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The map label for this gene is gcvPA

Identifier: 85374840

GI number: 85374840

Start: 2042491

End: 2043852

Strand: Reverse

Name: gcvPA

Synonym: ELI_10065

Alternate gene names: 85374840

Gene position: 2043852-2042491 (Counterclockwise)

Preceding gene: 85374841

Following gene: 85374839

Centisome position: 66.96

GC content: 64.17

Gene sequence:

>1362_bases
ATGCGTTACCTACCCCTGACCGATACCGATCGCAGCGAGATGCTCAGCGTCGTCGGCGCGTCCTCAATCGACGACCTGTT
CGTGGACGTGCCCAAAGAGGCGCGGCTCGACGGGCCGATCCGCGATCTGCCGATGCATGCCAGCGAAATGGCGGTCGAAA
AGCACATGCGGGCGCGGGCGGCGAAAAATCTCGTCGCAGGTGACGTGCCGTTTTTCCTCGGGGCCGGGGCCTATCGCCAC
CACGTGCCGGCCAGCGTCGACCACATCATCCAGCGCGGTGAATTCCTGACCGCCTACACGCCCTACCAGCCGGAAATCGC
GCAGGGCACGCTGCAGATGCTGTTCGAATTCCAGACGCAGGTCGCCAAGCTCTATGGCTGCGAAGTCGCCAATGCCTCGA
TGTACGATGGCTCGACCGCATGCTGGGAGGCGATCAGCATGGCCAGCCGCGTAACCAAGCGGAACCGCGCGGTGCTGTCG
GGCGCGCTCCACCCGCATTATTCCGAAGTCGCCAAGACCATGGCGAAATATCTCGGCCTCGAAATCGCCGACGCGCAGCC
CGCCATCCAGGCGGCACCGGACAATGCCGGCCTAACCTCGCGGATCGACGAGAACACCTCCTGCGTCGTCGTGCAGTATC
CCGATATTCTCGGCCGCATTGCCGACCTCACCGAAATCGCCGAAGCGGCCCATGCCAAGGGCGCGCTGTTGATCGTCGTC
AACACCGAGCCGGTGGCGCTTGGCGCGATAAAGTCGCCGGGAGAGATGGGCGCGGATATCGTAGTGGGGGAAGGCCAGTC
ACTCGGGGTCGGCCTGCAATTCGGAGGGCCTTATCTCGGCCTCTTCGCGGTGCGCGACAAGAAGCACGTGCGCCAGATGC
CGGGCCGCCTGTGCGGCGAGACCGTCGATGCCGAGGGCAAACGTGGCTTCGTCCTGACGCTCTCGACCCGCGAGCAACAT
ATCCGCCGCGAGAAAGCGACCTCCAATATCTGCACCAACAGCGGCCTGTGCGCGCTTGCCTTCAGTGTCCATATGACCTT
GCTCGGCGAGGTCGGATTGCGACGGCTGGCGGCTGAGAACCACCGGTTGGCCTGCTTGACGGCGGACCGGCTGGCAAAAG
TGCCGGGCGTCACTGTGCTCAACGATACGTTCTTCAACGAATTCACGATCCAGGTCGGGCAGGATGCGCGTGAAATTGTG
CGCACCCTCGCCGACAAGGGCGTGCTCGCAGGCGTCTCGCTCGGGCGGCTCTATCCCGATGTCGAGCGGCTGTCCGATGC
GCTCATCGTCGCAACGACCGAAACCACGAGCGAGGACGACATCGAAGCCCTCGGCTCCGCTCTCGAGGAGGTGCTGGCAT
GA

Upstream 100 bases:

>100_bases
AACTTTAACCGTTATCCCAGCGCAAGCTGGGATATCTGTCCGCCTTATCGGACATCACTGCAACAGATCCCAGCGTCCGC
TGGGATGACGAGATGGCACC

Downstream 100 bases:

>100_bases
ACGCGCCGAACGCATCGGGCTGGAAGCCCGCCATGGTCCCCGCAGGCGAAGATGGCCTCCATAACGGTCCGGCCACCACC
ACCGGCAACCGCGCTCTGAT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRYLPLTDTDRSEMLSVVGASSIDDLFVDVPKEARLDGPIRDLPMHASEMAVEKHMRARAAKNLVAGDVPFFLGAGAYRH
HVPASVDHIIQRGEFLTAYTPYQPEIAQGTLQMLFEFQTQVAKLYGCEVANASMYDGSTACWEAISMASRVTKRNRAVLS
GALHPHYSEVAKTMAKYLGLEIADAQPAIQAAPDNAGLTSRIDENTSCVVVQYPDILGRIADLTEIAEAAHAKGALLIVV
NTEPVALGAIKSPGEMGADIVVGEGQSLGVGLQFGGPYLGLFAVRDKKHVRQMPGRLCGETVDAEGKRGFVLTLSTREQH
IRREKATSNICTNSGLCALAFSVHMTLLGEVGLRRLAAENHRLACLTADRLAKVPGVTVLNDTFFNEFTIQVGQDAREIV
RTLADKGVLAGVSLGRLYPDVERLSDALIVATTETTSEDDIEALGSALEEVLA

Sequences:

>Translated_453_residues
MRYLPLTDTDRSEMLSVVGASSIDDLFVDVPKEARLDGPIRDLPMHASEMAVEKHMRARAAKNLVAGDVPFFLGAGAYRH
HVPASVDHIIQRGEFLTAYTPYQPEIAQGTLQMLFEFQTQVAKLYGCEVANASMYDGSTACWEAISMASRVTKRNRAVLS
GALHPHYSEVAKTMAKYLGLEIADAQPAIQAAPDNAGLTSRIDENTSCVVVQYPDILGRIADLTEIAEAAHAKGALLIVV
NTEPVALGAIKSPGEMGADIVVGEGQSLGVGLQFGGPYLGLFAVRDKKHVRQMPGRLCGETVDAEGKRGFVLTLSTREQH
IRREKATSNICTNSGLCALAFSVHMTLLGEVGLRRLAAENHRLACLTADRLAKVPGVTVLNDTFFNEFTIQVGQDAREIV
RTLADKGVLAGVSLGRLYPDVERLSDALIVATTETTSEDDIEALGSALEEVLA
>Mature_453_residues
MRYLPLTDTDRSEMLSVVGASSIDDLFVDVPKEARLDGPIRDLPMHASEMAVEKHMRARAAKNLVAGDVPFFLGAGAYRH
HVPASVDHIIQRGEFLTAYTPYQPEIAQGTLQMLFEFQTQVAKLYGCEVANASMYDGSTACWEAISMASRVTKRNRAVLS
GALHPHYSEVAKTMAKYLGLEIADAQPAIQAAPDNAGLTSRIDENTSCVVVQYPDILGRIADLTEIAEAAHAKGALLIVV
NTEPVALGAIKSPGEMGADIVVGEGQSLGVGLQFGGPYLGLFAVRDKKHVRQMPGRLCGETVDAEGKRGFVLTLSTREQH
IRREKATSNICTNSGLCALAFSVHMTLLGEVGLRRLAAENHRLACLTADRLAKVPGVTVLNDTFFNEFTIQVGQDAREIV
RTLADKGVLAGVSLGRLYPDVERLSDALIVATTETTSEDDIEALGSALEEVLA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=446, Percent_Identity=35.4260089686099, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI1789269, Length=401, Percent_Identity=33.6658354114713, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535605, Length=393, Percent_Identity=36.1323155216285, Blast_Score=215, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323843, Length=459, Percent_Identity=32.8976034858388, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24645648, Length=394, Percent_Identity=37.5634517766497, Blast_Score=223, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_ERYLH (Q2N886)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458902.1
- ProteinModelPortal:   Q2N886
- SMR:   Q2N886
- STRING:   Q2N886
- GeneID:   3870006
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_10065
- NMPDR:   fig|314225.3.peg.1021
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   ELIT314225:ELI_10065-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48757; Mature: 48757

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPLTDTDRSEMLSVVGASSIDDLFVDVPKEARLDGPIRDLPMHASEMAVEKHMRARA
CCCCCCCCCCHHHHHHHHCCCCCCHHHEECCCHHCCCCCCHHCCCCHHHHHHHHHHHHHH
AKNLVAGDVPFFLGAGAYRHHVPASVDHIIQRGEFLTAYTPYQPEIAQGTLQMLFEFQTQ
HHHHHCCCCCHHHCCCCHHCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
VAKLYGCEVANASMYDGSTACWEAISMASRVTKRNRAVLSGALHPHYSEVAKTMAKYLGL
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
EIADAQPAIQAAPDNAGLTSRIDENTSCVVVQYPDILGRIADLTEIAEAAHAKGALLIVV
EEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEE
NTEPVALGAIKSPGEMGADIVVGEGQSLGVGLQFGGPYLGLFAVRDKKHVRQMPGRLCGE
CCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEECCCEEEEEEECCHHHHHHCCHHHCCC
TVDAEGKRGFVLTLSTREQHIRREKATSNICTNSGLCALAFSVHMTLLGEVGLRRLAAEN
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HRLACLTADRLAKVPGVTVLNDTFFNEFTIQVGQDAREIVRTLADKGVLAGVSLGRLYPD
CEEEEEEHHHHHHCCCCEEEECCCCCEEEEEECCCHHHHHHHHHCCCEEECCHHHHCCCC
VERLSDALIVATTETTSEDDIEALGSALEEVLA
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRYLPLTDTDRSEMLSVVGASSIDDLFVDVPKEARLDGPIRDLPMHASEMAVEKHMRARA
CCCCCCCCCCHHHHHHHHCCCCCCHHHEECCCHHCCCCCCHHCCCCHHHHHHHHHHHHHH
AKNLVAGDVPFFLGAGAYRHHVPASVDHIIQRGEFLTAYTPYQPEIAQGTLQMLFEFQTQ
HHHHHCCCCCHHHCCCCHHCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
VAKLYGCEVANASMYDGSTACWEAISMASRVTKRNRAVLSGALHPHYSEVAKTMAKYLGL
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
EIADAQPAIQAAPDNAGLTSRIDENTSCVVVQYPDILGRIADLTEIAEAAHAKGALLIVV
EEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEEE
NTEPVALGAIKSPGEMGADIVVGEGQSLGVGLQFGGPYLGLFAVRDKKHVRQMPGRLCGE
CCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEECCCEEEEEEECCHHHHHHCCHHHCCC
TVDAEGKRGFVLTLSTREQHIRREKATSNICTNSGLCALAFSVHMTLLGEVGLRRLAAEN
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HRLACLTADRLAKVPGVTVLNDTFFNEFTIQVGQDAREIVRTLADKGVLAGVSLGRLYPD
CEEEEEEHHHHHHCCCCEEEECCCCCEEEEEECCCHHHHHHHHHCCCEEECCHHHHCCCC
VERLSDALIVATTETTSEDDIEALGSALEEVLA
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA