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The map label for this gene is pepA

Identifier: 86749601

GI number: 86749601

Start: 2839536

End: 2841038

Strand: Direct

Name: pepA

Synonym: RPB_2481

Alternate gene names: 86749601

Gene position: 2839536-2841038 (Clockwise)

Preceding gene: 86749592

Following gene: 86749602

Centisome position: 53.26

GC content: 66.13

Gene sequence:

>1503_bases
ATGCCCGACGCCGTCAAGGTCGGCTTCGTCCCGTTTTCCGTTGCCGCGCGCGGCACGCTCGTTGTGCTTTGCGACGACGC
GCTGAAATTCGGCCCGGCGACCAGCAAGGCGCTGGGGGTCGCGGTCAGCACGGTCAAACGGGCGGTGGCGGCGAGCCAGT
TCAAGGGCAAGTCGGGCTCTGCGCTCGACCTGTTGGCGCCCGAGGGCCTCAAGGTCGGACGGCTGGTCGTGATCGGGACC
GGGAAGGCGGCAGCACTCAAGGACTACGACGTCCTCAAGCTCGGCGGCGCAATTGCGGGCAAGATCGGGGCAGGCGACAC
GGCCGTCACCGTGATCGCCGAGCTGCCGGGCGGCGCGATGAAGCCCGAGCAGGCCGCGGCGATCGCCTCCGGCATCCTGC
TCCGGGCCTACAAGTTCGATCGCTACAAGACCAAGAAGAAGGACGATGACGCGAATGCGCTGAACGCCAACGTGTCGATC
GCTGTTGCGGACGCCGCCGCGGCGAAGAAGGCATTCGCGCCCGACAGTGCCGTCGTCGACGGTGTGATCCTGGCGCGCGA
ACTCGTCAACGAGCCGCCGAACGTGCTGTATCCGGAAGAATTCGCCAAGCGCGCGGCGCAGCTGAAGAAGCTCGGCGTCG
ACATCCAGATCCTCGACGTCAAGGCGATGACGCAACTCAAGATGGGCGCGCTGCTCGGGGTGTCGCAGGGCTCGGCGCAT
CCGGGCCGCACCGTGATCATGCGCTGGAACGGCGGCAAGCGCGGCGAACAGCCGGTCGCCTTCGTCGGCAAGGGCGTGTG
CTTCGACACCGGCGGCATCTCGATCAAGCCGTCGGCCAGCATGGAAGACATGAAGGGCGACATGGGCGGCGCTGCCTGCG
TCGTCGGCCTGATGCACGCGCTCGCCGCGCGCAAGGCCAAGGTCAATGTGATCGGCGCCATCGGTCTGGTGGAGAACATG
CCGGACGGCAACGCGCAGCGCCCTGGCGATATCGTGACCTCGATGTCGGGCCAGACCATCGAGATCATCAACACCGACGC
CGAGGGCCGTCTCGTGCTCGCCGACGTGCTCTGGTACGTGGCGCAGAAGCACAAGCCGAAATTCATGGTCGACCTCGCCA
CGCTGACCGGCGCCATCATGGTCGCGCTCGGCACCGATCACGCCGGCCTGTTCTCGAACAACGACGAACTCGCCGAACGG
CTGACTGCGGTCGGTGTTTCGACCGGCGAGAAGGTGTGGCGGATGCCGCTCGGTCCGGAATACGACAAGCAGATCGACTC
GCAATTCGCCGACATGAAGAACACCGGTTCGCGCAACGGCGGCTCGATCACCGCGGCGCAGTTCCTGCAGCGCTTCGTCG
ACAATACGCCCTGGGCGCATCTCGACATCGCCGGCACGGCGATGGGCGCACCGAAGAACGACATCAACCAGAGCTGGGGT
TCGGGCTACGGCGTGCGGCTCTTGAACGCGCTCGTCGCGGAGTACTACGAAGCCAAGAAGTAA

Upstream 100 bases:

>100_bases
CGATGCCGGCTTGACTTGACGACGCAGGGCACCAAAACAACAGGTTGCACCGCCTGCCGGATTCCGTCACTGCCCGACAG
CCCCATTTGGAGGAATGCCC

Downstream 100 bases:

>100_bases
TCCGATCCGATGCGATGACCGAGGTCCTGTTCTATCACCTGCAGGGACGGACGATCGAGCAGGTGCTGCCGCCGTTGCTC
GAGAAGTCGCTGGCGCGCGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MPDAVKVGFVPFSVAARGTLVVLCDDALKFGPATSKALGVAVSTVKRAVAASQFKGKSGSALDLLAPEGLKVGRLVVIGT
GKAAALKDYDVLKLGGAIAGKIGAGDTAVTVIAELPGGAMKPEQAAAIASGILLRAYKFDRYKTKKKDDDANALNANVSI
AVADAAAAKKAFAPDSAVVDGVILARELVNEPPNVLYPEEFAKRAAQLKKLGVDIQILDVKAMTQLKMGALLGVSQGSAH
PGRTVIMRWNGGKRGEQPVAFVGKGVCFDTGGISIKPSASMEDMKGDMGGAACVVGLMHALAARKAKVNVIGAIGLVENM
PDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVAQKHKPKFMVDLATLTGAIMVALGTDHAGLFSNNDELAER
LTAVGVSTGEKVWRMPLGPEYDKQIDSQFADMKNTGSRNGGSITAAQFLQRFVDNTPWAHLDIAGTAMGAPKNDINQSWG
SGYGVRLLNALVAEYYEAKK

Sequences:

>Translated_500_residues
MPDAVKVGFVPFSVAARGTLVVLCDDALKFGPATSKALGVAVSTVKRAVAASQFKGKSGSALDLLAPEGLKVGRLVVIGT
GKAAALKDYDVLKLGGAIAGKIGAGDTAVTVIAELPGGAMKPEQAAAIASGILLRAYKFDRYKTKKKDDDANALNANVSI
AVADAAAAKKAFAPDSAVVDGVILARELVNEPPNVLYPEEFAKRAAQLKKLGVDIQILDVKAMTQLKMGALLGVSQGSAH
PGRTVIMRWNGGKRGEQPVAFVGKGVCFDTGGISIKPSASMEDMKGDMGGAACVVGLMHALAARKAKVNVIGAIGLVENM
PDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVAQKHKPKFMVDLATLTGAIMVALGTDHAGLFSNNDELAER
LTAVGVSTGEKVWRMPLGPEYDKQIDSQFADMKNTGSRNGGSITAAQFLQRFVDNTPWAHLDIAGTAMGAPKNDINQSWG
SGYGVRLLNALVAEYYEAKK
>Mature_499_residues
PDAVKVGFVPFSVAARGTLVVLCDDALKFGPATSKALGVAVSTVKRAVAASQFKGKSGSALDLLAPEGLKVGRLVVIGTG
KAAALKDYDVLKLGGAIAGKIGAGDTAVTVIAELPGGAMKPEQAAAIASGILLRAYKFDRYKTKKKDDDANALNANVSIA
VADAAAAKKAFAPDSAVVDGVILARELVNEPPNVLYPEEFAKRAAQLKKLGVDIQILDVKAMTQLKMGALLGVSQGSAHP
GRTVIMRWNGGKRGEQPVAFVGKGVCFDTGGISIKPSASMEDMKGDMGGAACVVGLMHALAARKAKVNVIGAIGLVENMP
DGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVAQKHKPKFMVDLATLTGAIMVALGTDHAGLFSNNDELAERL
TAVGVSTGEKVWRMPLGPEYDKQIDSQFADMKNTGSRNGGSITAAQFLQRFVDNTPWAHLDIAGTAMGAPKNDINQSWGS
GYGVRLLNALVAEYYEAKK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=350, Percent_Identity=40.5714285714286, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI47155554, Length=326, Percent_Identity=34.9693251533742, Blast_Score=156, Evalue=5e-38,
Organism=Escherichia coli, GI1790710, Length=429, Percent_Identity=39.6270396270396, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87082123, Length=328, Percent_Identity=38.4146341463415, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=350, Percent_Identity=30.8571428571429, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=434, Percent_Identity=24.8847926267281, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI20129969, Length=287, Percent_Identity=33.4494773519164, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24662227, Length=287, Percent_Identity=34.1463414634146, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21355725, Length=282, Percent_Identity=36.8794326241135, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24661038, Length=282, Percent_Identity=37.2340425531915, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI161077148, Length=292, Percent_Identity=32.8767123287671, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20130057, Length=292, Percent_Identity=32.8767123287671, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21355645, Length=287, Percent_Identity=29.9651567944251, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24662223, Length=287, Percent_Identity=29.9651567944251, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19922386, Length=287, Percent_Identity=33.1010452961672, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI20129963, Length=406, Percent_Identity=29.5566502463054, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=32.2884012539185, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=32.2884012539185, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=32.2884012539185, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646701, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24646703, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21358201, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_RHOP2 (Q2IX74)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486097.1
- HSSP:   P00727
- ProteinModelPortal:   Q2IX74
- SMR:   Q2IX74
- STRING:   Q2IX74
- GeneID:   3910270
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2481
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   NMHLMRY
- ProtClustDB:   PRK00913
- BioCyc:   RPAL316058:RPB_2481-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52174; Mature: 52043

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 276-276 ACT_SITE 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDAVKVGFVPFSVAARGTLVVLCDDALKFGPATSKALGVAVSTVKRAVAASQFKGKSGS
CCCCEEEEEEEEEECCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
ALDLLAPEGLKVGRLVVIGTGKAAALKDYDVLKLGGAIAGKIGAGDTAVTVIAELPGGAM
EEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEECCCEECCCCCCCCEEEEEEECCCCCC
KPEQAAAIASGILLRAYKFDRYKTKKKDDDANALNANVSIAVADAAAAKKAFAPDSAVVD
CCHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCEECCCEEEEEECHHHHHHHCCCCHHHHH
GVILARELVNEPPNVLYPEEFAKRAAQLKKLGVDIQILDVKAMTQLKMGALLGVSQGSAH
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHEECCCCCCC
PGRTVIMRWNGGKRGEQPVAFVGKGVCFDTGGISIKPSASMEDMKGDMGGAACVVGLMHA
CCCEEEEEECCCCCCCCCCEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHH
LAARKAKVNVIGAIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYV
HHHCCCEEEEEEEEHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHH
AQKHKPKFMVDLATLTGAIMVALGTDHAGLFSNNDELAERLTAVGVSTGEKVWRMPLGPE
HHCCCCCEEEEHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCC
YDKQIDSQFADMKNTGSRNGGSITAAQFLQRFVDNTPWAHLDIAGTAMGAPKNDINQSWG
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHCCC
SGYGVRLLNALVAEYYEAKK
CCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDAVKVGFVPFSVAARGTLVVLCDDALKFGPATSKALGVAVSTVKRAVAASQFKGKSGS
CCCEEEEEEEEEECCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
ALDLLAPEGLKVGRLVVIGTGKAAALKDYDVLKLGGAIAGKIGAGDTAVTVIAELPGGAM
EEEEECCCCCCCCEEEEEECCCCCCCCCCCCEEECCCEECCCCCCCCEEEEEEECCCCCC
KPEQAAAIASGILLRAYKFDRYKTKKKDDDANALNANVSIAVADAAAAKKAFAPDSAVVD
CCHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCEECCCEEEEEECHHHHHHHCCCCHHHHH
GVILARELVNEPPNVLYPEEFAKRAAQLKKLGVDIQILDVKAMTQLKMGALLGVSQGSAH
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHEECCCCCCC
PGRTVIMRWNGGKRGEQPVAFVGKGVCFDTGGISIKPSASMEDMKGDMGGAACVVGLMHA
CCCEEEEEECCCCCCCCCCEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHH
LAARKAKVNVIGAIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYV
HHHCCCEEEEEEEEHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHH
AQKHKPKFMVDLATLTGAIMVALGTDHAGLFSNNDELAERLTAVGVSTGEKVWRMPLGPE
HHCCCCCEEEEHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCC
YDKQIDSQFADMKNTGSRNGGSITAAQFLQRFVDNTPWAHLDIAGTAMGAPKNDINQSWG
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHCCC
SGYGVRLLNALVAEYYEAKK
CCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA