| Definition | Synechococcus sp. JA-2-3B'a(2-13), complete genome. |
|---|---|
| Accession | NC_007776 |
| Length | 3,046,682 |
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The map label for this gene is coaBC [H]
Identifier: 86608462
GI number: 86608462
Start: 1018038
End: 1019276
Strand: Direct
Name: coaBC [H]
Synonym: CYB_0983
Alternate gene names: 86608462
Gene position: 1018038-1019276 (Clockwise)
Preceding gene: 86608458
Following gene: 86608468
Centisome position: 33.41
GC content: 61.82
Gene sequence:
>1239_bases ATGGATCCCTTTTGGTCGGGGCGGCGTCTCCTCATTGGGGTGAGCGGGGGGATTGCTGCTTACAAAACGGCAGCTTTGGT GTCTGCTCTGGTGCAGCAGGGAGCAGAGCTCAAGGTGGTTTTGACAAAAGCTGCGGAACATTTTATTTCTCCTTTGACTT TTGCCACCTTGTCCCGCCAGCCGGCTTTTACGGATGCCGCCTTTTGGCAGGCAACACGAGGACGACCGCTGCACATCGAG TTGGGGGAATGGGCGGAGGCTCTCCTCATTGCACCCTTGTCGGCCAACACCTTGGGCAAGTTGGCTCATGGGCTGGCGGA TAATTTGCTCACCAATGTGGTTTTGGCTTCCCGGTGTCCGGTGGCGGTGGCACCGGCTATGAATACGCAGATGTGGAAGG CGGAGAAGGTGGCCGAGAATTGGCAGCGGCTACACCAGGATCCCCGTTTTTGGGCCTTGCCGACGGCCAGTGGCCGCCTG GCCTGTGATGCGGTGGGGGAAGGGCGCATGTTGGAGCCGGAGGCGCTGCAGGAGTATGTGCGGGCTTTGCTCTGGACAGG GGGGAAAAAAGATTGGCAGGGCAAGCGGGTGTTGGTGACGGCGGGGGGGACACGGGAGCCCATCGACGCGGTGCGTTTTA TCGGCAACCCGGCCAGTGGTCGGATGGGCGTGGCATTGGCGGTGGCGGCGGCCTGCCGAGGAGCGACGGTGACGCTGGTT CATGGGCCGTTGGGGATCCCTTTTGAGCCGGAACCCTTTGGCATTCGGGCCATTCGAGTGGAAACGGCAGCCCAACTGGA GGCGGCTTTGCAGGCGGAATTTCCCCAGGCGGATCTCTTGTGGATGGCTGCTGCTGTGGGGGATGTGCGCCCCTCTCAGG TTTACGCGGGGAAGCTGCCCAAAGCCGATCTACCCCAGATGTTGCCGTTGGAGCCGATCCCTGACCTGCTGGCAGCTCTG GCCCGCCACAAACGCCCTGGCCAACGCCTCATCGGCTTTGCCGCCCAAAGTGGGGATCCCTTGCCGCCGGCCAGAGAGAA GCTCCGCCAGAAGGGCCTGGATGCTATTGTGGCCAACCCCATCGACCAACCGGATAGCGGCTTTGGCAGCAGCCACAACC AAGGCTATTGGATCCCCCAGCAGGGAAGTCCAGAGCGGATCCCATTGGCAACCAAGCCAACCCTGGCCCACCGGCTGCTG GATCTGGCCCGGCAATTGGAGTTGGGCTACTTTAGTTAA
Upstream 100 bases:
>100_bases TCCAAGTCAAAGTATCTTTGGGCGAGGGATCCCCGCTTTGCCGCCGGAATTGAGCAAAAGCAGGGAAACTGGAAACAAGG CTGTTTGCGTGTCACTCGAT
Downstream 100 bases:
>100_bases ACTCCCTCTCCCTCTGGAAGAGGGGCCGGGGGTGGGGGCTGTGCGGTACAGAACGCTAAACTTCCCGGAATAGCTGTTCG CGAACTGCCTCAAGAACCTG
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 412; Mature: 412
Protein sequence:
>412_residues MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQPAFTDAAFWQATRGRPLHIE LGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCPVAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRL ACDAVGEGRMLEPEALQEYVRALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLPKADLPQMLPLEPIPDLLAAL ARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANPIDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLL DLARQLELGYFS
Sequences:
>Translated_412_residues MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQPAFTDAAFWQATRGRPLHIE LGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCPVAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRL ACDAVGEGRMLEPEALQEYVRALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLPKADLPQMLPLEPIPDLLAAL ARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANPIDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLL DLARQLELGYFS >Mature_412_residues MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQPAFTDAAFWQATRGRPLHIE LGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCPVAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRL ACDAVGEGRMLEPEALQEYVRALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLPKADLPQMLPLEPIPDLLAAL ARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANPIDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLL DLARQLELGYFS
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=184, Percent_Identity=39.1304347826087, Blast_Score=105, Evalue=5e-23, Organism=Escherichia coli, GI87082301, Length=399, Percent_Identity=38.5964912280702, Blast_Score=230, Evalue=1e-61, Organism=Caenorhabditis elegans, GI17560194, Length=202, Percent_Identity=33.6633663366337, Blast_Score=90, Evalue=2e-18, Organism=Saccharomyces cerevisiae, GI6322762, Length=187, Percent_Identity=35.2941176470588, Blast_Score=94, Evalue=5e-20, Organism=Saccharomyces cerevisiae, GI6322925, Length=90, Percent_Identity=40, Blast_Score=65, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6324629, Length=89, Percent_Identity=39.3258426966292, Blast_Score=63, Evalue=9e-11, Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=35.7142857142857, Blast_Score=91, Evalue=1e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 44326; Mature: 44326
Theoretical pI: Translated: 9.41; Mature: 9.41
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQ CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHCCC PAFTDAAFWQATRGRPLHIELGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCP CCCCHHHHHHHCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC VAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRLACDAVGEGRMLEPEALQEYV EEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHH RALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEE HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLP ECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCC KADLPQMLPLEPIPDLLAALARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANP CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCHHHHHHHHCCCCEEECCC IDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLLDLARQLELGYFS CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQ CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHCCC PAFTDAAFWQATRGRPLHIELGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCP CCCCHHHHHHHCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC VAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRLACDAVGEGRMLEPEALQEYV EEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHH RALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEE HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLP ECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCC KADLPQMLPLEPIPDLLAALARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANP CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCHHHHHHHHCCCCEEECCC IDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLLDLARQLELGYFS CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8905231 [H]