Click here to switch to the map view.

The map label for this gene is cysM [C]

Identifier: 84622345

GI number: 84622345

Start: 740372

End: 741475

Strand: Direct

Name: cysM [C]

Synonym: XOO_0688

Alternate gene names: 84622345

Gene position: 740372-741475 (Clockwise)

Preceding gene: 84622340

Following gene: 84622346

Centisome position: 14.99

GC content: 66.03

Gene sequence:

>1104_bases
ATGTCGCAGCGCCAGTGGGTGGCCGCCGCCATCCAGAAGATCGAAGCCGATTTCAATCGTTCGGCCGACACCCATCTGAT
CCCGATGGATCTGCAGGGCTATCCGGGCATCGATCTGTACTTCAAGGACGAGTCCAGCCACCCGACCGGCAGCCTCAAGC
ACCGTCTGGCGCGCTCGCTGTTCCTGTACGCGCTGACCAACGGTTGGCTGCGCGCCGGGCGCCCGGTGATCGAGGCGTCC
AGCGGCTCCACCGCCATTTCCGAAGCGTATTTCGCGCGCCTGCTGGGCGTGCCCTTCATCGCGGTGATGCCGGCTTCGAC
CTCGCCGGAGAAGATCGCTGCGATCGAATTCCAGGGTGGTCGTTGCCATCTGGTCGCGCGCGCCTGCGATCTGGACAGCG
CCTCGCACCAGCTTGCGCACGAGACCGGCGGGCACTTCATGGACCAGTTCACTTACGCCGAGCGTGCCACCGATTGGCGC
GCCAACAACAACATCGCCGAATCGATCTTCAAGCAACTGGCCGAGGAGCCGCACCCGATTCCGGACTGGATCGTGTGCAG
CCCCGGCACCGGCGGCACCAGCGCCACCTTGGGCCGCTACGTGCGCTATCGGCGCCACGCCACCCGCATCCTCTGCGCCG
ATCCGGAAGTGTCGGTGTTCTTCGACGGCTATTGCCGCACGGTGGATGGCCACTGCCCCAAGGAGCTGGCCATCACCGGC
GGCTCGCGCATCGAGGGCATCGGCCGCCCACGGGTGGAGTCGAGCTTCATTGCCAGCTGCGTGGACGTGATGATCAAGGT
ACCCGATGCATTGAGCCTGGCGGCGATGCGGCACGTCAGCGCCACGCTCGGCCGCCGCGTCGGTGGCTCCACCGGCACCA
ACTTCGTTGGCGTGCTGCATGCCGCCCGCCGCATGCGCGACGAGGGCCGGCAGGGCTCCATCGTCACCATCCTGTGCGAT
GCCGGCGAGCGTTACGCGCACAGTTATTACGATCCGGCCTGGTACGTGGCGCGCGAGATCGATGTCAGCGACAACGATGC
GGCCATTGCGCTGGCCGTGAATGGCGGCGATTTGCCTGCTTTGCCTTGTGCAGCGCTGGAATGA

Upstream 100 bases:

>100_bases
AGCATCGGCCTCCAGCCAGCTGCCGGCCCGATGACCTGGCTGCGCGGGCGCGCGGGCGACGGCGGTAGAATTGAGACTAC
TTTCGCAGCCAAGTCCTGCC

Downstream 100 bases:

>100_bases
CCGCCATATCGGGCAATCATCCAGTCCACCACCGGAGCGCCCCATGACCAACCCGCTGCTCGATCTGTCCGGACTGCCGT
CCTTCGATGCGATCCGCCCC

Product: cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSQRQWVAAAIQKIEADFNRSADTHLIPMDLQGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGRPVIEAS
SGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGGRCHLVARACDLDSASHQLAHETGGHFMDQFTYAERATDWR
ANNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRTVDGHCPKELAITG
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLHAARRMRDEGRQGSIVTILCD
AGERYAHSYYDPAWYVAREIDVSDNDAAIALAVNGGDLPALPCAALE

Sequences:

>Translated_367_residues
MSQRQWVAAAIQKIEADFNRSADTHLIPMDLQGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGRPVIEAS
SGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGGRCHLVARACDLDSASHQLAHETGGHFMDQFTYAERATDWR
ANNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRTVDGHCPKELAITG
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLHAARRMRDEGRQGSIVTILCD
AGERYAHSYYDPAWYVAREIDVSDNDAAIALAVNGGDLPALPCAALE
>Mature_366_residues
SQRQWVAAAIQKIEADFNRSADTHLIPMDLQGYPGIDLYFKDESSHPTGSLKHRLARSLFLYALTNGWLRAGRPVIEASS
GSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGGRCHLVARACDLDSASHQLAHETGGHFMDQFTYAERATDWRA
NNNIAESIFKQLAEEPHPIPDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRTVDGHCPKELAITGG
SRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLHAARRMRDEGRQGSIVTILCDA
GERYAHSYYDPAWYVAREIDVSDNDAAIALAVNGGDLPALPCAALE

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=27.0967741935484, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=27.0967741935484, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=27.0967741935484, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=27.2108843537415, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=353, Percent_Identity=34.2776203966006, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17539800, Length=361, Percent_Identity=30.4709141274238, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17539640, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321449, Length=347, Percent_Identity=28.5302593659942, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=308, Percent_Identity=26.2987012987013, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643623, Length=337, Percent_Identity=28.486646884273, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI20129101, Length=337, Percent_Identity=28.486646884273, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39882; Mature: 39751

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRQWVAAAIQKIEADFNRSADTHLIPMDLQGYPGIDLYFKDESSHPTGSLKHRLARSL
CCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYALTNGWLRAGRPVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGG
HHHHHHHCHHHCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCC
RCHLVARACDLDSASHQLAHETGGHFMDQFTYAERATDWRANNNIAESIFKQLAEEPHPI
EEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
PDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRTVDGHCPKELAITG
CCEEEECCCCCCCHHHHHHHHHHHHHHCEEEECCCCEEEEECCEEEECCCCCCCCEEECC
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLH
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AARRMRDEGRQGSIVTILCDAGERYAHSYYDPAWYVAREIDVSDNDAAIALAVNGGDLPA
HHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCCCC
LPCAALE
CCCCCCC
>Mature Secondary Structure 
SQRQWVAAAIQKIEADFNRSADTHLIPMDLQGYPGIDLYFKDESSHPTGSLKHRLARSL
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYALTNGWLRAGRPVIEASSGSTAISEAYFARLLGVPFIAVMPASTSPEKIAAIEFQGG
HHHHHHHCHHHCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCC
RCHLVARACDLDSASHQLAHETGGHFMDQFTYAERATDWRANNNIAESIFKQLAEEPHPI
EEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
PDWIVCSPGTGGTSATLGRYVRYRRHATRILCADPEVSVFFDGYCRTVDGHCPKELAITG
CCEEEECCCCCCCHHHHHHHHHHHHHHCEEEECCCCEEEEECCEEEECCCCCCCCEEECC
GSRIEGIGRPRVESSFIASCVDVMIKVPDALSLAAMRHVSATLGRRVGGSTGTNFVGVLH
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AARRMRDEGRQGSIVTILCDAGERYAHSYYDPAWYVAREIDVSDNDAAIALAVNGGDLPA
HHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCCCC
LPCAALE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]