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The map label for this gene is phbA [H]

Identifier: 86747635

GI number: 86747635

Start: 570434

End: 571612

Strand: Reverse

Name: phbA [H]

Synonym: RPB_0509

Alternate gene names: 86747635

Gene position: 571612-570434 (Counterclockwise)

Preceding gene: 86747637

Following gene: 86747634

Centisome position: 10.72

GC content: 66.58

Gene sequence:

>1179_bases
ATGTCGGACGATGTCGTCATCGTCAGCGCTGCACGCACCGCTGTCGGAAGCTTCAACGGCGCCTTCGCCAATACGCCCGC
GCACGAATTGGGCGCCGTCGCCATCAAGGCGGCCCTCGAACGCGCGGGCATCGAGCCGGCGCGCGTCTCCGAAGTGATCA
TGGGGCAGATCCTCACCGCCGCACAGGGCCAGAATCCCGCCCGCCAGGCGTCGATCGCCGCCGGCATTCCGGTCGAGAGC
CCGGCCTGGGGCGTCAATCAATTGTGCGGAAGCGGCCTGCGCACCGTCGCGCTCGGCTATCAGGCACTGCTCAACGGCGA
TTCCGACATCGTCGTCGCCGGCGGCCAGGAATCGATGAGCATGGCGCCGCATGCCCAGTATCTGCGCGGTGGCGTGAAGA
TGGGCGCGGTCGAATTCGTCGACACCATGATCAAGGACGGTCTGTGGGACGCCTTCAACGGCTACCACATGGGCAACACC
GCCGAGAACGTCGCCAAGCAGTATCAGATCACCCGTCAGCAGCAGGACGAGTTCGCCGTCGCTTCGCAGCAGAAGGCCGA
AGCCGCGCAGAAGTCCGGTCGGTTCAAGGACGAGATCGTGCCGTTCACGATCAAGACCCGCAAGGGCGACATCGTCGTCG
ACAGCGACGAATATCCGCGCCACGGTGCCACCATCGAGGCGATGACCAAGCTGAAGCCGGCGTTCGAGAAGGACGGCACC
GTGACCGCGGCGAACGCCTCGGGCATCAATGACGGCGCCGCCGCCGTGGTGCTGATGACGGCCAAGCAGGCCGCCAAGGA
AGGCAAGACGCCGCTGGCCCGCATCGTGTCGTGGGCGCATGCCGGCGTCGATCCGAAGATCATGGGCACCGGCCCGATTC
CGGCGTCGCGCGCGGCGCTGAAGAAGGCCGGCTGGGCGATCGGCGATCTCGACCTGATCGAAGCCAACGAAGCCTTCGCG
GCGCAGGCCTGTGCGGTGAACAAGGATCTCGGCTGGGACGTTTCCAAAGTGAACGTCAATGGCGGCGCGATCGCGATCGG
CCATCCGGTCGGCGCGTCGGGCGCGCGCGTGCTGGTGACGCTGCTGCACGAGATGCAGAAGCGCGACGCCAAGAAGGGAC
TGGCGACGCTGTGCATCGGCGGCGGCATGGGCATCGCGATGTGCCTTGCGCGCGATTGA

Upstream 100 bases:

>100_bases
GGGACGGCATTCTCAGGATGGGGGCGACGCTGGCCGTCCCAACCGGCACCCGCCGTCCAAACAAACGCGTTTCAAACAAC
CCAAGCCCCAGGAGATGTCC

Downstream 100 bases:

>100_bases
CGCAACAATCAGCAACGCGACTCGGCACGATCTTTGCGGAGTTGCGCTGCACCACCGAATGTTCAAACGCCCGGCAGATT
GCCGGGCGTTTTTGCTTGAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSDDVVIVSAARTAVGSFNGAFANTPAHELGAVAIKAALERAGIEPARVSEVIMGQILTAAQGQNPARQASIAAGIPVES
PAWGVNQLCGSGLRTVALGYQALLNGDSDIVVAGGQESMSMAPHAQYLRGGVKMGAVEFVDTMIKDGLWDAFNGYHMGNT
AENVAKQYQITRQQQDEFAVASQQKAEAAQKSGRFKDEIVPFTIKTRKGDIVVDSDEYPRHGATIEAMTKLKPAFEKDGT
VTAANASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWAHAGVDPKIMGTGPIPASRAALKKAGWAIGDLDLIEANEAFA
AQACAVNKDLGWDVSKVNVNGGAIAIGHPVGASGARVLVTLLHEMQKRDAKKGLATLCIGGGMGIAMCLARD

Sequences:

>Translated_392_residues
MSDDVVIVSAARTAVGSFNGAFANTPAHELGAVAIKAALERAGIEPARVSEVIMGQILTAAQGQNPARQASIAAGIPVES
PAWGVNQLCGSGLRTVALGYQALLNGDSDIVVAGGQESMSMAPHAQYLRGGVKMGAVEFVDTMIKDGLWDAFNGYHMGNT
AENVAKQYQITRQQQDEFAVASQQKAEAAQKSGRFKDEIVPFTIKTRKGDIVVDSDEYPRHGATIEAMTKLKPAFEKDGT
VTAANASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWAHAGVDPKIMGTGPIPASRAALKKAGWAIGDLDLIEANEAFA
AQACAVNKDLGWDVSKVNVNGGAIAIGHPVGASGARVLVTLLHEMQKRDAKKGLATLCIGGGMGIAMCLARD
>Mature_391_residues
SDDVVIVSAARTAVGSFNGAFANTPAHELGAVAIKAALERAGIEPARVSEVIMGQILTAAQGQNPARQASIAAGIPVESP
AWGVNQLCGSGLRTVALGYQALLNGDSDIVVAGGQESMSMAPHAQYLRGGVKMGAVEFVDTMIKDGLWDAFNGYHMGNTA
ENVAKQYQITRQQQDEFAVASQQKAEAAQKSGRFKDEIVPFTIKTRKGDIVVDSDEYPRHGATIEAMTKLKPAFEKDGTV
TAANASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWAHAGVDPKIMGTGPIPASRAALKKAGWAIGDLDLIEANEAFAA
QACAVNKDLGWDVSKVNVNGGAIAIGHPVGASGARVLVTLLHEMQKRDAKKGLATLCIGGGMGIAMCLARD

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=59.7964376590331, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=43.9897698209719, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=43.9897698209719, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=41.025641025641, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4504327, Length=420, Percent_Identity=30.2380952380952, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI194353979, Length=386, Percent_Identity=30.3108808290155, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=54.8717948717949, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=58.0152671755725, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1787663, Length=398, Percent_Identity=41.9597989949749, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=40.8060453400504, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=33.9024390243902, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=46.2724935732648, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=40.6735751295337, Blast_Score=293, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=41.1616161616162, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=29.7872340425532, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=30.690537084399, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=391, Percent_Identity=46.0358056265985, Blast_Score=297, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=38.5390428211587, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=58.5051546391753, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24640423, Length=383, Percent_Identity=48.3028720626632, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=43.298969072165, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=31.4553990610329, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40685; Mature: 40554

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDVVIVSAARTAVGSFNGAFANTPAHELGAVAIKAALERAGIEPARVSEVIMGQILTA
CCCCEEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AQGQNPARQASIAAGIPVESPAWGVNQLCGSGLRTVALGYQALLNGDSDIVVAGGQESMS
HCCCCHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
MAPHAQYLRGGVKMGAVEFVDTMIKDGLWDAFNGYHMGNTAENVAKQYQITRQQQDEFAV
CCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASQQKAEAAQKSGRFKDEIVPFTIKTRKGDIVVDSDEYPRHGATIEAMTKLKPAFEKDGT
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCC
VTAANASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWAHAGVDPKIMGTGPIPASRAAL
EEEECCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
KKAGWAIGDLDLIEANEAFAAQACAVNKDLGWDVSKVNVNGGAIAIGHPVGASGARVLVT
HHCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHH
LLHEMQKRDAKKGLATLCIGGGMGIAMCLARD
HHHHHHHHHHHCCCEEEEECCCCCEEEEEECC
>Mature Secondary Structure 
SDDVVIVSAARTAVGSFNGAFANTPAHELGAVAIKAALERAGIEPARVSEVIMGQILTA
CCCEEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AQGQNPARQASIAAGIPVESPAWGVNQLCGSGLRTVALGYQALLNGDSDIVVAGGQESMS
HCCCCHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCC
MAPHAQYLRGGVKMGAVEFVDTMIKDGLWDAFNGYHMGNTAENVAKQYQITRQQQDEFAV
CCCHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASQQKAEAAQKSGRFKDEIVPFTIKTRKGDIVVDSDEYPRHGATIEAMTKLKPAFEKDGT
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCC
VTAANASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWAHAGVDPKIMGTGPIPASRAAL
EEEECCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
KKAGWAIGDLDLIEANEAFAAQACAVNKDLGWDVSKVNVNGGAIAIGHPVGASGARVLVT
HHCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHH
LLHEMQKRDAKKGLATLCIGGGMGIAMCLARD
HHHHHHHHHHHCCCEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2878929; 2670935; 1673680; 10764581; 10545327; 12501183 [H]