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The map label for this gene is mdtE [H]

Identifier: 86361016

GI number: 86361016

Start: 318654

End: 319727

Strand: Reverse

Name: mdtE [H]

Synonym: RHE_PF00286

Alternate gene names: 86361016

Gene position: 319727-318654 (Counterclockwise)

Preceding gene: 86361019

Following gene: 86361015

Centisome position: 49.76

GC content: 63.87

Gene sequence:

>1074_bases
ATGAGAACCATTCTGGTCGCCACAGCGATCGTATGCACGATCGGTCTCGTCTCCTGCAGCGAGCCAGGCGGGCCGAGCGA
ACCTGCCGCGCGGCAGGTCGGCGTCGTCGTCGCCAGGTCTGAGCCGCTGAGCGAGGGCGGTGCGCTGACGGGAGAGGTCC
GCGCCCGTGTTCAGACCGATCTGTCGTTCCGCGTCAGTGGCAAGATCGTCGAGCGGCTGGTCGAGGTCGGGCAGTCCGTA
AAGGCAGGGCAGCTGCTGGCGCGCATCGATCCGGAAGAACAGAAGGCCGATCTGGATGTAGCGGCCGCGAATCTTCAGTC
CGCTGAGGCTCAGCAGACCCAGGCGCAGCTTGCCTTCGACCGCCAGCAGAGCCTGTTTCGAACACAAGTGACAACGCGCG
CTGCGCTCGACCAGGCGCAGGAGGCGCTTCTGACCGCGCAGGCATCGACGAAGTCGGCGCAGGCGCTTTTTGAAACCGCG
CAGGATACCTTATCCTACACGGAGCTGAAGGCGGATGCCGCCGGGGTGATCACCGCCCGCAATGCAGAGGTCGGACAGGT
GGCGCAGGCCGCCCAGGTCGTCTTCACCCTTGCCCATGACGGCGACCGGGACGCCGTCTTCGAAGTGGTCGAGAGCGCCT
TCCTGCGCCCGATCGACGGCGACGGCACTGTGGCCCTGCTGTCGAATCCCTCGCAGAAGATCACGGCGAAGGTTCGCGAG
ATTTCGCCGACCATCGATTCTTCCACCGGCACCATCAGGGTCAAGGTCGCGATATCGAGCGATGCTCCTATTCCGCTCGG
CGCTCCCGTCGTCGGGAAGTTCAGTTATGTCCCCCAGGACGTCATCCAGCTGCCCTGGTCGGCAATGACCTCCAAGGACG
GCAAGCCCGCCGTCTGGATCGTCGATCCCTCATCCTCTGTGGTCTCAGTGAGAGCGATTGAAGTCGCCGGCTACGAGACC
GGCAGCTTCATCGTCAAGTCGGGCGTGTCGGCAGGCGACGTCGTGGTGACCGACGGCACCAAATTCCTCAGACCCGGTGA
AATCGTGTCTTACGTCAAGGAAGCATCCAAGTGA

Upstream 100 bases:

>100_bases
TGCCTTGACTTGATTGCCCGCCGTCGTTGTCGTGAAAGTTTCATTGACTAATCCGTCAGTCAATTATATAGCAGCTGCCG
TTGAGAGCAAGAGGTCAACC

Downstream 100 bases:

>100_bases
GTATTCGTCCCAAGATAATCGCACTGATGATGGGTACGGCCCTGATCTCCTCTTGCACGAAGCAGGAGGAAAGCACTGGT
GAAGCGCCCCGTCCCGTGCT

Product: HlyD family protein secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRTILVATAIVCTIGLVSCSEPGGPSEPAARQVGVVVARSEPLSEGGALTGEVRARVQTDLSFRVSGKIVERLVEVGQSV
KAGQLLARIDPEEQKADLDVAAANLQSAEAQQTQAQLAFDRQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALFETA
QDTLSYTELKADAAGVITARNAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKITAKVRE
ISPTIDSSTGTIRVKVAISSDAPIPLGAPVVGKFSYVPQDVIQLPWSAMTSKDGKPAVWIVDPSSSVVSVRAIEVAGYET
GSFIVKSGVSAGDVVVTDGTKFLRPGEIVSYVKEASK

Sequences:

>Translated_357_residues
MRTILVATAIVCTIGLVSCSEPGGPSEPAARQVGVVVARSEPLSEGGALTGEVRARVQTDLSFRVSGKIVERLVEVGQSV
KAGQLLARIDPEEQKADLDVAAANLQSAEAQQTQAQLAFDRQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALFETA
QDTLSYTELKADAAGVITARNAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKITAKVRE
ISPTIDSSTGTIRVKVAISSDAPIPLGAPVVGKFSYVPQDVIQLPWSAMTSKDGKPAVWIVDPSSSVVSVRAIEVAGYET
GSFIVKSGVSAGDVVVTDGTKFLRPGEIVSYVKEASK
>Mature_357_residues
MRTILVATAIVCTIGLVSCSEPGGPSEPAARQVGVVVARSEPLSEGGALTGEVRARVQTDLSFRVSGKIVERLVEVGQSV
KAGQLLARIDPEEQKADLDVAAANLQSAEAQQTQAQLAFDRQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALFETA
QDTLSYTELKADAAGVITARNAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKITAKVRE
ISPTIDSSTGTIRVKVAISSDAPIPLGAPVVGKFSYVPQDVIQLPWSAMTSKDGKPAVWIVDPSSSVVSVRAIEVAGYET
GSFIVKSGVSAGDVVVTDGTKFLRPGEIVSYVKEASK

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=369, Percent_Identity=25.7452574525745, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082036, Length=307, Percent_Identity=28.0130293159609, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786668, Length=362, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789665, Length=378, Percent_Identity=26.7195767195767, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081796, Length=324, Percent_Identity=25, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37406; Mature: 37406

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTILVATAIVCTIGLVSCSEPGGPSEPAARQVGVVVARSEPLSEGGALTGEVRARVQTD
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCEEHHHHEEEEEC
LSFRVSGKIVERLVEVGQSVKAGQLLARIDPEEQKADLDVAAANLQSAEAQQTQAQLAFD
CEEEECHHHHHHHHHHCCCCCCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALFETAQDTLSYTELKADAAGVITAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
NAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKITAKVRE
CCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
ISPTIDSSTGTIRVKVAISSDAPIPLGAPVVGKFSYVPQDVIQLPWSAMTSKDGKPAVWI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEE
VDPSSSVVSVRAIEVAGYETGSFIVKSGVSAGDVVVTDGTKFLRPGEIVSYVKEASK
ECCCCCEEEEEEEEEECCCCCCHHEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRTILVATAIVCTIGLVSCSEPGGPSEPAARQVGVVVARSEPLSEGGALTGEVRARVQTD
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCEEHHHHEEEEEC
LSFRVSGKIVERLVEVGQSVKAGQLLARIDPEEQKADLDVAAANLQSAEAQQTQAQLAFD
CEEEECHHHHHHHHHHCCCCCCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALFETAQDTLSYTELKADAAGVITAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
NAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKITAKVRE
CCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
ISPTIDSSTGTIRVKVAISSDAPIPLGAPVVGKFSYVPQDVIQLPWSAMTSKDGKPAVWI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEE
VDPSSSVVSVRAIEVAGYETGSFIVKSGVSAGDVVVTDGTKFLRPGEIVSYVKEASK
ECCCCCEEEEEEEEEECCCCCCHHEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]