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The map label for this gene is cobC [H]

Identifier: 86748280

GI number: 86748280

Start: 1327005

End: 1328039

Strand: Reverse

Name: cobC [H]

Synonym: RPB_1155

Alternate gene names: 86748280

Gene position: 1328039-1327005 (Counterclockwise)

Preceding gene: 86748281

Following gene: 86748271

Centisome position: 24.91

GC content: 72.46

Gene sequence:

>1035_bases
TTGACGGCAGACGCGGCGACGGCGCTGCGGATTCACGGCGGCCGGATCGACATCGCGGCGACATGCTATCCCGACGCGCC
GCGGCCCTGGATCGATCTGTCGACCGGGATCAATCCGATCGCTTATCCGGTGCCGCCGCTGGCGCCGTCATGGTTCGCGC
GGCTGCCGCTGACGAGCGAGCTCGACGATCTGTGCGCCGCTGCCGCACAGGCCTACGGCCTACCGGACGGCGCCGCGATG
CTGCCGGTGCCGGGCAGCGAGATCGCGATCCGGCTGGCACCGCTTGCGCGGACTGCGTCCGGTTCGATCGCGCAAGTCGG
CATCCTCGGGCCGACCTACGGCTCGCACGCGGCGGCGTGGTGCGCGGCGGGCGCCGAGGTGCATGAGATCGACACCCTGC
CCGATCCGCAGGCGGCGTTCGACGTCGTGGTCGTGGTGAACCCGAACAATCCGGACGGCCGGCTGATCGCGCGCGAGCCT
CTGACCGAATTCGCACAGCACTGGAGCGCGGCCGGGCGCCGCCTCGTGGTCGACGAAGCCTTCGGCGATCTCAGGCCGGA
GGCGTCGCTGCTGCGCGGCGCGGCGTTGCCGCGTGGCGTGGTGGTGCTGCGCTCGCTTGGAAAATTCTTCGGCCTCGCCG
GGCTGCGGCTGGGCTTCGTCGCGGTGAATGCCGACGAGGCGCAGCGCTGGCGCGATCTGCTCGGCGACTGGGCGGCGTCC
GGACCGGCCTGCACGATCGCGACGGCCGCGCTGCGCGACACCGCGTGGATCGACGCGACGCGGGGGCGGCTGCGTGAGGA
TCGCCGCCGGCTCGACGCGACGCTGGCCGCTGCCGAACTCACGCCGTGCGGCGGCACCGATCTGTACGGGCTGTATGAGA
ACGCAGACGATCGCGATCTGGTCGATCGCTTCGCGCGCGCGGGCATTCTGATCCGCGCCTTCGCGCACAGCCCGCGCCGA
TATCGCTTCGGACTGCCGGCGGACGAGCCCGCCTGGCAGCGGCTGGCGCAGAGCTGCGCGCAGCGGGCGGGCTGA

Upstream 100 bases:

>100_bases
TCGACGAGCACAGCCTGCCGCAGATCATCATCGCGGTGCTCGGCGTGATCATTGTGCTGGCGCTGATCCTGGTGGTCGGC
GGCTATTGGCTGGTGACGCC

Downstream 100 bases:

>100_bases
TCGCAGCCAGCCCGGAGCGCGGTTGCGGCCGGGGGCTCAGGCCGCCCGGCGCATCGAGGGTTTGCGGACCGGCGGGGCCG
GGGCGCGGGCCACGGCGTCG

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTADAATALRIHGGRIDIAATCYPDAPRPWIDLSTGINPIAYPVPPLAPSWFARLPLTSELDDLCAAAAQAYGLPDGAAM
LPVPGSEIAIRLAPLARTASGSIAQVGILGPTYGSHAAAWCAAGAEVHEIDTLPDPQAAFDVVVVVNPNNPDGRLIAREP
LTEFAQHWSAAGRRLVVDEAFGDLRPEASLLRGAALPRGVVVLRSLGKFFGLAGLRLGFVAVNADEAQRWRDLLGDWAAS
GPACTIATAALRDTAWIDATRGRLREDRRRLDATLAAAELTPCGGTDLYGLYENADDRDLVDRFARAGILIRAFAHSPRR
YRFGLPADEPAWQRLAQSCAQRAG

Sequences:

>Translated_344_residues
MTADAATALRIHGGRIDIAATCYPDAPRPWIDLSTGINPIAYPVPPLAPSWFARLPLTSELDDLCAAAAQAYGLPDGAAM
LPVPGSEIAIRLAPLARTASGSIAQVGILGPTYGSHAAAWCAAGAEVHEIDTLPDPQAAFDVVVVVNPNNPDGRLIAREP
LTEFAQHWSAAGRRLVVDEAFGDLRPEASLLRGAALPRGVVVLRSLGKFFGLAGLRLGFVAVNADEAQRWRDLLGDWAAS
GPACTIATAALRDTAWIDATRGRLREDRRRLDATLAAAELTPCGGTDLYGLYENADDRDLVDRFARAGILIRAFAHSPRR
YRFGLPADEPAWQRLAQSCAQRAG
>Mature_343_residues
TADAATALRIHGGRIDIAATCYPDAPRPWIDLSTGINPIAYPVPPLAPSWFARLPLTSELDDLCAAAAQAYGLPDGAAML
PVPGSEIAIRLAPLARTASGSIAQVGILGPTYGSHAAAWCAAGAEVHEIDTLPDPQAAFDVVVVVNPNNPDGRLIAREPL
TEFAQHWSAAGRRLVVDEAFGDLRPEASLLRGAALPRGVVVLRSLGKFFGLAGLRLGFVAVNADEAQRWRDLLGDWAASG
PACTIATAALRDTAWIDATRGRLREDRRRLDATLAAAELTPCGGTDLYGLYENADDRDLVDRFARAGILIRAFAHSPRRY
RFGLPADEPAWQRLAQSCAQRAG

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=184, Percent_Identity=30.9782608695652, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36626; Mature: 36495

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADAATALRIHGGRIDIAATCYPDAPRPWIDLSTGINPIAYPVPPLAPSWFARLPLTSE
CCCCCCEEEEEECCEEEEEEEECCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCHH
LDDLCAAAAQAYGLPDGAAMLPVPGSEIAIRLAPLARTASGSIAQVGILGPTYGSHAAAW
HHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHH
CAAGAEVHEIDTLPDPQAAFDVVVVVNPNNPDGRLIAREPLTEFAQHWSAAGRRLVVDEA
HHCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEEHH
FGDLRPEASLLRGAALPRGVVVLRSLGKFFGLAGLRLGFVAVNADEAQRWRDLLGDWAAS
HCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHCCC
GPACTIATAALRDTAWIDATRGRLREDRRRLDATLAAAELTPCGGTDLYGLYENADDRDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHH
VDRFARAGILIRAFAHSPRRYRFGLPADEPAWQRLAQSCAQRAG
HHHHHHCCCEEEEHHCCCCEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TADAATALRIHGGRIDIAATCYPDAPRPWIDLSTGINPIAYPVPPLAPSWFARLPLTSE
CCCCCEEEEEECCEEEEEEEECCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCHH
LDDLCAAAAQAYGLPDGAAMLPVPGSEIAIRLAPLARTASGSIAQVGILGPTYGSHAAAW
HHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHH
CAAGAEVHEIDTLPDPQAAFDVVVVVNPNNPDGRLIAREPLTEFAQHWSAAGRRLVVDEA
HHCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEEHH
FGDLRPEASLLRGAALPRGVVVLRSLGKFFGLAGLRLGFVAVNADEAQRWRDLLGDWAAS
HCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHCCC
GPACTIATAALRDTAWIDATRGRLREDRRRLDATLAAAELTPCGGTDLYGLYENADDRDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHH
VDRFARAGILIRAFAHSPRRYRFGLPADEPAWQRLAQSCAQRAG
HHHHHHCCCEEEEHHCCCCEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]