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The map label for this gene is yrbG [H]

Identifier: 86749524

GI number: 86749524

Start: 2757609

End: 2758682

Strand: Reverse

Name: yrbG [H]

Synonym: RPB_2404

Alternate gene names: 86749524

Gene position: 2758682-2757609 (Counterclockwise)

Preceding gene: 86749525

Following gene: 86749520

Centisome position: 51.74

GC content: 62.57

Gene sequence:

>1074_bases
ATGCTGACCCTGCTCAGTTTTCTGTTGGGACTTGTCGCTCTTGTCGTCGGCGCAGAATTGCTGGTCCGAGGGGCCTCCAA
ACTGGCGCTCACGTTCGGAATATCGCCGCTGGTGGTCGGCCTGACGGTGGTGGCCTTCGGTACCAGCTCTCCGGAACTGG
CGGTCTCGATTCAGGCGGCGATGTCGAACCAGGCCGACATTACGATCGGCAATGTCGTCGGCAGCAACATTCTGAATGTG
CTCTTCATCCTCGGTCTGTCGGCGCTCATCACGCCGTTGATCGTCAACCGACAACTGATCCGCCAGGAGGTTCCGATCAT
GGTCGGAGCATCCTTGCTGCTGGCCGCGCTGGCGTGGGATGGCAATCTGTCGCGCGTGGACGGATTGATCCTGATAGGCC
TCATGGCCGCCTATACGGCATTCCTGATCGTGCAGAGCCGTCGTCAGGAAACGGCCTCGGATGAGGCGGCACCGACCACC
GCCGACGCGGGAACGGGGTGGGACTCGAAGCTGCCGGTGCAAATCGCGCTGATCATCGTAGGCCTAATCTTGCTGGTGAT
CGGCGCGACCTTTCTGGTCGAGGCGGCCGTCACGTTCGCGAAACTGTTCGGCGTCAGCGAAATGGTGATCGGTCTGACCA
TCGTCGCGGCGGGCACCTCGCTGCCCGAGGTCGCGACCTCGATCATGGCGGCCATCCGCGGTCAGCGCGACATCGCCGTC
GGCAATGTGGTGGGCAGCAACACCTTCAACATTCTCGGCGTGCTCGGCCTGTCCGCCGGGGTGGCGCCGGACGGCCTTAA
TATCGCTCCGGCCATGATGGCGTTCGATATCCCGGTGATGGTCGCGGTGGCGATTGCCTGCCTGCCGATCTTCTTCACCG
GCAGCCTGATCGCCAGGTGGGAAGGCGGGCTGTTTCTGGCGCTCTACGTCGCCTACACCGTTTACCTGGTGATGGCGGCA
CAGCAGCACGACGGACTCTCGACCTATGGCTTCGTCCTCGGCACCGTCGTTCTTCCGCTGTGCGGGTTGACCCTTGTCGT
CATCAGTTGGCGTGAATGGCGTGCCCGACACTAA

Upstream 100 bases:

>100_bases
AGAAGGAAGACACCGCCGTCCTGGAAGGCCACGCCGAGAAACTGAAGGCGGCTCTGGCGCAGGGTTAGCCTCCCGCGATC
CCGATAGCGAGTCGAGAAAA

Downstream 100 bases:

>100_bases
TCGTATTAGAGCATGATCCCGAAAGGCGGATGCCGGTTTTCGGGATCATGCTCAATCAAGACAACAAGCATCCGGCCATC
ACGGCCTTGTCTGGTTACTT

Product: K+-dependent Na+/Ca+ exchanger related-protein

Products: Na (I) [Cytoplasm]; Ca (II) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLTLLSFLLGLVALVVGAELLVRGASKLALTFGISPLVVGLTVVAFGTSSPELAVSIQAAMSNQADITIGNVVGSNILNV
LFILGLSALITPLIVNRQLIRQEVPIMVGASLLLAALAWDGNLSRVDGLILIGLMAAYTAFLIVQSRRQETASDEAAPTT
ADAGTGWDSKLPVQIALIIVGLILLVIGATFLVEAAVTFAKLFGVSEMVIGLTIVAAGTSLPEVATSIMAAIRGQRDIAV
GNVVGSNTFNILGVLGLSAGVAPDGLNIAPAMMAFDIPVMVAVAIACLPIFFTGSLIARWEGGLFLALYVAYTVYLVMAA
QQHDGLSTYGFVLGTVVLPLCGLTLVVISWREWRARH

Sequences:

>Translated_357_residues
MLTLLSFLLGLVALVVGAELLVRGASKLALTFGISPLVVGLTVVAFGTSSPELAVSIQAAMSNQADITIGNVVGSNILNV
LFILGLSALITPLIVNRQLIRQEVPIMVGASLLLAALAWDGNLSRVDGLILIGLMAAYTAFLIVQSRRQETASDEAAPTT
ADAGTGWDSKLPVQIALIIVGLILLVIGATFLVEAAVTFAKLFGVSEMVIGLTIVAAGTSLPEVATSIMAAIRGQRDIAV
GNVVGSNTFNILGVLGLSAGVAPDGLNIAPAMMAFDIPVMVAVAIACLPIFFTGSLIARWEGGLFLALYVAYTVYLVMAA
QQHDGLSTYGFVLGTVVLPLCGLTLVVISWREWRARH
>Mature_357_residues
MLTLLSFLLGLVALVVGAELLVRGASKLALTFGISPLVVGLTVVAFGTSSPELAVSIQAAMSNQADITIGNVVGSNILNV
LFILGLSALITPLIVNRQLIRQEVPIMVGASLLLAALAWDGNLSRVDGLILIGLMAAYTAFLIVQSRRQETASDEAAPTT
ADAGTGWDSKLPVQIALIIVGLILLVIGATFLVEAAVTFAKLFGVSEMVIGLTIVAAGTSLPEVATSIMAAIRGQRDIAV
GNVVGSNTFNILGVLGLSAGVAPDGLNIAPAMMAFDIPVMVAVAIACLPIFFTGSLIARWEGGLFLALYVAYTVYLVMAA
QQHDGLSTYGFVLGTVVLPLCGLTLVVISWREWRARH

Specific function: Unknown

COG id: COG0530

COG function: function code P; Ca2+/Na+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Homo sapiens, GI300796347, Length=147, Percent_Identity=31.2925170068027, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI9966787, Length=147, Percent_Identity=31.2925170068027, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789587, Length=268, Percent_Identity=40.6716417910448, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004481
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 37110; Mature: 37110

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLLSFLLGLVALVVGAELLVRGASKLALTFGISPLVVGLTVVAFGTSSPELAVSIQAA
CHHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHCCHHHHHHHHHHHCCCCCCCEEEEEHHH
MSNQADITIGNVVGSNILNVLFILGLSALITPLIVNRQLIRQEVPIMVGASLLLAALAWD
HCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
GNLSRVDGLILIGLMAAYTAFLIVQSRRQETASDEAAPTTADAGTGWDSKLPVQIALIIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
GLILLVIGATFLVEAAVTFAKLFGVSEMVIGLTIVAAGTSLPEVATSIMAAIRGQRDIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEE
GNVVGSNTFNILGVLGLSAGVAPDGLNIAPAMMAFDIPVMVAVAIACLPIFFTGSLIARW
CCEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGGLFLALYVAYTVYLVMAAQQHDGLSTYGFVLGTVVLPLCGLTLVVISWREWRARH
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTLLSFLLGLVALVVGAELLVRGASKLALTFGISPLVVGLTVVAFGTSSPELAVSIQAA
CHHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHCCHHHHHHHHHHHCCCCCCCEEEEEHHH
MSNQADITIGNVVGSNILNVLFILGLSALITPLIVNRQLIRQEVPIMVGASLLLAALAWD
HCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
GNLSRVDGLILIGLMAAYTAFLIVQSRRQETASDEAAPTTADAGTGWDSKLPVQIALIIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
GLILLVIGATFLVEAAVTFAKLFGVSEMVIGLTIVAAGTSLPEVATSIMAAIRGQRDIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEE
GNVVGSNTFNILGVLGLSAGVAPDGLNIAPAMMAFDIPVMVAVAIACLPIFFTGSLIARW
CCEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGGLFLALYVAYTVYLVMAAQQHDGLSTYGFVLGTVVLPLCGLTLVVISWREWRARH
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; Ca (II) [Cytoplasm] [C]

Specific reaction: Na (I) [Periplasm] + Ca (II) [Cytoplasm] = Na (I) [Cytoplasm] + Ca (II) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]