Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 86749146

GI number: 86749146

Start: 2299877

End: 2302414

Strand: Reverse

Name: uvrD [H]

Synonym: RPB_2023

Alternate gene names: 86749146

Gene position: 2302414-2299877 (Counterclockwise)

Preceding gene: 86749148

Following gene: 86749145

Centisome position: 43.18

GC content: 66.31

Gene sequence:

>2538_bases
ATGACTGAACCGAACAAGCGCGCCAATCCCGACCTCTCCGGCTATCAGCCCGCCGCCGGCGGCATCGCCGCGCGGGCGCG
CGCCTCCGCGGCGCCGGCCTATCTGTCGGGGCTCAATCCGGAGCAGCGCGAGGCGGTCGAGACGCTGGACGGCCCGGTGC
TGGTGCTGGCCGGCGCGGGCACCGGCAAGACCCGGGTGCTGACGACGCGGATCGCCCACATCCTCTCCACCGGCCGCGCC
CGCCCCGCCGAGATCCTGTCGGTGACCTTCACCAACAAGGCCGCGCGCGAGATGAAGCTGCGGCTGGGGCAGATGCTCGG
CCAGGCGGTCGAGGGCATGCCGTGGCTCGGCACCTTCCATTCCATCGGCGGCCGCATCCTGCGCTATCACGCCGAACTGG
TGCAGCTCACCTCGAACTTCACCGTGCTCGACACCGACGACCAGATAAGGCTGCTGAAGCAGCTCCTCGCCGCCGACAAT
ATCGACGACAAGCGCTGGCCGGCGCGGATGCTGGCCGGGCTGATCGACGGCTGGAAGAACCGCGGCCTGACGCCGTCGCA
GGTGCCCGCCGGCGAAGCCGCGAGCTTCGGCAACGGCCGCGGCGGCAAGCTCTACGCCGCCTATCAGGAGCGGCTGAAAG
TGCTGAACGCCGCCGATTTCGGCGATCTGCTGCTGGAGAACATAAGGCTGTTCCGCGAGCACCCCGACGTGCTGCGGCAA
TATCAAAGCCGCTTCAAGTTCATCCTGGTCGACGAGTATCAGGACACGAACGTCGCGCAGTATCTCTGGCTGCGGCTGCT
GTCGCAGGCGCCGTCGTCCTCCTCGTCGTCATTGCCGGGCTTGACCCGGCAATCCATCATTTCTCAAGAAGATGGATCAC
CGGGTCGCGACGCTTCGCGTCGGCCCGGTGATGACGACAGAACAAGCGGCGATGTCGCTGCGCCTTCCTCGCCCCCCAAA
AACATCTGCTGCGTCGGCGACGACGATCAGTCGATCTATGGCTGGCGCGGTGCCGAGGTCGACAACATCCTGCGCTTCGA
CCACGATTTCCCCGGCGCCAAGGTCATTCGCCTCGAACGCAATTATCGCTCGACCGGCCACATCCTCGCCGCCGCCTCGC
ATCTGATCGCCCATAACGAAGGCCGGCTCGGCAAGACGCTGCGCACCGAGGACGTCGACGGCGAGATGGTCACCGTCACC
GGCGCGTGGGACTCCGAGGAAGAAGCCCGAGGCATCGGCGAGGAGATCGAGCAGCTGCAGCGCCAGGGCCACAAGCTCAA
CGAGATCGCCATCCTGGTGCGCGCCTCGTTCCAGATGCGCGAATTCGAAGACCGCTTCGTCACCCTCGGCCTGCCCTATC
GCGTCATCGGCGGTCCGCGGTTCTACGAGCGCGCCGAAATCCGCGACGCGCTGGCGTATCTGCGCGTGATCAATTCGCCG
GCCGACGATCTCGCCTTCGAGCGCATCGTCAACGTGCCGAAGCGCGGCCTCGGCGACGCCACCGTGCAGCTCTTGCACGA
CCACGCCCGCAAGCGCCGCATTCCGCTGTTCGAAGCGTCGCGGCTGGTGGTCGAGACCGACGAGCTGAAGCCGAAGGCGC
GCAGTTCGCTGCGCGGGCTGATCGAGAATTTCGAGCGCTGGCAGGTGCAGCGCAACGCGCTGTCGCATACCGAACTCGCC
GAGATCGTGCTCGACGAGAGCGGCTACACCGAGATGTGGCAGAAGGACCGCTCCGCCGACGCCGCCGGCCGGCTGGAGAA
CCTGAAGGAACTCGTCCGCTCGATGGAGGAGTTCGAGAACCTGCAAGGATTTCTCGAACACATCTCGCTGGTGATGGACC
GCGACGGCGCCGCCGACGAGGACGCCGTCAGCGTGATGACGCTGCATTCCGCCAAGGGCCTGGAATTCGAGACGGTGTTC
CTGCCCGGCTGGGAGGAAGGCCTGTTTCCACATCAGCGCGCGCTCGACGATCAGGGCCGCGCCGGGCTGGAAGAAGAACG
CCGCCTCGCCCATGTCGGCATTACGCGGGCGAGGCGCCGGGCGAAGTTGTACTTCGCCACCAACCGCCGCATCCACGGCA
CCTGGAACACCACGATCCCGTCGCGCTTTCTCGACGAACTGCCGCAGGCCAATGTCGAGATCACCGAGTCGAAAGGCGGC
TCCGGCTGGGGCGGCATGAGCGGCTACGGCCCGTCGCGCTTCGACAATGTCGAATCGTTCGGCTCCAGCTACTCGACGCC
GGGCTGGCAGCGCGCCCAGGCGCAACGTAAAAACGGCGGCGGCCGCAGCGGCGGCGGCGGTTTCAGCGAAAGCGGCGCGT
CCTACTCATCCAGCCCCCGCCGCGCCCCGTTCACCATCGAAGGCGAACTGGTCGCCAAATCCACCGGCACCGACTCCGAC
TTCACCGTCAGCGACCGGGTGTTTCATCAAAAGTTCGGCTACGGCCAAGTGACGAAAATCGACGGCAACAAGCTCACCAT
CGCCTTCGACAAGGCCGGCGAAAAGAAGGTGGTCGATAGTTTCGTGCAGCGGGTGTAG

Upstream 100 bases:

>100_bases
TGTCGTTTCGGGCTCGCAGACCCCATATCGCCGGATAATCCTGCTATGAAGGCTCCCCATCGCAAGCCCGCGGTGCCAAC
GTGGGTCAAAGACGATTCGC

Downstream 100 bases:

>100_bases
AGGCCACGATGGTTCACTACGTCGCCTTGATCCACCAGGACGCTGACGGCAGCTACAGCGTGTCGTTTCCCGATATCCCC
GGGGTCGTCACCGCCGGCGA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 845; Mature: 844

Protein sequence:

>845_residues
MTEPNKRANPDLSGYQPAAGGIAARARASAAPAYLSGLNPEQREAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSTGRA
RPAEILSVTFTNKAAREMKLRLGQMLGQAVEGMPWLGTFHSIGGRILRYHAELVQLTSNFTVLDTDDQIRLLKQLLAADN
IDDKRWPARMLAGLIDGWKNRGLTPSQVPAGEAASFGNGRGGKLYAAYQERLKVLNAADFGDLLLENIRLFREHPDVLRQ
YQSRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSSSSLPGLTRQSIISQEDGSPGRDASRRPGDDDRTSGDVAAPSSPPK
NICCVGDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEGRLGKTLRTEDVDGEMVTVT
GAWDSEEEARGIGEEIEQLQRQGHKLNEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAYLRVINSP
ADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEASRLVVETDELKPKARSSLRGLIENFERWQVQRNALSHTELA
EIVLDESGYTEMWQKDRSADAAGRLENLKELVRSMEEFENLQGFLEHISLVMDRDGAADEDAVSVMTLHSAKGLEFETVF
LPGWEEGLFPHQRALDDQGRAGLEEERRLAHVGITRARRRAKLYFATNRRIHGTWNTTIPSRFLDELPQANVEITESKGG
SGWGGMSGYGPSRFDNVESFGSSYSTPGWQRAQAQRKNGGGRSGGGGFSESGASYSSSPRRAPFTIEGELVAKSTGTDSD
FTVSDRVFHQKFGYGQVTKIDGNKLTIAFDKAGEKKVVDSFVQRV

Sequences:

>Translated_845_residues
MTEPNKRANPDLSGYQPAAGGIAARARASAAPAYLSGLNPEQREAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSTGRA
RPAEILSVTFTNKAAREMKLRLGQMLGQAVEGMPWLGTFHSIGGRILRYHAELVQLTSNFTVLDTDDQIRLLKQLLAADN
IDDKRWPARMLAGLIDGWKNRGLTPSQVPAGEAASFGNGRGGKLYAAYQERLKVLNAADFGDLLLENIRLFREHPDVLRQ
YQSRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSSSSLPGLTRQSIISQEDGSPGRDASRRPGDDDRTSGDVAAPSSPPK
NICCVGDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEGRLGKTLRTEDVDGEMVTVT
GAWDSEEEARGIGEEIEQLQRQGHKLNEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAYLRVINSP
ADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEASRLVVETDELKPKARSSLRGLIENFERWQVQRNALSHTELA
EIVLDESGYTEMWQKDRSADAAGRLENLKELVRSMEEFENLQGFLEHISLVMDRDGAADEDAVSVMTLHSAKGLEFETVF
LPGWEEGLFPHQRALDDQGRAGLEEERRLAHVGITRARRRAKLYFATNRRIHGTWNTTIPSRFLDELPQANVEITESKGG
SGWGGMSGYGPSRFDNVESFGSSYSTPGWQRAQAQRKNGGGRSGGGGFSESGASYSSSPRRAPFTIEGELVAKSTGTDSD
FTVSDRVFHQKFGYGQVTKIDGNKLTIAFDKAGEKKVVDSFVQRV
>Mature_844_residues
TEPNKRANPDLSGYQPAAGGIAARARASAAPAYLSGLNPEQREAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSTGRAR
PAEILSVTFTNKAAREMKLRLGQMLGQAVEGMPWLGTFHSIGGRILRYHAELVQLTSNFTVLDTDDQIRLLKQLLAADNI
DDKRWPARMLAGLIDGWKNRGLTPSQVPAGEAASFGNGRGGKLYAAYQERLKVLNAADFGDLLLENIRLFREHPDVLRQY
QSRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSSSSLPGLTRQSIISQEDGSPGRDASRRPGDDDRTSGDVAAPSSPPKN
ICCVGDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLERNYRSTGHILAAASHLIAHNEGRLGKTLRTEDVDGEMVTVTG
AWDSEEEARGIGEEIEQLQRQGHKLNEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAYLRVINSPA
DDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEASRLVVETDELKPKARSSLRGLIENFERWQVQRNALSHTELAE
IVLDESGYTEMWQKDRSADAAGRLENLKELVRSMEEFENLQGFLEHISLVMDRDGAADEDAVSVMTLHSAKGLEFETVFL
PGWEEGLFPHQRALDDQGRAGLEEERRLAHVGITRARRRAKLYFATNRRIHGTWNTTIPSRFLDELPQANVEITESKGGS
GWGGMSGYGPSRFDNVESFGSSYSTPGWQRAQAQRKNGGGRSGGGGFSESGASYSSSPRRAPFTIEGELVAKSTGTDSDF
TVSDRVFHQKFGYGQVTKIDGNKLTIAFDKAGEKKVVDSFVQRV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=693, Percent_Identity=42.5685425685426, Blast_Score=510, Evalue=1e-145,
Organism=Escherichia coli, GI48994965, Length=693, Percent_Identity=37.0851370851371, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322369, Length=796, Percent_Identity=26.8844221105528, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 93577; Mature: 93446

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPNKRANPDLSGYQPAAGGIAARARASAAPAYLSGLNPEQREAVETLDGPVLVLAGAG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCEEEEEECC
TGKTRVLTTRIAHILSTGRARPAEILSVTFTNKAAREMKLRLGQMLGQAVEGMPWLGTFH
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SIGGRILRYHAELVQLTSNFTVLDTDDQIRLLKQLLAADNIDDKRWPARMLAGLIDGWKN
HHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
RGLTPSQVPAGEAASFGNGRGGKLYAAYQERLKVLNAADFGDLLLENIRLFREHPDVLRQ
CCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
YQSRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSSSSLPGLTRQSIISQEDGSPGRDASR
HHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
RPGDDDRTSGDVAAPSSPPKNICCVGDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLER
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEC
NYRSTGHILAAASHLIAHNEGRLGKTLRTEDVDGEMVTVTGAWDSEEEARGIGEEIEQLQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
RQGHKLNEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAYLRVINSP
HCCCCHHHEEEEEHHHHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCC
ADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEASRLVVETDELKPKARSSLRGL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHH
IENFERWQVQRNALSHTELAEIVLDESGYTEMWQKDRSADAAGRLENLKELVRSMEEFEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LQGFLEHISLVMDRDGAADEDAVSVMTLHSAKGLEFETVFLPGWEEGLFPHQRALDDQGR
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCCC
AGLEEERRLAHVGITRARRRAKLYFATNRRIHGTWNTTIPSRFLDELPQANVEITESKGG
CCCHHHHHHHHHHHHHHHHHEEEEEEECCEEEEEECCCCHHHHHHHCCCCCEEEEECCCC
SGWGGMSGYGPSRFDNVESFGSSYSTPGWQRAQAQRKNGGGRSGGGGFSESGASYSSSPR
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
RAPFTIEGELVAKSTGTDSDFTVSDRVFHQKFGYGQVTKIDGNKLTIAFDKAGEKKVVDS
CCCEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHH
FVQRV
HHHCC
>Mature Secondary Structure 
TEPNKRANPDLSGYQPAAGGIAARARASAAPAYLSGLNPEQREAVETLDGPVLVLAGAG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCEEEEEECC
TGKTRVLTTRIAHILSTGRARPAEILSVTFTNKAAREMKLRLGQMLGQAVEGMPWLGTFH
CCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SIGGRILRYHAELVQLTSNFTVLDTDDQIRLLKQLLAADNIDDKRWPARMLAGLIDGWKN
HHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
RGLTPSQVPAGEAASFGNGRGGKLYAAYQERLKVLNAADFGDLLLENIRLFREHPDVLRQ
CCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
YQSRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSSSSLPGLTRQSIISQEDGSPGRDASR
HHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
RPGDDDRTSGDVAAPSSPPKNICCVGDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLER
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEC
NYRSTGHILAAASHLIAHNEGRLGKTLRTEDVDGEMVTVTGAWDSEEEARGIGEEIEQLQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
RQGHKLNEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAYLRVINSP
HCCCCHHHEEEEEHHHHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCC
ADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEASRLVVETDELKPKARSSLRGL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHH
IENFERWQVQRNALSHTELAEIVLDESGYTEMWQKDRSADAAGRLENLKELVRSMEEFEN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LQGFLEHISLVMDRDGAADEDAVSVMTLHSAKGLEFETVFLPGWEEGLFPHQRALDDQGR
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCCC
AGLEEERRLAHVGITRARRRAKLYFATNRRIHGTWNTTIPSRFLDELPQANVEITESKGG
CCCHHHHHHHHHHHHHHHHHEEEEEEECCEEEEEECCCCHHHHHHHCCCCCEEEEECCCC
SGWGGMSGYGPSRFDNVESFGSSYSTPGWQRAQAQRKNGGGRSGGGGFSESGASYSSSPR
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
RAPFTIEGELVAKSTGTDSDFTVSDRVFHQKFGYGQVTKIDGNKLTIAFDKAGEKKVVDS
CCCEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHH
FVQRV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA