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The map label for this gene is accC [H]

Identifier: 85374807

GI number: 85374807

Start: 2010385

End: 2012253

Strand: Direct

Name: accC [H]

Synonym: ELI_09900

Alternate gene names: 85374807

Gene position: 2010385-2012253 (Clockwise)

Preceding gene: 85374806

Following gene: 85374808

Centisome position: 65.86

GC content: 65.44

Gene sequence:

>1869_bases
ATGATTTCCAAGCTCCTCATCGCCAACAGAGGCGAGATCGCCTGCCGTATCATTCGCACCGCGCGCGAGATGGGTGTCGC
GACGGTCGCGGTCTATTCGGACGCCGATGCCAAGGCGCTGCATGTGCGCAGTGCCGACGAGGCGGTGCATATCGGCCCCT
CGCCCGCCGCCGAGAGCTATCTCGTGGGCGAGAAAATCATTGCGGCAGCGAAGAAGACCGGCGCCGAGGCGATCCATCCA
GGCTACGGCTTCCTGTCGGAGAATGCGGGCTTCGCGCAGGCCGTGATCGACGCGGGGCTGATCTGGGTCGGGCCCCCGCC
CGCCGCCATTGACGCGATGGGCCTCAAGGATGCCGCCAAGAAGCTGATGCGCGAGGCGGGCGTGCCGGTGACGCCCGGTT
ACGAGGGCGAGGACCAGTCGGTCGAACGGCTGAAGAAGGAAGCCGATGCGATCGGCTATCCGGTGTTGATCAAGGCGGTC
GCAGGCGGCGGCGGCAAGGGGATGCGCAAGGTCGATGCCGCGGCGGACTTCGTAGCGAGCCTCGAAAGCTGCCGGCGCGA
GGCCAAGGCGAGCTTCTCCAACGACGAGGTGCTGCTCGAAAAGTGGATCACCAGCCCCCGCCATATCGAGGTGCAGGTGT
TCGGCGACAGCCACGGCAATGTCGTCCACCTGTTCGAACGCGACTGCTCGTTGCAACGCCGCCACCAGAAGGTGATCGAG
GAAGCCCCCGCCCCCGGCATGGACGAGGCCACCCGCGAGGAAATCTGCGCCGCCGCCGTGCGCGCCGCCAAGGCGGTAGA
TTACGAAGGCGCAGGCACGATCGAATTCATCGCCGACGCCAGCGAAGGCCTGCGCGCCGACCGCATCTTCTTCATGGAAA
TGAACACGCGGCTTCAGGTCGAACACCCTGTAACCGAAGAGATCACCGGGGTCGATCTGGTGGAGTGGCAGCTGCGCGTA
GCGAGTGGTGAGCCGATCCCGCTGAAGCAGGAAGAGCTCTTCATCGACGGCCATTCGATCGAGGCGCGCCTCTATGCCGA
GGACCCCAATGGCGGCTTCCTGCCGTCGACCGGAAGGCTCGAGCATTTCAACCTCGGCCTGGAAGGCAGGATCGAGACCG
GCGTCGAGGAAGGCGACATGATATCGCCCTTTTACGATCCCATGGTCGCCAAGCTGGTGATTTGGGGCGAAACCCGCGCC
GAGGCCATCGATCAGCTCGCAGGCATCGCCGAAAGCGTCGAAATCTGGCCGGTGAAGACCAATGCCGCGTTCATCGCCAA
CTGCCTGCGCGACGAGGAGTTCGAAGAGGCGAACCTCGATACCGGCTTCATCGCTGCCAAGCTCGAGACGCTAGTCAGCT
CTGACGAGGCCGACGACGACATCTGGCAGAGCGCTGCCGATTTCATCGTGCTCGCCGACACCGAAGAACACGAGGCCCTG
CCCATCGGCCTGCGCCTCAATGCGCCCGGCGTGATTTCGACCACGCTCACCCACAAGGGCGAGATACGAAAGGTCAGCGC
CGCGCGTTCCGGCGCGCAAGCCTTTGCCACGGGCTTCGTCGACCCTGCACGCGCCGTGGTCTTCGCCGACGGTCAGAGCT
TCGCTTTCGAGCGCCAATCGCGAGGCTCTGGCGCGGCTGCGGCAGGCGACGGCGCAATCCTCGCGCCCATGCCGGGCAAG
GTCATCGCTCTCGATGTGGCCGAGGGGGATGCGGTTACTGCGGGTCAGCGGCTGATGGTGCTCGAGGCGATGAAGATGGA
ACACGCGCTCACCGCGCCCTTCGACGGGACCGTGGCAGAGCTTGCCGCCAGCGAAGGCGCGCAGGTGCAGGTCGAGGCGG
TGCTGTGCGTGGTGGAGCCTTCGGACTAG

Upstream 100 bases:

>100_bases
GCGACATTCCGGAACAGGAAATCAAGCCGCTGCCGGACGAGGAATAGCGGGCCGCCATAGCGACTTGCCGTAAGCGCATG
GCTGGCCTAGCCGTGCTGCC

Downstream 100 bases:

>100_bases
CGCTTCCGTCCAAAACCCGTTCGTGCTGAGCTTGTCGAAGCACTGCACTTTCTTCTAGCGCTGATCCCCGAAGTGAAAGA
CAGCCCTTCGACAAGCTCAG

Product: acetyl/propionyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MISKLLIANRGEIACRIIRTAREMGVATVAVYSDADAKALHVRSADEAVHIGPSPAAESYLVGEKIIAAAKKTGAEAIHP
GYGFLSENAGFAQAVIDAGLIWVGPPPAAIDAMGLKDAAKKLMREAGVPVTPGYEGEDQSVERLKKEADAIGYPVLIKAV
AGGGGKGMRKVDAAADFVASLESCRREAKASFSNDEVLLEKWITSPRHIEVQVFGDSHGNVVHLFERDCSLQRRHQKVIE
EAPAPGMDEATREEICAAAVRAAKAVDYEGAGTIEFIADASEGLRADRIFFMEMNTRLQVEHPVTEEITGVDLVEWQLRV
ASGEPIPLKQEELFIDGHSIEARLYAEDPNGGFLPSTGRLEHFNLGLEGRIETGVEEGDMISPFYDPMVAKLVIWGETRA
EAIDQLAGIAESVEIWPVKTNAAFIANCLRDEEFEEANLDTGFIAAKLETLVSSDEADDDIWQSAADFIVLADTEEHEAL
PIGLRLNAPGVISTTLTHKGEIRKVSAARSGAQAFATGFVDPARAVVFADGQSFAFERQSRGSGAAAAGDGAILAPMPGK
VIALDVAEGDAVTAGQRLMVLEAMKMEHALTAPFDGTVAELAASEGAQVQVEAVLCVVEPSD

Sequences:

>Translated_622_residues
MISKLLIANRGEIACRIIRTAREMGVATVAVYSDADAKALHVRSADEAVHIGPSPAAESYLVGEKIIAAAKKTGAEAIHP
GYGFLSENAGFAQAVIDAGLIWVGPPPAAIDAMGLKDAAKKLMREAGVPVTPGYEGEDQSVERLKKEADAIGYPVLIKAV
AGGGGKGMRKVDAAADFVASLESCRREAKASFSNDEVLLEKWITSPRHIEVQVFGDSHGNVVHLFERDCSLQRRHQKVIE
EAPAPGMDEATREEICAAAVRAAKAVDYEGAGTIEFIADASEGLRADRIFFMEMNTRLQVEHPVTEEITGVDLVEWQLRV
ASGEPIPLKQEELFIDGHSIEARLYAEDPNGGFLPSTGRLEHFNLGLEGRIETGVEEGDMISPFYDPMVAKLVIWGETRA
EAIDQLAGIAESVEIWPVKTNAAFIANCLRDEEFEEANLDTGFIAAKLETLVSSDEADDDIWQSAADFIVLADTEEHEAL
PIGLRLNAPGVISTTLTHKGEIRKVSAARSGAQAFATGFVDPARAVVFADGQSFAFERQSRGSGAAAAGDGAILAPMPGK
VIALDVAEGDAVTAGQRLMVLEAMKMEHALTAPFDGTVAELAASEGAQVQVEAVLCVVEPSD
>Mature_622_residues
MISKLLIANRGEIACRIIRTAREMGVATVAVYSDADAKALHVRSADEAVHIGPSPAAESYLVGEKIIAAAKKTGAEAIHP
GYGFLSENAGFAQAVIDAGLIWVGPPPAAIDAMGLKDAAKKLMREAGVPVTPGYEGEDQSVERLKKEADAIGYPVLIKAV
AGGGGKGMRKVDAAADFVASLESCRREAKASFSNDEVLLEKWITSPRHIEVQVFGDSHGNVVHLFERDCSLQRRHQKVIE
EAPAPGMDEATREEICAAAVRAAKAVDYEGAGTIEFIADASEGLRADRIFFMEMNTRLQVEHPVTEEITGVDLVEWQLRV
ASGEPIPLKQEELFIDGHSIEARLYAEDPNGGFLPSTGRLEHFNLGLEGRIETGVEEGDMISPFYDPMVAKLVIWGETRA
EAIDQLAGIAESVEIWPVKTNAAFIANCLRDEEFEEANLDTGFIAAKLETLVSSDEADDDIWQSAADFIVLADTEEHEAL
PIGLRLNAPGVISTTLTHKGEIRKVSAARSGAQAFATGFVDPARAVVFADGQSFAFERQSRGSGAAAAGDGAILAPMPGK
VIALDVAEGDAVTAGQRLMVLEAMKMEHALTAPFDGTVAELAASEGAQVQVEAVLCVVEPSD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=662, Percent_Identity=47.1299093655589, Blast_Score=562, Evalue=1e-160,
Organism=Homo sapiens, GI295821183, Length=629, Percent_Identity=38.9507154213037, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=47.085201793722, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=47.085201793722, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=43.6807095343681, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=43.6807095343681, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=43.6807095343681, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI38679977, Length=699, Percent_Identity=29.0414878397711, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679967, Length=699, Percent_Identity=29.0414878397711, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679971, Length=699, Percent_Identity=29.0414878397711, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI38679960, Length=699, Percent_Identity=29.0414878397711, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI38679974, Length=699, Percent_Identity=29.0414878397711, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI134142062, Length=725, Percent_Identity=27.8620689655172, Blast_Score=231, Evalue=2e-60,
Organism=Escherichia coli, GI1789654, Length=451, Percent_Identity=47.6718403547672, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=655, Percent_Identity=45.9541984732824, Blast_Score=523, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=46.5168539325843, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=43.0155210643016, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=28.515625, Blast_Score=208, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=28.515625, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI133931226, Length=498, Percent_Identity=29.5180722891566, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=43.7219730941704, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=480, Percent_Identity=41.6666666666667, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6321376, Length=480, Percent_Identity=41.875, Blast_Score=323, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6324343, Length=726, Percent_Identity=26.5840220385675, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=481, Percent_Identity=30.3534303534304, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24651757, Length=454, Percent_Identity=55.5066079295154, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651759, Length=416, Percent_Identity=53.8461538461538, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI281363050, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652224, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652222, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652220, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652218, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652212, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652210, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652214, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI19921944, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24652216, Length=455, Percent_Identity=45.2747252747253, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI161076409, Length=706, Percent_Identity=29.6033994334278, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586458, Length=706, Percent_Identity=29.6033994334278, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI161076407, Length=706, Percent_Identity=29.6033994334278, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586460, Length=706, Percent_Identity=29.6033994334278, Blast_Score=244, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 66265; Mature: 66265

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKLLIANRGEIACRIIRTAREMGVATVAVYSDADAKALHVRSADEAVHIGPSPAAESY
CCCCEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCHH
LVGEKIIAAAKKTGAEAIHPGYGFLSENAGFAQAVIDAGLIWVGPPPAAIDAMGLKDAAK
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCEEEECCCCHHHHHCCHHHHHH
KLMREAGVPVTPGYEGEDQSVERLKKEADAIGYPVLIKAVAGGGGKGMRKVDAAADFVAS
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
LESCRREAKASFSNDEVLLEKWITSPRHIEVQVFGDSHGNVVHLFERDCSLQRRHQKVIE
HHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAPAPGMDEATREEICAAAVRAAKAVDYEGAGTIEFIADASEGLRADRIFFMEMNTRLQV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEEECCEEEE
EHPVTEEITGVDLVEWQLRVASGEPIPLKQEELFIDGHSIEARLYAEDPNGGFLPSTGRL
CCCCCHHCCCCEEEEEEEEEECCCCCCCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCE
EHFNLGLEGRIETGVEEGDMISPFYDPMVAKLVIWGETRAEAIDQLAGIAESVEIWPVKT
EEECCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEC
NAAFIANCLRDEEFEEANLDTGFIAAKLETLVSSDEADDDIWQSAADFIVLADTEEHEAL
CHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCEEEEECCCCCCCE
PIGLRLNAPGVISTTLTHKGEIRKVSAARSGAQAFATGFVDPARAVVFADGQSFAFERQS
EEEEEECCCCEEEEEECCCCCCEEEHHHHCCHHHHHHCCCCCCCEEEEECCCCEEEEHHC
RGSGAAAAGDGAILAPMPGKVIALDVAEGDAVTAGQRLMVLEAMKMEHALTAPFDGTVAE
CCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCCCHHHH
LAASEGAQVQVEAVLCVVEPSD
HHHCCCCEEEEEEEEEEEECCC
>Mature Secondary Structure
MISKLLIANRGEIACRIIRTAREMGVATVAVYSDADAKALHVRSADEAVHIGPSPAAESY
CCCCEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCHH
LVGEKIIAAAKKTGAEAIHPGYGFLSENAGFAQAVIDAGLIWVGPPPAAIDAMGLKDAAK
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCEEEECCCCHHHHHCCHHHHHH
KLMREAGVPVTPGYEGEDQSVERLKKEADAIGYPVLIKAVAGGGGKGMRKVDAAADFVAS
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
LESCRREAKASFSNDEVLLEKWITSPRHIEVQVFGDSHGNVVHLFERDCSLQRRHQKVIE
HHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAPAPGMDEATREEICAAAVRAAKAVDYEGAGTIEFIADASEGLRADRIFFMEMNTRLQV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEEECCEEEE
EHPVTEEITGVDLVEWQLRVASGEPIPLKQEELFIDGHSIEARLYAEDPNGGFLPSTGRL
CCCCCHHCCCCEEEEEEEEEECCCCCCCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCE
EHFNLGLEGRIETGVEEGDMISPFYDPMVAKLVIWGETRAEAIDQLAGIAESVEIWPVKT
EEECCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCHHHHHHHHHHCCCCCCEEEEEEC
NAAFIANCLRDEEFEEANLDTGFIAAKLETLVSSDEADDDIWQSAADFIVLADTEEHEAL
CHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCEEEEECCCCCCCE
PIGLRLNAPGVISTTLTHKGEIRKVSAARSGAQAFATGFVDPARAVVFADGQSFAFERQS
EEEEEECCCCEEEEEECCCCCCEEEHHHHCCHHHHHHCCCCCCCEEEEECCCCEEEEHHC
RGSGAAAAGDGAILAPMPGKVIALDVAEGDAVTAGQRLMVLEAMKMEHALTAPFDGTVAE
CCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCCCHHHH
LAASEGAQVQVEAVLCVVEPSD
HHHCCCCEEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]