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The map label for this gene is rnd [H]

Identifier: 86749614

GI number: 86749614

Start: 2853544

End: 2854692

Strand: Reverse

Name: rnd [H]

Synonym: RPB_2494

Alternate gene names: 86749614

Gene position: 2854692-2853544 (Counterclockwise)

Preceding gene: 86749615

Following gene: 86749609

Centisome position: 53.54

GC content: 65.97

Gene sequence:

>1149_bases
ATGGACCTGATTTCGACCACTGAGCAGCTCGCCAGCGCCTGCACCCGCCTCGCCAGCCACCCCGTCATCACGGTCGATAC
CGAGTTTCTGCGCGAGACCACCTACTACCCTCTGCTCTGCGTCGTGCAGATGGCAAGCCGGGATGAGGCGGTTGTCGTCG
ATACGCTGGCACCCGGGATCGACCTGAAGCCGTTCTTCGACCTGATGGCCAACGAGAACGTCCTCAAGGTCTTCCACGCC
GCCCGCCAGGACATCGAAATCGTCTGGCACCGCGCCGGCATCGTCCCACACCCGATCTTCGACACCCAGGTCGCGGCCAT
GGTGCTCGGCTATGGCGACAGCATCGCCTACGACCAGCTCGTCGAGCGCATCACCGGCCACCGTCCGGACAAGACTCACC
GCTTCACCGACTGGTCGCGCCGCCCGCTGACCGACGAGCAGCTGCACTATGCCGTCTCCGACGTCACCCATCTGCGCGAC
GTCTTCGCCGCACTGGATGCGGACCTGAAACAGCGGGGCCGCAGCGATTGGGTCAGCGAGGAGATGGAAGTTCTGACCTC
GCCGAAAACTTACGACTTCCATCCCGAAAGTGCCTGGGAGCGGCTGAAGACCCGCGTGCGCAAGCCGAAAGAGCTCGCGG
TGCTGATGGAGGTGGCGGCCTGGCGCGAGCAGGAAGCGCAAACCCGCGACGTGCCGCGCTCGCGCGTGTTGAAGGACGAC
GCGCTCGGCGACATCGCAACCCACGCGCCGACCTCACTCGAGCGGCTCGCCAATCTGCGCTCGCTGCCGAAGGGGTTCGA
CCGCTCGAAATGGGGTTCCGAGATCGTGGCCGCGGTCCAGCGCGGTCTGGCGCGAGATCCGCAGACGCTGCCCAAGATCG
ACAAGCCGCGGAATAATTCCAACGGCGGCGCCATCGTCGAACTGCTCAAAGTATTGCTGCGCATGACGTCCGAGCGCCAC
GCCGTCGCCGCCAAAGTGATCGCCACCGTCGACGATCTCGAGCAGATCGCCTGCGACGACAAGGCCGAAGTCGGGGCGCT
GCGGGGGTGGCGACGCGAATTGTTCGGCGAAGCGGCGCTGGCGCTCAAGCACGGCCAGCTCGCGCTCGCGATCGAGAAGG
GCCGCGTGATCCACGTCGACCGCGGCTGA

Upstream 100 bases:

>100_bases
GGCGAGCGTGTCTAGTGGTCCGGAGTCGACGGCTTTCTGGGCAGACGGCGCTTTGCCGCTTGTTGCCTATGCCACCATTT
CCGGAACGTGACAGAGTTTG

Downstream 100 bases:

>100_bases
GCGCTATCGCCTGACGATCGTCCCCGAGCGCCCGACCATACGGCCGAGCTGCTTGAAGCGGCTGCCGACTCGATCGGCGA
CCAGGTCGACCAGCCTGTGC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDLISTTEQLASACTRLASHPVITVDTEFLRETTYYPLLCVVQMASRDEAVVVDTLAPGIDLKPFFDLMANENVLKVFHA
ARQDIEIVWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQLVERITGHRPDKTHRFTDWSRRPLTDEQLHYAVSDVTHLRD
VFAALDADLKQRGRSDWVSEEMEVLTSPKTYDFHPESAWERLKTRVRKPKELAVLMEVAAWREQEAQTRDVPRSRVLKDD
ALGDIATHAPTSLERLANLRSLPKGFDRSKWGSEIVAAVQRGLARDPQTLPKIDKPRNNSNGGAIVELLKVLLRMTSERH
AVAAKVIATVDDLEQIACDDKAEVGALRGWRRELFGEAALALKHGQLALAIEKGRVIHVDRG

Sequences:

>Translated_382_residues
MDLISTTEQLASACTRLASHPVITVDTEFLRETTYYPLLCVVQMASRDEAVVVDTLAPGIDLKPFFDLMANENVLKVFHA
ARQDIEIVWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQLVERITGHRPDKTHRFTDWSRRPLTDEQLHYAVSDVTHLRD
VFAALDADLKQRGRSDWVSEEMEVLTSPKTYDFHPESAWERLKTRVRKPKELAVLMEVAAWREQEAQTRDVPRSRVLKDD
ALGDIATHAPTSLERLANLRSLPKGFDRSKWGSEIVAAVQRGLARDPQTLPKIDKPRNNSNGGAIVELLKVLLRMTSERH
AVAAKVIATVDDLEQIACDDKAEVGALRGWRRELFGEAALALKHGQLALAIEKGRVIHVDRG
>Mature_382_residues
MDLISTTEQLASACTRLASHPVITVDTEFLRETTYYPLLCVVQMASRDEAVVVDTLAPGIDLKPFFDLMANENVLKVFHA
ARQDIEIVWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQLVERITGHRPDKTHRFTDWSRRPLTDEQLHYAVSDVTHLRD
VFAALDADLKQRGRSDWVSEEMEVLTSPKTYDFHPESAWERLKTRVRKPKELAVLMEVAAWREQEAQTRDVPRSRVLKDD
ALGDIATHAPTSLERLANLRSLPKGFDRSKWGSEIVAAVQRGLARDPQTLPKIDKPRNNSNGGAIVELLKVLLRMTSERH
AVAAKVIATVDDLEQIACDDKAEVGALRGWRRELFGEAALALKHGQLALAIEKGRVIHVDRG

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=257, Percent_Identity=25.6809338521401, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI50301240, Length=257, Percent_Identity=25.6809338521401, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788105, Length=371, Percent_Identity=29.1105121293801, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17531757, Length=262, Percent_Identity=27.0992366412214, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=265, Percent_Identity=26.4150943396226, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI161078302, Length=261, Percent_Identity=26.8199233716475, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42896; Mature: 42896

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLISTTEQLASACTRLASHPVITVDTEFLRETTYYPLLCVVQMASRDEAVVVDTLAPGI
CCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCC
DLKPFFDLMANENVLKVFHAARQDIEIVWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQL
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
VERITGHRPDKTHRFTDWSRRPLTDEQLHYAVSDVTHLRDVFAALDADLKQRGRSDWVSE
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EMEVLTSPKTYDFHPESAWERLKTRVRKPKELAVLMEVAAWREQEAQTRDVPRSRVLKDD
HHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALGDIATHAPTSLERLANLRSLPKGFDRSKWGSEIVAAVQRGLARDPQTLPKIDKPRNNS
HHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NGGAIVELLKVLLRMTSERHAVAAKVIATVDDLEQIACDDKAEVGALRGWRRELFGEAAL
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALKHGQLALAIEKGRVIHVDRG
HHCCCCEEEEEECCCEEEECCC
>Mature Secondary Structure
MDLISTTEQLASACTRLASHPVITVDTEFLRETTYYPLLCVVQMASRDEAVVVDTLAPGI
CCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCC
DLKPFFDLMANENVLKVFHAARQDIEIVWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQL
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
VERITGHRPDKTHRFTDWSRRPLTDEQLHYAVSDVTHLRDVFAALDADLKQRGRSDWVSE
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EMEVLTSPKTYDFHPESAWERLKTRVRKPKELAVLMEVAAWREQEAQTRDVPRSRVLKDD
HHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ALGDIATHAPTSLERLANLRSLPKGFDRSKWGSEIVAAVQRGLARDPQTLPKIDKPRNNS
HHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NGGAIVELLKVLLRMTSERHAVAAKVIATVDDLEQIACDDKAEVGALRGWRRELFGEAAL
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALKHGQLALAIEKGRVIHVDRG
HHCCCCEEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]