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The map label for this gene is prlC [H]

Identifier: 84622346

GI number: 84622346

Start: 741519

End: 743543

Strand: Direct

Name: prlC [H]

Synonym: XOO_0689

Alternate gene names: 84622346

Gene position: 741519-743543 (Clockwise)

Preceding gene: 84622345

Following gene: 84622347

Centisome position: 15.01

GC content: 64.1

Gene sequence:

>2025_bases
ATGACCAACCCGCTGCTCGATCTGTCCGGACTGCCGTCCTTCGATGCGATCCGCCCCGAACACGTGGGCCCGGCGATCGA
CCAATTGCTCGCCGAGGCCGAGGCGGCGGTGAAGGCAGCCGAGCAGGTCAGCCCGGTGCGCTGGGACAGCTTCGTGACGC
CGCTGGACGATGCCACCGAGCGGCTGTGGCGTGCGTGGGCGCAGGTGGGGCATCTGCAGGCGGTGGTCAACACGCCGGAG
CTGCGCGAGGCCTACAACAGCAATCTGCCCAAGGTGAGCCGCTTCGGCAGCGCGCTGGGTCAGAATCTGGCGCTGTATGC
GCAATACAAGGCGCTGGCGCAATCGCCGGAAGCCGCACACTTCGATGAAGCCCGTCGCAAGGTGCTGGAAAACGCGCTGC
GCGATTTCCGCCTGGGCGGTGCCGAGCTCGATGACGCCGCCAAGGCGCGGTTTGCGCAAATCCAGGAAGAACTCTCGGCA
TTGGCGGCCAAGTTTTTGCAGAACGTGCTCGACGCCACCGATGCGTGGTGTTACCTCACCGAAGACGACACGCAGTTATC
AGGGCTGACGGCCGAAGTGATCGCTGCGGCACGCGCTGCCGCAGAACAGGACCGCGTGCCAGGTTGGAAATTCACCTTGC
AGATGCCGTGCTATCTGCCGGTGCAAACCGATGCGGACAGCCGCGAGTTGCGCGCGCTGTTGTATCGCGCCAATGCCGAG
CGCGCGTCCGAATTTGGCGATGCCGCGCTGGACAACAGCGCCAACATCGATCGCATTCTGGCCTTGCGCGCCGAGTTGGC
ACAGCTGCTCGGCTTCGCCAGCTACGCGGACTATTCCGTCGCTACCAAGATGGCGCAGAGCCCCGATGAAGTGATGGGCT
TTCTGCGCGATCTGGCCGTGCGTGCCAAGCCGCACGCGCAGCGTGACCGTGCCGAGCTGGAAGCCTTTGCGCGCGACGAA
CTCGGTCTGCACGACCTGCATGCCTGGGACCTGGCGTACGCATCGGAAAAGCTCAAGCAGGCGCGTTACAGCTTCTCCGA
GCAGGAGGTGAAACAGTACTTCACCGAGCCGAAGGTGCTGGCCGGCCTGTTCGATGTGATCCACAGCCTGTACGGGCTTA
CGGTCAAGCCGGACAGCGCGCCGGTGTGGCATCCGGATGTGCGGTTTTACCGGCTGGAAGATGCGCAAGGCGCCCTGGTC
GGCCAGTTCTATCTGGACCTGTATGCGCGCGAGGGCAAGCGCGGTGGCGCGTGGATGGACGACTGCCGCAATCGTCGCAC
CACCGCCAACGGGGTGCAGACGCCGCTGGTGTATCTGGTGTGCAACTTCGGCCGCGGTAGCGGCAATGCACCGGCCACCT
TCCGCCACGGCGAAGTCACCACGCTGTTCCATGAGATGGGCCACGGCCTGCATCAGTTGCTGACGCGTATCGGCGAGCTG
GGTGTAGCGGGTATCAACGGCGTGGAGTGGGATGCAGTCGAGTTGCCGAGCCAGTTCATGGAAAACTTCTGCTGGGAATG
GGAGCGCGTGCAGGCAATGACCGCACACGTGCAGACCGGCGAGCCGCTGCCGCGCAACCTGTTCGATCGCCTGCTGGCAG
CACGCAATTTCCAGAGCGGCATGTTCACCGTGCGCCAGCTGGAATTCGCCTTGTTCGATATGCAGCTGCACAGCAACTTC
GACCCGAGCCGAGACAGCTTGCTGCAACTCATCGAGCGCGTGCGTGACGAAGTGGCGGTCAATCGGCCGCCGGCCTGGAA
TCGCTTCCCGCATCAGTTCAGCCACATCTTCGCAGGCGGCTACGCAGCCGGCTATTACAGCTACAAATGGGCCGAAGTGC
TCAGTGCCGATGCCTATGCTGCGTTCGAAGAGGCGCCGGAGCAGGTAGCTGACACTGGCGCACGTTTCCGCCATGAAGTG
TTGTCGCGCGGCGGCAGCCGCAGCGCGGCTGACAATTTCCGTGCTTTCCGTGGGCGCGCGCCAAGTATCGATGCGTTGCT
GCGCCACAGTGGCATGGCCGGCTGA

Upstream 100 bases:

>100_bases
GCGCTGGCCGTGAATGGCGGCGATTTGCCTGCTTTGCCTTGTGCAGCGCTGGAATGACCGCCATATCGGGCAATCATCCA
GTCCACCACCGGAGCGCCCC

Downstream 100 bases:

>100_bases
TACAGCGGTATGGCGCGCCGGTCGCCGGCGCGCCTTCGATGAACGCATGCACAACCGGCCACGCCGGGCTGGGCGGCGTA
TTGCAGAATTTACGCGGCCC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MTNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATERLWRAWAQVGHLQAVVNTPE
LREAYNSNLPKVSRFGSALGQNLALYAQYKALAQSPEAAHFDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSA
LAAKFLQNVLDATDAWCYLTEDDTQLSGLTAEVIAAARAAAEQDRVPGWKFTLQMPCYLPVQTDADSRELRALLYRANAE
RASEFGDAALDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAVRAKPHAQRDRAELEAFARDE
LGLHDLHAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGALV
GQFYLDLYAREGKRGGAWMDDCRNRRTTANGVQTPLVYLVCNFGRGSGNAPATFRHGEVTTLFHEMGHGLHQLLTRIGEL
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHSNF
DPSRDSLLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAPEQVADTGARFRHEV
LSRGGSRSAADNFRAFRGRAPSIDALLRHSGMAG

Sequences:

>Translated_674_residues
MTNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATERLWRAWAQVGHLQAVVNTPE
LREAYNSNLPKVSRFGSALGQNLALYAQYKALAQSPEAAHFDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSA
LAAKFLQNVLDATDAWCYLTEDDTQLSGLTAEVIAAARAAAEQDRVPGWKFTLQMPCYLPVQTDADSRELRALLYRANAE
RASEFGDAALDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAVRAKPHAQRDRAELEAFARDE
LGLHDLHAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGALV
GQFYLDLYAREGKRGGAWMDDCRNRRTTANGVQTPLVYLVCNFGRGSGNAPATFRHGEVTTLFHEMGHGLHQLLTRIGEL
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHSNF
DPSRDSLLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAPEQVADTGARFRHEV
LSRGGSRSAADNFRAFRGRAPSIDALLRHSGMAG
>Mature_673_residues
TNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATERLWRAWAQVGHLQAVVNTPEL
REAYNSNLPKVSRFGSALGQNLALYAQYKALAQSPEAAHFDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSAL
AAKFLQNVLDATDAWCYLTEDDTQLSGLTAEVIAAARAAAEQDRVPGWKFTLQMPCYLPVQTDADSRELRALLYRANAER
ASEFGDAALDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAVRAKPHAQRDRAELEAFARDEL
GLHDLHAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVLAGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGALVG
QFYLDLYAREGKRGGAWMDDCRNRRTTANGVQTPLVYLVCNFGRGSGNAPATFRHGEVTTLFHEMGHGLHQLLTRIGELG
VAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSGMFTVRQLEFALFDMQLHSNFD
PSRDSLLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAPEQVADTGARFRHEVL
SRGGSRSAADNFRAFRGRAPSIDALLRHSGMAG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=610, Percent_Identity=30.983606557377, Blast_Score=267, Evalue=3e-71,
Organism=Homo sapiens, GI14149738, Length=671, Percent_Identity=28.0178837555887, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI156105687, Length=673, Percent_Identity=24.3684992570579, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=49.2647058823529, Blast_Score=651, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=686, Percent_Identity=31.1953352769679, Blast_Score=268, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71999758, Length=560, Percent_Identity=24.4642857142857, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565901, Length=600, Percent_Identity=23.6666666666667, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319793, Length=686, Percent_Identity=27.6967930029155, Blast_Score=281, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322715, Length=602, Percent_Identity=24.9169435215947, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356111, Length=679, Percent_Identity=29.160530191458, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI20129717, Length=423, Percent_Identity=27.6595744680851, Blast_Score=147, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 75178; Mature: 75047

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATE
CCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHH
RLWRAWAQVGHLQAVVNTPELREAYNSNLPKVSRFGSALGQNLALYAQYKALAQSPEAAH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCH
FDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSALAAKFLQNVLDATDAWCYLT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
EDDTQLSGLTAEVIAAARAAAEQDRVPGWKFTLQMPCYLPVQTDADSRELRALLYRANAE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHCHH
RASEFGDAALDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAV
HHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKPHAQRDRAELEAFARDELGLHDLHAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVL
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHH
AGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGALVGQFYLDLYAREGKRGGAWMD
HHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHH
DCRNRRTTANGVQTPLVYLVCNFGRGSGNAPATFRHGEVTTLFHEMGHGLHQLLTRIGEL
HHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHC
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
MFTVRQLEFALFDMQLHSNFDPSRDSLLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
YAAGYYSYKWAEVLSADAYAAFEEAPEQVADTGARFRHEVLSRGGSRSAADNFRAFRGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
PSIDALLRHSGMAG
CCHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLDLSGLPSFDAIRPEHVGPAIDQLLAEAEAAVKAAEQVSPVRWDSFVTPLDDATE
CCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHH
RLWRAWAQVGHLQAVVNTPELREAYNSNLPKVSRFGSALGQNLALYAQYKALAQSPEAAH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCH
FDEARRKVLENALRDFRLGGAELDDAAKARFAQIQEELSALAAKFLQNVLDATDAWCYLT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
EDDTQLSGLTAEVIAAARAAAEQDRVPGWKFTLQMPCYLPVQTDADSRELRALLYRANAE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHCHH
RASEFGDAALDNSANIDRILALRAELAQLLGFASYADYSVATKMAQSPDEVMGFLRDLAV
HHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RAKPHAQRDRAELEAFARDELGLHDLHAWDLAYASEKLKQARYSFSEQEVKQYFTEPKVL
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHH
AGLFDVIHSLYGLTVKPDSAPVWHPDVRFYRLEDAQGALVGQFYLDLYAREGKRGGAWMD
HHHHHHHHHHHCCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHH
DCRNRRTTANGVQTPLVYLVCNFGRGSGNAPATFRHGEVTTLFHEMGHGLHQLLTRIGEL
HHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHC
GVAGINGVEWDAVELPSQFMENFCWEWERVQAMTAHVQTGEPLPRNLFDRLLAARNFQSG
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
MFTVRQLEFALFDMQLHSNFDPSRDSLLQLIERVRDEVAVNRPPAWNRFPHQFSHIFAGG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
YAAGYYSYKWAEVLSADAYAAFEEAPEQVADTGARFRHEVLSRGGSRSAADNFRAFRGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
PSIDALLRHSGMAG
CCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]