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The map label for this gene is hslU [H]

Identifier: 84625420

GI number: 84625420

Start: 4255435

End: 4256802

Strand: Reverse

Name: hslU [H]

Synonym: XOO_3763

Alternate gene names: 84625420

Gene position: 4256802-4255435 (Counterclockwise)

Preceding gene: 84625421

Following gene: 84625414

Centisome position: 86.17

GC content: 60.67

Gene sequence:

>1368_bases
ATGCCAAATCCCGATACATCCACCATGACTCCGCGCGAAATCGTGCAGGAGCTCGACCGTCATATCGTTGGCCAGCACGA
CGCCAAGCGCGCGGTTGCCATCGCGCTGCGTAATCGCTGGCGTCGCATGCAGTTGCCGGAAGAACTGCGCAACGAAGTGA
TGCCCAAGAACATCCTGATGATCGGTCCCACCGGCGTGGGCAAGACCGAGATCGCGCGGCGTCTGGCCACGCTGGCCAAT
GCGCCCTTCGTCAAGGTGGAAGCCACGCGCTTTACCGAAGTGGGGTATGTGGGCAAGGACGTGGAGCAGATCATTCGTGA
CCTGGCCGACACCTCGGTCAAGCTGTACCGCGAGCAGGCCAAGGTGCGCGTGCGCAATCAGGCCGAAGAGCGTGCCGAAG
ATTGCATTCTGGATGCGCTGTTGCCGCGTCGTGCAACCGGAATTGGGTTCGACCCGGAAGCGGCGCGCAACGAGCCGTCG
TCGCAGGAAAACGACACCCGCATCAAGTTCCGCCGCATGCTGCGCAACGGCGAGCTGGACGAGCGCGAGATCGAACTGGA
AGTCGCCGTCAACGCCAGCATGGACATCATGACCCCGCCGGGCATGGAGGAAATGGGCCAACAATTGCGCCAGATGTTTT
CCAATCTGGGTAGCGGCAAGTCGCAGAAGCGCAAGCTCACCATCAAGGCGGCGCGCCCGCTGTTGATCGAAGAAGAGGCC
GGCAAGCTGGTCAACGAAGACGACGTGCGCACCGCAGCGATCAAAGCCTGCGAGCAGCACGGCATCGTATTTATCGATGA
GATCGATAAGGTGGCCAAGCGCGGCGAAGCCGGCTCCAATGGCGGCGATGTCAGTCGCGAAGGTGTGCAGCGCGATTTGT
TGCCGCTGGTGGAAGGCTCCAACGTGTCGACCAAGTACGGCACGGTCAAGACCGACCACATTCTGTTCATTGCATCAGGC
GCGTTTCACCTGGCCAAGCCCAGTGATCTGATTCCGGAATTGCAGGGCCGCTTCCCGATCCGCGTGGAATTGACAGCGCT
GACCAAGGCCGATTTCGTGCGCATTCTCACTGAGCCCAAAGCCGCGTTGATCAAGCAATACGAAGCCTTGTTGCAGACCG
AAGGCGTGTCGTTGACGTTCGCGCAAGATGCAGTGGATCGGCTGGCCGAGATTGCGGCTCAGGTCAACGAGCGCCAGGAA
AATATCGGCGCGCGTCGCCTGCACACTGTGCTGGAACGTTTGCTCGATGTGTTGAGCTACGAAGCGCCGGACCGCGATGG
ACAGAGCGTTACTGTCGATGCCGCGTATGTGGACGCGCAGCTGGGTGAGCTGGTGCAGGATCCGGATCTGAGCCGCTATA
TCCTCTGA

Upstream 100 bases:

>100_bases
GGGAATCGGCAATCGGCAATCGCAACAGCGGTTTCGTCCCCATGTCCTCGACCCATGCTCTTGCCATTTCCCTTTCCCTT
TCCCAATTCTCGATTCCCCA

Downstream 100 bases:

>100_bases
CGGTGCTGTACGGCGACGTGCAAACAGGTGGCGAATTCAACTCCGATTCGCAACGCTGTTGAGGAGCTCCTCGGAGAAGA
CTTCGAGGGGCTTAGACTCA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPNPDTSTMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLAN
APFVKVEATRFTEVGYVGKDVEQIIRDLADTSVKLYREQAKVRVRNQAEERAEDCILDALLPRRATGIGFDPEAARNEPS
SQENDTRIKFRRMLRNGELDEREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
GKLVNEDDVRTAAIKACEQHGIVFIDEIDKVAKRGEAGSNGGDVSREGVQRDLLPLVEGSNVSTKYGTVKTDHILFIASG
AFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPKAALIKQYEALLQTEGVSLTFAQDAVDRLAEIAAQVNERQE
NIGARRLHTVLERLLDVLSYEAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL

Sequences:

>Translated_455_residues
MPNPDTSTMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLAN
APFVKVEATRFTEVGYVGKDVEQIIRDLADTSVKLYREQAKVRVRNQAEERAEDCILDALLPRRATGIGFDPEAARNEPS
SQENDTRIKFRRMLRNGELDEREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
GKLVNEDDVRTAAIKACEQHGIVFIDEIDKVAKRGEAGSNGGDVSREGVQRDLLPLVEGSNVSTKYGTVKTDHILFIASG
AFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPKAALIKQYEALLQTEGVSLTFAQDAVDRLAEIAAQVNERQE
NIGARRLHTVLERLLDVLSYEAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL
>Mature_454_residues
PNPDTSTMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLANA
PFVKVEATRFTEVGYVGKDVEQIIRDLADTSVKLYREQAKVRVRNQAEERAEDCILDALLPRRATGIGFDPEAARNEPSS
QENDTRIKFRRMLRNGELDEREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEAG
KLVNEDDVRTAAIKACEQHGIVFIDEIDKVAKRGEAGSNGGDVSREGVQRDLLPLVEGSNVSTKYGTVKTDHILFIASGA
FHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPKAALIKQYEALLQTEGVSLTFAQDAVDRLAEIAAQVNERQEN
IGARRLHTVLERLLDVLSYEAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=37.8378378378378, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790366, Length=450, Percent_Identity=65.5555555555556, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1786642, Length=236, Percent_Identity=34.3220338983051, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71988663, Length=245, Percent_Identity=26.9387755102041, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6319704, Length=303, Percent_Identity=28.3828382838284, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648291, Length=249, Percent_Identity=31.7269076305221, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24648289, Length=249, Percent_Identity=31.7269076305221, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 50774; Mature: 50642

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPDTSTMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILM
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEE
IGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIIRDLADTSVKLYREQA
ECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVRVRNQAEERAEDCILDALLPRRATGIGFDPEAARNEPSSQENDTRIKFRRMLRNGELD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCC
EREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
CCEEEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEHHH
GKLVNEDDVRTAAIKACEQHGIVFIDEIDKVAKRGEAGSNGGDVSREGVQRDLLPLVEGS
CCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
NVSTKYGTVKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPK
CCCCCCCCEEECEEEEEECCCEECCCCHHHHHHHCCCCCEEEEEEEHHHHHHHHHHCCCH
AALIKQYEALLQTEGVSLTFAQDAVDRLAEIAAQVNERQENIGARRLHTVLERLLDVLSY
HHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL
CCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PNPDTSTMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILM
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEE
IGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIIRDLADTSVKLYREQA
ECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVRVRNQAEERAEDCILDALLPRRATGIGFDPEAARNEPSSQENDTRIKFRRMLRNGELD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCC
EREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
CCEEEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEHHH
GKLVNEDDVRTAAIKACEQHGIVFIDEIDKVAKRGEAGSNGGDVSREGVQRDLLPLVEGS
CCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
NVSTKYGTVKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPK
CCCCCCCCEEECEEEEEECCCEECCCCHHHHHHHCCCCCEEEEEEEHHHHHHHHHHCCCH
AALIKQYEALLQTEGVSLTFAQDAVDRLAEIAAQVNERQENIGARRLHTVLERLLDVLSY
HHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL
CCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]