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The map label for this gene is aspS1

Identifier: 85858293

GI number: 85858293

Start: 459534

End: 461705

Strand: Direct

Name: aspS1

Synonym: SYN_02602

Alternate gene names: 85858293

Gene position: 459534-461705 (Clockwise)

Preceding gene: 85858290

Following gene: 85858294

Centisome position: 14.45

GC content: 61.97

Gene sequence:

>2172_bases
GTGCCGAATCGCGGTGCGCACTTTTCGATTTCAAGGAGAAAGGATTTTCTCATGGACTTTTCAGAACGCGTGTTTTGCGG
GCATCTGACGCCGGATCATACGGGCCGCAGGGTGCTTTTAGCCGGATGGGTGGATGCCTTCCGGGATCATGGCGGGTTGC
TGTTCATTCACCTGCGGGATCGCAACGGCATCATCCAGATTGTTTTCAGCCCGGAAGCGGCGTCGGCCGACGTCTACCGC
CAGGCCGCGTCCCTGCGCGCCGAGTATTGCGTCGCCGTTCAGGGCGAAGTTCGAAAGCGCCTCCCGGGCACGGAGAATCC
CCACATCGAAACGGGCGATATCGAGGTCTTCGTCTCGGAGCTGACCGTCCTGAGCGAGTCGGAGGCGCTGCCCTTCGCCA
TTTCCGACAAGGCCATGGTGGCCGGGGCGTCATCCGCCGGCGCGGACCATGTGAACGAGGATCTGCGGATGCAGTACCGC
TACCTGGATATCCGCCGCCCGGCCATGCAGAAAAACCTGATCCTGAGGCACCGGATTTCCCAGTGCGTCCGGGAATTTCT
TGACAGCCGGGGCTTCGTGGAAGTCGAAACGCCCGTGCTGACGATGAGCACCCCTGAAGGGGCGCGGGACTATCTCGTTC
CCAGCCGCATCCATCCCCGGAGTTTCTACGCCCTGCCTCAGTCTCCCCAGCTCTTCAAGCAGCTCCTCATGATCGGCGGC
ATGGAGCGCTACTTTCAGCTTGCCCGGTGTTTCCGCGATGAAGACCTGCGCCCGAACCGCCAGCCGGAATTCACCCAGCT
CGACATCGAGGCGTCTTTCATCGACGAGGAGTTCCTCTATGAACTGATCGAAGAACTGACGGTGAGGATGTTCGCCATCG
GCGGGATAGCCCTTTCCCGGCCCTTTCCGCGCATGACCTACGCGGAGGCGATGGATACGACGGGCTCCGACCGCCCCGAT
CTGCGCTTCGGCCTGCGCATGGCGGATGTCACCGGAGTGTTCTCCCGGACGTCCTATTCCATTTTCAAACAGATCCTGCA
GCGCGGCGGTTCCATCAAGGGCATCAATATCAAGGGCCAGTCGGAAAAGCTCAGCAAAAATGTCCTGCAGAACGAATACG
CGAAGGAAATCGCCCCGTCTTTCGGCGCCAAGGGCATGACCTGGATGCGCGCCGAAGAAGGGAAGCTGGAATCCAATATT
GTCCAGTTCTTCAGCGCCGATGAACTGGAGGCGCTGAAGCGGGTCTTTCAGGTGGAGGACGGGGACGTCCTGATCATGGT
CGCCGATCCGTCCTGTGCCATTGTGAACTCCGCTCTGGGCCAGTTGCGCCTCCATCTGGGCAATCGCCTCGGCCTGATTC
CCGAAGGCGTCTTCTACCCGGTGTGGATCACGGAATTTCCCCTGTTCGAACCCACGGACGAAGGGGGAGTCACGTCCAGC
CACCATCCCTTCACCGCGCCGGACCGCACCGATTTCGATCCCGGCAACATCGAAGAGCTCCTGAGCCTGCGCTCCCGCGC
CTACGATCTTGTGGTCAACGGCGAAGAGCTGGGCGGCGGCAGCATCCGCATCAACGACCGCGAGGTGCAGCGCAGAATCT
TCGCCGCTCTGGGCCTTACGGAAGAGGATGTGAAGAACAAATTCGGCTTTTTCCTGCGGGCCTTCGATTTCGCCGCGCCG
CCCCATGGCGGCCTGGCCCTGGGCATGGACCGCGTCGTTTCCATGATCCTCCAGACTCCGTCCATCCGGGAGGTGATCGC
CTTCCCGAAGAACCGCTCCGCCGCCTGTCCCCTTACCGGCGCGCCTTCCGAGGTCAAACGCGAACAGCTGGCCGAGCTGG
GGCTGCTGAACCTGGGCGATAAGGACGTCCTGCCCGGAGACGCCGAGAAGGAGGACCGGATCGATCATCTTTCCTGGGTA
TCGCGCATCGGCATTGCCGAAGGAGAGCGTCCCGTGATGGAAAGCATTCTCGCCCAGGCCGAGGAACTGGCTGCCCAGGT
TGGGGATCTGGCGGGGAACGAAGAGCCGGTGCGGAGTGTGGCGCCCGTCGCCAACCGCGTCCGGGAGGGCCTCGAGGCCG
TGCGGTTGTCGTTTTCCGGTACCGGCCGGCTGCTCAAGAACGCCCCGGCGGTCAAGGGAGATTACTTCAAAGTCGCCGGC
ATTCTGGATTAA

