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The map label for this gene is gcvPB [H]

Identifier: 85374839

GI number: 85374839

Start: 2040863

End: 2042494

Strand: Reverse

Name: gcvPB [H]

Synonym: ELI_10060

Alternate gene names: 85374839

Gene position: 2042494-2040863 (Counterclockwise)

Preceding gene: 85374840

Following gene: 85374825

Centisome position: 66.91

GC content: 64.4

Gene sequence:

>1632_bases
ATGAACGCGCCGAACGCATCGGGCTGGAAGCCCGCCATGGTCCCCGCAGGCGAAGATGGCCTCCATAACGGTCCGGCCAC
CACCACCGGCAACCGCGCTCTGATGCTGGAGGAACCGCTGTTGTTCGAGATCGGTCATGCCGAAACGACCGGCGTCGACC
TGCCGGAGAATTCAGGCGAAAGTTCGTCACGCCTCGGTGGGTTGGATCGATCCGAGCCTATCGGCCTCGTCGGCCTGACC
GAACCGGAAACGGTGCGCCATTACACGCGCCTCAGCAGGCAAAACTACGGCATCGACCTCGGGCTCTTCCCGCTCGGCAG
CTGTACGATGAAACACAATCCGCGCCTCAACGAGAAGGTCGCGCGGATGCCGGGATTTGCCGATATCCATCCGCTGCAAC
CCGTGGCCACGGTGCGCGGCGCGCTGGAAGTCATCAACGAACTGGCATTCTGGCTGATCGACCTCACCGGCATGCACGGC
GTGGCGATGAGCCCCAAGGCGGGCGCGCATGGCGAACTGTGTGGCATATTGTGCATCCGCGCCGCGCTGGAGGCGCGCGG
GGACGCGCGCGAAGTGATCCTGGTGCCCGAAAGCGCGCATGGCACCAATCCGGCGACCGCCGCCTTTGCCGGCTACAAGG
TCGAGGATATCCCGGCGACGCCGGAGGGCCGTGTGGACCTCGACGCGTTGAAAAAGCGCCTTGGACCCGACGTGGCCGGG
GTGATGATCACCAATCCCAATACGTGCGGGCTGTTCGAACGCGACATGAAGGCGATTTCGGATGCGGTCCACGAAGCGGG
CGGCTTCGTCTATTGCGACGGCGCGAACTTCAACGCCATCGTCGGCAAGGTGCGGCCGGGCGATCTCGGCGTCGATGCCA
TGCACATCAACCTGCACAAGACGTTCTCCACTCCGCATGGCGGCGGCGGACCGGGCAGCGGGCCCGTGGTGCTCAGCGAA
GCCCTCTCGCCCTTCGGGCCCTTGCCCTACACCGCCCGCACCAAAGACGGCGTGGTGCATCTCATCGAAGAAGAAGATGC
CGAGAGATTTTCGCAGGAACATTTCGACGGGCGGATGCAGCATTTCGGGCGCATGACCGCGTTCCACGGACAGATGGGCA
TGTTCACCCGCGCGCTCAGCTACATCCTCAGCCATGGGGCCGACGGGTTGAAGCAGGTCGCGGAAGACGCGGTCCTCAAT
GCCAATTACGTGCTGCGTAGCCTCGAAGACGTGCTCGACGCGCCCTTCGGCAAGTCGGGGCCGTGCATGCACGAAGCGCT
CTTTAGCGATAGAGGCTTTACGGGCGACCTTTCCACACTCGATCTTGCCAAAGGTCTGATCGACGAAGGCTATCACCCGA
TGACGGTGTACTTCCCGCTCGTGGTGCACGGCGCAATGCTGGTCGAGCCGACCGAGACCGAAAGCAAGGCCGCGCTCGAC
CAGTTCATCACAGCTTTTCGCTCGGTCGCCGAGCGGGCCAAGGCGGGCGATGAGAGCTTGAAGGAAGCACCCTACTACGC
CCCGCGCAGGCGTCTCGACGAAACGCAGGCCGCGCGCAAGCCGATGCTGGCGTGGCAGGGGGAGACCGCGCCGGCGGGTA
AGCCGACGATGACGGAACAGGGCGGGAGCTAA

Upstream 100 bases:

>100_bases
ATGTCGAGCGGCTGTCCGATGCGCTCATCGTCGCAACGACCGAAACCACGAGCGAGGACGACATCGAAGCCCTCGGCTCC
GCTCTCGAGGAGGTGCTGGC

Downstream 100 bases:

>100_bases
CGCCTACTTGGCTGCGCGCGTTTCGCGCTCGTCGTCGCCGTCGACTTCGATGCGGATGCCCTGCTGGCCGAGGATCGCGA
CCCAGAAGCCGATCACGGCG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MNAPNASGWKPAMVPAGEDGLHNGPATTTGNRALMLEEPLLFEIGHAETTGVDLPENSGESSSRLGGLDRSEPIGLVGLT
EPETVRHYTRLSRQNYGIDLGLFPLGSCTMKHNPRLNEKVARMPGFADIHPLQPVATVRGALEVINELAFWLIDLTGMHG
VAMSPKAGAHGELCGILCIRAALEARGDAREVILVPESAHGTNPATAAFAGYKVEDIPATPEGRVDLDALKKRLGPDVAG
VMITNPNTCGLFERDMKAISDAVHEAGGFVYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPVVLSE
ALSPFGPLPYTARTKDGVVHLIEEEDAERFSQEHFDGRMQHFGRMTAFHGQMGMFTRALSYILSHGADGLKQVAEDAVLN
ANYVLRSLEDVLDAPFGKSGPCMHEALFSDRGFTGDLSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAALD
QFITAFRSVAERAKAGDESLKEAPYYAPRRRLDETQAARKPMLAWQGETAPAGKPTMTEQGGS

Sequences:

>Translated_543_residues
MNAPNASGWKPAMVPAGEDGLHNGPATTTGNRALMLEEPLLFEIGHAETTGVDLPENSGESSSRLGGLDRSEPIGLVGLT
EPETVRHYTRLSRQNYGIDLGLFPLGSCTMKHNPRLNEKVARMPGFADIHPLQPVATVRGALEVINELAFWLIDLTGMHG
VAMSPKAGAHGELCGILCIRAALEARGDAREVILVPESAHGTNPATAAFAGYKVEDIPATPEGRVDLDALKKRLGPDVAG
VMITNPNTCGLFERDMKAISDAVHEAGGFVYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPVVLSE
ALSPFGPLPYTARTKDGVVHLIEEEDAERFSQEHFDGRMQHFGRMTAFHGQMGMFTRALSYILSHGADGLKQVAEDAVLN
ANYVLRSLEDVLDAPFGKSGPCMHEALFSDRGFTGDLSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAALD
QFITAFRSVAERAKAGDESLKEAPYYAPRRRLDETQAARKPMLAWQGETAPAGKPTMTEQGGS
>Mature_543_residues
MNAPNASGWKPAMVPAGEDGLHNGPATTTGNRALMLEEPLLFEIGHAETTGVDLPENSGESSSRLGGLDRSEPIGLVGLT
EPETVRHYTRLSRQNYGIDLGLFPLGSCTMKHNPRLNEKVARMPGFADIHPLQPVATVRGALEVINELAFWLIDLTGMHG
VAMSPKAGAHGELCGILCIRAALEARGDAREVILVPESAHGTNPATAAFAGYKVEDIPATPEGRVDLDALKKRLGPDVAG
VMITNPNTCGLFERDMKAISDAVHEAGGFVYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPVVLSE
ALSPFGPLPYTARTKDGVVHLIEEEDAERFSQEHFDGRMQHFGRMTAFHGQMGMFTRALSYILSHGADGLKQVAEDAVLN
ANYVLRSLEDVLDAPFGKSGPCMHEALFSDRGFTGDLSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAALD
QFITAFRSVAERAKAGDESLKEAPYYAPRRRLDETQAARKPMLAWQGETAPAGKPTMTEQGGS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=420, Percent_Identity=38.8095238095238, Blast_Score=242, Evalue=5e-64,
Organism=Escherichia coli, GI1789269, Length=436, Percent_Identity=38.302752293578, Blast_Score=257, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17535605, Length=446, Percent_Identity=34.7533632286996, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI32564013, Length=381, Percent_Identity=35.9580052493438, Blast_Score=211, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6323843, Length=441, Percent_Identity=37.6417233560091, Blast_Score=243, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24645648, Length=453, Percent_Identity=36.8653421633554, Blast_Score=226, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 58079; Mature: 58079

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPNASGWKPAMVPAGEDGLHNGPATTTGNRALMLEEPLLFEIGHAETTGVDLPENSGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCC
SSSRLGGLDRSEPIGLVGLTEPETVRHYTRLSRQNYGIDLGLFPLGSCTMKHNPRLNEKV
CHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHH
ARMPGFADIHPLQPVATVRGALEVINELAFWLIDLTGMHGVAMSPKAGAHGELCGILCIR
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHH
AALEARGDAREVILVPESAHGTNPATAAFAGYKVEDIPATPEGRVDLDALKKRLGPDVAG
HHHHCCCCCCEEEEEECCCCCCCCCHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCEEE
VMITNPNTCGLFERDMKAISDAVHEAGGFVYCDGANFNAIVGKVRPGDLGVDAMHINLHK
EEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEE
TFSTPHGGGGPGSGPVVLSEALSPFGPLPYTARTKDGVVHLIEEEDAERFSQEHFDGRMQ
EECCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHH
HFGRMTAFHGQMGMFTRALSYILSHGADGLKQVAEDAVLNANYVLRSLEDVLDAPFGKSG
HHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PCMHEALFSDRGFTGDLSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAALD
CHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHCCEEEECCCCCHHHHHHH
QFITAFRSVAERAKAGDESLKEAPYYAPRRRLDETQAARKPMLAWQGETAPAGKPTMTEQ
HHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
GGS
CCC
>Mature Secondary Structure
MNAPNASGWKPAMVPAGEDGLHNGPATTTGNRALMLEEPLLFEIGHAETTGVDLPENSGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCC
SSSRLGGLDRSEPIGLVGLTEPETVRHYTRLSRQNYGIDLGLFPLGSCTMKHNPRLNEKV
CHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHH
ARMPGFADIHPLQPVATVRGALEVINELAFWLIDLTGMHGVAMSPKAGAHGELCGILCIR
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHH
AALEARGDAREVILVPESAHGTNPATAAFAGYKVEDIPATPEGRVDLDALKKRLGPDVAG
HHHHCCCCCCEEEEEECCCCCCCCCHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCEEE
VMITNPNTCGLFERDMKAISDAVHEAGGFVYCDGANFNAIVGKVRPGDLGVDAMHINLHK
EEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEE
TFSTPHGGGGPGSGPVVLSEALSPFGPLPYTARTKDGVVHLIEEEDAERFSQEHFDGRMQ
EECCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHH
HFGRMTAFHGQMGMFTRALSYILSHGADGLKQVAEDAVLNANYVLRSLEDVLDAPFGKSG
HHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PCMHEALFSDRGFTGDLSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAALD
CHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHCCEEEECCCCCHHHHHHH
QFITAFRSVAERAKAGDESLKEAPYYAPRRRLDETQAARKPMLAWQGETAPAGKPTMTEQ
HHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
GGS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]