Click here to switch to the map view.

The map label for this gene is 85374808

Identifier: 85374808

GI number: 85374808

Start: 2012396

End: 2013940

Strand: Direct

Name: 85374808

Synonym: ELI_09905

Alternate gene names: NA

Gene position: 2012396-2013940 (Clockwise)

Preceding gene: 85374807

Following gene: 85374810

Centisome position: 65.93

GC content: 65.76

Gene sequence:

>1545_bases
ATGTCGTGGCAAGACGAGCTTGAAGAGCTGAAAAGGCGCGAAGCGCTCGCCGAGGAGATGGGCGGCCCCGAAAAGGTCGC
GCGCCAGCATTCACGCGGCAAGATGGATGCACGCGCGCGGCTGGCAGCCTTGGTCGACGACGGCAGCTTCCGCGAAATCG
GCAAGATCGCGGGCGTGGCGCGCTATGACGACAACGGCGATCTCGAAGCCATCACCCCCGCGCCATACCTGTTCGGCAAG
GCGCTCATCAATGGCCGCCCCGTCGTCGCCACGGCGGACGATTTCACCATTCGCGGCGGCGCGGCCGATGCCGGAATCAG
GCGCAAGATGCTGCAGGCCGAGCAGATGGCGCACGAGCTCAAGCTGCCCATCATCCGGATGATCGACGGCACCGGCGGCG
GCGGCTCGGTCAAGACGCTGGAACAGATCGGCGCGACCTATATCCCCGCGGTTCCGGGCTGGGGCGACGTGGTCAAGAAC
CTCGACACGGTGCCAGTCGTGGCGCTGGCGCTGGGACCGACCGCAGGCCTCGGTGCCGCGCGCATCGTCGCCAGCCATTA
TTCGATCATGGTCAAGGGATTGAGCCAGATCTTTGCCGCCGGTCCTGCCGTGGTCGACGGCCTTGGCGCAGCCTACAAAG
GCTCCGACGATCACCAGCAGGCGAAGGAAGAGCTGGGCGGCAGCGACATTCACACCCGCAACGGCGTGGTCGATGACGAA
GTCGGCTCCGAGGCCGAAGCCTTCGCCCGTGCACGGCATTTTCTCAGCTTCATGCCCGAACATGTCGGGCAATTGGCGCG
CCGGTCCAACTGCACAGATCCGGTGGACCGCCGCGAGGAAGCGCTGCTCAGCCTCGTGCCGCGCGAGGAGAAGCAGGTCT
ATTCGATGCGGCGATGCCTCGACATGGTGTTCGACCGGGGCACGGTGTTCGAAATCGGCCGCAACTGGGGCCGTGCCTGC
ATTACTGCCCTTGCCCGGCTCGATGGCTGGCCGGTCTTCGTGCTGGCGAGCGACCCCAGCTATCTCGGCGGATCGTGGGA
GGCCAAGACCAGCGAGAAGGTCGAACGCTTCGTCAAGCTCGCCGACCAGTTCCGCTTGCCCATCGTCCACCTCGTCGACA
ACCCCGGCTTCATGATCGGGCGCGAGGCGGAAATAGCGGGCACGATCCGCTACGGCGTGCAGGCGATGAACGCGGTCTAC
AAGGCCACCGTCCCGCTGGCCTCCATCGTCATGCGCCGCGCCTATGGCATTGCCGGCAGCGCGATGAGTAATGCCGAACG
CTACCAGTATCGCTATTGCTGGCCCTCGGGCGACTGGGGCAGCCTGCCCATCGCGGGCGGGCTGGAAGTGGCCTACAAGT
CGGAGCTGGAGGCCGCCGAGGACCCGGAGGCCGAACTGGAAGCTATCCGTGCACGGCTCGACAAAGTCACCTCGCCCTTC
CGCAGCGCCGAGCGCTTCAACGTCGAGGATATCATCGATCCGCGCGACACGCGGCCACTGCTGTGCGAATTCGCCGATCT
TGCCTGGAGACGGCTGGCTTCATAG

Upstream 100 bases:

>100_bases
CTGCACTTTCTTCTAGCGCTGATCCCCGAAGTGAAAGACAGCCCTTCGACAAGCTCAGGGCGAACGGTAATGGGTTTGCT
CAGCCCGAACGGAGATTGGG

Downstream 100 bases:

>100_bases
CGTGATCCCAGCGAAAGCTGGGATCTCAGTCAGTTTCGCTCGACTTGGAGGAGACAGATCCCAGCGTTCGCTGGGATGAC
GGACTCAGGCCTAGGGCCCC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MSWQDELEELKRREALAEEMGGPEKVARQHSRGKMDARARLAALVDDGSFREIGKIAGVARYDDNGDLEAITPAPYLFGK
ALINGRPVVATADDFTIRGGAADAGIRRKMLQAEQMAHELKLPIIRMIDGTGGGGSVKTLEQIGATYIPAVPGWGDVVKN
LDTVPVVALALGPTAGLGAARIVASHYSIMVKGLSQIFAAGPAVVDGLGAAYKGSDDHQQAKEELGGSDIHTRNGVVDDE
VGSEAEAFARARHFLSFMPEHVGQLARRSNCTDPVDRREEALLSLVPREEKQVYSMRRCLDMVFDRGTVFEIGRNWGRAC
ITALARLDGWPVFVLASDPSYLGGSWEAKTSEKVERFVKLADQFRLPIVHLVDNPGFMIGREAEIAGTIRYGVQAMNAVY
KATVPLASIVMRRAYGIAGSAMSNAERYQYRYCWPSGDWGSLPIAGGLEVAYKSELEAAEDPEAELEAIRARLDKVTSPF
RSAERFNVEDIIDPRDTRPLLCEFADLAWRRLAS

Sequences:

>Translated_514_residues
MSWQDELEELKRREALAEEMGGPEKVARQHSRGKMDARARLAALVDDGSFREIGKIAGVARYDDNGDLEAITPAPYLFGK
ALINGRPVVATADDFTIRGGAADAGIRRKMLQAEQMAHELKLPIIRMIDGTGGGGSVKTLEQIGATYIPAVPGWGDVVKN
LDTVPVVALALGPTAGLGAARIVASHYSIMVKGLSQIFAAGPAVVDGLGAAYKGSDDHQQAKEELGGSDIHTRNGVVDDE
VGSEAEAFARARHFLSFMPEHVGQLARRSNCTDPVDRREEALLSLVPREEKQVYSMRRCLDMVFDRGTVFEIGRNWGRAC
ITALARLDGWPVFVLASDPSYLGGSWEAKTSEKVERFVKLADQFRLPIVHLVDNPGFMIGREAEIAGTIRYGVQAMNAVY
KATVPLASIVMRRAYGIAGSAMSNAERYQYRYCWPSGDWGSLPIAGGLEVAYKSELEAAEDPEAELEAIRARLDKVTSPF
RSAERFNVEDIIDPRDTRPLLCEFADLAWRRLAS
>Mature_513_residues
SWQDELEELKRREALAEEMGGPEKVARQHSRGKMDARARLAALVDDGSFREIGKIAGVARYDDNGDLEAITPAPYLFGKA
LINGRPVVATADDFTIRGGAADAGIRRKMLQAEQMAHELKLPIIRMIDGTGGGGSVKTLEQIGATYIPAVPGWGDVVKNL
DTVPVVALALGPTAGLGAARIVASHYSIMVKGLSQIFAAGPAVVDGLGAAYKGSDDHQQAKEELGGSDIHTRNGVVDDEV
GSEAEAFARARHFLSFMPEHVGQLARRSNCTDPVDRREEALLSLVPREEKQVYSMRRCLDMVFDRGTVFEIGRNWGRACI
TALARLDGWPVFVLASDPSYLGGSWEAKTSEKVERFVKLADQFRLPIVHLVDNPGFMIGREAEIAGTIRYGVQAMNAVYK
ATVPLASIVMRRAYGIAGSAMSNAERYQYRYCWPSGDWGSLPIAGGLEVAYKSELEAAEDPEAELEAIRARLDKVTSPFR
SAERFNVEDIIDPRDTRPLLCEFADLAWRRLAS

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=526, Percent_Identity=30.2281368821293, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI295821216, Length=546, Percent_Identity=29.4871794871795, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI11545863, Length=509, Percent_Identity=25.3438113948919, Blast_Score=144, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147359, Length=504, Percent_Identity=29.1666666666667, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI25147362, Length=504, Percent_Identity=29.1666666666667, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17552936, Length=515, Percent_Identity=27.9611650485437, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24586065, Length=516, Percent_Identity=26.5503875968992, Blast_Score=149, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56122; Mature: 55991

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQDELEELKRREALAEEMGGPEKVARQHSRGKMDARARLAALVDDGSFREIGKIAGVA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCEE
RYDDNGDLEAITPAPYLFGKALINGRPVVATADDFTIRGGAADAGIRRKMLQAEQMAHEL
EECCCCCEEEECCCHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHH
KLPIIRMIDGTGGGGSVKTLEQIGATYIPAVPGWGDVVKNLDTVPVVALALGPTAGLGAA
CCCEEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHCCCCHHHHHHEECCCCCCHHH
RIVASHYSIMVKGLSQIFAAGPAVVDGLGAAYKGSDDHQQAKEELGGSDIHTRNGVVDDE
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VGSEAEAFARARHFLSFMPEHVGQLARRSNCTDPVDRREEALLSLVPREEKQVYSMRRCL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
DMVFDRGTVFEIGRNWGRACITALARLDGWPVFVLASDPSYLGGSWEAKTSEKVERFVKL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ADQFRLPIVHLVDNPGFMIGREAEIAGTIRYGVQAMNAVYKATVPLASIVMRRAYGIAGS
HHHHCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AMSNAERYQYRYCWPSGDWGSLPIAGGLEVAYKSELEAAEDPEAELEAIRARLDKVTSPF
HHCCHHHCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RSAERFNVEDIIDPRDTRPLLCEFADLAWRRLAS
HHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWQDELEELKRREALAEEMGGPEKVARQHSRGKMDARARLAALVDDGSFREIGKIAGVA
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCEE
RYDDNGDLEAITPAPYLFGKALINGRPVVATADDFTIRGGAADAGIRRKMLQAEQMAHEL
EECCCCCEEEECCCHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHH
KLPIIRMIDGTGGGGSVKTLEQIGATYIPAVPGWGDVVKNLDTVPVVALALGPTAGLGAA
CCCEEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHCCCCHHHHHHEECCCCCCHHH
RIVASHYSIMVKGLSQIFAAGPAVVDGLGAAYKGSDDHQQAKEELGGSDIHTRNGVVDDE
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VGSEAEAFARARHFLSFMPEHVGQLARRSNCTDPVDRREEALLSLVPREEKQVYSMRRCL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
DMVFDRGTVFEIGRNWGRACITALARLDGWPVFVLASDPSYLGGSWEAKTSEKVERFVKL
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ADQFRLPIVHLVDNPGFMIGREAEIAGTIRYGVQAMNAVYKATVPLASIVMRRAYGIAGS
HHHHCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AMSNAERYQYRYCWPSGDWGSLPIAGGLEVAYKSELEAAEDPEAELEAIRARLDKVTSPF
HHCCHHHCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RSAERFNVEDIIDPRDTRPLLCEFADLAWRRLAS
HHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]