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The map label for this gene is ubiB [H]

Identifier: 85374936

GI number: 85374936

Start: 2138139

End: 2139695

Strand: Reverse

Name: ubiB [H]

Synonym: ELI_10545

Alternate gene names: 85374936

Gene position: 2139695-2138139 (Counterclockwise)

Preceding gene: 85374937

Following gene: 85374933

Centisome position: 70.1

GC content: 65.0

Gene sequence:

>1557_bases
ATGACGCGTCCCGTCACCCATATCTGGCGGCTCCTCAAATGGGGCCGCACTGCCGCCAAGCATGGGGCGCTGCGCGGGAT
CGAGCGCGACCCAAATACGCCTGCACCCGTCAAGCGGCTGGCAAGACTGGCGCGCCTCGGAACATTTCCACCGGCGACGC
CGGACTATGCCGGGGCGTTCCGCGATATCGGTCCAGCGGCCATCAAGCTCGGTCAATCGCTGGCGACGCGGCCGGATCTG
GTCGGCGAAGAGGCGGCGCACAACCTGCTCACCTTGCAGGATGATCTGCCGCCGATCCCGTTCGAGCGGATCGAGGCGGC
CGTTGCGGCGACTTTCGAACAGCCGCTCGACACATTGTTCAGCGATATCGATCCCGTTCCCGTCGGCGCCGCGTCGATTG
CGCAGGTCCATCGTGCGGTCACCGCGGAGGGAAGCGAGGTGGCGCTCAAGGTCTTGCGCCCCGGCATTCGCGAGCAATTC
GCCCGCGATATTCAGACCTACGAATGGGCTGCCGCGCATGTCGAGGCGATGGGCGGCGAGGCCGCGCGGCTGCGTCCGCG
CCAGACCATCGCCAATTTCAAGCGCTGGACCAATTCGGAGCTCGATCTGCGGCGTGAAGCGGCATCGGCCAGCGAGCTCG
CCGATGCGATGAGCGGCTTTCACGGCTATCGCATCCCAGCCATCGACTGGGACCGTACCAACGGCCGGGTGATGACGGTC
GAATGGATCGACGGGATCAAGATTTCCAAGCGCGACGAGTTGATCGCGGCGGGCCACGACCTGGAGGAGGTGGCCGAACG
GCTGGTGCTCGCTTTCCTCCACCAGGCGATCAGCGGTGGATTCTTCCACGCCGATATGCATCAGGGAAACCTGTTCGTGG
AGCCGGACGGCACCATCGTGGCGATCGATTTCGGCATCATGGGCCGGATCGACCGCCGCGCGCGGCAATGGCTGGCGGAA
ATCCTCTACGGCCTGACCACGGGCAATTACCAACGCGTCGCCGAAATCCATTTCGAAGCGCAGTATGTGCCGAGCTATCA
TTCGGTCGGCGAGTTCGCGACCGCCTTGCGCGCCGTGGGCGAGCCGATGCGCGGCAAACCGGTGAGCGAGTTGAGCGTCG
GCCAGATGCTCGACGGGCTGTTCGCCATCACGCGCGATTTCGACATGGCGACCCAGCCGCACCTTCTGCTGCTGCAGAAG
ACCATGGTAATGGTCGAAGGTATCGCCACTCAGCTCAATCCTCAGATCAATATGTGGGATGTCAGCGCTCCCTATGTCCG
CAGCTGGATCCGCGACGAGCTGGGCCCCGAAGCCGCGTTGGCGGATTCGCTCAAGGAAAACGTTTCGACCCTGCTGCGCC
TGCCGGACCTCGTGCGCCGGATCGAAGAAACATATCCGCCCAAGGGCGGCGCGCCCGAGCCGCAGCCGCTGCCCGATATC
GAACTGGTGTGGGAACGCCGCCAGCGCGAAGGGCGCGGCTGGCTCGGTTATGTCCTCAGCGCGGCGCTCGGTGCAGCGAC
TATCGCAGGGGCATTCGCGCTCGGCTGGATCGGTTAG