Upstream 100 bases:

>100_bases
CGGCCATTTCCATGTAAAATCCCGGCAACTTTCCTGCGTGTCGCCCTATTCAAGCCTTGAAAAATCAGGAGGGCTTTGAT
AGGGTCCGTGACACAAATTT

Downstream 100 bases:

>100_bases
ACACACAACAGAAGGAGAAGCCTTCATGGAAGACATTTTTTGCTATACCAGTCCTCAAACTGCCTCCTCCGGGAGTGGCC
CCCTGCGGGGACTCAAAACG

Product: bifunctional aspartyl-tRNA synthetase/aspartyl/glutamyl-tRNA amidotransferase subunit C

Products: NA

Alternate protein names: Aspartate--tRNA ligase 1; AspRS 1

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MPNRGAHFSISRRKDFLMDFSERVFCGHLTPDHTGRRVLLAGWVDAFRDHGGLLFIHLRDRNGIIQIVFSPEAASADVYR
QAASLRAEYCVAVQGEVRKRLPGTENPHIETGDIEVFVSELTVLSESEALPFAISDKAMVAGASSAGADHVNEDLRMQYR
YLDIRRPAMQKNLILRHRISQCVREFLDSRGFVEVETPVLTMSTPEGARDYLVPSRIHPRSFYALPQSPQLFKQLLMIGG
MERYFQLARCFRDEDLRPNRQPEFTQLDIEASFIDEEFLYELIEELTVRMFAIGGIALSRPFPRMTYAEAMDTTGSDRPD
LRFGLRMADVTGVFSRTSYSIFKQILQRGGSIKGINIKGQSEKLSKNVLQNEYAKEIAPSFGAKGMTWMRAEEGKLESNI
VQFFSADELEALKRVFQVEDGDVLIMVADPSCAIVNSALGQLRLHLGNRLGLIPEGVFYPVWITEFPLFEPTDEGGVTSS
HHPFTAPDRTDFDPGNIEELLSLRSRAYDLVVNGEELGGGSIRINDREVQRRIFAALGLTEEDVKNKFGFFLRAFDFAAP
PHGGLALGMDRVVSMILQTPSIREVIAFPKNRSAACPLTGAPSEVKREQLAELGLLNLGDKDVLPGDAEKEDRIDHLSWV
SRIGIAEGERPVMESILAQAEELAAQVGDLAGNEEPVRSVAPVANRVREGLEAVRLSFSGTGRLLKNAPAVKGDYFKVAG
ILD

Sequences:

>Translated_723_residues
MPNRGAHFSISRRKDFLMDFSERVFCGHLTPDHTGRRVLLAGWVDAFRDHGGLLFIHLRDRNGIIQIVFSPEAASADVYR
QAASLRAEYCVAVQGEVRKRLPGTENPHIETGDIEVFVSELTVLSESEALPFAISDKAMVAGASSAGADHVNEDLRMQYR
YLDIRRPAMQKNLILRHRISQCVREFLDSRGFVEVETPVLTMSTPEGARDYLVPSRIHPRSFYALPQSPQLFKQLLMIGG
MERYFQLARCFRDEDLRPNRQPEFTQLDIEASFIDEEFLYELIEELTVRMFAIGGIALSRPFPRMTYAEAMDTTGSDRPD
LRFGLRMADVTGVFSRTSYSIFKQILQRGGSIKGINIKGQSEKLSKNVLQNEYAKEIAPSFGAKGMTWMRAEEGKLESNI
VQFFSADELEALKRVFQVEDGDVLIMVADPSCAIVNSALGQLRLHLGNRLGLIPEGVFYPVWITEFPLFEPTDEGGVTSS
HHPFTAPDRTDFDPGNIEELLSLRSRAYDLVVNGEELGGGSIRINDREVQRRIFAALGLTEEDVKNKFGFFLRAFDFAAP
PHGGLALGMDRVVSMILQTPSIREVIAFPKNRSAACPLTGAPSEVKREQLAELGLLNLGDKDVLPGDAEKEDRIDHLSWV
SRIGIAEGERPVMESILAQAEELAAQVGDLAGNEEPVRSVAPVANRVREGLEAVRLSFSGTGRLLKNAPAVKGDYFKVAG
ILD
>Mature_722_residues
PNRGAHFSISRRKDFLMDFSERVFCGHLTPDHTGRRVLLAGWVDAFRDHGGLLFIHLRDRNGIIQIVFSPEAASADVYRQ
AASLRAEYCVAVQGEVRKRLPGTENPHIETGDIEVFVSELTVLSESEALPFAISDKAMVAGASSAGADHVNEDLRMQYRY
LDIRRPAMQKNLILRHRISQCVREFLDSRGFVEVETPVLTMSTPEGARDYLVPSRIHPRSFYALPQSPQLFKQLLMIGGM
ERYFQLARCFRDEDLRPNRQPEFTQLDIEASFIDEEFLYELIEELTVRMFAIGGIALSRPFPRMTYAEAMDTTGSDRPDL
RFGLRMADVTGVFSRTSYSIFKQILQRGGSIKGINIKGQSEKLSKNVLQNEYAKEIAPSFGAKGMTWMRAEEGKLESNIV
QFFSADELEALKRVFQVEDGDVLIMVADPSCAIVNSALGQLRLHLGNRLGLIPEGVFYPVWITEFPLFEPTDEGGVTSSH
HPFTAPDRTDFDPGNIEELLSLRSRAYDLVVNGEELGGGSIRINDREVQRRIFAALGLTEEDVKNKFGFFLRAFDFAAPP
HGGLALGMDRVVSMILQTPSIREVIAFPKNRSAACPLTGAPSEVKREQLAELGLLNLGDKDVLPGDAEKEDRIDHLSWVS
RIGIAEGERPVMESILAQAEELAAQVGDLAGNEEPVRSVAPVANRVREGLEAVRLSFSGTGRLLKNAPAVKGDYFKVAGI
LD

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI40789249, Length=604, Percent_Identity=39.5695364238411, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI45439306, Length=269, Percent_Identity=29.7397769516729, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI5031815, Length=296, Percent_Identity=27.7027027027027, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI194272210, Length=296, Percent_Identity=27.7027027027027, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI226491502, Length=265, Percent_Identity=26.4150943396226, Blast_Score=72, Evalue=3e-12,
Organism=Escherichia coli, GI1788173, Length=600, Percent_Identity=42.3333333333333, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1790571, Length=363, Percent_Identity=25.068870523416, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1789256, Length=326, Percent_Identity=26.3803680981595, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32566633, Length=604, Percent_Identity=34.7682119205298, Blast_Score=315, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17551876, Length=273, Percent_Identity=29.3040293040293, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994340, Length=141, Percent_Identity=30.4964539007092, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535925, Length=141, Percent_Identity=30.4964539007092, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535927, Length=141, Percent_Identity=30.4964539007092, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325153, Length=639, Percent_Identity=32.5508607198748, Blast_Score=262, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6323011, Length=261, Percent_Identity=29.8850574712644, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320242, Length=297, Percent_Identity=26.9360269360269, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321807, Length=334, Percent_Identity=23.9520958083832, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584738, Length=605, Percent_Identity=36.8595041322314, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI17136276, Length=244, Percent_Identity=27.8688524590164, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24640849, Length=262, Percent_Identity=26.7175572519084, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640851, Length=262, Percent_Identity=26.7175572519084, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYD1_SYNAS (Q2LPW5)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_460495.1
- ProteinModelPortal:   Q2LPW5
- STRING:   Q2LPW5
- GeneID:   3885262
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_02602
- NMPDR:   fig|56780.10.peg.448
- eggNOG:   COG0173
- HOGENOM:   HBG396032
- OMA:   NEYAKEI
- ProtClustDB:   PRK12820
- BioCyc:   SACI56780:SYN_02602-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00044_B
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:3.30.1360.30
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF5
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00459

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.12

Molecular weight: Translated: 80509; Mature: 80378

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNRGAHFSISRRKDFLMDFSERVFCGHLTPDHTGRRVLLAGWVDAFRDHGGLLFIHLRD
CCCCCCCEEEHHHHHHHHHHHCCEEECCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEEC
RNGIIQIVFSPEAASADVYRQAASLRAEYCVAVQGEVRKRLPGTENPHIETGDIEVFVSE
CCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEECHHHHHHCCCCCCCCEECCCHHEEEEH
LTVLSESEALPFAISDKAMVAGASSAGADHVNEDLRMQYRYLDIRRPAMQKNLILRHRIS
HHHHCCCCCCCEEECCCEEEECCCCCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QCVREFLDSRGFVEVETPVLTMSTPEGARDYLVPSRIHPRSFYALPQSPQLFKQLLMIGG
HHHHHHHCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCC
MERYFQLARCFRDEDLRPNRQPEFTQLDIEASFIDEEFLYELIEELTVRMFAIGGIALSR
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
PFPRMTYAEAMDTTGSDRPDLRFGLRMADVTGVFSRTSYSIFKQILQRGGSIKGINIKGQ
CCCCCHHHHHHCCCCCCCCCHHHCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
SEKLSKNVLQNEYAKEIAPSFGAKGMTWMRAEEGKLESNIVQFFSADELEALKRVFQVED
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
GDVLIMVADPSCAIVNSALGQLRLHLGNRLGLIPEGVFYPVWITEFPLFEPTDEGGVTSS
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCC
HHPFTAPDRTDFDPGNIEELLSLRSRAYDLVVNGEELGGGSIRINDREVQRRIFAALGLT
CCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEEECHHHHHHHHHHHHCCC
EEDVKNKFGFFLRAFDFAAPPHGGLALGMDRVVSMILQTPSIREVIAFPKNRSAACPLTG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC
APSEVKREQLAELGLLNLGDKDVLPGDAEKEDRIDHLSWVSRIGIAEGERPVMESILAQA
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EELAAQVGDLAGNEEPVRSVAPVANRVREGLEAVRLSFSGTGRLLKNAPAVKGDYFKVAG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHCCCCCCCCCEEEEE
ILD
CCC
>Mature Secondary Structure 
PNRGAHFSISRRKDFLMDFSERVFCGHLTPDHTGRRVLLAGWVDAFRDHGGLLFIHLRD
CCCCCCEEEHHHHHHHHHHHCCEEECCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEEC
RNGIIQIVFSPEAASADVYRQAASLRAEYCVAVQGEVRKRLPGTENPHIETGDIEVFVSE
CCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEECHHHHHHCCCCCCCCEECCCHHEEEEH
LTVLSESEALPFAISDKAMVAGASSAGADHVNEDLRMQYRYLDIRRPAMQKNLILRHRIS
HHHHCCCCCCCEEECCCEEEECCCCCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QCVREFLDSRGFVEVETPVLTMSTPEGARDYLVPSRIHPRSFYALPQSPQLFKQLLMIGG
HHHHHHHCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCC
MERYFQLARCFRDEDLRPNRQPEFTQLDIEASFIDEEFLYELIEELTVRMFAIGGIALSR
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
PFPRMTYAEAMDTTGSDRPDLRFGLRMADVTGVFSRTSYSIFKQILQRGGSIKGINIKGQ
CCCCCHHHHHHCCCCCCCCCHHHCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
SEKLSKNVLQNEYAKEIAPSFGAKGMTWMRAEEGKLESNIVQFFSADELEALKRVFQVED
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
GDVLIMVADPSCAIVNSALGQLRLHLGNRLGLIPEGVFYPVWITEFPLFEPTDEGGVTSS
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCC
HHPFTAPDRTDFDPGNIEELLSLRSRAYDLVVNGEELGGGSIRINDREVQRRIFAALGLT
CCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEEECHHHHHHHHHHHHCCC
EEDVKNKFGFFLRAFDFAAPPHGGLALGMDRVVSMILQTPSIREVIAFPKNRSAACPLTG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC
APSEVKREQLAELGLLNLGDKDVLPGDAEKEDRIDHLSWVSRIGIAEGERPVMESILAQA
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EELAAQVGDLAGNEEPVRSVAPVANRVREGLEAVRLSFSGTGRLLKNAPAVKGDYFKVAG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHCCCCCCCCCEEEEE
ILD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA