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The map label for this gene is yxbG [H]

Identifier: 85373123

GI number: 85373123

Start: 341137

End: 341922

Strand: Direct

Name: yxbG [H]

Synonym: ELI_01480

Alternate gene names: 85373123

Gene position: 341137-341922 (Clockwise)

Preceding gene: 85373122

Following gene: 85373124

Centisome position: 11.18

GC content: 64.25

Gene sequence:

>786_bases
ATGGAAGTATCAGCCAACACCCCCGCCGTCGTGACCGGTGGTGCATCGGGCCTCGGCGAGGCCACCGCCCGCGCGCTCGC
TGCCAAGGGCGCGAAGGTCGCCATCTTCGACATGAACGAAGAGAAGGGCGAAGCCGTCGCCAAGGATATCGGCGGCGTGT
TTTGCAAGGTCAATGTGACCAGCGATGAAGAGGTCGACGCCGGTTTCGCCAAGGCCCGCGACGCGCACGGGCAGGAGCGC
ATCCTGGTCAACTGCGCCGGCATCGGCAATGCGATCAAAACCGCCAGTCGCGACAAGCAGACCGGTGAAATCAAGCATTT
CCCGATTTCGGCTTTCGACTTCGTGATCCAGGTGAACCTGATCGGCACCTTCCGCTGCATCGCCAAGTCGGCCGCCGGGA
TGATGAGCCTCGACCCGCTTTCGGACGAAGGCGATCGCGGCGCTATCGTGAACACCGCTTCGGTCGCGGCTGAAGACGGG
CAGATGGGCCAGGCCGCCTATTCGGCATCGAAGGGCGGCGTCGTCGGCATGACCCTGCCGATCGCGCGCGACCTCATGCG
CGAAGGCATCCGCGTGAATACCATCCTGCCGGGCATCTTCAACACTCCGCTGATGAACGCCGCCCCGCCGCAGGTGAAGG
AAGCGCTCGCCGCCAGCGTCCCGTTCCCCAAGCGGCTCGGCAATGCGGAAGAATACGCCAATCTCGCCATGTGCATGATC
GAGACCGGCTATTTCAACGGCGAGGACGTCCGCTTGGACGGCGCCATCCGCATGGCACCGCGGTAA

Upstream 100 bases:

>100_bases
CGAAGCCCCGTCCTTTTCTTCGGGTGCGCGGTTCCAAAAAGAAGTACGGCCCTTCGACAGGCTCAGGGCGAACGGTTTTT
TTGTGTTTCAGGAGAGAATA

Downstream 100 bases:

>100_bases
GGATGGACTTTCCTACAGATAGGGCGAGCGCTAGCTTGTCGACATGATATACGCAGCGCCCCGCATTCCCCTGTTTCGGC
AGCGGAATCGGGGCGCTGCT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MEVSANTPAVVTGGASGLGEATARALAAKGAKVAIFDMNEEKGEAVAKDIGGVFCKVNVTSDEEVDAGFAKARDAHGQER
ILVNCAGIGNAIKTASRDKQTGEIKHFPISAFDFVIQVNLIGTFRCIAKSAAGMMSLDPLSDEGDRGAIVNTASVAAEDG
QMGQAAYSASKGGVVGMTLPIARDLMREGIRVNTILPGIFNTPLMNAAPPQVKEALAASVPFPKRLGNAEEYANLAMCMI
ETGYFNGEDVRLDGAIRMAPR

Sequences:

>Translated_261_residues
MEVSANTPAVVTGGASGLGEATARALAAKGAKVAIFDMNEEKGEAVAKDIGGVFCKVNVTSDEEVDAGFAKARDAHGQER
ILVNCAGIGNAIKTASRDKQTGEIKHFPISAFDFVIQVNLIGTFRCIAKSAAGMMSLDPLSDEGDRGAIVNTASVAAEDG
QMGQAAYSASKGGVVGMTLPIARDLMREGIRVNTILPGIFNTPLMNAAPPQVKEALAASVPFPKRLGNAEEYANLAMCMI
ETGYFNGEDVRLDGAIRMAPR
>Mature_261_residues
MEVSANTPAVVTGGASGLGEATARALAAKGAKVAIFDMNEEKGEAVAKDIGGVFCKVNVTSDEEVDAGFAKARDAHGQER
ILVNCAGIGNAIKTASRDKQTGEIKHFPISAFDFVIQVNLIGTFRCIAKSAAGMMSLDPLSDEGDRGAIVNTASVAAEDG
QMGQAAYSASKGGVVGMTLPIARDLMREGIRVNTILPGIFNTPLMNAAPPQVKEALAASVPFPKRLGNAEEYANLAMCMI
ETGYFNGEDVRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=51.7647058823529, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=49.0196078431373, Blast_Score=208, Evalue=3e-54,
Organism=Homo sapiens, GI15277342, Length=271, Percent_Identity=30.9963099630996, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI40254992, Length=253, Percent_Identity=30.0395256916996, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI31542939, Length=264, Percent_Identity=28.030303030303, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI5031737, Length=264, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI33667109, Length=207, Percent_Identity=31.4009661835749, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=202, Percent_Identity=29.7029702970297, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI66933014, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI224922801, Length=179, Percent_Identity=30.7262569832402, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=27.4809160305344, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=31.8897637795276, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789057, Length=219, Percent_Identity=31.0502283105023, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=30.078125, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI87082100, Length=268, Percent_Identity=27.6119402985075, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=259, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=29.296875, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788459, Length=262, Percent_Identity=27.0992366412214, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=27.34375, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=51.2, Blast_Score=239, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI25147288, Length=262, Percent_Identity=32.824427480916, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=33.8461538461538, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=284, Percent_Identity=26.4084507042254, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=204, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=250, Percent_Identity=28.4, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320089, Length=232, Percent_Identity=26.7241379310345, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=50.5836575875486, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24639444, Length=261, Percent_Identity=33.7164750957854, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=29.1187739463602, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571526, Length=201, Percent_Identity=30.3482587064677, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27193; Mature: 27193

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVSANTPAVVTGGASGLGEATARALAAKGAKVAIFDMNEEKGEAVAKDIGGVFCKVNVT
CCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCEEEEEECC
SDEEVDAGFAKARDAHGQERILVNCAGIGNAIKTASRDKQTGEIKHFPISAFDFVIQVNL
CCCCCCCCHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCCCCEEECCCHHEEEEEEEEH
IGTFRCIAKSAAGMMSLDPLSDEGDRGAIVNTASVAAEDGQMGQAAYSASKGGVVGMTLP
HHHHHHHHHHHCCCEEECCCCCCCCCCEEEEHHHHCCCCCCCCHHHHHCCCCCEEEEEHH
IARDLMREGIRVNTILPGIFNTPLMNAAPPQVKEALAASVPFPKRLGNAEEYANLAMCMI
HHHHHHHCCCEEEEECCCHHCCCCCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHEEEEEE
ETGYFNGEDVRLDGAIRMAPR
ECCCCCCCEEEECCEEEECCC
>Mature Secondary Structure
MEVSANTPAVVTGGASGLGEATARALAAKGAKVAIFDMNEEKGEAVAKDIGGVFCKVNVT
CCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCEEEEEECC
SDEEVDAGFAKARDAHGQERILVNCAGIGNAIKTASRDKQTGEIKHFPISAFDFVIQVNL
CCCCCCCCHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCCCCEEECCCHHEEEEEEEEH
IGTFRCIAKSAAGMMSLDPLSDEGDRGAIVNTASVAAEDGQMGQAAYSASKGGVVGMTLP
HHHHHHHHHHHCCCEEECCCCCCCCCCEEEEHHHHCCCCCCCCHHHHHCCCCCEEEEEHH
IARDLMREGIRVNTILPGIFNTPLMNAAPPQVKEALAASVPFPKRLGNAEEYANLAMCMI
HHHHHHHCCCEEEEECCCHHCCCCCCCCCHHHHHHHHHCCCCHHHCCCHHHHHHEEEEEE
ETGYFNGEDVRLDGAIRMAPR
ECCCCCCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]