Upstream 100 bases:

>100_bases
AGCGATGATCCGGGCGGCAGGATTCGCAAACACGCGCGTGGAGAAAATTCTGGGCGGCGCCGTGAACATTCATTCCGGCT
GGAAGATCTGACGCGCTCCC

Downstream 100 bases:

>100_bases
CTTTCCGGGGGCGGTCGCAGCGCGCCGTCGTCGGGTTTGCTGCCCATCGTCTTGAGCCGCCACACGATCGCCGAAACGAC
GCCAAGCATTGCCAGTATCG

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MTRPVTHIWRLLKWGRTAAKHGALRGIERDPNTPAPVKRLARLARLGTFPPATPDYAGAFRDIGPAAIKLGQSLATRPDL
VGEEAAHNLLTLQDDLPPIPFERIEAAVAATFEQPLDTLFSDIDPVPVGAASIAQVHRAVTAEGSEVALKVLRPGIREQF
ARDIQTYEWAAAHVEAMGGEAARLRPRQTIANFKRWTNSELDLRREAASASELADAMSGFHGYRIPAIDWDRTNGRVMTV
EWIDGIKISKRDELIAAGHDLEEVAERLVLAFLHQAISGGFFHADMHQGNLFVEPDGTIVAIDFGIMGRIDRRARQWLAE
ILYGLTTGNYQRVAEIHFEAQYVPSYHSVGEFATALRAVGEPMRGKPVSELSVGQMLDGLFAITRDFDMATQPHLLLLQK
TMVMVEGIATQLNPQINMWDVSAPYVRSWIRDELGPEAALADSLKENVSTLLRLPDLVRRIEETYPPKGGAPEPQPLPDI
ELVWERRQREGRGWLGYVLSAALGAATIAGAFALGWIG

Sequences:

>Translated_518_residues
MTRPVTHIWRLLKWGRTAAKHGALRGIERDPNTPAPVKRLARLARLGTFPPATPDYAGAFRDIGPAAIKLGQSLATRPDL
VGEEAAHNLLTLQDDLPPIPFERIEAAVAATFEQPLDTLFSDIDPVPVGAASIAQVHRAVTAEGSEVALKVLRPGIREQF
ARDIQTYEWAAAHVEAMGGEAARLRPRQTIANFKRWTNSELDLRREAASASELADAMSGFHGYRIPAIDWDRTNGRVMTV
EWIDGIKISKRDELIAAGHDLEEVAERLVLAFLHQAISGGFFHADMHQGNLFVEPDGTIVAIDFGIMGRIDRRARQWLAE
ILYGLTTGNYQRVAEIHFEAQYVPSYHSVGEFATALRAVGEPMRGKPVSELSVGQMLDGLFAITRDFDMATQPHLLLLQK
TMVMVEGIATQLNPQINMWDVSAPYVRSWIRDELGPEAALADSLKENVSTLLRLPDLVRRIEETYPPKGGAPEPQPLPDI
ELVWERRQREGRGWLGYVLSAALGAATIAGAFALGWIG
>Mature_517_residues
TRPVTHIWRLLKWGRTAAKHGALRGIERDPNTPAPVKRLARLARLGTFPPATPDYAGAFRDIGPAAIKLGQSLATRPDLV
GEEAAHNLLTLQDDLPPIPFERIEAAVAATFEQPLDTLFSDIDPVPVGAASIAQVHRAVTAEGSEVALKVLRPGIREQFA
RDIQTYEWAAAHVEAMGGEAARLRPRQTIANFKRWTNSELDLRREAASASELADAMSGFHGYRIPAIDWDRTNGRVMTVE
WIDGIKISKRDELIAAGHDLEEVAERLVLAFLHQAISGGFFHADMHQGNLFVEPDGTIVAIDFGIMGRIDRRARQWLAEI
LYGLTTGNYQRVAEIHFEAQYVPSYHSVGEFATALRAVGEPMRGKPVSELSVGQMLDGLFAITRDFDMATQPHLLLLQKT
MVMVEGIATQLNPQINMWDVSAPYVRSWIRDELGPEAALADSLKENVSTLLRLPDLVRRIEETYPPKGGAPEPQPLPDIE
LVWERRQREGRGWLGYVLSAALGAATIAGAFALGWIG

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=302, Percent_Identity=29.4701986754967, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI40254938, Length=273, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI217035081, Length=274, Percent_Identity=27.3722627737226, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI34147522, Length=373, Percent_Identity=25.7372654155496, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI27363457, Length=243, Percent_Identity=23.4567901234568, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI217416386, Length=248, Percent_Identity=22.9838709677419, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI2367309, Length=413, Percent_Identity=36.5617433414044, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17559152, Length=278, Percent_Identity=26.978417266187, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=439, Percent_Identity=21.6400911161731, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=313, Percent_Identity=23.961661341853, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24662575, Length=296, Percent_Identity=28.0405405405405, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI22024280, Length=252, Percent_Identity=26.1904761904762, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57162; Mature: 57031

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPVTHIWRLLKWGRTAAKHGALRGIERDPNTPAPVKRLARLARLGTFPPATPDYAGAF
CCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
RDIGPAAIKLGQSLATRPDLVGEEAAHNLLTLQDDLPPIPFERIEAAVAATFEQPLDTLF
HHCCHHHHHHHHHHHCCCCCCCHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
SDIDPVPVGAASIAQVHRAVTAEGSEVALKVLRPGIREQFARDIQTYEWAAAHVEAMGGE
HCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AARLRPRQTIANFKRWTNSELDLRREAASASELADAMSGFHGYRIPAIDWDRTNGRVMTV
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
EWIDGIKISKRDELIAAGHDLEEVAERLVLAFLHQAISGGFFHADMHQGNLFVEPDGTIV
EECCCCEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEE
AIDFGIMGRIDRRARQWLAEILYGLTTGNYQRVAEIHFEAQYVPSYHSVGEFATALRAVG
EEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEHHEECCCHHHHHHHHHHHHHHC
EPMRGKPVSELSVGQMLDGLFAITRDFDMATQPHLLLLQKTMVMVEGIATQLNPQINMWD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
VSAPYVRSWIRDELGPEAALADSLKENVSTLLRLPDLVRRIEETYPPKGGAPEPQPLPDI
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
ELVWERRQREGRGWLGYVLSAALGAATIAGAFALGWIG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRPVTHIWRLLKWGRTAAKHGALRGIERDPNTPAPVKRLARLARLGTFPPATPDYAGAF
CCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHH
RDIGPAAIKLGQSLATRPDLVGEEAAHNLLTLQDDLPPIPFERIEAAVAATFEQPLDTLF
HHCCHHHHHHHHHHHCCCCCCCHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
SDIDPVPVGAASIAQVHRAVTAEGSEVALKVLRPGIREQFARDIQTYEWAAAHVEAMGGE
HCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AARLRPRQTIANFKRWTNSELDLRREAASASELADAMSGFHGYRIPAIDWDRTNGRVMTV
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
EWIDGIKISKRDELIAAGHDLEEVAERLVLAFLHQAISGGFFHADMHQGNLFVEPDGTIV
EECCCCEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEE
AIDFGIMGRIDRRARQWLAEILYGLTTGNYQRVAEIHFEAQYVPSYHSVGEFATALRAVG
EEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEHHEECCCHHHHHHHHHHHHHHC
EPMRGKPVSELSVGQMLDGLFAITRDFDMATQPHLLLLQKTMVMVEGIATQLNPQINMWD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
VSAPYVRSWIRDELGPEAALADSLKENVSTLLRLPDLVRRIEETYPPKGGAPEPQPLPDI
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
ELVWERRQREGRGWLGYVLSAALGAATIAGAFALGWIG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA