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The map label for this gene is cycA [H]

Identifier: 84625461

GI number: 84625461

Start: 4304613

End: 4305989

Strand: Reverse

Name: cycA [H]

Synonym: XOO_3804

Alternate gene names: 84625461

Gene position: 4305989-4304613 (Counterclockwise)

Preceding gene: 84625464

Following gene: 84625459

Centisome position: 87.16

GC content: 60.71

Gene sequence:

>1377_bases
ATGTCTGACCCGTCCGCGCCCGATCATCTGCAACGCAGTCTGTCCAATCGTCACTTGCAGTTGATCGCCATCGGCGGAGC
GATCGGGACCGGCCTGTTCATGGGTTCGGGCAAGACCATCAGTCTGGCCGGGCCGTCCATCCTGTTCGTTTATCTCATCA
TCGGCGCGATGCTGTTCTTCGTGATGCGTGCGATGGGCGAGCTGCTGCTCTCCAATCTGGAATACAAGTCGTTCATCGAT
TTCTCCACCGACTTGCTCGGGCCGTGGGCCGGATTTTTCTGCGGATGGACGTACTGGTTTTGCTGGATCATCACCGCCAT
CGCCGATGTCATCGCCATTGCGGCCTATGCGCAGTTCTGGTTTCCAGGATTGGCGCCGTGGATTCCCGCGGTCTTGTGCG
TGTTGTTGCTGCTGAGCCTGAATCTGGTCAAGGTGAAATTGTTTGGTGAGATGGAATTCTGGTTTGCGCTGATCAAGATC
ATCGCCATTGCCGCATTGATCATGACCGGCGCCGGTCTGGTGGTGTGGGGCTTCCGCTCGCCGTCAGGCAACGTGGCCTC
GCTGTCGAATCTGTGGAACGACGGCGGCATGTTCCCGATGGGCATCGGCGGATTCTTTGCCGGCTTCCAGATTGCTGTGT
TCGCCTTCGTCGGTATCGAGTTGGTCGGCACCACTGCTGCAGAAACCGCCGACCCGCGCCGCAATCTGCCCAAGGCGATC
AATTCGATTCCGGTGCGGATTCTGATCTTCTACGTGCTTGCGTTGATCGCCATCATGGCGGTGACGCCGTGGCGGCAGGT
GGTGGCCGACAAGAGCCCGTTCGTGGAGTTGTTCGTACTGGCGGGCGTGCCGGCGGCGGCGAGCCTGATCAACTTCGTGG
TGCTGACCTCGGCCACCTCGTCGGCCAATAGCGGCATCTTTTCCACCAGCCGCATGCTTTACGGCCTGGCCGAAGAACAG
CATGCGCCCAACGGCTTCGCCAAGCTGTCGCGTGCGTCGGTGCCGGCGCGCGGCCTGCTGTTTTCCTGCCTGTGCCTGCT
GCTGGGCGCGATGCTGGTGTATCTGATCCCCAATCTGGTCACCGCGTTTACGCTGGTCACCACGCTGTCGGCGGTGCTTT
TCATGTTCGTGTGGTCGCTGATCCTGTGCGCCTACATCGCTTACCGCCGCAAGTGCCCGGAGCAGCACGCCGTCTCGGCG
TTCAAGATGCCCGGCGGCGTGCTGATGTGCTACGTGTGCCTGTCATTCTTTGCCTTCGTCATCGTGCTGCTGATGCTGCA
GGACGACACACGTCAGGCATTGCTGGCCAGCCCGGTGTGGTTCCTGCTCCTGGCCATTGGCTATGCAGTCAAACGCCGCC
AGAACCGGCAGCGCTGA

Upstream 100 bases:

>100_bases
AGACGTGTCCATCACAGCCTGGCACAAGGCGCGCCCCCTGGCACGCATGGGCGCGATCTCGTATCCTGACCAGTTTGCCC
ACTCCTCCGGTGCCGTGCCC

Downstream 100 bases:

>100_bases
GCGATCCGTGTGCAACTCATACCGTGTGCAGCGTGCAGCGTGCGGCGGTGAGCGCACGCTGCGAGCTGTGATGTCGATGC
GCGTGTACCTGGATCATTCA

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFFVMRAMGELLLSNLEYKSFID
FSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFWFPGLAPWIPAVLCVLLLLSLNLVKVKLFGEMEFWFALIKI
IAIAALIMTGAGLVVWGFRSPSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATSSANSGIFSTSRMLYGLAEEQ
HAPNGFAKLSRASVPARGLLFSCLCLLLGAMLVYLIPNLVTAFTLVTTLSAVLFMFVWSLILCAYIAYRRKCPEQHAVSA
FKMPGGVLMCYVCLSFFAFVIVLLMLQDDTRQALLASPVWFLLLAIGYAVKRRQNRQR

Sequences:

>Translated_458_residues
MSDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFFVMRAMGELLLSNLEYKSFID
FSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFWFPGLAPWIPAVLCVLLLLSLNLVKVKLFGEMEFWFALIKI
IAIAALIMTGAGLVVWGFRSPSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATSSANSGIFSTSRMLYGLAEEQ
HAPNGFAKLSRASVPARGLLFSCLCLLLGAMLVYLIPNLVTAFTLVTTLSAVLFMFVWSLILCAYIAYRRKCPEQHAVSA
FKMPGGVLMCYVCLSFFAFVIVLLMLQDDTRQALLASPVWFLLLAIGYAVKRRQNRQR
>Mature_457_residues
SDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFFVMRAMGELLLSNLEYKSFIDF
STDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFWFPGLAPWIPAVLCVLLLLSLNLVKVKLFGEMEFWFALIKII
AIAALIMTGAGLVVWGFRSPSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAIN
SIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATSSANSGIFSTSRMLYGLAEEQH
APNGFAKLSRASVPARGLLFSCLCLLLGAMLVYLIPNLVTAFTLVTTLSAVLFMFVWSLILCAYIAYRRKCPEQHAVSAF
KMPGGVLMCYVCLSFFAFVIVLLMLQDDTRQALLASPVWFLLLAIGYAVKRRQNRQR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=357, Percent_Identity=23.249299719888, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI181337167, Length=330, Percent_Identity=22.7272727272727, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790653, Length=462, Percent_Identity=67.3160173160173, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=39.6929824561403, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=41.3566739606127, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI1786789, Length=457, Percent_Identity=37.855579868709, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI48994972, Length=450, Percent_Identity=40.4444444444444, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI87081915, Length=452, Percent_Identity=38.0530973451327, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1789017, Length=451, Percent_Identity=31.0421286031042, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1788480, Length=443, Percent_Identity=35.2144469525959, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI87081708, Length=397, Percent_Identity=34.0050377833753, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI2367353, Length=375, Percent_Identity=24.8, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=357, Percent_Identity=22.1288515406162, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324924, Length=418, Percent_Identity=33.9712918660287, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324061, Length=441, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=444, Percent_Identity=30.4054054054054, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=454, Percent_Identity=30.3964757709251, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=481, Percent_Identity=29.1060291060291, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324553, Length=391, Percent_Identity=30.1790281329923, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6324059, Length=447, Percent_Identity=31.5436241610738, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=483, Percent_Identity=26.0869565217391, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=405, Percent_Identity=27.4074074074074, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=26.8472906403941, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319542, Length=407, Percent_Identity=25.7985257985258, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321629, Length=435, Percent_Identity=27.3563218390805, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=391, Percent_Identity=27.3657289002558, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=27.8048780487805, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319608, Length=395, Percent_Identity=26.3291139240506, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321053, Length=396, Percent_Identity=26.5151515151515, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=424, Percent_Identity=27.122641509434, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=444, Percent_Identity=23.8738738738739, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45550968, Length=414, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921172, Length=414, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49915; Mature: 49784

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFF
CCCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHH
VMRAMGELLLSNLEYKSFIDFSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPGLAPWIPAVLCVLLLLSLNLVKVKLFGEMEFWFALIKIIAIAALIMTGAGLVVWGFRS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
PSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
SANSGIFSTSRMLYGLAEEQHAPNGFAKLSRASVPARGLLFSCLCLLLGAMLVYLIPNLV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TAFTLVTTLSAVLFMFVWSLILCAYIAYRRKCPEQHAVSAFKMPGGVLMCYVCLSFFAFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
IVLLMLQDDTRQALLASPVWFLLLAIGYAVKRRQNRQR
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDPSAPDHLQRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFVYLIIGAMLFF
CCCCCHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHH
VMRAMGELLLSNLEYKSFIDFSTDLLGPWAGFFCGWTYWFCWIITAIADVIAIAAYAQFW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPGLAPWIPAVLCVLLLLSLNLVKVKLFGEMEFWFALIKIIAIAALIMTGAGLVVWGFRS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
PSGNVASLSNLWNDGGMFPMGIGGFFAGFQIAVFAFVGIELVGTTAAETADPRRNLPKAI
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHH
NSIPVRILIFYVLALIAIMAVTPWRQVVADKSPFVELFVLAGVPAAASLINFVVLTSATS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
SANSGIFSTSRMLYGLAEEQHAPNGFAKLSRASVPARGLLFSCLCLLLGAMLVYLIPNLV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TAFTLVTTLSAVLFMFVWSLILCAYIAYRRKCPEQHAVSAFKMPGGVLMCYVCLSFFAFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
IVLLMLQDDTRQALLASPVWFLLLAIGYAVKRRQNRQR
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]