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The map label for this gene is coaBC [H]

Identifier: 85374933

GI number: 85374933

Start: 2134745

End: 2136424

Strand: Reverse

Name: coaBC [H]

Synonym: ELI_10530

Alternate gene names: 85374933

Gene position: 2136424-2134745 (Counterclockwise)

Preceding gene: 85374936

Following gene: 85374932

Centisome position: 69.99

GC content: 64.58

Gene sequence:

>1680_bases
ATGGCGAGCGAAGCGGGGCCGAAGATCCTGCTCGTCATCGGAGGCGGTATCGCGGCGTACAAGTCGTGCGAACTCGTGCG
CCTGATCCGCAAGCAGGGGGGCTCGGTCACGTGCGTGCTGACCGGAGGCGGGGCGAAGTTCGTGACCCCCATGGCGCTAG
CTGCCCTCAGCGAGAACGAGGTGCATACGACGCTGTGGGATCTCAGGAACGAGGTCGAGATGGGCCATATCCAGCTCAGC
CGCGAGGCGGACCTGGTGGTGGTGTGCCCGGCGACGGCCAATATGCTTGCCAAGATGGCTGCCGGGATCGCCGACGATCT
CGCGACTACGCTGCTGCTTGCGACCGACAAGCCGGTGATGGTTGCGCCTGCGATGAACGTGAAGATGTGGCAGCACGATG
CCACGCAGATGAATGTCGAACGCCTGCGCGCGGCGGGCGTGCATGTGATCGATCCCGATGAAGGCGCGATGGCCTGCGGC
GAATTCGGCCCCGGACGTTTGCGCGAGCCGGAAGCGATCTGGAACGCCATGGCCGAGATGTTCGGCGCCGAGGCGGTGGA
AGAGAAAGAACCTGCGGCGCTCGCCCCGGTGCCGGAAATCGAAGTTTTGGAACCGGAGCCCGAGCCGGAGCCGGAGAGCA
GGGGTATGCTCGGCGGCCTTCTGTCCTCGATCATTCCGCGCACAACACCCAAGCGCAGCGTCGAAGAAATCGAAGCGCAG
TGGGAAGAGCCAGAAGAGTTCGAAACCGAACCGGACACGGAAGTCGCCGAGGAAGAGGAGGCGAACCAAGGCGCGACAGA
CGATGCGCCGATTGCCGGTGCGGGCCCGCTCCTTGCCACCAAGGGCAAGGCCAATTCCGCCCCGCCGACCGATGCCGAGG
CGATAAATCACACGGTAGCAACCGGCACCGGGGCACAAAAGCCGGAGCCGATCGACGAGGACGGCCCGCTAGTCGAGGAA
GAGCCGCTGGAAGGGAATCCGCTCGACGGGCAACCCGCTTTCGACACCGAGCCGGAACACCGTCCACTATTCGGCAAGCA
CGTGCTCGTCACCGCCGGGCCGACGCATGAACCGATCGACCCGGTGCGCTATATCGCCAACCGGTCGAGCGGAAAGCAGG
GCTTTGCCATTGCCGCCGCCGCTGCCGCAGCCGGTGCGCGGGTCACGCTGGTAGCAGGACCGGTCCATTTGCAAACGCCG
CGCGGGGTCGACCGCATCAATGTCGAAAGCGCGCGGGAAATGGCGGACGAAGTGCGCAATGCCTTGCCTGCCGATATCGC
TGTGATGGTTGCAGCCGTCGCCGACTGGCGCACCAAGGACTTCGCCGACCAGAAGATGAAAAAACGCGGCTCCGCCCCAC
CGGCGCTGCTGCTGGAAGAGAACCCCGACATTCTCACCAACCTGTCAGCGGGCAAGAAGCGGCCAACGCTGGTGATCGGC
TTTGCCGCTGAAACGCAGGACGTGATCGAGAATGCCCGGTCCAAGCGCAAGCGCAAGGGCGCGGACTGGATCGTGGCCAA
CGATGTGTCGGGCGATGTCATGGGCGGCGATCTCAACGATGTGCACATCGTCACGTCGCGCGGAGTGGAGGACCTGCCGG
AAATGCCCAAGGATCAGGTCGCCTATGCACTGGTCGAACGGATGGCCGAGGCGCTGGAGAAAGTGCACGAGGATGACTGA

Upstream 100 bases:

>100_bases
CGCTAGGCAAATCGTAACCATTACCTAGGAGGACTTTCGCGCGATTGCGCGCGCGGCTAGGCTGCGAGCGGTTAGGCAAG
GCTGCATGAAGGGGAAAACT

Downstream 100 bases:

>100_bases
CACAAGCGCTCAAGTGGCCGCAGGCGGTAGCGCGCACGAAGTCCCCGTGCAGTTGAAACGCCTGCCGAACGGCCATGGCT
TGCCGCTCCCCGAATACGCC

Product: CoaB, phosphopantothenoylcysteinedecarboxylase/phosphopantothena te--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MASEAGPKILLVIGGGIAAYKSCELVRLIRKQGGSVTCVLTGGGAKFVTPMALAALSENEVHTTLWDLRNEVEMGHIQLS
READLVVVCPATANMLAKMAAGIADDLATTLLLATDKPVMVAPAMNVKMWQHDATQMNVERLRAAGVHVIDPDEGAMACG
EFGPGRLREPEAIWNAMAEMFGAEAVEEKEPAALAPVPEIEVLEPEPEPEPESRGMLGGLLSSIIPRTTPKRSVEEIEAQ
WEEPEEFETEPDTEVAEEEEANQGATDDAPIAGAGPLLATKGKANSAPPTDAEAINHTVATGTGAQKPEPIDEDGPLVEE
EPLEGNPLDGQPAFDTEPEHRPLFGKHVLVTAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGARVTLVAGPVHLQTP
RGVDRINVESAREMADEVRNALPADIAVMVAAVADWRTKDFADQKMKKRGSAPPALLLEENPDILTNLSAGKKRPTLVIG
FAAETQDVIENARSKRKRKGADWIVANDVSGDVMGGDLNDVHIVTSRGVEDLPEMPKDQVAYALVERMAEALEKVHEDD

Sequences:

>Translated_559_residues
MASEAGPKILLVIGGGIAAYKSCELVRLIRKQGGSVTCVLTGGGAKFVTPMALAALSENEVHTTLWDLRNEVEMGHIQLS
READLVVVCPATANMLAKMAAGIADDLATTLLLATDKPVMVAPAMNVKMWQHDATQMNVERLRAAGVHVIDPDEGAMACG
EFGPGRLREPEAIWNAMAEMFGAEAVEEKEPAALAPVPEIEVLEPEPEPEPESRGMLGGLLSSIIPRTTPKRSVEEIEAQ
WEEPEEFETEPDTEVAEEEEANQGATDDAPIAGAGPLLATKGKANSAPPTDAEAINHTVATGTGAQKPEPIDEDGPLVEE
EPLEGNPLDGQPAFDTEPEHRPLFGKHVLVTAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGARVTLVAGPVHLQTP
RGVDRINVESAREMADEVRNALPADIAVMVAAVADWRTKDFADQKMKKRGSAPPALLLEENPDILTNLSAGKKRPTLVIG
FAAETQDVIENARSKRKRKGADWIVANDVSGDVMGGDLNDVHIVTSRGVEDLPEMPKDQVAYALVERMAEALEKVHEDD
>Mature_558_residues
ASEAGPKILLVIGGGIAAYKSCELVRLIRKQGGSVTCVLTGGGAKFVTPMALAALSENEVHTTLWDLRNEVEMGHIQLSR
EADLVVVCPATANMLAKMAAGIADDLATTLLLATDKPVMVAPAMNVKMWQHDATQMNVERLRAAGVHVIDPDEGAMACGE
FGPGRLREPEAIWNAMAEMFGAEAVEEKEPAALAPVPEIEVLEPEPEPEPESRGMLGGLLSSIIPRTTPKRSVEEIEAQW
EEPEEFETEPDTEVAEEEEANQGATDDAPIAGAGPLLATKGKANSAPPTDAEAINHTVATGTGAQKPEPIDEDGPLVEEE
PLEGNPLDGQPAFDTEPEHRPLFGKHVLVTAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGARVTLVAGPVHLQTPR
GVDRINVESAREMADEVRNALPADIAVMVAAVADWRTKDFADQKMKKRGSAPPALLLEENPDILTNLSAGKKRPTLVIGF
AAETQDVIENARSKRKRKGADWIVANDVSGDVMGGDLNDVHIVTSRGVEDLPEMPKDQVAYALVERMAEALEKVHEDD

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=33.8983050847458, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87082301, Length=179, Percent_Identity=46.3687150837989, Blast_Score=160, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=30.4093567251462, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24657262, Length=108, Percent_Identity=37.037037037037, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 59522; Mature: 59391

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEAGPKILLVIGGGIAAYKSCELVRLIRKQGGSVTCVLTGGGAKFVTPMALAALSENE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCC
VHTTLWDLRNEVEMGHIQLSREADLVVVCPATANMLAKMAAGIADDLATTLLLATDKPVM
HHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCEE
VAPAMNVKMWQHDATQMNVERLRAAGVHVIDPDEGAMACGEFGPGRLREPEAIWNAMAEM
EECCCCEEEECCCHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHH
FGAEAVEEKEPAALAPVPEIEVLEPEPEPEPESRGMLGGLLSSIIPRTTPKRSVEEIEAQ
HCCHHHHCCCCCCCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHCCCCCCHHHHHHHHHH
WEEPEEFETEPDTEVAEEEEANQGATDDAPIAGAGPLLATKGKANSAPPTDAEAINHTVA
CCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHCCEEE
TGTGAQKPEPIDEDGPLVEEEPLEGNPLDGQPAFDTEPEHRPLFGKHVLVTAGPTHEPID
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
PVRYIANRSSGKQGFAIAAAAAAAGARVTLVAGPVHLQTPRGVDRINVESAREMADEVRN
HHHHHHCCCCCCCCEEEEHHHHHCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHH
ALPADIAVMVAAVADWRTKDFADQKMKKRGSAPPALLLEENPDILTNLSAGKKRPTLVIG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCEEEEE
FAAETQDVIENARSKRKRKGADWIVANDVSGDVMGGDLNDVHIVTSRGVEDLPEMPKDQV
ECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHCCCHHHH
AYALVERMAEALEKVHEDD
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASEAGPKILLVIGGGIAAYKSCELVRLIRKQGGSVTCVLTGGGAKFVTPMALAALSENE
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCC
VHTTLWDLRNEVEMGHIQLSREADLVVVCPATANMLAKMAAGIADDLATTLLLATDKPVM
HHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEECCCCEE
VAPAMNVKMWQHDATQMNVERLRAAGVHVIDPDEGAMACGEFGPGRLREPEAIWNAMAEM
EECCCCEEEECCCHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHH
FGAEAVEEKEPAALAPVPEIEVLEPEPEPEPESRGMLGGLLSSIIPRTTPKRSVEEIEAQ
HCCHHHHCCCCCCCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHCCCCCCHHHHHHHHHH
WEEPEEFETEPDTEVAEEEEANQGATDDAPIAGAGPLLATKGKANSAPPTDAEAINHTVA
CCCCHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHCCEEE
TGTGAQKPEPIDEDGPLVEEEPLEGNPLDGQPAFDTEPEHRPLFGKHVLVTAGPTHEPID
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
PVRYIANRSSGKQGFAIAAAAAAAGARVTLVAGPVHLQTPRGVDRINVESAREMADEVRN
HHHHHHCCCCCCCCEEEEHHHHHCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHH
ALPADIAVMVAAVADWRTKDFADQKMKKRGSAPPALLLEENPDILTNLSAGKKRPTLVIG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCEEEEE
FAAETQDVIENARSKRKRKGADWIVANDVSGDVMGGDLNDVHIVTSRGVEDLPEMPKDQV
ECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHCCCHHHH
AYALVERMAEALEKVHEDD
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]