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The map label for this gene is norM [H]

Identifier: 83720398

GI number: 83720398

Start: 1897421

End: 1898815

Strand: Reverse

Name: norM [H]

Synonym: BTH_I1686

Alternate gene names: 83720398

Gene position: 1898815-1897421 (Counterclockwise)

Preceding gene: 83720446

Following gene: 161723165

Centisome position: 49.85

GC content: 71.76

Gene sequence:

>1395_bases
ATGTCGCCTTCCGGTTTCACTCGAGCGGCCGCCGCGCCGCCTCCCACGCTGTCCCGCCACGCCGCCGATACGGCGCGCCT
CGCCGCGCCGCTCGCGATCGCGCAGCTCTCGCAAATGGCGATGAGCGTCACCGACACGGTGCTGCTCGGCTCGCTCGGCC
CCGACGCGCTCGCGGCGGGCGGCCTCGGCGCGAATCTGTTCTTCGTCGTCGTGACGCTGCTGCAAGGCGTGCTGACGTCG
GTCAGCGTGAGCGTCGCGCACGCGCGCGGCGCCATGGCCGACGATCGCGTGCCGCATATCTACTGGACGGGCTTCGCGCT
GTCGCTGTTGCTCGCGGTTCCCGCATTCGCGCTGCTGTCGTTCGCGCAGCCGCTGTTGCTCGCGTTCGGCGAACCGGCGG
CGCTCGCGCGCAACGTCGGCGAATATGCGGCCGTACTGCGCTTCGCGGCGCCCGGCAGCCTGATCGGCGTCGGGCTGATG
CGCTCGTTCTTGCCCGCGATCGGCGCGGCGAAGCGGCTGCTGTGGGTGTCGCTCGCGGGCGTCGGCGTCAACGCGTTTCT
CAACTACGGGCTGATCCACGGCGCGTTTGGGCTGCCGCGGCTCGGCTTCCTCGGCTCCGCAACGGCAACGACGATCACGA
TCTGGCTCACCGCGATCACGCTCGTCGCGCTGCTGCACGGACGGCCGGCGTTCAAGCACTTCGTCGCCGCCACGCGCCCG
CGCCTGCCGCTGATGGGCGAGCTGTTCGGCATCGGCTGGCCGGTCGCGATCACGTACGGCGTCGAGTCGACGCTCTTTCT
CGCGACGGGCCTGACCGTCGGCGTGCTCGGCGAAGCGTCGCTCGCCGCGCATCAGATCGCGCTCAACGTCGCGTCGGTGG
CCTTCATGGTGCCGCTCGCGATCGGGCAGGCGGCGAACGTGCGCGTCGGCTACTGGGCGGGCGCGGGCGCGCCCGTCGCC
GCGCGGCATGCGGGCTTCGTCGCGCTCGGGCTCGGCGTCGCGTTCATGTCGCTGTCGGGGCTCGCGCTGATCGTCGCGCC
GCACGCGATCGTCGGCCTCTATCTGAAGCTCGACGATCCCGCGAACGCACATACGGTCGCGCTCGCGACGTCGCTGCTCG
GCATCGCCGCGGTGTTCCAGATCGTCGACGGGATGCAGACCGTCGGCTCCGGCTGCCTGCGCGGCCTGAAAGACACGCGC
GTGCCGATGCTCGCCGCGACGCTCGGCTACTGGGGCATCGGCTTTCCGACCGGCTACTGGTTCGCGTTCCACGCAGGCCT
CGGCGCGCGCGGATTATGGTGGGGGCTCGCGGCCGGCCTCGCGAGCGTCGCGGTGCTGATGACGTGGCGATTCCATCGGA
AGAGCGCCGCGCTCGGCGCGCGGGCGGGAGCTTGA

Upstream 100 bases:

>100_bases
ATCGGCAACGGCTCATCGACAGCACTCGCGGAAACTCGTAAGCTGATCGTTTCCAAAAAATAAGCAAAGCGCGGGCGGGC
CGCTCGTGCGAACGCGTCCC

Downstream 100 bases:

>100_bases
GGGCGGGCTTCGGCGTGGGCGCGTGAGCATGCAAGCTCGCGAGGACTCGGGCGCGTTTGCGCGTTTGCGCGGATAAACGG
ATAAGCGGATAAACGGATAA

Product: multidrug resistance protein NorM

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSPSGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTS
VSVSVAHARGAMADDRVPHIYWTGFALSLLLAVPAFALLSFAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLM
RSFLPAIGAAKRLLWVSLAGVGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRPAFKHFVAATRP
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGEASLAAHQIALNVASVAFMVPLAIGQAANVRVGYWAGAGAPVA
ARHAGFVALGLGVAFMSLSGLALIVAPHAIVGLYLKLDDPANAHTVALATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTR
VPMLAATLGYWGIGFPTGYWFAFHAGLGARGLWWGLAAGLASVAVLMTWRFHRKSAALGARAGA

Sequences:

>Translated_464_residues
MSPSGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTS
VSVSVAHARGAMADDRVPHIYWTGFALSLLLAVPAFALLSFAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLM
RSFLPAIGAAKRLLWVSLAGVGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRPAFKHFVAATRP
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGEASLAAHQIALNVASVAFMVPLAIGQAANVRVGYWAGAGAPVA
ARHAGFVALGLGVAFMSLSGLALIVAPHAIVGLYLKLDDPANAHTVALATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTR
VPMLAATLGYWGIGFPTGYWFAFHAGLGARGLWWGLAAGLASVAVLMTWRFHRKSAALGARAGA
>Mature_463_residues
SPSGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGANLFFVVVTLLQGVLTSV
SVSVAHARGAMADDRVPHIYWTGFALSLLLAVPAFALLSFAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLMR
SFLPAIGAAKRLLWVSLAGVGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRPAFKHFVAATRPR
LPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGEASLAAHQIALNVASVAFMVPLAIGQAANVRVGYWAGAGAPVAA
RHAGFVALGLGVAFMSLSGLALIVAPHAIVGLYLKLDDPANAHTVALATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTRV
PMLAATLGYWGIGFPTGYWFAFHAGLGARGLWWGLAAGLASVAVLMTWRFHRKSAALGARAGA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=424, Percent_Identity=27.3584905660377, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI153792564, Length=445, Percent_Identity=25.1685393258427, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994890, Length=435, Percent_Identity=31.264367816092, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI226510954, Length=446, Percent_Identity=26.6816143497758, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320545, Length=430, Percent_Identity=23.0232558139535, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47491; Mature: 47360

Theoretical pI: Translated: 10.87; Mature: 10.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
GLGANLFFVVVTLLQGVLTSVSVSVAHARGAMADDRVPHIYWTGFALSLLLAVPAFALLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
FAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLMRSFLPAIGAAKRLLWVSLAG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRPAFKHFVAATRP
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGEASLAAHQIALNVASVAFMVPLA
CCCHHHHHHCCCCCEEEEECCCHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHH
IGQAANVRVGYWAGAGAPVAARHAGFVALGLGVAFMSLSGLALIVAPHAIVGLYLKLDDP
CCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEECHHHEEEEEEECCC
ANAHTVALATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTRVPMLAATLGYWGIGFPTGYW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCCCCHHH
FAFHAGLGARGLWWGLAAGLASVAVLMTWRFHRKSAALGARAGA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SPSGFTRAAAAPPPTLSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
GLGANLFFVVVTLLQGVLTSVSVSVAHARGAMADDRVPHIYWTGFALSLLLAVPAFALLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
FAQPLLLAFGEPAALARNVGEYAAVLRFAAPGSLIGVGLMRSFLPAIGAAKRLLWVSLAG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVNAFLNYGLIHGAFGLPRLGFLGSATATTITIWLTAITLVALLHGRPAFKHFVAATRP
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
RLPLMGELFGIGWPVAITYGVESTLFLATGLTVGVLGEASLAAHQIALNVASVAFMVPLA
CCCHHHHHHCCCCCEEEEECCCHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHH
IGQAANVRVGYWAGAGAPVAARHAGFVALGLGVAFMSLSGLALIVAPHAIVGLYLKLDDP
CCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEECHHHEEEEEEECCC
ANAHTVALATSLLGIAAVFQIVDGMQTVGSGCLRGLKDTRVPMLAATLGYWGIGFPTGYW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCCCCHHH
FAFHAGLGARGLWWGLAAGLASVAVLMTWRFHRKSAALGARAGA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA