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The map label for this gene is lip2 [H]

Identifier: 85374242

GI number: 85374242

Start: 1466823

End: 1467773

Strand: Direct

Name: lip2 [H]

Synonym: ELI_07075

Alternate gene names: 85374242

Gene position: 1466823-1467773 (Clockwise)

Preceding gene: 85374239

Following gene: 85374243

Centisome position: 48.05

GC content: 65.62

Gene sequence:

>951_bases
ATGCAAGACACCGAATTCTTCGTGCGCGATGACGTGCGCAACTTCCTGGCGATGCTGGAGCAGGCCGGGGGCGCACCGAT
CGACGAGGTCTCGCTTGAGGAAGCGCGCGCCGCCTATATGGCATTGCACCAGATGGCCGATGCGCCCGCGCGCGAACTGG
CGGTGATCAAGGATTTGAGCTGCCCCGGCCCGGCCGGCGACATCGGTTTGCGGCTCTACGATACGCAGGAAAGCCGCGAT
CCCGGTCCGGTCATCGTGTTCTACCATGGCGGCGGTTTCGTGATCGGCGATCTCGATACGCACAATGCATTGTGCACGGA
GATCGCGGCGCAGATGGACCTGCCGGTCGTGGCGGTCGACTATCGCCTTGCGCCCGAGCATCCCTTCCCCGCCCCGATCG
AGGATTGCATCGCCGCAACGCGCTGGATCGCCGGATCGCCCGACGCCCTGGGTCGCGGCGCGACGGGCGTCATCCCGATC
GGCGACAGCGCCGGCGGCAATGCCACAATCGTCGTCAGCCAGGCGCTTGCGCAGGAGCCCGCCGATGCGCCGGTCGTGCT
GCAAGTGCCGATCTTTCCGCTGGCGAGCGACAGCGCCAGGTCCAACAGCATCGAGGCCTTCGCGGAAGGCTTCGTGCTGA
CCAAGGCCGCAATCGAATTTTTCGAAGCCGCCTACAAGCCCGACAAGAACGACCCGCGGGCCATGCCGATCCTCGGCAGG
CACGAGGACACGCCGCCGACCGTGCTGGTCACTGCCAGCCTCGACCCGATCCGCGATTCAGGGCGCGACTATGCCGCCGC
CCTCGCCCATGCGGGTATCGACCACGTCTTCCTCGAAGTCGAAGGCGGCACCCACAGCTTCACCAACCTGCGGCAAGCAG
TCCCGAGCTACCAGCGCGAGCTCGACAACGTCATCCAGGTCATGAAGCTGATGCTGGCGGTGAAAAGTTGA

Upstream 100 bases:

>100_bases
TGTGGGCGGGCAATCAAGTTTTTCTGTCACATCGGGTAATCGCGGCAGGTGGACAGTTTGCGCGCTGCCGCTATGCCTTT
GAGACAAGAGGAGAGCCGCG

Downstream 100 bases:

>100_bases
CTATGGCCAGCGGCTCGGCGGACCACGAGGACTTGCGATACCGGCAATGCGCCGGCGTCATGCTCGCCAACCGCGAAGGG
TTGGTCTTCGCAGCGCAACG

Product: putative lipase/esterase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MQDTEFFVRDDVRNFLAMLEQAGGAPIDEVSLEEARAAYMALHQMADAPARELAVIKDLSCPGPAGDIGLRLYDTQESRD
PGPVIVFYHGGGFVIGDLDTHNALCTEIAAQMDLPVVAVDYRLAPEHPFPAPIEDCIAATRWIAGSPDALGRGATGVIPI
GDSAGGNATIVVSQALAQEPADAPVVLQVPIFPLASDSARSNSIEAFAEGFVLTKAAIEFFEAAYKPDKNDPRAMPILGR
HEDTPPTVLVTASLDPIRDSGRDYAAALAHAGIDHVFLEVEGGTHSFTNLRQAVPSYQRELDNVIQVMKLMLAVKS

Sequences:

>Translated_316_residues
MQDTEFFVRDDVRNFLAMLEQAGGAPIDEVSLEEARAAYMALHQMADAPARELAVIKDLSCPGPAGDIGLRLYDTQESRD
PGPVIVFYHGGGFVIGDLDTHNALCTEIAAQMDLPVVAVDYRLAPEHPFPAPIEDCIAATRWIAGSPDALGRGATGVIPI
GDSAGGNATIVVSQALAQEPADAPVVLQVPIFPLASDSARSNSIEAFAEGFVLTKAAIEFFEAAYKPDKNDPRAMPILGR
HEDTPPTVLVTASLDPIRDSGRDYAAALAHAGIDHVFLEVEGGTHSFTNLRQAVPSYQRELDNVIQVMKLMLAVKS
>Mature_316_residues
MQDTEFFVRDDVRNFLAMLEQAGGAPIDEVSLEEARAAYMALHQMADAPARELAVIKDLSCPGPAGDIGLRLYDTQESRD
PGPVIVFYHGGGFVIGDLDTHNALCTEIAAQMDLPVVAVDYRLAPEHPFPAPIEDCIAATRWIAGSPDALGRGATGVIPI
GDSAGGNATIVVSQALAQEPADAPVVLQVPIFPLASDSARSNSIEAFAEGFVLTKAAIEFFEAAYKPDKNDPRAMPILGR
HEDTPPTVLVTASLDPIRDSGRDYAAALAHAGIDHVFLEVEGGTHSFTNLRQAVPSYQRELDNVIQVMKLMLAVKS

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=128, Percent_Identity=39.84375, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI206597554, Length=285, Percent_Identity=27.3684210526316, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI61966717, Length=131, Percent_Identity=32.0610687022901, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21328446, Length=90, Percent_Identity=37.7777777777778, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI157041237, Length=95, Percent_Identity=36.8421052631579, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786682, Length=276, Percent_Identity=26.4492753623188, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17567059, Length=278, Percent_Identity=25.5395683453237, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533410, Length=95, Percent_Identity=37.8947368421053, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533412, Length=95, Percent_Identity=37.8947368421053, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001146, Length=147, Percent_Identity=34.6938775510204, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540028, Length=111, Percent_Identity=36.036036036036, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71996133, Length=111, Percent_Identity=35.1351351351351, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656084, Length=105, Percent_Identity=37.1428571428571, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24656076, Length=105, Percent_Identity=37.1428571428571, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI20130169, Length=105, Percent_Identity=37.1428571428571, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 33741; Mature: 33741

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDTEFFVRDDVRNFLAMLEQAGGAPIDEVSLEEARAAYMALHQMADAPARELAVIKDLS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
CPGPAGDIGLRLYDTQESRDPGPVIVFYHGGGFVIGDLDTHNALCTEIAAQMDLPVVAVD
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCEEEEE
YRLAPEHPFPAPIEDCIAATRWIAGSPDALGRGATGVIPIGDSAGGNATIVVSQALAQEP
EEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHHCCC
ADAPVVLQVPIFPLASDSARSNSIEAFAEGFVLTKAAIEFFEAAYKPDKNDPRAMPILGR
CCCCEEEEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECC
HEDTPPTVLVTASLDPIRDSGRDYAAALAHAGIDHVFLEVEGGTHSFTNLRQAVPSYQRE
CCCCCCEEEEEECCCCHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
LDNVIQVMKLMLAVKS
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDTEFFVRDDVRNFLAMLEQAGGAPIDEVSLEEARAAYMALHQMADAPARELAVIKDLS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
CPGPAGDIGLRLYDTQESRDPGPVIVFYHGGGFVIGDLDTHNALCTEIAAQMDLPVVAVD
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCEEEEE
YRLAPEHPFPAPIEDCIAATRWIAGSPDALGRGATGVIPIGDSAGGNATIVVSQALAQEP
EEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHHCCC
ADAPVVLQVPIFPLASDSARSNSIEAFAEGFVLTKAAIEFFEAAYKPDKNDPRAMPILGR
CCCCEEEEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECC
HEDTPPTVLVTASLDPIRDSGRDYAAALAHAGIDHVFLEVEGGTHSFTNLRQAVPSYQRE
CCCCCCEEEEEECCCCHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
LDNVIQVMKLMLAVKS
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]