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The map label for this gene is rppH

Identifier: 85374243

GI number: 85374243

Start: 1467776

End: 1468270

Strand: Direct

Name: rppH

Synonym: ELI_07080

Alternate gene names: 85374243

Gene position: 1467776-1468270 (Clockwise)

Preceding gene: 85374242

Following gene: 85374249

Centisome position: 48.09

GC content: 61.21

Gene sequence:

>495_bases
ATGGCCAGCGGCTCGGCGGACCACGAGGACTTGCGATACCGGCAATGCGCCGGCGTCATGCTCGCCAACCGCGAAGGGTT
GGTCTTCGCAGCGCAACGGATCGACTCGAAAAACCTCGGCGCATGGCAAATGCCGCAAGGCGGGATAGATCCGGGCGAGA
CGCAACAAGAAGCGGCGATGCGCGAGTTGGAAGAGGAAACCGGCGTTTCCGCCGATCTGGCCGATGTGATTGCGCGCATG
CCCTACCCGGTCCGCTATGATTTGCCGGAGGAATTGCAGGGCAAGCTATGGGGAGGGAGATACCGAGGCCAGGAGCAGCA
CTGGTTCCTCGCCCGCTTCACGGGCACGGATGCCGACATCGATATCGCTGCCCATAATCCCCCCGAATTCAGCGAGTGGA
AATGGGTCGAACCCGACGAACTTCCGCGTCTTATCGTGCCCTTCAAGCGCGAAGTTTACCGCGCCGTCGTCAAGGAATTC
CGGTCGTTGATCTAG

Upstream 100 bases:

>100_bases
ACAGCTTCACCAACCTGCGGCAAGCAGTCCCGAGCTACCAGCGCGAGCTCGACAACGTCATCCAGGTCATGAAGCTGATG
CTGGCGGTGAAAAGTTGACT

Downstream 100 bases:

>100_bases
CTCTCGTCATCCCGACGAAATCAGGGATTTCGTAAGGGCAGAACGGCGCTGGTTCGAATGCATCCCAGCCTTCGCTGGAT
TACGCGGAACCATCAATTCT

Product: NUDIX family hydrolase NudH subfamily hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MASGSADHEDLRYRQCAGVMLANREGLVFAAQRIDSKNLGAWQMPQGGIDPGETQQEAAMRELEEETGVSADLADVIARM
PYPVRYDLPEELQGKLWGGRYRGQEQHWFLARFTGTDADIDIAAHNPPEFSEWKWVEPDELPRLIVPFKREVYRAVVKEF
RSLI

Sequences:

>Translated_164_residues
MASGSADHEDLRYRQCAGVMLANREGLVFAAQRIDSKNLGAWQMPQGGIDPGETQQEAAMRELEEETGVSADLADVIARM
PYPVRYDLPEELQGKLWGGRYRGQEQHWFLARFTGTDADIDIAAHNPPEFSEWKWVEPDELPRLIVPFKREVYRAVVKEF
RSLI
>Mature_163_residues
ASGSADHEDLRYRQCAGVMLANREGLVFAAQRIDSKNLGAWQMPQGGIDPGETQQEAAMRELEEETGVSADLADVIARMP
YPVRYDLPEELQGKLWGGRYRGQEQHWFLARFTGTDADIDIAAHNPPEFSEWKWVEPDELPRLIVPFKREVYRAVVKEFR
SLI

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=158, Percent_Identity=39.873417721519, Blast_Score=112, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_ERYLH (Q2N9Y3)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458305.1
- ProteinModelPortal:   Q2N9Y3
- SMR:   Q2N9Y3
- STRING:   Q2N9Y3
- GeneID:   3868887
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_07080
- NMPDR:   fig|314225.3.peg.1632
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   AGRAWKG
- PhylomeDB:   Q2N9Y3
- BioCyc:   ELIT314225:ELI_07080-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18705; Mature: 18574

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGSADHEDLRYRQCAGVMLANREGLVFAAQRIDSKNLGAWQMPQGGIDPGETQQEAAM
CCCCCCCHHHHHHHHHHCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
RELEEETGVSADLADVIARMPYPVRYDLPEELQGKLWGGRYRGQEQHWFLARFTGTDADI
HHHHHHHCCCHHHHHHHHHCCCCEECCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCCE
DIAAHNPPEFSEWKWVEPDELPRLIVPFKREVYRAVVKEFRSLI
EEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASGSADHEDLRYRQCAGVMLANREGLVFAAQRIDSKNLGAWQMPQGGIDPGETQQEAAM
CCCCCCHHHHHHHHHHCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
RELEEETGVSADLADVIARMPYPVRYDLPEELQGKLWGGRYRGQEQHWFLARFTGTDADI
HHHHHHHCCCHHHHHHHHHCCCCEECCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCCE
DIAAHNPPEFSEWKWVEPDELPRLIVPFKREVYRAVVKEFRSLI
EEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA