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The map label for this gene is gmk

Identifier: 86749592

GI number: 86749592

Start: 2828504

End: 2829166

Strand: Direct

Name: gmk

Synonym: RPB_2472

Alternate gene names: 86749592

Gene position: 2828504-2829166 (Clockwise)

Preceding gene: 86749591

Following gene: 86749601

Centisome position: 53.05

GC content: 64.86

Gene sequence:

>663_bases
ATGAAGGACGGGGCGGCAGGCAGCCTGAACGGCATCGAGCGGCGCGGATTGATGTTCGTGCTGTCGTCGCCGTCGGGCGC
CGGCAAGACGACGCTCTCGCGTATGCTGGTCGACGAGGCGCCGGGATTGCGGATGTCGGTGTCGGCGACGACCCGGCCGA
AGCGGCCGGGCGAAGTCGACGGCCGTGACTACTACTTCGTCGATCGGCCGAAATTCGACGCCATGGTCGAGGCCGGCGAG
TTTCTCGAATGGGCCAACGTTTTCGACAATTGTTACGGCACGCCGCGCGCGCCGGTCGAAGCGGCGCTCTCGGCCGGCAA
CGACGTGCTGTTCGACATCGACTGGCAGGGCACCCAACAGTTGCGCAGCCGGGCGTCGAACGACGTCGTCAGCGTCTTCA
TCCTTCCGCCGTCAGTTCAGGACCTCGAGCATCGGCTCCACACGCGGGCGCAGGATTCCGACGAGGTGATCCGCGGGCGG
ATGAAAAAGGCCGGCGACGAGATGAGCCATTTCGACGCCTACGACTACATCGTCGTCAACGACAACATCGGCGTCGCCTT
CGAGTCCGTCAAAGCGATCCTGCGCGCGGAACAGCTCAAGCGCGAGCGGCAGATCGGGATCGACGCCTTCGTGCGGGAGA
TGCGGCGCGAACTCGAAAAATAG

Upstream 100 bases:

>100_bases
GCTGCTCCAAGTCGATCGATCTCGAACTGACCAACACCGGCCTTGCGATGAAGAACGTGGTCGAGCAGTTCCGCGAGCAA
GTGCAGAATCTGGAGTGAGG

Downstream 100 bases:

>100_bases
CGGGCCGGCAGCGCCGCCACTCTCGTGCAGGCTCGCTCAGGCCGCCGGACGCTTCTGCGCGCGCGCCAGCAACTCTTCGA
TCTCATTGGTGCTCTGTACT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKDGAAGSLNGIERRGLMFVLSSPSGAGKTTLSRMLVDEAPGLRMSVSATTRPKRPGEVDGRDYYFVDRPKFDAMVEAGE
FLEWANVFDNCYGTPRAPVEAALSAGNDVLFDIDWQGTQQLRSRASNDVVSVFILPPSVQDLEHRLHTRAQDSDEVIRGR
MKKAGDEMSHFDAYDYIVVNDNIGVAFESVKAILRAEQLKRERQIGIDAFVREMRRELEK

Sequences:

>Translated_220_residues
MKDGAAGSLNGIERRGLMFVLSSPSGAGKTTLSRMLVDEAPGLRMSVSATTRPKRPGEVDGRDYYFVDRPKFDAMVEAGE
FLEWANVFDNCYGTPRAPVEAALSAGNDVLFDIDWQGTQQLRSRASNDVVSVFILPPSVQDLEHRLHTRAQDSDEVIRGR
MKKAGDEMSHFDAYDYIVVNDNIGVAFESVKAILRAEQLKRERQIGIDAFVREMRRELEK
>Mature_220_residues
MKDGAAGSLNGIERRGLMFVLSSPSGAGKTTLSRMLVDEAPGLRMSVSATTRPKRPGEVDGRDYYFVDRPKFDAMVEAGE
FLEWANVFDNCYGTPRAPVEAALSAGNDVLFDIDWQGTQQLRSRASNDVVSVFILPPSVQDLEHRLHTRAQDSDEVIRGR
MKKAGDEMSHFDAYDYIVVNDNIGVAFESVKAILRAEQLKRERQIGIDAFVREMRRELEK

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=193, Percent_Identity=35.7512953367876, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI226874833, Length=193, Percent_Identity=35.7512953367876, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI4504221, Length=193, Percent_Identity=35.7512953367876, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI21361598, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI111154074, Length=174, Percent_Identity=27.0114942528736, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=25.3886010362694, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=47.9166666666667, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=32.967032967033, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=182, Percent_Identity=32.967032967033, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71984092, Length=149, Percent_Identity=32.8859060402685, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=167, Percent_Identity=26.9461077844311, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=167, Percent_Identity=26.9461077844311, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=38.4615384615385, Blast_Score=134, Evalue=9e-33,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=33.8461538461538, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI221330164, Length=187, Percent_Identity=31.5508021390374, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330166, Length=187, Percent_Identity=31.5508021390374, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330162, Length=187, Percent_Identity=31.5508021390374, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362230, Length=180, Percent_Identity=28.3333333333333, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648808, Length=180, Percent_Identity=28.3333333333333, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161078487, Length=180, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161078485, Length=180, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648810, Length=180, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281362232, Length=180, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI116007136, Length=201, Percent_Identity=26.3681592039801, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45554481, Length=188, Percent_Identity=26.5957446808511, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI85724806, Length=188, Percent_Identity=26.5957446808511, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_RHOP2 (Q2IX83)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486088.1
- ProteinModelPortal:   Q2IX83
- SMR:   Q2IX83
- STRING:   Q2IX83
- GeneID:   3910261
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2472
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   RPAL316058:RPB_2472-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24616; Mature: 24616

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDGAAGSLNGIERRGLMFVLSSPSGAGKTTLSRMLVDEAPGLRMSVSATTRPKRPGEVD
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
GRDYYFVDRPKFDAMVEAGEFLEWANVFDNCYGTPRAPVEAALSAGNDVLFDIDWQGTQQ
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCHHH
LRSRASNDVVSVFILPPSVQDLEHRLHTRAQDSDEVIRGRMKKAGDEMSHFDAYDYIVVN
HHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEE
DNIGVAFESVKAILRAEQLKRERQIGIDAFVREMRRELEK
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKDGAAGSLNGIERRGLMFVLSSPSGAGKTTLSRMLVDEAPGLRMSVSATTRPKRPGEVD
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
GRDYYFVDRPKFDAMVEAGEFLEWANVFDNCYGTPRAPVEAALSAGNDVLFDIDWQGTQQ
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCHHH
LRSRASNDVVSVFILPPSVQDLEHRLHTRAQDSDEVIRGRMKKAGDEMSHFDAYDYIVVN
HHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEE
DNIGVAFESVKAILRAEQLKRERQIGIDAFVREMRRELEK
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA