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The map label for this gene is pdxA

Identifier: 85374606

GI number: 85374606

Start: 1811479

End: 1812489

Strand: Direct

Name: pdxA

Synonym: ELI_08895

Alternate gene names: 85374606

Gene position: 1811479-1812489 (Clockwise)

Preceding gene: 85374605

Following gene: 85374607

Centisome position: 59.35

GC content: 66.17

Gene sequence:

>1011_bases
GTGGGCGAGCCGCAGCGCCCGCTCGCCGTTTCGCTGGGTGATCCGGCCGGCATCGGACCGGAAATCATCGTCCATGCCTG
GCGCATGCGCGATTCCGCAAATTTAGCACCGTTTGCGGTGGCGGGCGGTGCGAATGTTCTGCGCTCAGCGACGGAAGCGC
TGGGCGTTCCATGCCCCATCCAAGAGATTGACGATATCGCTGAGGCGAACTCCGCTTTCCTGGAGGCGTTGCCGGTGATC
AAGGGGCTGGATGGAGCCTACCTCCCCGGCGCGCCTGACCCGATCGGCGCCAAACTGGCTCTGAAATCGCTCGAAATGGC
GACCAGGCTTGCCACCGCTGGCCACGCTTCGGGGGTCGTGACCGCCCCCATCGCCAAGGGTCTGCTCGAACAGGTCGGTT
TCACCCATCCCGGCCAGACCGAATTTCTCGCCGCCGCCTGCGGGCTGCCGGAAGATGCATCAGTGATGATGCTCGCCGGG
CCGAGCCTGCGGGCCGTGCCGCTCACCGTCCATTGTCCCCTCGCCGAGGTTCCCGGCCTGCTCAGCATCGGCCTGATCGT
CGAACGCGGACGGATTGTCGCTTCGGCCTTGCAGCGCGATTTCGGCATTGAGCGTCCCAGACTGGCGGTCACCGGTCTCA
ATCCGCATGCGGGCGAGGACGGCAAGTTCGGCAACGAGGAGCAGGACGTTATCGCCCCCGCCATCGCCGAACTGCTCGCA
GACGGCATCACCGCGACCGGCCCGCATCCGGCCGACGCATTGTTCAGCCCGCACAGCCGGGCGGGCTTTGATGCGGCGCT
ATGCATGTATCATGACCAGGCGCTGATCCCGGTGAAGGCGCTCGATTTCGACCAGGGGGTCAATGTGACGCTGGGCTTGC
CGATCGTCCGCACCAGCCCGGACCATGGAACAGCCTTCGACATTGCCGGACGCGGCACCGCGCATCCGGGCGCCATGGTT
TTCGCTTTGCTCATGGCAGGCGAATGCGCAGCGCGCCGGGCCGATGCCTGA

Upstream 100 bases:

>100_bases
GTTCTGATGAGCCGGATGGAAGAGGAGCGCATCCAGAAGCGCGCCCGCCGTTACCTGCGCGATCTGCGCAACGACGCCTA
TATCGAGTACAACTGAGCGG

Downstream 100 bases:

>100_bases
GCTTCCGCCGCTGCGCGACGTCATCGCGAAACATGGCCTCTCCGCCTCGAAGGCGCTGGGGCAGAACTTCCTGTTCGATG
CGCAATTGCTCGACCGCATC

Product: pyridoxal phosphate biosynthesis protein

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MGEPQRPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPIQEIDDIAEANSAFLEALPVI
KGLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHASGVVTAPIAKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAG
PSLRAVPLTVHCPLAEVPGLLSIGLIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAELLA
DGITATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVRTSPDHGTAFDIAGRGTAHPGAMV
FALLMAGECAARRADA

Sequences:

>Translated_336_residues
MGEPQRPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPIQEIDDIAEANSAFLEALPVI
KGLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHASGVVTAPIAKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAG
PSLRAVPLTVHCPLAEVPGLLSIGLIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAELLA
DGITATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVRTSPDHGTAFDIAGRGTAHPGAMV
FALLMAGECAARRADA
>Mature_335_residues
GEPQRPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPIQEIDDIAEANSAFLEALPVIK
GLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHASGVVTAPIAKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAGP
SLRAVPLTVHCPLAEVPGLLSIGLIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAELLAD
GITATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVRTSPDHGTAFDIAGRGTAHPGAMVF
ALLMAGECAARRADA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=36.7781155015198, Blast_Score=179, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_ERYLH (Q2N8X0)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458668.1
- ProteinModelPortal:   Q2N8X0
- SMR:   Q2N8X0
- STRING:   Q2N8X0
- GeneID:   3870181
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_08895
- NMPDR:   fig|314225.3.peg.1264
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   KSGKFSF
- PhylomeDB:   Q2N8X0
- BioCyc:   ELIT314225:ELI_08895-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 34465; Mature: 34334

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: BINDING 140-140 BINDING 279-279 BINDING 288-288 BINDING 297-297

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEPQRPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPI
CCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCH
QEIDDIAEANSAFLEALPVIKGLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHASGVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEE
TAPIAKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAGPSLRAVPLTVHCPLAEVPGL
EHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEECCHHHCCCH
LSIGLIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAELLA
HHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DGITATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVRTSP
CCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEECCEEEEECC
DHGTAFDIAGRGTAHPGAMVFALLMAGECAARRADA
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GEPQRPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPI
CCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCH
QEIDDIAEANSAFLEALPVIKGLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHASGVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEE
TAPIAKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAGPSLRAVPLTVHCPLAEVPGL
EHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEECCHHHCCCH
LSIGLIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAELLA
HHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DGITATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVRTSP
CCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEECCEEEEECC
DHGTAFDIAGRGTAHPGAMVFALLMAGECAARRADA
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA