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The map label for this gene is argD

Identifier: 85375610

GI number: 85375610

Start: 2804626

End: 2805819

Strand: Direct

Name: argD

Synonym: ELI_13915

Alternate gene names: 85375610

Gene position: 2804626-2805819 (Clockwise)

Preceding gene: 85375609

Following gene: 85375611

Centisome position: 91.88

GC content: 63.07

Gene sequence:

>1194_bases
ATGTCGATCACACCGCTCATGCCAGTCTACCCCCGCTGCGGGGTTCGTCCGGTCCGCGGCGAGCACTGCCACCTGATCGA
CGAGGACGGCACGCGCTATCTCGACTTTGCCAGCGGCATTGCCGTCAATCTGCTCGGCCATTCGCATGAAGGCCTGATCG
GTGCGATCCAGCAGCAGGCCGCGACGCTGATGCATGTTTCCAACCTCTACGGCAGCCCACAGGGCGAGGAACTGGCGCGG
AAGCTGGTCGACAAGACTTTCGCCGACACGGTGTTCTTCACGAACTCTGGCGCGGAGGCGGTGGAAACGGCGATCAAGAC
CGCGCGCGCCTATCACCAGCAAGAGGATGGTGACGCGCAGCGTACCGAACTGATCACGTTCACCAACGCCTTCCACGGGC
GGACGATGGCGACCATCAGTGCGTCCAACCAGGAGAAGATGCACAAGGGCTTCCAGCCGCTTCTCCCGGGCTTCAAATAT
TGCGAGTTCGACGATCTCGACATGGCCAAGAGCCTGATCGGTCCGCAGACGGCGGGCTTCCTGGTCGAACCGATCCAGGG
CGAAGGCGGCATCCGCCCCGCCTCGGACGCATTCATGCACGGCCTGCGCGACCTGTGCGACGAGCATGACCTCATGCTCG
CGCTCGACGAAGTGCAATGCGGTGTCGCGCGCACCGGCACGCTCTACGCCTATGAGCAATACGGGATCGAACCCGACATT
CTCGCCACGGCAAAAGGCATCGGCGGCGGCTTCCCGCTGGGGGCCTGCCTTGCCACGGAAAAGGCGGCGCGCGGCATGGT
CTTCGGCACGCACGGCTCGACCTATGGCGGCAATCCGCTGGCCATGGCGGCCGGAATGGCGGTGATGACAGCCGTCGCGA
ACGACGAGTTTCTTGCTGAAGTACGCGAAAAGGGTGAACGGATCCGGACCCGGCTCGAACAGTTCATCGGCAACTATCCC
GACCTGTTCGAACTGGTCCGCGGCAAGGGGCTGATGCTCGGCATCAAGATGAAGGTCGAAAGCCGTCCCTTCTTTGTCCA
CCTGCGCGATCATCACCAGTTACTGACCGTCGCGGCCGGCGACAATACGCTGCGGGTTCTCCCGCCGCTGGTCATCGGCG
ATGCGGAGATCGATGAATTTTTCGACAAACTTTCCGCGGGTGCGGCAAGCTACAAGGTGCCCGAGGCGGCGTGA

Upstream 100 bases:

>100_bases
TTGACCGGGGTTGAGCGACAATCTAAACAGCGCGAAATGGCGGCCTCGTTTGGGGCCGCCATTTCCCTTTGAGCCGAAAC
AGTTTCGAGGAATTGCCACG

Downstream 100 bases:

>100_bases
TGCCCGCACCGGCGACAGTACGGCATTTTCTCGACCTGTCGGATGCCGGCGGCGATGCGATCGCCGCGATGATTAATGAC
GCGCAGGACCGCAAGGCCGC

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSITPLMPVYPRCGVRPVRGEHCHLIDEDGTRYLDFASGIAVNLLGHSHEGLIGAIQQQAATLMHVSNLYGSPQGEELAR
KLVDKTFADTVFFTNSGAEAVETAIKTARAYHQQEDGDAQRTELITFTNAFHGRTMATISASNQEKMHKGFQPLLPGFKY
CEFDDLDMAKSLIGPQTAGFLVEPIQGEGGIRPASDAFMHGLRDLCDEHDLMLALDEVQCGVARTGTLYAYEQYGIEPDI
LATAKGIGGGFPLGACLATEKAARGMVFGTHGSTYGGNPLAMAAGMAVMTAVANDEFLAEVREKGERIRTRLEQFIGNYP
DLFELVRGKGLMLGIKMKVESRPFFVHLRDHHQLLTVAAGDNTLRVLPPLVIGDAEIDEFFDKLSAGAASYKVPEAA

Sequences:

