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The map label for this gene is fadA [H]

Identifier: 86748805

GI number: 86748805

Start: 1915002

End: 1916177

Strand: Reverse

Name: fadA [H]

Synonym: RPB_1682

Alternate gene names: 86748805

Gene position: 1916177-1915002 (Counterclockwise)

Preceding gene: 86748814

Following gene: 86748804

Centisome position: 35.94

GC content: 66.67

Gene sequence:

>1176_bases
ATGGCCGAGGCCTATATCGTCGCCGCCGCACGCACCGCCGGTGGCCGCAAGGGAGGCCGTCTCGCCGGCTGGCATCCGGC
CGATCTGGCCGCGTCCGTGCTGAACGCGCTGGTCGATCGCTCCGGCGCTGCGCCGGACCAGATCGAGGACGTGATCATGG
GCTGCGTCGGCCAGGGCGGCGAGCAGGCCGTCAATATCGGCCGCAACGCGGTGCTGGCCTCGAAACTGCCGGAAAGCGTG
CCCGGCACCTCGATCGACCGGCAGTGCGGCTCGTCGCAGCAGGCGCTGCATTTTGCCGCACAGGCGGTGATGGCCGGCTC
GATGGACATCGTGATCGCGGCTGGCGTCGAGAGCATGACGCGGGTGCCGATGGGCTCGCCGAGCATCCTCGCCGCCAAGG
CCGGGATGGGCACCTACAAGAGCCCGCAGATGGAACAGCGCTACCCGAACATCCAGTTCAACCAGTTTACCGGCGCCGAA
ATGGTTGCCCACAAATACGATCTGTCGAAGGACCAGCTCGACGAATACGCCTACCAGAGCCACCAGCGGGCGATCGCCGC
GACCCAGGCCGGCAAGTTCAAGGACGAGATCATCCCGCTGCCGATCACCCGCGCCGACGGCTCGACCGATACGCACGCGA
TCGACGAGGGCATCCGCTTCGACGTCACGCTCGACGGCATCAAGGGCGTCAAGCTGATCAACGAAAAAGGAGGCCGGCTG
ACCGCCGCGACCGCGAGCCAGATCTGCGACGGCGCCTCCGGCGTGATGGTGGTGAACGAAAAAGGCTTGCGGCAACTCGG
TGTCAAACCGATGGCACGCATTCACCACATGACGATGATCGGCGGCGACCCGGTGATCATGCTGGAAGCGCCGCTGCCGG
CGACCGAGCGGGCGCTGAAGAAGGCCGGCATGACCATCGACGACATCGACCTGTTCGAGGTCAACGAAGCCTTCGCCTCG
ATCCCGACCGCGTGGCTGAAGGCGACCGGCGCCGATCCGGAACGGCTCAACGTCAACGGCGGCGCGATCGCGCTCGGGCA
TCCGTTGGGAGGCTCCGGCACCAAGCTGATGACCACGCTGGTGCACGCCTTGCAGCAGTCCGGCAAGCGCTACGGCCTGC
AGACGATGTGCGAAGGCGGCGGCATGGCCAACGTCACCATCGTCGAGCGGCTGTAA

Upstream 100 bases:

>100_bases
GGGCTCAAGCGTTAATTGATTGATTGACTAAATCGCTCCCCACCCCTTAAATCCGCGCCCATCAGCCCCGCCAAACAAAC
ACGAAACAGGGAGAAAACGC

Downstream 100 bases:

>100_bases
GCGACAAGCGTCGGCCCTCATCCTGAGGAGCGGTGCTTTCGCCGCGTCTCGAAGGATGAGTTGATCATCCTCATGGTTCG
AGACGCGCGCCAACAGGCGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MAEAYIVAAARTAGGRKGGRLAGWHPADLAASVLNALVDRSGAAPDQIEDVIMGCVGQGGEQAVNIGRNAVLASKLPESV
PGTSIDRQCGSSQQALHFAAQAVMAGSMDIVIAAGVESMTRVPMGSPSILAAKAGMGTYKSPQMEQRYPNIQFNQFTGAE
MVAHKYDLSKDQLDEYAYQSHQRAIAATQAGKFKDEIIPLPITRADGSTDTHAIDEGIRFDVTLDGIKGVKLINEKGGRL
TAATASQICDGASGVMVVNEKGLRQLGVKPMARIHHMTMIGGDPVIMLEAPLPATERALKKAGMTIDDIDLFEVNEAFAS
IPTAWLKATGADPERLNVNGGAIALGHPLGGSGTKLMTTLVHALQQSGKRYGLQTMCEGGGMANVTIVERL

Sequences:

>Translated_391_residues
MAEAYIVAAARTAGGRKGGRLAGWHPADLAASVLNALVDRSGAAPDQIEDVIMGCVGQGGEQAVNIGRNAVLASKLPESV
PGTSIDRQCGSSQQALHFAAQAVMAGSMDIVIAAGVESMTRVPMGSPSILAAKAGMGTYKSPQMEQRYPNIQFNQFTGAE
MVAHKYDLSKDQLDEYAYQSHQRAIAATQAGKFKDEIIPLPITRADGSTDTHAIDEGIRFDVTLDGIKGVKLINEKGGRL
TAATASQICDGASGVMVVNEKGLRQLGVKPMARIHHMTMIGGDPVIMLEAPLPATERALKKAGMTIDDIDLFEVNEAFAS
IPTAWLKATGADPERLNVNGGAIALGHPLGGSGTKLMTTLVHALQQSGKRYGLQTMCEGGGMANVTIVERL
>Mature_390_residues
AEAYIVAAARTAGGRKGGRLAGWHPADLAASVLNALVDRSGAAPDQIEDVIMGCVGQGGEQAVNIGRNAVLASKLPESVP
GTSIDRQCGSSQQALHFAAQAVMAGSMDIVIAAGVESMTRVPMGSPSILAAKAGMGTYKSPQMEQRYPNIQFNQFTGAEM
VAHKYDLSKDQLDEYAYQSHQRAIAATQAGKFKDEIIPLPITRADGSTDTHAIDEGIRFDVTLDGIKGVKLINEKGGRLT
AATASQICDGASGVMVVNEKGLRQLGVKPMARIHHMTMIGGDPVIMLEAPLPATERALKKAGMTIDDIDLFEVNEAFASI
PTAWLKATGADPERLNVNGGAIALGHPLGGSGTKLMTTLVHALQQSGKRYGLQTMCEGGGMANVTIVERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=35.3092783505155, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=34.3511450381679, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=34.6835443037975, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=33.3333333333333, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=29.5508274231678, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=28.4615384615385, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=39.2947103274559, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=39.2059553349876, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=38.0710659898477, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788554, Length=402, Percent_Identity=37.8109452736318, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=29.5843520782396, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=35.4591836734694, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=30.9823677581864, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=29.6758104738155, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=28.5035629453682, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=26.980198019802, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=32.8320802005013, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322031, Length=387, Percent_Identity=33.5917312661499, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=36.1323155216285, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=34.5268542199489, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=31.8181818181818, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=28.0660377358491, Blast_Score=151, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41032; Mature: 40900

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIVAAARTAGGRKGGRLAGWHPADLAASVLNALVDRSGAAPDQIEDVIMGCVGQGG
CCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
EQAVNIGRNAVLASKLPESVPGTSIDRQCGSSQQALHFAAQAVMAGSMDIVIAAGVESMT
HHHHHCCCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHH
RVPMGSPSILAAKAGMGTYKSPQMEQRYPNIQFNQFTGAEMVAHKYDLSKDQLDEYAYQS
HCCCCCCCEEEEECCCCCCCCCCHHHHCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHHH
HQRAIAATQAGKFKDEIIPLPITRADGSTDTHAIDEGIRFDVTLDGIKGVKLINEKGGRL
HHHHHHHHHCCCCCCCEECCEEECCCCCCCCHHHCCCCEEEEEECCCCCEEEEECCCCEE
TAATASQICDGASGVMVVNEKGLRQLGVKPMARIHHMTMIGGDPVIMLEAPLPATERALK
EEHHHHHHCCCCCCEEEECCCCHHHHCCCHHHHHHEEEEECCCEEEEEECCCCHHHHHHH
KAGMTIDDIDLFEVNEAFASIPTAWLKATGADPERLNVNGGAIALGHPLGGSGTKLMTTL
HCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEECCCCEEEECCCCCCCCHHHHHHH
VHALQQSGKRYGLQTMCEGGGMANVTIVERL
HHHHHHCCHHCCCHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
AEAYIVAAARTAGGRKGGRLAGWHPADLAASVLNALVDRSGAAPDQIEDVIMGCVGQGG
CCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
EQAVNIGRNAVLASKLPESVPGTSIDRQCGSSQQALHFAAQAVMAGSMDIVIAAGVESMT
HHHHHCCCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHH
RVPMGSPSILAAKAGMGTYKSPQMEQRYPNIQFNQFTGAEMVAHKYDLSKDQLDEYAYQS
HCCCCCCCEEEEECCCCCCCCCCHHHHCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHHH
HQRAIAATQAGKFKDEIIPLPITRADGSTDTHAIDEGIRFDVTLDGIKGVKLINEKGGRL
HHHHHHHHHCCCCCCCEECCEEECCCCCCCCHHHCCCCEEEEEECCCCCEEEEECCCCEE
TAATASQICDGASGVMVVNEKGLRQLGVKPMARIHHMTMIGGDPVIMLEAPLPATERALK
EEHHHHHHCCCCCCEEEECCCCHHHHCCCHHHHHHEEEEECCCEEEEEECCCCHHHHHHH
KAGMTIDDIDLFEVNEAFASIPTAWLKATGADPERLNVNGGAIALGHPLGGSGTKLMTTL
HCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEECCCCEEEECCCCCCCCHHHHHHH
VHALQQSGKRYGLQTMCEGGGMANVTIVERL
HHHHHHCCHHCCCHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA