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The map label for this gene is alr [H]

Identifier: 86749577

GI number: 86749577

Start: 2813220

End: 2814491

Strand: Reverse

Name: alr [H]

Synonym: RPB_2457

Alternate gene names: 86749577

Gene position: 2814491-2813220 (Counterclockwise)

Preceding gene: 86749578

Following gene: 86749574

Centisome position: 52.79

GC content: 69.18

Gene sequence:

>1272_bases
ATGGAATTCGGGCAGCGATTATTGTGCGGCATGAACATCCTCCCCGATCCGAATGCGACCGTCGCCAGCCTGTTGACACC
TGAAGCCGCGAAGGCAGCGGCGCTCGCTGCGGCGACCGCCACAGCCCCCGGCATTCTCACCATCGACCTCGACGCGATCG
TCGCCAATTGGCGCAAGCTGGAGAAGACCGCGGTGCCGGCCGAAGCCGCCGCCGTGGTCAAGGGCGACGCCTATGGCTGC
GGCATCGCGCCGGTCACCAAGGCGCTCGTGGCCGCCGGCTGCAAGACCTTCTTCGTCGCAACGCTCGCCGAGGCCGCCGC
CGTCCGTGCGACCGCGCCGGACGCGGCGATCTACGTTCTCGACGGCTTCTTCCAGAGCACCGGCGATGAATTCGCCAGGC
TGAACTGCCGCCCGGTGATCGGCGACCTCTATGAACTCGCCGAGTGGGACGTGTATTGCCGCCGCACGCAGTGGAGCGGC
GGCGCGGCGATCCATATCGACACCGGCATGAACCGCCTCGGCCTGACGATCTCCGAAGCGCAGGGCATCGTGCCGCGGAT
CGCCACGGGGGATCACGGCATCACGCTGGTGATCAGTCACCTCGCCGCGGCCGAGGCGCTCAACCATCCGATGAACGCCC
GACAGGTCACGGCGTTTCGCGAGATCGCGAGCCTGTTCACCGGCGTGCCGGCGTCGCTGTCGGCCTCCTCCGGCATCTTC
CTCGACCCGCAATTCGCCTTCGACATGGTGCGCCCAGGTGCCGCGCTCTACGGCATCAACCCGACGCCGGAGGCCGACAA
TCCGATGCAGCCGGTGGTCGATCTCAAGGCCCGCATCCTGCAGGTCCGCAGCGTCGAGCGCGGCGACAGCGTCGGCTATG
GCGGCACCTGGACGGCGCGGCGCCCGACCAAGATCGCGGTGCTGTCCGCCGGCTATGCCGACGGTTACTTCCGCGCCGCC
GGCTCCAACGATGGCACCCGCGGCGCCGACGTGATCATCGCCGGCCAGCGCTGCCCGGTCGCCGGACGGATTTCGATGGA
CCTGCTCGCGGTCGACGTCACCGACCTGCCCGCCAACGCCGCCCGCCGCGGCCAGATGGCGACGCTGATCGGCGACGGCA
TCACCGTCGACGAACTCGGGCATCATTTCGGCAGCATCGGCTACGAAGTGCTGACCAGCCTCGGCCGCCGCTACGCGAGG
GTCTACAACGGCGGTGACGCGAAGCCGGCGGACAAGCCGGCGGCCGACACGCCGCCGGCGGCATTGAGCTGA

Upstream 100 bases:

>100_bases
CGGTCGACCTGCAGTTCGAGGGCCAGTTCACGCGCTTCAGCGATCTGGTCAGCGAAGGCCACCTGCCGGAACGGATCTGA
GCTGCAGCAACTCCCGTTGA

Downstream 100 bases:

>100_bases
CGGCGGCGGACGGTCACCGCCGACCTAGTCCTCGTGCACCAGAAACAGGAAGCCGGTGATCGCCGCGAGAAACGCAAACG
AGCCGGCGATGCCGACGACC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MEFGQRLLCGMNILPDPNATVASLLTPEAAKAAALAAATATAPGILTIDLDAIVANWRKLEKTAVPAEAAAVVKGDAYGC
GIAPVTKALVAAGCKTFFVATLAEAAAVRATAPDAAIYVLDGFFQSTGDEFARLNCRPVIGDLYELAEWDVYCRRTQWSG
GAAIHIDTGMNRLGLTISEAQGIVPRIATGDHGITLVISHLAAAEALNHPMNARQVTAFREIASLFTGVPASLSASSGIF
LDPQFAFDMVRPGAALYGINPTPEADNPMQPVVDLKARILQVRSVERGDSVGYGGTWTARRPTKIAVLSAGYADGYFRAA
GSNDGTRGADVIIAGQRCPVAGRISMDLLAVDVTDLPANAARRGQMATLIGDGITVDELGHHFGSIGYEVLTSLGRRYAR
VYNGGDAKPADKPAADTPPAALS

Sequences:

>Translated_423_residues
MEFGQRLLCGMNILPDPNATVASLLTPEAAKAAALAAATATAPGILTIDLDAIVANWRKLEKTAVPAEAAAVVKGDAYGC
GIAPVTKALVAAGCKTFFVATLAEAAAVRATAPDAAIYVLDGFFQSTGDEFARLNCRPVIGDLYELAEWDVYCRRTQWSG
GAAIHIDTGMNRLGLTISEAQGIVPRIATGDHGITLVISHLAAAEALNHPMNARQVTAFREIASLFTGVPASLSASSGIF
LDPQFAFDMVRPGAALYGINPTPEADNPMQPVVDLKARILQVRSVERGDSVGYGGTWTARRPTKIAVLSAGYADGYFRAA
GSNDGTRGADVIIAGQRCPVAGRISMDLLAVDVTDLPANAARRGQMATLIGDGITVDELGHHFGSIGYEVLTSLGRRYAR
VYNGGDAKPADKPAADTPPAALS
>Mature_423_residues
MEFGQRLLCGMNILPDPNATVASLLTPEAAKAAALAAATATAPGILTIDLDAIVANWRKLEKTAVPAEAAAVVKGDAYGC
GIAPVTKALVAAGCKTFFVATLAEAAAVRATAPDAAIYVLDGFFQSTGDEFARLNCRPVIGDLYELAEWDVYCRRTQWSG
GAAIHIDTGMNRLGLTISEAQGIVPRIATGDHGITLVISHLAAAEALNHPMNARQVTAFREIASLFTGVPASLSASSGIF
LDPQFAFDMVRPGAALYGINPTPEADNPMQPVVDLKARILQVRSVERGDSVGYGGTWTARRPTKIAVLSAGYADGYFRAA
GSNDGTRGADVIIAGQRCPVAGRISMDLLAVDVTDLPANAARRGQMATLIGDGITVDELGHHFGSIGYEVLTSLGRRYAR
VYNGGDAKPADKPAADTPPAALS

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1790487, Length=369, Percent_Identity=31.9783197831978, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787439, Length=374, Percent_Identity=31.8181818181818, Blast_Score=151, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 44092; Mature: 44092

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFGQRLLCGMNILPDPNATVASLLTPEAAKAAALAAATATAPGILTIDLDAIVANWRKL
CCCHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
EKTAVPAEAAAVVKGDAYGCGIAPVTKALVAAGCKTFFVATLAEAAAVRATAPDAAIYVL
HHHCCCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
DGFFQSTGDEFARLNCRPVIGDLYELAEWDVYCRRTQWSGGAAIHIDTGMNRLGLTISEA
EHHHHCCCCHHHEECCCCHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCHHCEEEHHC
QGIVPRIATGDHGITLVISHLAAAEALNHPMNARQVTAFREIASLFTGVPASLSASSGIF
CCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LDPQFAFDMVRPGAALYGINPTPEADNPMQPVVDLKARILQVRSVERGDSVGYGGTWTAR
ECCHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCC
RPTKIAVLSAGYADGYFRAAGSNDGTRGADVIIAGQRCPVAGRISMDLLAVDVTDLPANA
CCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCH
ARRGQMATLIGDGITVDELGHHFGSIGYEVLTSLGRRYARVYNGGDAKPADKPAADTPPA
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ALS
CCC
>Mature Secondary Structure
MEFGQRLLCGMNILPDPNATVASLLTPEAAKAAALAAATATAPGILTIDLDAIVANWRKL
CCCHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
EKTAVPAEAAAVVKGDAYGCGIAPVTKALVAAGCKTFFVATLAEAAAVRATAPDAAIYVL
HHHCCCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
DGFFQSTGDEFARLNCRPVIGDLYELAEWDVYCRRTQWSGGAAIHIDTGMNRLGLTISEA
EHHHHCCCCHHHEECCCCHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCHHCEEEHHC
QGIVPRIATGDHGITLVISHLAAAEALNHPMNARQVTAFREIASLFTGVPASLSASSGIF
CCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LDPQFAFDMVRPGAALYGINPTPEADNPMQPVVDLKARILQVRSVERGDSVGYGGTWTAR
ECCHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCC
RPTKIAVLSAGYADGYFRAAGSNDGTRGADVIIAGQRCPVAGRISMDLLAVDVTDLPANA
CCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCH
ARRGQMATLIGDGITVDELGHHFGSIGYEVLTSLGRRYARVYNGGDAKPADKPAADTPPA
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ALS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA