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The map label for this gene is folK [H]

Identifier: 84625368

GI number: 84625368

Start: 4195603

End: 4196118

Strand: Reverse

Name: folK [H]

Synonym: XOO_3711

Alternate gene names: 84625368

Gene position: 4196118-4195603 (Counterclockwise)

Preceding gene: 84625369

Following gene: 84625366

Centisome position: 84.94

GC content: 65.31

Gene sequence:

>516_bases
ATGACTACCGTGCTTCTCAGCCTCGGCAGCAATGTCCAGCCGACCCACTACCTGCGCTTGGCCGTCGCCGCCCTGCGCGC
GCGCTTTGGCCAGATCGACGTTTCCCCTGCGTACCGCACGCCGGCGGTGGGCTTCGATGGCCCGGACTTCGTCAACAACG
CGGTGGTATTGCAGACCGATCTGGAGCTGGACGCGCTGGATCACTGGTTGCATGCGTTGGAAGATGCGCATGGGCGCGAT
CGCAGCGGCCCGCGTTTCAGCAACCGCACGCTGGATATGGATGTGGTGTTCTTTGGCGACTGCATCGTCGAAGGCTCCGG
GCACCCGCGCATCCCGCGGCCCGAGCTCAAACATGCATTCGTGCTCAAGCCGCTGGCCGATATCGCGCCGGACTTCATCG
ACCCGCTGAGCGGGCAGACGTTGGCAGCATTGTGGCAGGCGCATCCGCAGTACGGCGGCGCGTTTACGACGGTGGAACTG
GATGCCGCTGCGCCGGAGTTGAGCGCGGCGCAGTAG

Upstream 100 bases:

>100_bases
GTGGCCTGACAGCACGTTTCTGCGCACCCGATGCGGGCTGGATAGATGCGATACGATTGCAACAGTTGACGCCCACGCCG
GCCGCATGCGCGAATAACGT

Downstream 100 bases:

>100_bases
CAGGGGTCTGGCGGCTTGGCTGCGTGTGGCTGGGCGCGCGTGCGGGCAGCGATACGACGTGCGACACCTGTGTGGAAGTG
GCACCTAGCGCTGCGGCAGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTTVLLSLGSNVQPTHYLRLAVAALRARFGQIDVSPAYRTPAVGFDGPDFVNNAVVLQTDLELDALDHWLHALEDAHGRD
RSGPRFSNRTLDMDVVFFGDCIVEGSGHPRIPRPELKHAFVLKPLADIAPDFIDPLSGQTLAALWQAHPQYGGAFTTVEL
DAAAPELSAAQ

Sequences:

>Translated_171_residues
MTTVLLSLGSNVQPTHYLRLAVAALRARFGQIDVSPAYRTPAVGFDGPDFVNNAVVLQTDLELDALDHWLHALEDAHGRD
RSGPRFSNRTLDMDVVFFGDCIVEGSGHPRIPRPELKHAFVLKPLADIAPDFIDPLSGQTLAALWQAHPQYGGAFTTVEL
DAAAPELSAAQ
>Mature_170_residues
TTVLLSLGSNVQPTHYLRLAVAALRARFGQIDVSPAYRTPAVGFDGPDFVNNAVVLQTDLELDALDHWLHALEDAHGRDR
SGPRFSNRTLDMDVVFFGDCIVEGSGHPRIPRPELKHAFVLKPLADIAPDFIDPLSGQTLAALWQAHPQYGGAFTTVELD
AAAPELSAAQ

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=143, Percent_Identity=35.6643356643357, Blast_Score=71, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18551; Mature: 18420

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVLLSLGSNVQPTHYLRLAVAALRARFGQIDVSPAYRTPAVGFDGPDFVNNAVVLQTD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCHHHHCCEEEEEEC
LELDALDHWLHALEDAHGRDRSGPRFSNRTLDMDVVFFGDCIVEGSGHPRIPRPELKHAF
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCCHHH
VLKPLADIAPDFIDPLSGQTLAALWQAHPQYGGAFTTVELDAAAPELSAAQ
HCCCHHHHCHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TTVLLSLGSNVQPTHYLRLAVAALRARFGQIDVSPAYRTPAVGFDGPDFVNNAVVLQTD
EEEEEECCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCHHHHCCEEEEEEC
LELDALDHWLHALEDAHGRDRSGPRFSNRTLDMDVVFFGDCIVEGSGHPRIPRPELKHAF
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCCHHH
VLKPLADIAPDFIDPLSGQTLAALWQAHPQYGGAFTTVELDAAAPELSAAQ
HCCCHHHHCHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]