>Translated_397_residues
MSITPLMPVYPRCGVRPVRGEHCHLIDEDGTRYLDFASGIAVNLLGHSHEGLIGAIQQQAATLMHVSNLYGSPQGEELAR
KLVDKTFADTVFFTNSGAEAVETAIKTARAYHQQEDGDAQRTELITFTNAFHGRTMATISASNQEKMHKGFQPLLPGFKY
CEFDDLDMAKSLIGPQTAGFLVEPIQGEGGIRPASDAFMHGLRDLCDEHDLMLALDEVQCGVARTGTLYAYEQYGIEPDI
LATAKGIGGGFPLGACLATEKAARGMVFGTHGSTYGGNPLAMAAGMAVMTAVANDEFLAEVREKGERIRTRLEQFIGNYP
DLFELVRGKGLMLGIKMKVESRPFFVHLRDHHQLLTVAAGDNTLRVLPPLVIGDAEIDEFFDKLSAGAASYKVPEAA
>Mature_396_residues
SITPLMPVYPRCGVRPVRGEHCHLIDEDGTRYLDFASGIAVNLLGHSHEGLIGAIQQQAATLMHVSNLYGSPQGEELARK
LVDKTFADTVFFTNSGAEAVETAIKTARAYHQQEDGDAQRTELITFTNAFHGRTMATISASNQEKMHKGFQPLLPGFKYC
EFDDLDMAKSLIGPQTAGFLVEPIQGEGGIRPASDAFMHGLRDLCDEHDLMLALDEVQCGVARTGTLYAYEQYGIEPDIL
ATAKGIGGGFPLGACLATEKAARGMVFGTHGSTYGGNPLAMAAGMAVMTAVANDEFLAEVREKGERIRTRLEQFIGNYPD
LFELVRGKGLMLGIKMKVESRPFFVHLRDHHQLLTVAAGDNTLRVLPPLVIGDAEIDEFFDKLSAGAASYKVPEAA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=383, Percent_Identity=33.9425587467363, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI284507298, Length=305, Percent_Identity=35.4098360655738, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI13994255, Length=411, Percent_Identity=29.9270072992701, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI188536080, Length=434, Percent_Identity=25.8064516129032, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI38679950, Length=434, Percent_Identity=25.8064516129032, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI38679946, Length=434, Percent_Identity=25.8064516129032, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI37574042, Length=415, Percent_Identity=26.2650602409639, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI226442705, Length=415, Percent_Identity=25.5421686746988, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=25.974025974026, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=25.2380952380952, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1788044, Length=384, Percent_Identity=43.75, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1789759, Length=388, Percent_Identity=40.7216494845361, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=33.9195979899498, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI145693181, Length=363, Percent_Identity=33.3333333333333, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1787560, Length=402, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1786991, Length=337, Percent_Identity=33.2344213649852, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=31.2302839116719, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=371, Percent_Identity=32.6145552560647, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32564660, Length=460, Percent_Identity=28.4782608695652, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI25144274, Length=258, Percent_Identity=32.5581395348837, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=414, Percent_Identity=28.743961352657, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17541228, Length=425, Percent_Identity=24.9411764705882, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=157, Percent_Identity=34.3949044585987, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=378, Percent_Identity=36.7724867724868, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6323470, Length=376, Percent_Identity=30.8510638297872, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=429, Percent_Identity=24.9417249417249, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321456, Length=362, Percent_Identity=27.0718232044199, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357415, Length=371, Percent_Identity=34.2318059299191, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=28.6713286713287, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI161085790, Length=359, Percent_Identity=29.2479108635098, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=27.9236276849642, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281366494, Length=417, Percent_Identity=24.220623501199, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24667139, Length=417, Percent_Identity=24.220623501199, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24667143, Length=417, Percent_Identity=24.220623501199, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 43052; Mature: 42920

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITPLMPVYPRCGVRPVRGEHCHLIDEDGTRYLDFASGIAVNLLGHSHEGLIGAIQQQA
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEHHCCCEEEEECCCCCHHHHHHHHHH
ATLMHVSNLYGSPQGEELARKLVDKTFADTVFFTNSGAEAVETAIKTARAYHQQEDGDAQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCH
RTELITFTNAFHGRTMATISASNQEKMHKGFQPLLPGFKYCEFDDLDMAKSLIGPQTAGF
HEEEEEEECCCCCCEEEEEECCCHHHHHCCCHHHCCCCCCCCCCCHHHHHHHCCCCCCCE
LVEPIQGEGGIRPASDAFMHGLRDLCDEHDLMLALDEVQCGVARTGTLYAYEQYGIEPDI
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEEEHHHCCCCCCH
LATAKGIGGGFPLGACLATEKAARGMVFGTHGSTYGGNPLAMAAGMAVMTAVANDEFLAE
HHHHCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
VREKGERIRTRLEQFIGNYPDLFELVRGKGLMLGIKMKVESRPFFVHLRDHHQLLTVAAG
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEECCCCEEEEEECCCEEEEEEEC
DNTLRVLPPLVIGDAEIDEFFDKLSAGAASYKVPEAA
CCEEEECCCEEECCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SITPLMPVYPRCGVRPVRGEHCHLIDEDGTRYLDFASGIAVNLLGHSHEGLIGAIQQQA
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEHHCCCEEEEECCCCCHHHHHHHHHH
ATLMHVSNLYGSPQGEELARKLVDKTFADTVFFTNSGAEAVETAIKTARAYHQQEDGDAQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCH
RTELITFTNAFHGRTMATISASNQEKMHKGFQPLLPGFKYCEFDDLDMAKSLIGPQTAGF
HEEEEEEECCCCCCEEEEEECCCHHHHHCCCHHHCCCCCCCCCCCHHHHHHHCCCCCCCE
LVEPIQGEGGIRPASDAFMHGLRDLCDEHDLMLALDEVQCGVARTGTLYAYEQYGIEPDI
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEEEHHHCCCCCCH
LATAKGIGGGFPLGACLATEKAARGMVFGTHGSTYGGNPLAMAAGMAVMTAVANDEFLAE
HHHHCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHH
VREKGERIRTRLEQFIGNYPDLFELVRGKGLMLGIKMKVESRPFFVHLRDHHQLLTVAAG
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEECCCCEEEEEECCCEEEEEEEC
DNTLRVLPPLVIGDAEIDEFFDKLSAGAASYKVPEAA
CCEEEECCCEEECCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]