVAEGCRESGCALIGGETAEMPGLYKDGDYDLAGFAVGAAERGTLLPSPDITAG
HHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
DAVIGLASSGVHSNGFSLVRKIVEKSGLPYDAKAPFSPVMTLGGALLTPTRLYVKSCLQA
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHCHHHHHHHHHHHH
IRTTGAIKGLAHITGGGFTDNIPRVLPKHLGVGIDLPRLPVLPVFKWLAEQGDIAELELL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
RTFNCGIGMIAIVKADAVDAVTEALTAGGESVHLLGEVIAAKGEHRVVYDGHLDLSW
HHHCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA