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The map label for this gene is trxC [H]

Identifier: 86747574

GI number: 86747574

Start: 494698

End: 495135

Strand: Direct

Name: trxC [H]

Synonym: RPB_0448

Alternate gene names: 86747574

Gene position: 494698-495135 (Clockwise)

Preceding gene: 86747571

Following gene: 86747576

Centisome position: 9.28

GC content: 69.18

Gene sequence:

>438_bases
ATGTCCGATCGTCTGGTGGTGTGCACGCAATGCGGCGGGGTCAACCGGCTGCCGGAACAGCGCTCCGCGCTCGAGGCCAA
ATGCGGCAAATGCGGCGCGAAGATATTCGACGGGCATCCCGCCGATGTCGGCGCCGAGATCTTCGACAAGCAGATCGCGC
GCAGCTCGGTGCCGGTGCTGGTCGATGTCTGGGCGCCGTGGTGCGGCCCGTGCCGGGCGATGGCGCCGGCCTACGAGATC
GCGGCGCGCGAACTCGAGCCGCGGGTGCGGCTGATCAAGCTGAATTCCGACAACGAGCAGCAGATCGCGGCGAAGCTCGG
CATCAGCGGCATTCCGACCATGATCCTGTTCGCGGACGGCCGCGAACGCGCCCGCACCTCCGGCGCGATGCCGGCCAGCG
CGATCGTGCGCTGGGTGCGCGAGCATCTGCCGGGCTGA

Upstream 100 bases:

>100_bases
GTCGCCGCGACAGCGCCGGCCGATTTCGCGCCGGCGCACGTCTTGGCGCTGTGGCATGCGCGCCCTAGATAACAGCTCGG
CAATGACCGGGGTCCGTCAC

Downstream 100 bases:

>100_bases
GCCGCGGCGCTACGCCGGCTTCGGCAGCGGCAGCGGGCCGTCGAGCTTGTCGCTGCGCATCGCGAACGAGGTGCGGATGT
CGCGCACCGTCGGCAGCGCC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MSDRLVVCTQCGGVNRLPEQRSALEAKCGKCGAKIFDGHPADVGAEIFDKQIARSSVPVLVDVWAPWCGPCRAMAPAYEI
AARELEPRVRLIKLNSDNEQQIAAKLGISGIPTMILFADGRERARTSGAMPASAIVRWVREHLPG

Sequences:

>Translated_145_residues
MSDRLVVCTQCGGVNRLPEQRSALEAKCGKCGAKIFDGHPADVGAEIFDKQIARSSVPVLVDVWAPWCGPCRAMAPAYEI
AARELEPRVRLIKLNSDNEQQIAAKLGISGIPTMILFADGRERARTSGAMPASAIVRWVREHLPG
>Mature_144_residues
SDRLVVCTQCGGVNRLPEQRSALEAKCGKCGAKIFDGHPADVGAEIFDKQIARSSVPVLVDVWAPWCGPCRAMAPAYEIA
ARELEPRVRLIKLNSDNEQQIAAKLGISGIPTMILFADGRERARTSGAMPASAIVRWVREHLPG

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=38.0952380952381, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI4758304, Length=79, Percent_Identity=39.2405063291139, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1788936, Length=138, Percent_Identity=39.8550724637681, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI87082331, Length=96, Percent_Identity=36.4583333333333, Blast_Score=77, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=112, Percent_Identity=33.9285714285714, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25144092, Length=100, Percent_Identity=37, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=77, Percent_Identity=40.2597402597403, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17507915, Length=96, Percent_Identity=36.4583333333333, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=39.5348837209302, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=36.046511627907, Blast_Score=64, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19921434, Length=98, Percent_Identity=37.7551020408163, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=29.8969072164948, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17647799, Length=93, Percent_Identity=36.5591397849462, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15709; Mature: 15578

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRLVVCTQCGGVNRLPEQRSALEAKCGKCGAKIFDGHPADVGAEIFDKQIARSSVPVL
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
VDVWAPWCGPCRAMAPAYEIAARELEPRVRLIKLNSDNEQQIAAKLGISGIPTMILFADG
EEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEECC
RERARTSGAMPASAIVRWVREHLPG
HHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDRLVVCTQCGGVNRLPEQRSALEAKCGKCGAKIFDGHPADVGAEIFDKQIARSSVPVL
CCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
VDVWAPWCGPCRAMAPAYEIAARELEPRVRLIKLNSDNEQQIAAKLGISGIPTMILFADG
EEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEECC
RERARTSGAMPASAIVRWVREHLPG
HHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]